Overexpression of EWSR1 (Ewing sarcoma breakpoint region 1/EWS RNA binding protein 1) predicts poor survival in patients with hepatocellular carcinoma

References

• Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66(2):115–132.
   PubMed Web of Science ®Google Scholar
• Feng RM, Zong YN, Cao SM, et al. Current cancer situation in China: good or bad news from the 2018 global cancer statistics? Cancer Commun (Lond). 2019;39(1):22.
   PubMed Web of Science ®Google Scholar
• Delattre O, Zucman J, Plougastel B, et al. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature. 1992;359(6391):162–165.
   PubMed Web of Science ®Google Scholar
• Grunewald TGP, Cidre-Aranaz F, Surdez D, et al. Ewing sarcoma. Nat Rev Dis Primers. 2018;4:5.
   PubMed Web of Science ®Google Scholar
• Chen S, Deniz K, Sung YS, et al. Ewing sarcoma with ERG gene rearrangements: a molecular study focusing on the prevalence of FUS-ERG and common pitfalls in detecting EWSR1-ERG fusions by FISH. Genes Chromosomes Cancer. 2016;55:340–349.
   PubMed Web of Science ®Google Scholar
• Thway K, Noujaim J, Zaidi S, et al. Desmoplastic small round cell tumor: pathology, genetics, and potential therapeutic strategies. Int J Surg Pathol. 2016;24(8):672–684.
   PubMed Web of Science ®Google Scholar
• Baranov E, Black MA, Fletcher CDM, et al. Nuclear expression of DDIT3 distinguishes high-grade myxoid liposarcoma from other round cell sarcomas. Mod Pathol. 2021;34(7):1367–1372.
   PubMed Web of Science ®Google Scholar
• Bale TA, Oviedo A, Kozakewich H, et al. Intracranial myxoid mesenchymal tumors with EWSR1-CREB family gene fusions: myxoid variant of angiomatoid fibrous histiocytoma or novel entity? Brain Pathol. 2018;28:183–191.
   PubMed Web of Science ®Google Scholar
• Lee J, Nguyen PT, Shim HS, et al. EWSR1, a multifunctional protein, regulates cellular function and aging via genetic and epigenetic pathways. Biochim Biophys Acta Mol Basis Dis. 2019;1865(7):1938–1945.
   PubMed Web of Science ®Google Scholar
• Tomczak K, Czerwinska P, Wiznerowicz M. The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge. Contemp Oncol (Pozn). 2015;19:A68–77.
   PubMedGoogle Scholar
• Bin Lim S, Chua MLK, Yeong JPS, et al. Pan-cancer analysis connects tumor matrisome to immune response. NPJ Precis Oncol. 2019;3(1):15.
   PubMedGoogle Scholar
• Nagtegaal ID, Odze RD, Klimstra D, et al. The 2019 WHO classification of tumours of the digestive system. Histopathology. 2020;76(2):182–188.
   PubMed Web of Science ®Google Scholar
• Zhang X, Gu G, Song L, et al. ID4 promotes breast cancer chemotherapy resistance via CBF1-MRP1 pathway. J Cancer. 2020;11(13):3846–3857.
   PubMed Web of Science ®Google Scholar
• Zhang H, Ma RR, Wang XJ, et al. KIF26B, a novel oncogene, promotes proliferation and metastasis by activating the VEGF pathway in gastric cancer. Oncogene. 2017;36(40):5609–5619.
   PubMed Web of Science ®Google Scholar
• Lv BB, Ma RR, Chen X, et al. E2F1-activated SPIN1 promotes tumor growth via a MDM2-p21-E2F1 feedback loop in gastric cancer. Mol Oncol. 2020;14(10):2629–2645.
   PubMed Web of Science ®Google Scholar
• Jones A, Kroneman TN, Blahnik AJ, et al. Ki-67 “hot spot” digital analysis is useful in the distinction of hepatic adenomas and well-differentiated hepatocellular carcinomas. Virchows Arch. 2021;478(2):201–207.
