MicroRNA-140-5p represses chondrocyte pyroptosis and relieves cartilage injury in osteoarthritis by inhibiting cathepsin B/Nod-like receptor protein 3

References

• Hwang HS, Kim HA. Chondrocyte apoptosis in the pathogenesis of osteoarthritis. Int J Mol Sci. 2015;16(11):26035–26054.
   PubMed Web of Science ®Google Scholar
• An S, Hu H, Li Y, et al. Pyroptosis plays a role in osteoarthritis. Aging Dis. 2020;11(5):1146–1157.
   PubMed Web of Science ®Google Scholar
• Swingler TE, Niu L, Smith P, et al. The function of microRNAs in cartilage and osteoarthritis. Clin Exp Rheumatol. 2019;37 120(Suppl 5):40–47.
   Web of Science ®Google Scholar
• Singh P, Marcu KB, Goldring MB, et al. Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy. Ann N Y Acad Sci. 2019;1442(1):17–34.
   PubMed Web of Science ®Google Scholar
• Zhao LR, Xing RL, Wang PM, et al. NLRP1 and NLRP3 inflammasomes mediate LPS/ATPinduced pyroptosis in knee osteoarthritis. Mol Med Rep. 2018;17(4):5463–5469.
   PubMed Web of Science ®Google Scholar
• Dong Z, Jiang H, Jian X, et al. Change of miRNA expression profiles in patients with knee osteoarthritis before and after celecoxib treatment. J Clin Lab Anal. 2019;33(1):e22648.
   PubMed Web of Science ®Google Scholar
• Miyaki S, Sato T, Inoue A, et al. MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev. 2010;24(11):1173–1185.
   PubMed Web of Science ®Google Scholar
• Yin CM, Suen WC, Lin S, et al. Dysregulation of both miR-140-3p and miR-140-5p in synovial fluid correlate with osteoarthritis severity. Bone Joint Res. 2017;6(11):612–618.
   PubMed Web of Science ®Google Scholar
• Wang Y, Shen S, Li Z, et al. MIR-140-5p affects chondrocyte proliferation, apoptosis, and inflammation by targeting HMGB1 in osteoarthritis. Inflamm Res. 2020;69(1):63–73.
   PubMed Web of Science ®Google Scholar
• Li W, Zhao S, Yang H, et al. Potential novel prediction of TMJ-OA: miR-140-5p regulates inflammation through smad/TGF-beta signaling. Front Pharmacol. 2019;10:15.
   PubMed Web of Science ®Google Scholar
• Huang X, Qiao F, Xue P. The protective role of microRNA-140-5p in synovial injury of rats with knee osteoarthritis via inactivating the TLR4/Myd88/NF-kappaB signaling pathway. Cell Cycle. 2019;18(18):2344–2358.
   PubMed Web of Science ®Google Scholar
• Karlsen TA, de Souza GA, Odegaard B, et al. microRNA-140 inhibits inflammation and stimulates chondrogenesis in a model of interleukin 1beta-induced osteoarthritis. Mol Ther Nucleic Acids. 2016;5(10):e373.
   PubMedGoogle Scholar
• Li YY, Fang J, Ao GZ. Cathepsin B and L inhibitors: a patent review (2010 - present). Expert Opin Ther Pat. 2017;27(6):643–656.
   PubMed Web of Science ®Google Scholar
• Ben-Aderet L, Merquiol E, Fahham D, et al. Detecting cathepsin activity in human osteoarthritis via activity-based probes. Arthritis Res Ther. 2015;17(69: DOI:10.1186/s13075-015-0586-5.
   Web of Science ®Google Scholar
• Glasson SS, Blanchet TJ, Morris EA. The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse. Osteoarthritis Cartilage. 2007;15(9):1061–1069.
   PubMed Web of Science ®Google Scholar
• Cai D, Wang J, Chen S, et al. Coniferaldehyde prevents articular cartilage destruction in a murine model via Nrf2/HO1 pathway. Mol Med Rep. 2021;23(3):3.
   PubMed Web of Science ®Google Scholar
• Glasson SS, Chambers MG, Van den berg WB, et al. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis Cartilage. 2010;18(Suppl 3):S17–23.
   PubMed Web of Science ®Google Scholar
• Fujita Y, Matsuoka N, Temmoku J, et al. Hydroxychloroquine inhibits IL-1beta production from amyloid-stimulated human neutrophils. Arthritis Res Ther. 2019;21(1):250.
   PubMed Web of Science ®Google Scholar
• Zu Y, Mu Y, Li Q, et al. Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis. J Orthop Surg Res. 2019;14(1):307.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods. 2001;25(4):402–408.
   PubMed Web of Science ®Google Scholar
• Li Z, Huang Z, Zhang H, et al. P2X7 receptor induces pyroptotic inflammation and cartilage degradation in osteoarthritis via NF-kappaB/NLRP3 crosstalk. Oxid Med Cell Longev. 2021;2021:8868361.
