1,612
Views
13
CrossRef citations to date
0
Altmetric
Research Paper

Protective effect of limonin against doxorubicin-induced cardiotoxicity via activating nuclear factor - like 2 and Sirtuin 2 signaling pathways

, &
Pages 7975-7984 | Received 03 Aug 2021, Accepted 17 Sep 2021, Published online: 08 Oct 2021

References

  • Gong C, Qi L, Huo Y, et al. Anticancer effect of Limonin against benzo(a)pyrene-induced lung carcinogenesis in Swiss aslbino rat and the inhibition of A549 cell proliferation through apoptotic pathway. J Biochem Mol Toxicol. 2019;33(12):e22374.
  • Shimizu S, Miyamoto S, Fujii G, et al. Suppression of intestinal carcinogenesis in Apc-mutant mice by limonin. J Clin Biochem Nutr. 2015;57(1):39–43.
  • Zhao W, Wu M, Cui L, et al. Limonin attenuates the stemness of cervical carcinoma cells by promoting YAP nuclear-cytoplasmic translocation. Food Chem Toxicol. 2019;125:621–628.
  • Tang Z, Tang Y, Li L, et al. Limonin provokes hepatocellular carcinoma cells with stemness entry into cycle via activating PI3K/Akt signaling. Biomed Pharmacother. 2019;117:109051.
  • Su Z, Wang C, Chang D, et al. Limonin attenuates the stemness of breast cancer cells via suppressing MIR216A methylation. Biomed Pharmacother. 2019;112:108699.
  • Gao L, Sang JZ, Cao H. Limonin enhances the radiosensitivity of nasopharyngeal carcinoma cells via attenuating Stat3-induced cell stemness. Biomed Pharmacother. 2019;118:109366.
  • Mahmoud MF, Gamal S, El-Fayoumi HM. Limonin attenuates hepatocellular injury following liver ischemia and reperfusion in rats via toll-like receptor dependent pathway. Eur J Pharmacol. 2014;740:676–682.
  • Yang R, Song C, Chen J, et al. Limonin ameliorates Acetaminophen-induced hepatotoxicity by activating Nrf2 antioxidative pathway and inhibiting NF-κB inflammatory response via upregulating Sirt1. Phytomedicine. 2020;69:153211.
  • Song C, Chen J, Li X, et al. Limonin ameliorates dextran sulfate sodium-induced chronic colitis in rat by inhibiting PERK-ATF4-CHOP pathway of ER stress and NF-κB signaling. Int Immunopharmacol. 2021;90:107161.
  • Gandhi L, Harding MW, Neubauer M, et al. A phase II study of the safety and efficacy of the multidrug resistance inhibitor VX-710 combined with doxorubicin and vincristine in patients with recurrent small cell lung cancer. Cancer. 2007;109(5):924–932.
  • Minderman H, O’Loughlin KL, Pendyala L, et al. VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein. Clin Cancer Res. 2004;10(5):1826–1834.
  • Maayah ZH, Alam AS, Takahara S, et al. Resveratrol reduces cardiac NLRP3-inflammasome activation and systemic inflammation to lessen doxorubicin-induced cardiotoxicity in juvenile rat. Molecules. 2021.
  • Zhou W, Ouyang J, Hu N, et al. Protective effect of two alkaloids from hippophae rhamnoides linn. against doxorubicin-Induced toxicity in H9c2 cardiomyoblasts. Animals (Basel). 2021;26.
  • Elblehi SS, El-Sayed YS, Soliman MM, et al. Date palm pollen extract avert doxorubicin-Induced cardiomyopathy fibrosis and associated oxidative/nitrosative stress, inflammatory cascade, and apoptosis-Targeting Bax/Bcl-2 and caspase-3 signaling pathways. FEBS Lett. 2021;11.
  • Liu J, Jin Y, Wang B, et al. Dopamine D1 receptor alleviates doxorubicin-induced cardiac injury by inhibiting NLRP3 inflammasome. Biochem Biophys Res Commun. 2021;561:7–13.
  • Christidi E, Brunham LR. Regulated cell death pathways in doxorubicin-induced cardiotoxicity. Cell Death Dis. 2021;12(4):339.
  • Zhao L, Qi Y, Xu L, et al. MicroRNA-140-5p aggravates doxorubicin-induced cardiotoxicity by promoting myocardial oxidative stress via targeting Nrf2 and Sirt2. Redox Biol. 2018;15:284–296.
  • Zhao D, Xue C, Li J, et al. Adiponectin agonist ADP355 ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and oxidative stress. Biochem Biophys Res Commun. 2020;533(3):304–312.
  • Li Z, Ye Z, Ma J, et al. MicroRNA‑133b alleviates doxorubicin‑induced cardiomyocyte apoptosis and cardiac fibrosis by targeting PTBP1 and TAGLN2. Int J Mol Med. 2021;48(1). DOI:10.3892/ijmm.2021.4958
  • Pan Y, Pan YM, Liu FT, et al. MicroRNA-98 ameliorates doxorubicin-induced cardiotoxicity via regulating caspase-8 dependent Fas/RIP3 pathway. Environ Toxicol Pharmacol. 2021;85:103624.
  • Zhang WB, Lai X, Guo XF. Activation of Nrf2 by miR-152 inhibits doxorubicin-induced cardiotoxicity via attenuation of oxidative stress, inflammation, and apoptosis. Oxid Med Cell Longev. 2021;2021:8860883.