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Research Paper

Firmicutes and Blautia in gut microbiota lessened in chronic liver diseases and hepatocellular carcinoma patients: a pilot study

, , , , , , , , , & ORCID Icon show all
Pages 8233-8246 | Received 26 Jun 2021, Accepted 11 Sep 2021, Published online: 19 Oct 2021

References

  • Albhaisi SAM, Bajaj JS, Sanyal AJ. Role of gut microbiota in liver disease. Am J Physiol Gastrointest Liver Physiol. 2020 Jan 1;318(1):G84–G98.
  • Levy M, Kolodziejczyk AA, Thaiss CA, et al. Dysbiosis and the immune system. Nat Rev Immunol. 2017 Apr;17(4):219–232.
  • Berer K, Gerdes LA, Cekanaviciute E, et al. Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proc Natl Acad Sci USA. 2017 Oct 3;114(40):10719–10724.
  • Ellekilde M, Selfjord E, Larsen CS, et al. Transfer of gut microbiota from lean and obese mice to antibiotic-treated mice. Sci Rep. 2014 Aug 1;4:5922.
  • Kostic AD, Gevers D, Siljander H, et al. The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes. Cell Host Microbe. 2015 Feb 11;17(2):260–273.
  • Scheperjans F, Aho V, Pereira PA, et al. Gut microbiota are related to Parkinson’s disease and clinical phenotype. Mov Disord. 2015 Mar;30(3):350–358.
  • Giuffre M, Campigotto M, Campisciano G, et al. A story of liver and gut microbes: how does the intestinal flora affect liver disease? A review of the literature. Am J Physiol Gastrointest Liver Physiol. 2020 May 1;318(5):G889–G906.
  • Betrapally NS, Gillevet PM, Bajaj JS. Gut microbiome and liver disease. Transl Res. 2017 Jan;179:49–59.
  • Altamirano-Barrera A, Uribe M, Chavez-Tapia NC, et al. The role of the gut microbiota in the pathology and prevention of liver disease. J Nutr Biochem. 2018 Oct;60:1–8.
  • Lu H, Wu Z, Xu W, et al. Intestinal microbiota was assessed in cirrhotic patients with hepatitis B virus infection. Intestinal microbiota of HBV cirrhotic patients. Microb Ecol. 2011 Apr;61(3):693–703.
  • Jun DW, Kim KT, Lee OY, et al. Association between small intestinal bacterial overgrowth and peripheral bacterial DNA in cirrhotic patients. Dig Dis Sci. 2010 May;55(5):1465–1471.
  • Ponziani FR, Bhoori S, Castelli C, et al. Hepatocellular carcinoma is associated with gut microbiota profile and inflammation in nonalcoholic fatty liver disease. Hepatology. 2019 Jan;69(1):107–120.
  • Yoshimoto S, Loo TM, Atarashi K, et al. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature. 2013 Jul 4;499(7456):97–101.
  • Department of Medical Administration NH, Health Commission of the People’s Republic of C. Guidelines for diagnosis and treatment of primary liver cancer in China (2019 edition) . Zhonghua Gan Zang Bing Za Zhi. 2020 Feb 20;28(2):112–128.
  • Huang JN, Wen B, Zhu JG, et al. Exposure to microplastics impairs digestive performance, stimulates immune response and induces microbiota dysbiosis in the gut of juvenile guppy (Poecilia reticulata). Sci Total Environ. 2020 Sep 1;733:138929.
  • Jiang W, Wang T, Liu C, et al. A 16S rRNA gene sequencing based study of oral microbiota in migraine patients in China. Bioengineered. 2021 Dec;12(1):2523–2533.
  • Chen S, Zhou Y, Chen Y, et al. fastp: an ultra-fast all-in-one FASTQ preprocessor. Bioinformatics. 2018 Sep 1;34(17):i884–i890.
  • Magoc T, Salzberg SL. FLASH: fast length adjustment of short reads to improve genome assemblies. Bioinformatics. 2011 Nov 1;27(21):2957–2963.
  • Wang G, Li X, Zhou Y, et al. Effects of heat stress on gut-microbial metabolites, gastrointestinal peptides, glycolipid metabolism, and performance of broilers. Animals (Basel). 2021 Apr 30;11(5):1286.
  • Edgar RC. UPARSE: highly accurate OTU sequences from microbial amplicon reads. Nat Methods. 2013 Oct;10(10):996–998.
  • Peace TA, Brock KV, Stills HF Jr. Comparative analysis of the 16S rRNA gene sequence of the putative agent of proliferative ileitis of hamsters. Int J Syst Bacteriol. 1994 Oct;44(4):832–835.
  • Wang Q, Garrity GM, Tiedje JM, et al. Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Appl Environ Microbiol. 2007 Aug;73(16):5261–5267.
  • Pushpanathan P, Mathew GS, Selvarajan S, et al. Gut microbiota and its mysteries. Indian J Med Microbiol. 2019 Apr-Jun;37(2):268–277.
  • Marchesi JR, Adams DH, Fava F, et al. The gut microbiota and host health: a new clinical frontier. Gut. 2016 Feb;65(2):330–339.
  • Chadha J, Nandi D, Atri Y, et al. Significance of human microbiome in breast cancer: tale of an invisible and an invincible. Semin Cancer Biol. 2021 May;70:112–127.
  • Fang Y, Yan C, Zhao Q, et al. The roles of microbial products in the development of colorectal cancer: a review. Bioengineered. 2021 Dec;12(1):720–735.