   PubMed Web of Science ®Google Scholar
• Li JH, Liu S, Zhou H, et al. starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res. 2014;42(D1):D92–7.
   PubMed Web of Science ®Google Scholar
• Meng X, Sun Y, Wang L, et al. Slow release of oxygen from carbamide peroxide for promoting the proliferation of human brain microvascular endothelial cells under hypoxia. Ann Transl Med. 2021;9(2):157.
   PubMed Web of Science ®Google Scholar
• Liu G, Liu Q, Yan B, et al. USP7 inhibition alleviates H2O2-induced injury in chondrocytes via inhibiting NOX4/NLRP3 pathway. Front Pharmacol. 2020;11:617270.
   PubMed Web of Science ®Google Scholar
• Fang W, Deng Z, Benadjaoud F, et al. Cathepsin B deficiency ameliorates liver lipid deposition, inflammatory cell infiltration, and fibrosis after diet-induced nonalcoholic steatohepatitis. Transl Res. 2020;222(28-40: DOI:10.1016/j.trsl.2020.04.011.
   Web of Science ®Google Scholar
• Qiu T, Pei P, Yao X, et al. Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway. Cell Death Dis. 2018;9(10):946.
   PubMedGoogle Scholar
• Pereira D, Ramos E, Branco J. Osteoarthritis. Acta Med Port. 2015;28(1):99–106.
   PubMed Web of Science ®Google Scholar
• Choi MC, Jo J, Park J, et al. NF-kappaB signaling pathways in osteoarthritic cartilage destruction. Cells. 2019;8(7):7.
   Web of Science ®Google Scholar
• Wang Z, Hu J, Pan Y, et al. miR-140-5p/miR-149 affects chondrocyte proliferation, apoptosis, and autophagy by targeting FUT1 in osteoarthritis. Inflammation. 2018;41(3):959–971.
   PubMed Web of Science ®Google Scholar
• Al-Modawi RN, Brinchmann JE, Karlsen TA. Multi-pathway protective effects of MicroRNAs on human chondrocytes in an in vitro model of osteoarthritis. Mol Ther Nucleic Acids. 2019;17(776-90: DOI:10.1016/j.omtn.2019.07.011.
   Google Scholar
• Santini P, Politi L, Vedova PD, et al. The inflammatory circuitry of miR-149 as a pathological mechanism in osteoarthritis. Rheumatol Int. 2014;34(5):711–716.
   PubMed Web of Science ®Google Scholar
• Yang B, Xu L, Wang S. Regulation of lncRNA-H19/miR-140-5p in cartilage matrix degradation and calcification in osteoarthritis. Ann Palliat Med. 2020;9(4):1896–1904.
   PubMed Web of Science ®Google Scholar
• Musumeci G, Castrogiovanni P, Trovato FM, et al. Biomarkers of chondrocyte apoptosis and autophagy in osteoarthritis. Int J Mol Sci. 2015;16(9):20560–20575.
   PubMed Web of Science ®Google Scholar
• Shi J, Gao W, Shao F. Pyroptosis: gasdermin-mediated programmed necrotic cell death. Trends Biochem Sci. 2017;42(4):245–254.
   PubMed Web of Science ®Google Scholar
• Miao EA, Rajan JV, Aderem A. Caspase-1-induced pyroptotic cell death. Immunol Rev. 2011;243(1):206–214.
   PubMed Web of Science ®Google Scholar
• Chen S, Zhou C, Yu H, et al. 27-Hydroxycholesterol contributes to lysosomal membrane permeabilization-mediated pyroptosis in Co-cultured SH-SY5Y cells and C6 cells. Front Mol Neurosci. 2019;12:14.
   PubMed Web of Science ®Google Scholar
• Zeng C, Duan F, Hu J, et al. NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy. Redox Biol. 2020;34:101523.
   PubMed Web of Science ®Google Scholar
• Cheng F, Yan FF, Liu YP, et al. Dexmedetomidine inhibits the NF-kappaB pathway and NLRP3 inflammasome to attenuate papain-induced osteoarthritis in rats. Pharm Biol. 2019;57(1):649–659.
   PubMed Web of Science ®Google Scholar
• Yan Z, Qi W, Zhan J, et al. Activating Nrf2 signalling alleviates osteoarthritis development by inhibiting inflammasome activation. J Cell Mol Med. 2020;24(22):13046–13057.
   PubMed Web of Science ®Google Scholar
• Yang Y, Wang Y, Kong Y, et al. Moderate mechanical stimulation protects rats against osteoarthritis through the regulation of TRAIL via the NF-kappaB/NLRP3 pathway. Oxid Med Cell Longev. 2020;2020:6196398.
   PubMed Web of Science ®Google Scholar
• Wang B, Li J, Tian F. Downregulation of lncRNA SNHG14 attenuates osteoarthritis by inhibiting FSTL-1 mediated NLRP3 and TLR4/NF-kappaB pathway through miR-124-3p. Life Sci. 2021;270:119143.
   PubMed Web of Science ®Google Scholar