POU class 2 homeobox associating factor 1 (POU2AF1) participates in abdominal aortic aneurysm enlargement based on integrated bioinformatics analysis

References

• Golledge J, Muller J, Daugherty A, et al. Abdominal aortic aneurysm: pathogenesis and implications for management. Arterioscler Thromb Vasc Biol. 2006;26:2605–2613.
   PubMed Web of Science ®Google Scholar
• Kuivaniemi H, Ryer EJ, Elmore JR, et al. Understanding the pathogenesis of abdominal aortic aneurysms. Expert Rev Cardiovasc Ther. 2015;13:975–987.
   PubMed Web of Science ®Google Scholar
• Golledge J. Abdominal aortic aneurysm: update on pathogenesis and medical treatments. Nat Rev Cardiol. 2019;16:225–242.
   PubMed Web of Science ®Google Scholar
• Chaikof EL, Dalman RL, Eskandari MK, et al. The society for vascular surgery practice guidelines on the care of patients with an abdominal aortic aneurysm. J Vasc Surg. 2018;67:2–77 e2.
   PubMed Web of Science ®Google Scholar
• Moll FL, Powell JT, Fraedrich G, et al. Management of abdominal aortic aneurysms clinical practice guidelines of the European society for vascular surgery. Eur J Vasc Endovasc Surg. 2011;41(Suppl 1):S1–S58.
   PubMed Web of Science ®Google Scholar
• Patel R, Sweeting MJ, Powell JT, et al. Endovascular versus open repair of abdominal aortic aneurysm in 15-years’ follow-up of the UK endovascular aneurysm repair trial 1 (EVAR trial 1): a randomised controlled trial. Lancet. 2016;388:2366–2374.
   PubMed Web of Science ®Google Scholar
• Golledge J, Norman PE. Current status of medical management for abdominal aortic aneurysm. Atherosclerosis. 2011;217:57–63.
   PubMed Web of Science ®Google Scholar
• Sakalihasan N, Michel JB, Katsargyris A, et al. Abdominal aortic aneurysms. Nat Rev Dis Primers. 2018;4:34.
   PubMed Web of Science ®Google Scholar
• Groeneveld ME, Meekel JP, Rubinstein SM, et al. Systematic review of circulating, biomechanical, and genetic markers for the prediction of abdominal aortic aneurysm growth and rupture. J Am Heart Assoc. 2018;7(13): e007791.
   Web of Science ®Google Scholar
• Tian L, Hu X, He Y, et al. Construction of lncRNA-miRNA-mRNA networks reveals functional lncRNAs in abdominal aortic aneurysm. Exp Ther Med. 2018;16:3978–3986.
   PubMed Web of Science ®Google Scholar
• Yang P, Cai Z, Wu K, et al. Identification of key microRNAs and genes associated with abdominal aortic aneurysm based on the gene expression profile. Exp Physiol. 2020;105:160–173.
   PubMed Web of Science ®Google Scholar
• Zhang B, Horvath S. A general framework for weighted gene co-expression network analysis. Stat Appl Genet Mol Biol. Article17. 2005;4. DOI:10.2202/1544-6115.1128.
   PubMed Web of Science ®Google Scholar
• Mason MJ, Fan G, Plath K, et al. Signed weighted gene co-expression network analysis of transcriptional regulation in murine embryonic stem cells. BMC Genomics. 2009;10:327.
   PubMed Web of Science ®Google Scholar
• Biros E, Gabel G, Moran CS, et al. Differential gene expression in human abdominal aortic aneurysm and aortic occlusive disease. Oncotarget. 2015;6:12984–12996.
   PubMedGoogle Scholar
• Barrett T, Wilhite SE, Ledoux P, et al. NCBI GEO: archive for functional genomics data sets—update. Nucleic Acids Res. 2013;39:1005–1010.
   Web of Science ®Google Scholar
• Lenk GM, Tromp G, Weinsheimer S, et al. Whole genome expression profiling reveals a significant role for immune function in human abdominal aortic aneurysms. BMC Genomics. 2007;8:237.
