KLF9 (Kruppel Like Factor 9) induced PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2, 6-Biphosphatase 3) downregulation inhibits the proliferation, metastasis and aerobic glycolysis of cutaneous squamous cell carcinoma cells

References

• Ratushny V, Gober MD, Hick R. Ridky TW and Seykora JT. From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma. J Clin Invest. 2012;122(2):464–472.
   PubMed Web of Science ®Google Scholar
• Jellouli-Elloumi A, Kochbati L, Dhraief S. Ben Romdhane K and Maalej M. [Cancers arising from burn scars: 62 cases]. Annales de dermatologie et de venereologie. 2003;130:413–416.
   PubMed Web of Science ®Google Scholar
• Flower C, Gaskin D, Bhamjee S. Bhamjee S and Bynoe Z. High-risk variants of cutaneous squamous cell carcinoma in patients with discoid lupus erythematosus: a case series. Lupus. 2013;22(7):736–739.
   PubMed Web of Science ®Google Scholar
• Das KK, Chakaraborty A, Rahman A. Rahman A and Khandkar S. Incidences of malignancy in chronic burn scar ulcers: experience from Bangladesh. Burns. 2015;41(6):1315–1321.
   PubMed Web of Science ®Google Scholar
• Knackstedt TJ, Collins LK, Li Z, et al. Squamous cell carcinoma arising in hypertrophic lichen planus: a review and analysis of 38 cases. Dermatologic Surg. 2015;41(12):1411–1418.
   PubMed Web of Science ®Google Scholar
• Waldman A, Schmults C. Cutaneous squamous cell carcinoma. Hematol Oncol Clin North Am. 2019;33(1):1–12.
   PubMed Web of Science ®Google Scholar
• Erlendsson AM, Thaysen-Petersen D, Bay C, et al. Repeated treatments with ingenol mebutate for prophylaxis of UV-induced squamous cell carcinoma in hairless mice. Journal of Photochemistry and Photobiology B: Biology. 2016;163:144–149.
   PubMed Web of Science ®Google Scholar
• Gressel K, Oberyszyn T, Everts H. Oberyszyn T and Everts H. Effects of acute UVB on retinoid metabolism. The FASEB Journal. 2015;29(S1):604–606.
   Google Scholar
• Kim C, Ko CJ, Leffell DJ. Cutaneous squamous cell carcinomas of the lower extremity: a distinct subset of squamous cell carcinomas. J Am Acad Dermatol. 2014;70(1):70–74.
   PubMed Web of Science ®Google Scholar
• Szeimies RM, Karrer S. Towards a more specific therapy: targeting nonmelanoma skin cancer cells. Br J Dermatol. 2006;154(Suppl 1):16–21.
   PubMedGoogle Scholar
• Pilkis SJ, Claus TH. Kurland IJ and Lange AJ. 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme. Annu Rev Biochem. 1995;64(1):799–835.
   PubMedGoogle Scholar
• Okar DA, Manzano A, Navarro-Sabatè A, et al. PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2,6-bisphosphate. Trends Biochem Sci. 2001;26(1):30–35.
   PubMed Web of Science ®Google Scholar
• Minchenko OH, Tsuchihara K, Minchenko DO. Bikfalvi A and Esumi H. Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells. World J Gastroenterol. 2014;20(38):13705–13717.
   PubMed Web of Science ®Google Scholar
• Imbert-Fernandez Y, Clem BF, O’Neal J, et al. Estradiol stimulates glucose metabolism via 6-phosphofructo-2-kinase (PFKFB3). J Biol Chem. 2014;289:9440–9448.
   PubMed Web of Science ®Google Scholar
• Clem B. Telang S and Yalcin A. Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer. Exp Mol Pathol. 2009;86:174–179.
   PubMed Web of Science ®Google Scholar
• Chen L, Cao Y, Wu B, et al. MicroRNA-3666 suppresses cell growth in head and neck squamous cell carcinoma through inhibition of PFKFB3-mediated warburg effect. Onco Targets Ther. 2020;13:9029–9041.
   PubMed Web of Science ®Google Scholar
• Liu J, Liu ZX, Wu QN, et al. Long noncoding RNA AGPG regulates PFKFB3-mediated tumor glycolytic reprogramming. Nat Commun. 2020;11: 1507.
   Web of Science ®Google Scholar
• Li -J-J, Mao X-H, Tian T, et al. Role of PFKFB3 and CD163 in oral squamous cell carcinoma angiogenesis. Curr Med Sci. 2019;39(3):410–414.
   PubMed Web of Science ®Google Scholar
• Li HM, Yang JG, Liu ZJ, et al. Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma. J Exp Clin Cancer Res. 2017;36: 7.
   Web of Science ®Google Scholar
• Kang L, Lai M. BTEB/KLF9 and its transcriptional regulation. Hereditas. 2007;29:515–522.
   PubMedGoogle Scholar
• Qiao F, Yao F, Chen L, et al. Krüppel-like factor 9 was down-regulated in esophageal squamous cell carcinoma and negatively regulated beta-catenin/TCF signaling. Mol Carcinog. 2016;55(3):280–291.
   PubMed Web of Science ®Google Scholar
• Jin Y, Yang L, Li X. MicroRNA-652 promotes cell proliferation and osteosarcoma invasion by directly targeting KLF9. Exp Ther Med. 2020;20:2953–2960.
   PubMed Web of Science ®Google Scholar
• Li Y, Sun Q, Jiang M, et al. KLF9 suppresses gastric cancer cell invasion and metastasis through transcriptional inhibition of MMP28. The FASEB Journal. 2019;33(7):7915–7928.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods. 2001;25(4):402–408.
