Mechanism of methyltransferase like 3 in epithelial-mesenchymal transition process, invasion, and metastasis in esophageal cancer

References

• Watanabe M, Otake R, Kozuki R, et al. Recent progress in multidisciplinary treatment for patients with esophageal cancer. Surg Today. 2020;50(1):12–20.
   PubMed Web of Science ®Google Scholar
• Alsop BR, Sharma P. Esophageal cancer. Gastroenterol Clin North Am. 2016;45(3):399–412.
   PubMed Web of Science ®Google Scholar
• Lin EW, Karakasheva TA, Hicks PD, et al. The tumor microenvironment in esophageal cancer. Oncogene. 2016;35(41):5337–5349.
   PubMed Web of Science ®Google Scholar
• Zhao Q, Yu J, Meng X. A good start of immunotherapy in esophageal cancer. Cancer Med. 2019;8(10):4519–4526.
   PubMed Web of Science ®Google Scholar
• Mittal V. Epithelial mesenchymal transition in tumor metastasis. Annu Rev Pathol. 2018;13(1):395–412.
   PubMed Web of Science ®Google Scholar
• Olea-Flores M, Juarez-Cruz JC, Zuniga-Eulogio MD, et al. New actors driving the epithelial-mesenchymal transition in cancer: the role of leptin. Biomolecules 2020;10(12):12.
   Web of Science ®Google Scholar
• Huang S, Luo S, Gong C, et al. MTTL3 upregulates microRNA-1246 to promote occurrence and progression of NSCLC via targeting paternally expressed gene 3. Mol Ther Nucleic Acids. 2021;24:542–553.
   PubMedGoogle Scholar
• Zeng C, Huang W, Li Y, et al. Roles of METTL3 in cancer: mechanisms and therapeutic targeting. J Hematol Oncol. 2020;13(1):117.
   PubMed Web of Science ®Google Scholar
• Chen X, Huang L, Yang T, et al. METTL3 promotes esophageal squamous cell carcinoma metastasis through enhancing GLS2 expression. Front Oncol. 2021;11:667451.
   PubMedGoogle Scholar
• Hou H, Zhao H, Yu X, et al. METTL3 promotes the proliferation and invasion of esophageal cancer cells partly through AKT signaling pathway. Pathol Res Pract. 2020;216(9):153087.
   PubMed Web of Science ®Google Scholar
• Hua W, Zhao Y, Jin X, et al. METTL3 promotes ovarian carcinoma growth and invasion through the regulation of AXL translation and epithelial to mesenchymal transition. Gynecol Oncol. 2018;151(2):356–365.
   PubMed Web of Science ®Google Scholar
• Yue B, Song C, Yang L, et al. METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer. Mol Cancer. 2019;18(1):142.
   PubMed Web of Science ®Google Scholar
• Mei LL, Qiu YT, Zhang B, et al. MicroRNAs in esophageal squamous cell carcinoma: potential biomarkers and therapeutic targets. Cancer Biomark. 2017;19(1):1–9.
   PubMed Web of Science ®Google Scholar
• Alarcon CR, Lee H, Goodarzi H, et al. N6-methyladenosine marks primary microRNAs for processing. Nature. 2015;519(7544):482–485.
   PubMed Web of Science ®Google Scholar
• He FC, Meng WW, Qu YH, et al. Expression of circulating microRNA-20a and let-7a in esophageal squamous cell carcinoma. World J Gastroenterol. 2015;21(15):4660–4665.
   PubMed Web of Science ®Google Scholar
• Bai X, Han G, Liu Y, et al. MiRNA-20a-5p promotes the growth of triple-negative breast cancer cells through targeting RUNX3. Biomed Pharmacother. 2018;103:1482–1489.
   PubMed Web of Science ®Google Scholar
• Cheng D, Zhao S, Tang H, et al. MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4. Oncotarget. 2016;7(29):45199–45213.
   PubMedGoogle Scholar
• Li Y, Sun C, Tan Y, et al. Transcription levels and prognostic significance of the NFI family members in human cancers. PeerJ. 2020;8:e8816.
   PubMed Web of Science ®Google Scholar
• Wang H, Shi X, Wu S. miR-550a-3/NFIC plays a driving role in esophageal squamous cell cancer cells proliferation and metastasis partly through EMT process. Mol Cell Biochem. 2020;472(1–2):115–123.
