The angiotensin-converting enzyme inhibitor, captopril, suppressed hepatic stellate cell activation via NF-kappaB or wnt3α/β-catenin pathway

References

• Fujii H, Kawada N, Japan Study Group Of Nafld J-N. The Role of Insulin Resistance and Diabetes in Nonalcoholic Fatty Liver Disease. Int J Mol Sci. 2020;21(11):3863.
   Web of Science ®Google Scholar
• Zhao B, Li S, Guo Z, et al. Dopamine receptor D2 inhibition alleviates diabetic hepatic stellate cells fibrosis by regulating the TGF-β1/Smads and NFκB pathways. Clin Exp Pharmacol Physiol. 2021;48(3):370–380.
   PubMed Web of Science ®Google Scholar
• Li Z, Li P, Lu Y, et al. A non-autonomous role of MKL1 in the activation of hepatic stellate cells. Biochim Biophys Acta Gene Regul Mech. 2019;1862(6):609–618.
   PubMed Web of Science ®Google Scholar
• Sakai M, Sumiyoshi T, Aoyama T, et al. GPR91 antagonist and TGF-β inhibitor suppressed collagen production of high glucose and succinate induced HSC activation. Biochem Biophys Res Commun. 2020;530(2):362–366.
   PubMed Web of Science ®Google Scholar
• Wang Y, Sun Y, Zuo L, et al. ASIC1a promotes high glucose and PDGF-induced hepatic stellate cell activation by inducing autophagy through CaMKKβ/ERK signaling pathway. Toxicol Lett. 2019;300:1–9.
   PubMed Web of Science ®Google Scholar
• Mizar SMM, Kozman MR, Abo-Saif AA, et al. Combination of Captopril with Gliclazide Decreases Vascular and Renal Complications and Improves Glycemic Control in Rats with Streptozotocin-induced Diabetes Mellitus. Endocr Metab Immune Disord Drug Targets. 2021;21(6):1096-1106.
   PubMed Web of Science ®Google Scholar
• Ebadi Z, Moradi N, Kazemi Fard T, et al. Captopril and Spironolactone Can Attenuate Diabetic Nephropathy in Wistar Rats by Targeting microRNA-192 and microRNA-29a/b/c. DNA Cell Biol. 2019;38(10):1134–1142.
   PubMed Web of Science ®Google Scholar
• Fouad AA, Al-Mulhim AS, Jresat I, et al. Protective effects of captopril in diabetic rats exposed to ischemia/reperfusion renal injury. J Pharm Pharmacol. 2013;65(2):243–252.
   PubMed Web of Science ®Google Scholar
• Gan Z, Huang D, Jiang J, et al. Captopril alleviates hypertension-induced renal damage, inflammation, and NF-κB activation. Braz J Med Biol Res. 2018;51(11):e7338.
   PubMed Web of Science ®Google Scholar
• Boskabadi J, Askari VR, Hosseini M, et al. Immunomodulatory properties of captopril, an ACE inhibitor, on LPS-induced lung inflammation and fibrosis as well as oxidative stress. Inflammopharmacology. 2019;27(3):639–647.
   PubMed Web of Science ®Google Scholar
• Xie Y, Song T, Huo M, et al. Fasudil alleviates hepatic fibrosis in type 1 diabetic rats: involvement of the inflammation and RhoA/ROCK pathway. Eur Rev Med Pharmacol Sci. 2018;22:5665–5677.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhang L, Fan X, et al. Captopril attenuates TAC-induced heart failure via inhibiting Wnt3a/β-catenin and Jak2/Stat3 pathways. Biomed Pharmacother. 2019;113:108780.
   PubMed Web of Science ®Google Scholar
• Zhang C, Liu XQ, Sun HN, et al. Octreotide attenuates hepatic fibrosis and hepatic stellate cells proliferation and activation by inhibiting Wnt/β-catenin signaling pathway, c-Myc and cyclin D1. Int Immunopharmacol. 2018;63:183–190.
   PubMed Web of Science ®Google Scholar
• Li W, Shen X, Wang Y, et al. The effect of Shengpuhuang-tang on retinal inflammation in streptozotocin-induced diabetic rats by NF-κB pathway. J Ethnopharmacol. 2020;247:112275.
   PubMed Web of Science ®Google Scholar
• Zhang S, Xu L, Liang R, et al. Baicalin suppresses renal fibrosis through microRNA-124/TLR4/NF-κB axis in streptozotocin-induced diabetic nephropathy mice and high glucose-treated human proximal tubule epithelial cells. J Physiol Biochem. 2020;76(3):407–416.
   PubMed Web of Science ®Google Scholar
• Wu Y, Wang Y, Liu B, et al. SN50 attenuates alveolar hypercoagulation and fibrinolysis inhibition in acute respiratory distress syndrome mice through inhibiting NF-κB p65 translocation. Respir Res. 2020;21(1):130.
   PubMed Web of Science ®Google Scholar
• Choi YJ, YH L, Lee ST. Galangin and kaempferol suppress phorbol-12-myristate-13-acetate-induced matrix metalloproteinase-9 expression in human fibrosarcoma HT-1080 cells. Mol Cells. 2015;38(2):151–155.
   PubMed Web of Science ®Google Scholar
• Kong R, Kang OH, Seo YS, et al. MAPKs and NF‑κB pathway inhibitory effect of bisdemethoxycurcumin on phorbol‑12‑myristate‑13‑acetate and A23187‑induced inflammation in human mast cells. Mol Med Rep. 2018;17:630–635.