   PubMed Web of Science ®Google Scholar
• Chin CH, Chen SH, Wu HH, et al. cytoHubba: identifying hub objects and sub-networks from complex interactome. BMC Syst Biol. 2014;8(Suppl 4):S11.
   PubMed Web of Science ®Google Scholar
• Gene Ontology Consortium. Gene Ontology Consortium: going forward. Nucleic Acids Res. 2015;43:D1049–56.
   PubMed Web of Science ®Google Scholar
• Kanehisa M. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000;28(1):27–30.
   PubMed Web of Science ®Google Scholar
• Hoell JI, Larsson E, Runge S, et al. RNA targets of wild-type and mutant FET family proteins. Nat Struct Mol Biol. 2011;18(12):1428–1431.
   PubMed Web of Science ®Google Scholar
• Tan AY, Manley JL. The TET family of proteins: functions and roles in disease. J Mol Cell Biol. 2009;1(2):82–92.
   PubMed Web of Science ®Google Scholar
• Thway K, Fisher C. Myoepithelial tumor of soft tissue: histology and genetics of an evolving entity. Adv Anat Pathol. 2014;21(6):411–419.
   PubMed Web of Science ®Google Scholar
• Porubsky S, Rudolph B, Ruckert JC, et al. EWSR1 translocation in primary hyalinising clear cell carcinoma of the thymus. Histopathology. 2019;75:431–436.
   PubMed Web of Science ®Google Scholar
• Fukuda H, Kato I, Furuya M, et al. A novel partner of TFE3 in the Xp11 translocation renal cell carcinoma: clinicopathological analyses and detection of EWSR1-TFE3 fusion. Virchows Arch. 2019;474(3):389–393.
   PubMed Web of Science ®Google Scholar
• Kovacevic B, Caramelo A, Skuletic V, et al. EWSR1 rearrangement in papillary thyroid microcarcinoma is related to classic morphology and the presence of small-cell phenotype. Bosn J Basic Med Sci. 2021. DOI:10.17305/bjbms.2021.6181
   PubMed Web of Science ®Google Scholar
• Nishiyama D, Chinen Y, Isa R, et al. EWSR1 overexpression is a pro-oncogenic event in multiple myeloma. Int J Hematol. 2021;113(3):381–394.
   PubMed Web of Science ®Google Scholar
• Gu Y, Li X, Bi Y, et al. CCL14 is a prognostic biomarker and correlates with immune infiltrates in hepatocellular carcinoma. Aging (Albany NY). 2020;12(1):784–807.
   PubMedGoogle Scholar
• Zhuo JY, Lu D, Tan WY, et al. CK19-positive hepatocellular carcinoma is a characteristic subtype. J Cancer. 2020;11:5069–5077.
   PubMed Web of Science ®Google Scholar
• Ma HP, Chang HL, Bamodu OA, et al. Collagen 1A1 (COL1A1) is a reliable biomarker and putative therapeutic target for hepatocellular carcinogenesis and metastasis. Cancers (Basel). 2019;11(6):786.
   Web of Science ®Google Scholar
• Xue J, Cao Z, Cheng Y, et al. Acetylation of alpha-fetoprotein promotes hepatocellular carcinoma progression. Cancer Lett. 2020;471:12–26.
   PubMed Web of Science ®Google Scholar
• Cantile M, Marra L, Franco R, et al. Molecular detection and targeting of EWSR1 fusion transcripts in soft tissue tumors. Med Oncol. 2013;30(1):412.
   PubMed Web of Science ®Google Scholar
• Wang YL, Chen H, Zhan YQ, et al. EWSR1 regulates mitosis by dynamically influencing microtubule acetylation. Cell Cycle. 2016;15(16):2202–2215.
   PubMed Web of Science ®Google Scholar