   PubMed Web of Science ®Google Scholar
• Gabel G, Northoff BH, Weinzierl I, et al. Molecular fingerprint for terminal abdominal aortic aneurysm disease. J Am Heart Assoc. 2017;6(12): e006798.
   Web of Science ®Google Scholar
• Kibbe PDWA, Lin SM, Lin SM. lumi: a pipeline for processing Illumina microarray. Bioinformatics. 2008;24:1547–1548.
   PubMed Web of Science ®Google Scholar
• Team R. R: A language and environment for statistical computing. Vienna, Austria. Computing: R Foundation for Statistical Computing. 2018. Vol. 14: 12–21.
   Google Scholar
• Pagès H, Carlson M, Carlson M, et al. AnnotationDbi: manipulation of SQLite-based annotations in bioconductor. R Package Version. 2020;1.50.3.
   Google Scholar
• Dunning M, Lynch A, Eldridge M. illuminaHumanv4.db: illumina HumanHT12v4 annotation data (chip illuminaHumanv4). R package version 1.26.0. 2015.
   Google Scholar
• Ritchie ME, Phipson B, Wu D, et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43:e47.
   PubMed Web of Science ®Google Scholar
• Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B: Methodol. 1995;57:289–300.
   Web of Science ®Google Scholar
• Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics. 2008;9:559.
   PubMed Web of Science ®Google Scholar
• Botia JA, Vandrovcova J, Forabosco P, United Kingdom Brain Expression C, et al. An additional k-means clustering step improves the biological features of WGCNA gene co-expression networks. BMC Syst Biol. 2017;11:47.
   PubMed Web of Science ®Google Scholar
• Szklarczyk D, Gable AL, Lyon D, et al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47:D607–d13.
   PubMed Web of Science ®Google Scholar
• Bader GD, Hogue CW. An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics. 2003;4:2.
   PubMed Web of Science ®Google Scholar
• Shannon P, Markiel A, Ozier O, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13:2498–2504.
   PubMed Web of Science ®Google Scholar
• Ashburner M, Ball CA, Blake JA, et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 2000;25:25–29.
   PubMed Web of Science ®Google Scholar
• Ogata H, Goto S, Sato K, et al. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 1999;27:29–34.
   PubMed Web of Science ®Google Scholar
• Huang Da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4:44–57.
   PubMed Web of Science ®Google Scholar
• Huang Da W, Sherman BT, Lempicki RA. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 2009;37:1–13.
   PubMed Web of Science ®Google Scholar
• Jie S, Qiu G, Mohammad I. A semi-automatic image analysis tool for biomarker detection in immunohistochemistry analysis. 2013 Seventh International Conference on Image and Graphics,  Qingdao, China. 2013.
   Google Scholar
• Schneider CA, Rasband WS, Eliceiri KW. NIH Image to ImageJ: 25 years of image analysis. Nat Methods. 2012;9:671–675.
   PubMed Web of Science ®Google Scholar
• Brunner C, Wirth T. BOB.1/OBF.1 – a critical regulator of B cell function. Curr Immunol Rev. 2006;2:3–12.
   Google Scholar
• Teitell MA. OCA-B regulation of B-cell development and function. Trends Immunol. 2003;24:546–553.
   PubMed Web of Science ®Google Scholar
• Hägg S, Salehpour M, Noori P, et al. Carotid plaque age is a feature of plaque stability inversely related to levels of plasma insulin. Plos One. 2011;6:80–82.
   Web of Science ®Google Scholar
• IJpma RT, Luijtgaarden VD, Heijningen V, et al. Inflammation and TGF-β signaling differ between abdominal aneurysms and occlusive disease. J Cardiovasc Dev Dis. 2019;6:38.
   PubMed Web of Science ®Google Scholar
• Kim U, Qin XF, Gong S, et al. The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes. Nature. 1996;383:542–547.
   PubMed Web of Science ®Google Scholar
• Nielsen PJ, Georgiev O, Lorenz B, et al. B lymphocytes are impaired in mice lacking the transcriptional co-activator Bob1/OCA-B/OBF1. Eur J Immunol. 1996;26:3214–3218.
   PubMed Web of Science ®Google Scholar
• Schubart DB, Rolink A, Kosco-Vilbois MH, et al. B-cell-specific coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation. Nature. 1996;383:538–542.