   PubMed Web of Science ®Google Scholar
• Zhou L, Wang Y, Zhou M, et al. HOXA9 inhibits HIF-1alpha-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development. Nat Commun. 2018;9: 1480.
   Web of Science ®Google Scholar
• Vaquerizas JM, Kummerfeld SK, Teichmann SA. Teichmann SA and Luscombe NM: a census of human transcription factors: function, expression and evolution. Nat Rev Genet. 2009;10(4):252–263.
   PubMed Web of Science ®Google Scholar
• Darnell, Darnell JE. Transcription factors as targets for cancer therapy. Nat Rev Cancer. 2002;2(10):740–749.
   PubMed Web of Science ®Google Scholar
• Simmen RCM, Zhang X-L, Michel FJ, Zhao G and Simmen FA, et al. Molecular markers of endometrial epithelial cell mitogenesis mediated by the Sp/Krüppel-like factor BTEB1. DNA Cell Biol. 2002;21(2):115–128.
   PubMed Web of Science ®Google Scholar
• Ying M, Sang Y, Li Y, et al. Krüppel-like family of transcription factor 9, a differentiation-associated transcription factor, suppresses Notch1 signaling and inhibits glioblastoma-initiating stem cells. Stem Cells. 2011;29(1):20–31.
   PubMed Web of Science ®Google Scholar
• Kong YJ, Tan XX, Zhang Y, et al. MiR-141 promotes cell proliferation and invasion in non-small cell lung cancer by targeting KLF9. Eur Rev Med Pharmacol Sci. 2019;23:10370–10378.
   PubMed Web of Science ®Google Scholar
• He Q, Huang L, Yan D, et al. CircPTPRA acts as a tumor suppressor in bladder cancer by sponging miR-636 and upregulating KLF9. Aging (Albany NY). 2019;11(23):11314–11328.
   PubMedGoogle Scholar
• Chen D-P, Ning W-R, Jiang -Z-Z, et al. Glycolytic activation of peritumoral monocytes fosters immune privilege via the PFKFB3-PD-L1 axis in human hepatocellular carcinoma. J Hepatol. 2019;71(2):333–343.
   PubMed Web of Science ®Google Scholar
• Deng X, Yi X, Deng J, et al. ROCK2 promotes osteosarcoma growth and metastasis by modifying PFKFB3 ubiquitination and degradation. Exp Cell Res. 2019;385(2):111689.
   PubMed Web of Science ®Google Scholar
• Peng F, Li Q, Sun JY, Chen M and Bao Y, et al. PFKFB3 is involved in breast cancer proliferation, migration, invasion and angiogenesis. Int J Oncol. 2018;52:945–954.
   PubMed Web of Science ®Google Scholar
• Chowdhury N, Vhora I, Patel K, Mondal A and Singh M, et al. liposomes co-loaded with 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) shRNA plasmid and docetaxel for the treatment of non-small cell lung cancer. Pharm Res. 2017;34(11):2371–2384.
   PubMed Web of Science ®Google Scholar
• Huang L, Yan S. Luo L and Yang L. Irisin regulates the expression of BDNF and glycometabolism in diabetic rats. Mol Med Rep. 2019;19:1074–1082.
   PubMed Web of Science ®Google Scholar
• Yu X-W, Wei D, Gao Y-S, et al. Synergistic combination of DT-13 and Topotecan inhibits aerobic glycolysis in human gastric carcinoma BGC-823 cells via NM IIA/EGFR/HK II axis. J Cell Mol Med. 2019;23(10):6622–6634.
   PubMed Web of Science ®Google Scholar
• Wakiyama K, Kitajima Y, Tanaka T, et al. Low-dose YC-1 combined with glucose and insulin selectively induces apoptosis in hypoxic gastric carcinoma cells by inhibiting anaerobic glycolysis. Sci Rep. 2017;7: 12653.
   Web of Science ®Google Scholar
• JELENIEWICZ W, CYBULSKI, CYBULSKI M, et al. MMP-2 mRNA expression in ovarian cancer tissues predicts patients‘ response to platinum-taxane chemotherapy. Anticancer Res. 2019;39(4):1821–1827.
   PubMed Web of Science ®Google Scholar
• Hung CY, Lee CH, Chiou HL, et al. Praeruptorin-B inhibits 12-O-tetradecanoylphorbol-13-acetate-induced cell invasion by targeting AKT/NF-κB via matrix metalloproteinase-2/-9 expression in human cervical cancer cells. Cell Physiol Biochem. 2019;52:1255–1266.
   PubMedGoogle Scholar
• Lou C, Zhu Z, Zhao Y, et al. Arctigenin, a lignan from Arctium lappa L., inhibits metastasis of human breast cancer cells through the downregulation of MMP-2/−9 and heparanase in MDA-MB-231 cells. Oncol Rep. 2017;37(1):179–184.
   PubMed Web of Science ®Google Scholar
• De Wever O, Pauwels P, De Craene B, et al. Molecular and pathological signatures of epithelial–mesenchymal transitions at the cancer invasion front. Histochem Cell Biol. 2008;130(3):481–494.
   PubMed Web of Science ®Google Scholar
• Das V, Bhattacharya S, Chikkaputtaiah C. The basics of epithelial–mesenchymal transition (EMT): a study from a structure, dynamics, and functional perspective. J Cell Physiol. 2019;234(9):14535–14555.
   PubMed Web of Science ®Google Scholar
• Hay ED. Interaction of embryonic cell surface and cytoskeleton with extracellular matrix. Am J Anat. 1982;165(1):1–12.
   PubMedGoogle Scholar
• Micalizzi DS, Farabaugh SM, Ford HL. Farabaugh SM and Ford HL. Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression. J Mammary Gland Biol Neoplasia. 2010;15(2):117–134.
   PubMed Web of Science ®Google Scholar