   PubMedGoogle Scholar
• Song Y, Huang Q, Zhang Z, et al. Separate administration of ammonium pyrrolidinedithiocarbamate and phorbol myristate acetate at early and late stages decreases secondary brain injury following intracerebral haemorrhage in rats via the NF-κB pathway. Folia Neuropathol. 2020;58(2):166–175.
   PubMed Web of Science ®Google Scholar
• Guo X, Chen Y, Hong T, et al. Induced pluripotent stem cell-derived conditional medium promotes Leydig cell anti-apoptosis and proliferation via autophagy and Wnt/β-catenin pathway. J Cell Mol Med. 2018;22(7):3614–3626.
   PubMed Web of Science ®Google Scholar
• Li ZT, Zhang X, Wang DW, et al. Overexpressed lncRNA GATA6-AS1 Inhibits LNM and EMT via FZD4 through the Wnt/β-Catenin Signaling Pathway in GC. Mol Ther Nucleic Acids. 2020;19:827–840.
   PubMedGoogle Scholar
• Zheng H, Jia L, Liu CC, et al. TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway. J Neurosci. 2017;37(7):1772–1784.
   PubMed Web of Science ®Google Scholar
• Bc T, Dj H, Wt L, et al. Functional potato bioactive peptide intensifies Nrf2-dependent antioxidant defense against renal damage in hypertensive rats. Food Res Int. 2020;129:108862.
   PubMed Web of Science ®Google Scholar
• Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology. 2008;134(6):1655–1669.
   PubMed Web of Science ®Google Scholar
• Schuppan D, Kim YO. Evolving therapies for liver fibrosis. J Clin Invest. 2013;123(5):1887–1901.
   PubMed Web of Science ®Google Scholar
• Al-Hashem F, Al Humayed S, Haidara MA, et al. Captopril suppresses hepatic mammalian target of rapamycin cell signaling and biomarkers of inflammation and oxidative stress in thioacetamide-induced hepatotoxicity in rats. Arch Physiol Biochem. 2019;127(5):414-421.
   Web of Science ®Google Scholar
• Kelleni MT, Sa I, Abdelrahman AM. Effect of captopril and telmisartan on methotrexate-induced hepatotoxicity in rats: impact of oxidative stress, inflammation and apoptosis. Toxicol Mech Methods. 2016;26(5):371–377.
   PubMed Web of Science ®Google Scholar
• Bao L, Li J, Zha D, et al. Chlorogenic acid prevents diabetic nephropathy by inhibiting oxidative stress and inflammation through modulation of the Nrf2/HO-1 and NF-ĸB pathways. Int Immunopharmacol. 2018;54:245–253.
   PubMed Web of Science ®Google Scholar
• Hu R, Wang MQ, Ni SH, et al. Salidroside ameliorates endothelial inflammation and oxidative stress by regulating the AMPK/NF-κB/NLRP3 signaling pathway in AGEs-induced HUVECs. Eur J Pharmacol. 2020;867:172797.
   PubMed Web of Science ®Google Scholar
• Muriach M, Flores-Bellver M, FJ R, et al. Diabetes and the brain: oxidative stress, inflammation, and autophagy. Oxid Med Cell Longev. 2014;2014:102158.
   PubMed Web of Science ®Google Scholar
• Chouhan S, Singh S, Athavale D, et al. Glucose induced activation of canonical Wnt signaling pathway in hepatocellular carcinoma is regulated by DKK4. Sci Rep. 2016;6(1):27558.
   PubMedGoogle Scholar
• Zaghloul RA, Elsherbiny NM, Kenawy HI, et al. Hepatoprotective effect of hesperidin in hepatocellular carcinoma: involvement of Wnt signaling pathways. Life Sci. 2017;185:114–125.
   PubMed Web of Science ®Google Scholar
• Wang Y, Wang Q, Li J, et al. Glutamine Improves Oxidative Stress through the Wnt3a/β-Catenin Signaling Pathway in Alzheimer’s Disease In Vitro and In Vivo. Biomed Res Int. 2019;2019:4690280.
   PubMed Web of Science ®Google Scholar
• Cui W, Zhang Z, Zhang P, et al. Nrf2 attenuates inflammatory response in COPD /emphysema: crosstalk with Wnt3a/β-catenin and AMP pathways. J Cell Mol Med. 2018;22(7):3514–3525.
   PubMed Web of Science ®Google Scholar
• Liu Y, Wei M, Liu G, et al. Receptor-2 alleviates ox-LDL-induced lipid accumulation, inflammation and apoptosis via activation of Wnt/β-catenin signaling. Gen Physiol Biophys. 2020;39(5):437–448.
   PubMed Web of Science ®Google Scholar
• Mu M, Zuo S, Wu RM, et al. Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway. Drug Des Devel Ther. 2018;12:4107–4115.
   PubMed Web of Science ®Google Scholar
• Munsterman ID, Kendall TJ, Khelil N, et al. Extracellular matrix components indicate remodelling activity in different fibrosis stages of human non-alcoholic fatty liver disease. Histopathology. 2018;73(4):612–621.
   PubMed Web of Science ®Google Scholar
• Yu DK, Zhang CX, Zhao SS, et al. The anti-fibrotic effects of epigallocatechin-3-gallate in bile duct-ligated cholestatic rats and human hepatic stellate LX-2 cells are mediated by the PI3K/Akt/Smad pathway. Acta Pharmacol Sin. 2015;36(4):473–482.
   PubMed Web of Science ®Google Scholar
• Perumal N, Perumal M, Halagowder D, et al. Morin attenuates diethylnitrosamine-induced rat liver fibrosis and hepatic stellate cell activation by co-ordinated regulation of Hippo/Yap and TGF-β1/Smad signaling. Biochimie. 2017;140:10–19.
   PubMed Web of Science ®Google Scholar