   PubMed Web of Science ®Google Scholar
• Levels MJ, Fehres CM, van Baarsen LGM, et al. BOB.1 controls memory B-cell fate in the germinal center reaction. J Autoimmun. 2019;101:131–144.
   PubMed Web of Science ®Google Scholar
• Schaheen B, Downs EA, Serbulea V, et al. B-cell depletion promotes aortic infiltration of immunosuppressive cells and is protective of experimental aortic aneurysm. Arterioscler Thromb Vasc Biol. 2016;36:2191–2202.
   PubMed Web of Science ®Google Scholar
• Koch AE, Haines GK, Rizzo RJ, et al. Human abdominal aortic aneurysms. Immunophenotypic analysis suggesting an immune-mediated response. Am J Pathol. 1990;137:1199–1213.
   PubMed Web of Science ®Google Scholar
• Bobryshev YV, Lord RS. Vascular-associated lymphoid tissue (VALT) involvement in aortic aneurysm. Atherosclerosis. 2001;154:15–21.
   PubMed Web of Science ®Google Scholar
• Houtkamp MA, De Boer OJ, Van Der Loos CM, et al. Adventitial infiltrates associated with advanced atherosclerotic plaques: structural organization suggests generation of local humoral immune responses. J Pathol. 2001;193:263–269.
   PubMed Web of Science ®Google Scholar
• Ocana E, Bohorquez JC, Perez-Requena J, et al. Characterisation of T and B lymphocytes infiltrating abdominal aortic aneurysms. Atherosclerosis. 2003;170:39–48.
   PubMed Web of Science ®Google Scholar
• Li J, Deng Z, Zhang X, et al. Deficiency of immunoglobulin E protects mice from experimental abdominal aortic aneurysms. FASEB J. 2020;34:3091–3104.
   PubMed Web of Science ®Google Scholar
• Furusho A, Aoki H, Ohno-Urabe S, et al. Involvement of B cells, immunoglobulins, and syk in the pathogenesis of abdominal aortic aneurysm. J Am Heart Assoc. 2018;7(6): e007750.
   Web of Science ®Google Scholar
• Hinterseher I, Erdman R, Donoso LA, et al. Role of complement cascade in abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol. 2011;31:1653–1660.
   PubMed Web of Science ®Google Scholar
• Pagano MB, Zhou HF, Ennis TL, et al. Complement-dependent neutrophil recruitment is critical for the development of elastase-induced abdominal aortic aneurysm. Circulation. 2009;119:1805–1813.
   PubMed Web of Science ®Google Scholar
• Zhou HF, Yan H, Bertram P, et al. Fibrinogen-specific antibody induces abdominal aortic aneurysm in mice through complement lectin pathway activation. Proc Natl Acad Sci U S A. 2013;110:E4335–44.
   PubMed Web of Science ®Google Scholar
• Zhou HF, Yan H, Stover CM, et al. Antibody directs properdin-dependent activation of the complement alternative pathway in a mouse model of abdominal aortic aneurysm. Proc Natl Acad Sci U S A 2012; 109:E415–22. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289386/
   Google Scholar
• Karnowski A, Chevrier S, Belz GT, et al. B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1. J Exp Med. 2012;209:2049–2064.
   PubMed Web of Science ®Google Scholar
• Zwilling S, Dieckmann A, Pfisterer P, et al. Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells. Science. 1997;277:221–225.
   PubMed Web of Science ®Google Scholar
• Sagan A, Mikolajczyk TP, Mrowiecki W, et al. T cells are dominant population in human abdominal aortic aneurysms and their infiltration in the perivascular tissue correlates with disease severity. Front Immunol. 2019;10:1979.
   PubMed Web of Science ®Google Scholar
• Dale MA, Ruhlman MK, Baxter BT. Inflammatory cell phenotypes in AAAs: their role and potential as targets for therapy. Arterioscler Thromb Vasc Biol. 2015;35:1746–1755.
   PubMed Web of Science ®Google Scholar
• Brunner C, Sindrilaru A, Girkontaite I, et al. BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responses. EMBO J. 2007;26:3191–3202.
