1,389
Views
1
CrossRef citations to date
0
Altmetric
Research paper

The mechanism of sevoflurane post-treatment alleviating hypoxic-ischemic encephalopathy by affecting histone methyltransferase G9a in rats

, , , &
Pages 9790-9805 | Received 02 Aug 2021, Accepted 13 Oct 2021, Published online: 07 Dec 2021

References

  • Yildiz EP, Ekici B, Tatli B. Neonatal hypoxic ischemic encephalopathy: an update on disease pathogenesis and treatment. Expert Rev Neurother. 2017;17:449–459.
  • Dixon BJ, Reis C, Ho WM, et al. Neuroprotective strategies after neonatal hypoxic ischemic encephalopathy. Int J Mol Sci. 2015;16:22368–22401.
  • Douglas-Escobar M, Weiss MD. Hypoxic-ischemic encephalopathy: a review for the clinician. JAMA Pediatr. 2015;169:397–403.
  • Greco P, Nencini G, Piva I, et al. Pathophysiology of hypoxic-ischemic encephalopathy: a review of the past and a view on the future. Acta Neurol Belg. 2020;120:277–288.
  • Lee BL, Glass HC. Cognitive outcomes in late childhood and adolescence of neonatal hypoxic-ischemic encephalopathy. Clin Exp Pediatr. 2021.
  • Reinboth BS, Koster C, Abberger H, et al. Endogenous hypothermic response to hypoxia reduces brain injury: implications for modeling hypoxic-ischemic encephalopathy and therapeutic hypothermia in neonatal mice. Exp Neurol. 2016;283:264–275.
  • Wang H, Li P, Xu N, et al. Paradigms and mechanisms of inhalational anesthetics mediated neuroprotection against cerebral ischemic stroke. Med Gas Res. 2016;6:194–205.
  • Yang T, Zhuang L, Rei Fidalgo AM, et al. Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia. PLoS One. 2012;7:e37020.
  • Adamczyk S, Robin E, Simerabet M, et al. Sevoflurane pre- and post-conditioning protect the brain via the mitochondrial K ATP channel. Br J Anaesth. 2010;104:191–200.
  • Bedirli N, Bagriacik EU, Emmez H, et al. Sevoflurane and isoflurane preconditioning provides neuroprotection by inhibition of apoptosis-related mRNA expression in a rat model of focal cerebral ischemia. J Neurosurg Anesthesiol. 2012;24:336–344.
  • Kim HC, Kim E, Bae JI, et al. Sevoflurane postconditioning reduces apoptosis by activating the JAK-STAT pathway after transient global cerebral ischemia in rats. J Neurosurg Anesthesiol. 2017;29:37–45.
  • Bustelo M, Barkhuizen M, van den Hove DLA, et al. Clinical implications of epigenetic dysregulation in perinatal hypoxic-ischemic brain damage. Front Neurol. 2020;11:483.
  • Grinan-Ferre C, Marsal-Garcia L, Bellver-Sanchis A, et al. Pharmacological inhibition of G9a/GLP restores cognition and reduces oxidative stress, neuroinflammation and beta-Amyloid plaques in an early-onset Alzheimer’s disease mouse model. Aging (Albany NY). 2019;11:11591–11608.
  • Gupta-Agarwal S, Franklin AV, Deramus T, et al. G9a/GLP histone lysine dimethyltransferase complex activity in the hippocampus and the entorhinal cortex is required for gene activation and silencing during memory consolidation. J Neurosci. 2012;32:5440–5453.
  • Schweizer S, Harms C, Lerch H, et al. Inhibition of histone methyltransferases SUV39H1 and G9a leads to neuroprotection in an in vitro model of cerebral ischemia. J Cereb Blood Flow Metab. 2015;35:1640–1647.
  • Sharma M, Dierkes T, Sajikumar S. Epigenetic regulation by G9a/GLP complex ameliorates amyloid-beta 1-42 induced deficits in long-term plasticity and synaptic tagging/capture in hippocampal pyramidal neurons. Aging Cell. 2017;16:1062–1072.
  • Berson A, Nativio R, Berger SL, et al. Epigenetic regulation in neurodegenerative diseases. Trends Neurosci. 2018;41:587–598.
  • Huang J, Liu W, Doycheva DM, et al. Ghrelin attenuates oxidative stress and neuronal apoptosis via GHSR-1alpha/AMPK/Sirt1/PGC-1alpha/UCP2 pathway in a rat model of neonatal HIE. Free Radic Biol Med. 2019;141:322–337.
  • Von Hovel FF, Rumpel R, Ratzka A, et al. AAV2/DJ-mediated alpha-synuclein overexpression in the rat substantia nigra as early stage model of Parkinson’s disease. Cell Tissue Res. 2019;378:1–14.
  • Longa EZ, Weinstein PR, Carlson S, et al. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989;20:84–91.