  • Dailey FE, Turse EP, Rossow B, et al. Probiotics for gastrointestinal and liver diseases: an updated review of the published literature. Endocr Metab Immune Disord Drug Targets. 2019;19(5):549–570.
  • Ponziani FR, Nicoletti A, Gasbarrini A, et al. Diagnostic and therapeutic potential of the gut microbiota in patients with early hepatocellular carcinoma. Ther Adv Med Oncol. 2019;11:1758835919848184.
  • Jasirwan COM, Muradi A, Hasan I, et al. Correlation of gut Firmicutes/Bacteroidetes ratio with fibrosis and steatosis stratified by body mass index in patients with non-alcoholic fatty liver disease. Biosci Microbiota Food Health. 2021;40(1):50–58.
  • Turnbaugh PJ, Ley RE, Mahowald MA, et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006 Dec 21;444(7122):1027–1031.
  • Dominianni C, Sinha R, Goedert JJ, et al. Sex, body mass index, and dietary fiber intake influence the human gut microbiome. PLoS One. 2015;10(4):e0124599.
  • Galle F, Valeriani F, Cattaruzza MS, et al. Mediterranean diet, physical activity and gut microbiome composition: a cross-sectional study among Healthy Young Italian adults. Nutrients. 2020 Jul 21;12(7). DOI:10.3390/nu12072164.
  • Chen YH, Chiu CC, Hung SW, et al. Gnotobiotic mice inoculated with Firmicutes, but not bacteroidetes, deteriorate nonalcoholic fatty liver disease severity by modulating hepatic lipid metabolism. Nutr Res. 2019 Sep;69:20–29.
  • Mouzaki M, Comelli EM, Arendt BM, et al. Intestinal microbiota in patients with nonalcoholic fatty liver disease. Hepatology. 2013 Jul;58(1):120–127.
  • Ley RE. Obesity and the human microbiome. Curr Opin Gastroenterol. 2010 Jan;26(1):5–11.
  • Grigor’eva IN. Gallstone Disease, Obesity and the Firmicutes/Bacteroidetes ratio as a possible biomarker of gut dysbiosis. J Pers Med. 2020 Dec 25;11:1.
  • Cosorich I, Dalla-Costa G, Sorini C, et al. High frequency of intestinal TH17 cells correlates with microbiota alterations and disease activity in multiple sclerosis. Sci Adv. 2017 Jul;3(7):e1700492.
  • Kozhieva M, Naumova N, Alikina T, et al. The core of gut life: firmicutes profile in patients with relapsing-remitting multiple sclerosis. Life (Basel). 2021 Jan 14;11(1):55.
  • Fujio-Vejar S, Vasquez Y, Morales P, et al. The gut microbiota of healthy Chilean subjects reveals a high abundance of the phylum verrucomicrobia. Front Microbiol. 2017;8:1221.
  • Ozato N, Saito S, Yamaguchi T, et al. Blautia genus associated with visceral fat accumulation in adults 20-76 years of age. NPJ Biofilms Microbiomes. 2019;5(1):28.
  • Liu X, Mao B, Gu J, et al. Blautia-a new functional genus with potential probiotic properties? Gut Microbes. 2021 Jan-Dec;13(1):1–21.
  • Kalyana Chakravarthy S, Jayasudha R, Sai Prashanthi G, et al. Dysbiosis in the gut bacterial microbiome of patients with uveitis, an inflammatory disease of the eye. Indian J Microbiol. 2018 Dec;58(4):457–469.
  • Benitez-Paez A, Gomez Del Pugar EM, Lopez-Almela I, et al. Depletion of Blautia species in the microbiota of obese children relates to intestinal inflammation and metabolic phenotype worsening. mSystems. 2020 Mar 24;5:2.
  • Luu TH, Michel C, Bard JM, et al. Proportion of Blautia sp. is associated with clinical stage and histoprognostic grade in patients with early-stage breast cancer. Nutr Cancer. 2017 Feb–Mar;69(2):267–275.
  • Inoue R, Ohue-Kitano R, Tsukahara T, et al. Prediction of functional profiles of gut microbiota from 16S rRNA metagenomic data provides a more robust evaluation of gut dysbiosis occurring in Japanese type 2 diabetic patients. J Clin Biochem Nutr. 2017 Nov;61(3):217–221.
  • Murri M, Leiva I, Gomez-Zumaquero JM, et al. Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study. BMC Med. 2013 Feb 21;11:46.
  • Tong X, Xu J, Lian F, et al. Structural alteration of gut microbiota during the amelioration of human type 2 diabetes with hyperlipidemia by metformin and a traditional Chinese herbal formula: a multicenter, randomized, open label clinical trial. mBio. 2018 May 22;9(3). DOI:10.1128/mBio.02392-17.
  • Jenq RR, Taur Y, Devlin SM, et al. Intestinal blautia is associated with reduced death from graft-versus-host disease. Biol Blood Marrow Transplant. 2015 Aug;21(8):1373–1383.
  • Kakiyama G, Pandak WM, Gillevet PM, et al. Modulation of the fecal bile acid profile by gut microbiota in cirrhosis. J Hepatol. 2013 May;58(5):949–955.
  • Indiani C, Rizzardi KF, Castelo PM, et al. Firmicutes/bacteroidetes ratio in the gut microbiota: a systematic review. Child Obes. 2018 Nov/Dec;14(8):501–509.
  • Haro C, Rangel-Zuniga OA, Alcala-Diaz JF, et al. Intestinal microbiota is influenced by gender and body mass index. PLoS One. 2016;11(5):e0154090.
  • Zhang YK, Zhang Q, Wang YL, et al. A comparison study of age and colorectal cancer-related gut bacteria. Front Cell Infect Microbiol. 2021;11:606490.