   PubMed Web of Science ®Google Scholar
• Yosef N, Shalek AK, Gaublomme JT, et al. Dynamic regulatory network controlling TH17 cell differentiation. Nature. 2013;496:461–468.
   PubMed Web of Science ®Google Scholar
• Ikegami I, Takaki H, Kamiya S, et al. Bob1 enhances RORgammat-mediated IL-17A expression in Th17cells through interaction with RORgammat. Biochem Biophys Res Commun. 2019;514:1167–1171.
   PubMed Web of Science ®Google Scholar
• Shakya A, Goren A, Shalek A, et al. Oct1 and OCA-B are selectively required for CD4 memory T cell function. J Exp Med. 2015;212:2115–2131.
   PubMed Web of Science ®Google Scholar
• Yamashita K, Mitsuhashi Y, Nagaya T, et al. POU2AF1 arranges systemic distribution of follicular helper T cells (IRC10P.466). 2014.
   Google Scholar
• Corcoran L, Emslie D, Kratina T, et al. Oct2 and Obf1 as facilitators of B:T cell collaboration during a humoral immune response. Front Immunol. 2014;5:108.
   PubMed Web of Science ®Google Scholar
• Zhou H, Brekman A, Zuo WL, et al. POU2AF1 functions in the human airway epithelium to regulate expression of host defense genes. J Immunol. 2016;196:3159–3167.
   PubMed Web of Science ®Google Scholar
• Yuan Z, Lu Y, Wei J, et al. Abdominal aortic aneurysm: roles of inflammatory cells. Front Immunol. 2021;11:609161.
   PubMed Web of Science ®Google Scholar
• Ijaz Talha, Sun Hong, Pinchuk Irina V et al. Deletion of NF-κB/RelA in Angiotensin II-Sensitive Mesenchymal Cells Blocks Aortic Vascular Inflammation and Abdominal Aortic Aneurysm Formation.[J] .Arterioscler Thromb Vasc Biol, 2017, 37: 1881–1890.
   Google Scholar
• Tang Y, Fan W, Zou B, et al. TGF-β signaling and microRNA cross-talk regulates abdominal aortic aneurysm progression. Clin Chim Acta. 2021;515:90–95.
   PubMed Web of Science ®Google Scholar
• Ghosh A, DiMusto PD, Ehrlichman LK, et al. The role of extracellular signal-related kinase during abdominal aortic aneurysm formation. J Am Coll Surg. 2012;215(5):668–680.e1.
   PubMed Web of Science ®Google Scholar
• Sharma N, Dev R, Ruiz-Rosado JD, et al. Pharmacological inhibition of Notch signaling regresses pre-established abdominal aortic aneurysm. Sci Rep. 2019;9:13458.
   PubMed Web of Science ®Google Scholar
• Paige E, Clément M, Lareyre F, et al. Interleukin-6 receptor signaling and abdominal aortic aneurysm growth rates. Circ: Genomic Precis Med. 2019;12:e002413.
   PubMed Web of Science ®Google Scholar
• Kan KJ, Guo F, Zhu L, et al. Weighted gene co-expression network analysis reveals key genes and potential drugs in abdominal aortic aneurysm. Biomedicines. 2021;9(5): 546.
   Web of Science ®Google Scholar
• Xie X, Wang EC, Xu D, et al. Bioinformatics analysis reveals the potential diagnostic biomarkers for abdominal aortic aneurysm. Front Cardiovasc Med. 2021;8:656263.
   PubMed Web of Science ®Google Scholar
• Zhang H, Yang D, Chen S, et al. Identification of potential proteases for abdominal aortic aneurysm by weighted gene coexpression network analysis. Genome. 2020;63:561–575.
   PubMed Web of Science ®Google Scholar
• Li T, Wang T, Zhao X. Profiles of immune infiltration in abdominal aortic aneurysm and their associated marker genes: a gene expression-based study. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2021;54:e11372.
   PubMed Web of Science ®Google Scholar
• Chen S, Yang D, Lei C, et al. Identification of crucial genes in abdominal aortic aneurysm by WGCNA. PeerJ. 2019;7:e7873.
   PubMed Web of Science ®Google Scholar