  • Kim H, Yu T, Cam-Etoz B, et al. Treatment of traumatic brain injury with 17alpha-ethinylestradiol-3-sulfate in a rat model. J Neurosurg. 2017;127:23–31.
  • Cao C, Zhang Y, Chai Y, et al. Attenuation of sepsis-induced cardiomyopathy by regulation of MicroRNA-23b is mediated through targeting of MyD88-Mediated NF-kappaB activation. Inflammation. 2019;42:973–986.
  • Jiang B, Li L, Chen Q, et al. Role of glibenclamide in brain injury after intracerebral hemorrhage. Transl Stroke Res. 2017;8:183–193.
  • Cardiff RD, Miller CH, Munn RJ. Manual hematoxylin and eosin staining of mouse tissue sections. Cold Spring Harb Protoc. 2014;2014:655–658.
  • Ren X, Wang Z, Guo C. MiR-195-5p ameliorates cerebral ischemia-reperfusion injury by regulating the PTEN-AKT signaling pathway. Neuropsychiatr Dis Treat. 2021;17:1231–1242.
  • Liu Y, Wang H, Liu N, et al. Oxymatrine protects neonatal rat against hypoxic-ischemic brain damage via PI3K/Akt/GSK3beta pathway. Life Sci. 2020;254:116444.
  • Ma J, Ni H, Rui Q, et al. Potential roles of NIX/BNIP3L pathway in rat traumatic brain injury. Cell Transplant. 2019;28:585–595.
  • Wang H, Xu Y, Zhu S, et al. Post-treatment sevoflurane protects against hypoxic-ischemic brain injury in neonatal rats by downregulating histone methyltransferase G9a and upregulating nuclear factor erythroid 2-related factor 2 (NRF2). Med Sci Monit. 2021;27:e930042.
  • Zhao M, Wang W, Jiang Z, et al. Long-term effect of post-traumatic stress in adolescence on dendrite development and H3K9me2/BDNF expression in male rat hippocampus and prefrontal cortex. Front Cell Dev Biol. 2020;8:682.
  • Mozzetta C, Pontis J, Fritsch L, et al. The histone H3 lysine 9 methyltransferases G9a and GLP regulate polycomb repressive complex 2-mediated gene silencing. Mol Cell. 2014;53:277–289.
  • Shinkai Y, Tachibana M. H3K9 methyltransferase G9a and the related molecule GLP. Genes Dev. 2011;25:781–788.
  • Pan MR, Hsu MC, Chen LT, et al. G9a orchestrates PCL3 and KDM7A to promote histone H3K27 methylation. Sci Rep. 2015;5:18709.
  • Zhang Y, Gao Q, Wu Z, et al. Sevoflurane postconditioning ameliorates neuronal migration disorder through Reelin/Dab1 and improves long-term cognition in neonatal rats after hypoxic-ischemic injury. Neurotox Res. 2021;39:1524–1542.
  • Ding L, Ning J, Wang Q, et al. Sevoflurane improves nerve regeneration and repair of neurological deficit in brain damage rats via microRNA-490-5p/CDK1 axis. Life Sci. 2021;271:119111.
  • Subbanna S, Shivakumar M, Umapathy NS, et al. G9a-mediated histone methylation regulates ethanol-induced neurodegeneration in the neonatal mouse brain. Neurobiol Dis. 2013;54:475–485.
  • Liang L, Gu X, Zhao JY, et al. G9a participates in nerve injury-induced Kcna2 downregulation in primary sensory neurons. Sci Rep. 2016;6:37704.
  • Maze I, Covington HE 3rd, Dietz DM, et al. Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science. 2010;327:213–216.
  • Schaefer A, Sampath SC, Intrator A, et al. Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex. Neuron. 2009;64:678–691.
  • Hwang JY, Aromolaran KA, Zukin RS. The emerging field of epigenetics in neurodegeneration and neuroprotection. Nat Rev Neurosci. 2017;18:347–361.
  • Pang KKL, Sharma M, Sajikumar S. Epigenetics and memory: emerging role of histone lysine methyltransferase G9a/GLP complex as bidirectional regulator of synaptic plasticity. Neurobiol Learn Mem. 2019;159:1–5.
  • Tan T, Xie J, Liu T, et al. Low-frequency (1 Hz) repetitive transcranial magnetic stimulation (rTMS) reverses Abeta(1-42)-mediated memory deficits in rats. Exp Gerontol. 2013;48:786–794.
  • Grinan-Ferre C, Corpas R, Puigoriol-Illamola D, et al. Understanding epigenetics in the neurodegeneration of Alzheimer’s Disease: SAMP8 mouse model. J Alzheimers Dis. 2018;62:943–963.
  • Harman MF, Martin MG. Epigenetic mechanisms related to cognitive decline during aging. J Neurosci Res. 2020;98:234–246.
  • Delgado-Morales R, Agis-Balboa RC, Esteller M, et al. Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders. Clin Epigenetics. 2017;9:67.