   PubMed Web of Science ®Google Scholar
• Jones-Bolin S. Guidelines for the care and use of laboratory animals in biomedical research. Curr Protoc Pharmacol. 2012;59(1): Appendix 4(Appendix 4B. DOI:10.1002/0471141755.pha04bs59.
   Google Scholar
• Chen X, Xu M, Xu X, et al. METTL14 suppresses CRC progression via regulating N6-methyladenosine-dependent primary miR-375 processing. Mol Ther. 2020;28(2):599–612.
   PubMed Web of Science ®Google Scholar
• Cheng Y, Li Y, Nian Y, et al. STAT3 is involved in miR-124-mediated suppressive effects on esophageal cancer cells. BMC Cancer. 2015;15(1):306.
   PubMedGoogle Scholar
• Yang F, Xiong H, Duan L, et al. MiR-1246 promotes metastasis and invasion of A549 cells by targeting GSK-3betaMediated Wnt/beta-catenin pathway. Cancer Res Treat. 2019;51(4):1420–1429.
   PubMed Web of Science ®Google Scholar
• Sun Y, Li S, Yu W, et al. N(6)-methyladenosine-dependent pri-miR-17-92 maturation suppresses PTEN/TMEM127 and promotes sensitivity to everolimus in gastric cancer. Cell Death Dis. 2020;11(10):836.
   PubMed Web of Science ®Google Scholar
• Cheng C, Wu Y, Xiao T, et al. METTL3-mediated m(6)A modification of ZBTB4 mRNA is involved in the smoking-induced EMT in cancer of the lung. Mol Ther Nucleic Acids. 2021;23:487–500.
   PubMedGoogle Scholar
• Zhou D, Gu J, Wang Y, et al. Long non-coding RNA NEAT1 transported by extracellular vesicles contributes to breast cancer development by sponging microRNA-141-3p and regulating KLF12. Cell Biosci. 2021;11(1):68.
   PubMed Web of Science ®Google Scholar
• Cai Y, Feng R, Lu T, et al. Novel insights into the m(6) A-RNAmethyltransferase METTL3 in cancer. Biomark Res. 2021;9(1):27.
   PubMed Web of Science ®Google Scholar
• Huang J, Chen Z, Chen X, et al. The role of RNA N (6)-methyladenosine methyltransferase in cancers. Mol Ther Nucleic Acids. 2021;23:887–896.
   PubMedGoogle Scholar
• Pandompatam G, Kashani K, Vallabhajosyula S. The role of natriuretic peptides in the management, outcomes and prognosis of sepsis and septic shock. Rev Bras Ter Intensiva. 2019;31(3):368–378.
   PubMedGoogle Scholar
• Lin X, Chai G, Wu Y, et al. RNA m(6)A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail. Nat Commun. 2019;10(1):2065.
   PubMed Web of Science ®Google Scholar
• Xia TL, Yan SM, Yuan L, et al. Upregulation of METTL3 expression predicts poor prognosis in patients with esophageal squamous cell carcinoma. Cancer Manag Res. 2020;12:5729–5737.
   PubMed Web of Science ®Google Scholar
• Wanna-Udom S, Terashima M, Lyu H, et al. The m6A methyltransferase METTL3 contributes to Transforming Growth Factor-beta-induced epithelial-mesenchymal transition of lung cancer cells through the regulation of JUNB. Biochem Biophys Res Commun. 2020;524(1):150–155.
   PubMed Web of Science ®Google Scholar
• Peng W, Li J, Chen R, et al. Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway. J Exp Clin Cancer Res. 2019;38(1):393.
   PubMed Web of Science ®Google Scholar
• Li J, Ye D, Shen P, et al. Mir-20a-5p induced WTX deficiency promotes gastric cancer progressions through regulating PI3K/AKT signaling pathway. J Exp Clin Cancer Res. 2020;39(1):212.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Xu Y, Li Z, et al. Identification of the key transcription factors in esophageal squamous cell carcinoma. J Thorac Dis. 2018;10(1):148–161.
   PubMed Web of Science ®Google Scholar
• Brun M, Jain S, Monckton EA, et al. Nuclear factor I represses the notch effector HEY1 in Glioblastoma. Neoplasia. 2018;20(10):1023–1037.
   PubMed Web of Science ®Google Scholar
• Liang X, Gao J, Wang Q, et al. ECRG4 represses cell proliferation and invasiveness via NFIC/OGN/NF-kappaB signaling pathway in bladder cancer. Front Genet. 2020;11:846.
   PubMed Web of Science ®Google Scholar