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Research paper

Cullin3 (CUL3) suppresses proliferation, migration and phenotypic transformation of PDGF-BB-stimulated vascular smooth muscle cells and mitigates inflammatory response by repressing Hedgehog signaling pathway

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Pages 9463-9472 | Received 30 Apr 2021, Accepted 14 Oct 2021, Published online: 02 Dec 2021

References

  • Shi X, Xie X, Sun Y, et al. Paeonol inhibits NLRP3 mediated inflammation in rat endothelial cells by elevating hyperlipidemic rats plasma exosomal miRNA-223. Eur J Pharmacol. 2020;885:173473.
  • Marín C, Yubero-Serrano EM, López-Miranda J, et al. Endothelial aging associated with oxidative stress can be modulated by a healthy Mediterranean diet. Int J Mol Sci. 2013;14(5):8869–8889.
  • Tsai SY, Shen RS, Kuo CJ, et al. The association between carotid atherosclerosis and treatment with lithium and antipsychotics in patients with bipolar disorder. Aust N Z J Psychiatry. 2020;54(11):1125-1134.
  • Guo M, Cai Y, He C, et al. Coupled modeling of lipid deposition, inflammatory response and intraplaque angiogenesis in atherosclerotic plaque. Ann Biomed Eng. 2019;47(2):439–452.
  • Zhu Y, Qu J, He L, et al. Calcium in vascular smooth muscle cell elasticity and adhesion: novel insights into the mechanism of action. Front Physiol. 2019;10:852.
  • He X, Lian Z, Yang Y, et al. Long non-coding RNA PEBP1P2 suppresses proliferative VSMCs phenotypic switching and proliferation in atherosclerosis. Mol Ther Nucleic Acids. 2020;22:84–98.
  • Hwang YJ, Park JH, Cho DH. Activation of AMPK by telmisartan decreases basal and PDGF-stimulated VSMC proliferation via inhibiting the mTOR/p70S6K signaling axis. J Korean Med Sci. 2020;35(35):e289.
  • Greenwood S, Struhl G. Progression of the morphogenetic furrow in the Drosophila eye: the roles of Hedgehog, Decapentaplegic and the Raf pathway. Development. 1999;126(24):5795–5808.
  • Weng Y, Lieberthal TJ, Zhou VX, et al. Liver epithelial focal adhesion kinase modulates fibrogenesis and hedgehog signaling. JCI Insight. 2020;5(20). DOI:10.1172/jci.insight.141217.
  • Lin Y, Shao Y, Li J, et al. The hierarchical micro-/nanotextured topographies promote the proliferation and angiogenesis-related genes expression in human umbilical vein endothelial cells by initiation of Hedgehog-Gli1 signaling. Artif Cells Nanomed Biotechnol. 2018;46(sup3):S1141–S1151.
  • Lézot F, Corre I, Morice S, et al. SHH signaling pathway drives pediatric bone sarcoma progression. Cells. 2020;9(3):3.
  • Lee J, Platt KA, Censullo P, et al. Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development. 1997;124(13):2537–2552.
  • Zeng Q, Wei B, Zhao Y, et al. Shh mediates PDGF-induced contractile-to-synthetic phenotypic modulation in vascular smooth muscle cells through regulation of KLF4. Exp Cell Res. 2016;345(1):82–92.
  • Xu J, Zhang Y, You S, et al. Paired box 9 regulates VSMC phenotypic transformation, proliferation, and migration via sonic hedgehog. Life Sci. 2020;257:118053.
  • Lutz LM, Pace CR, Arnold MM. Rotavirus NSP1 associates with components of the Cullin RING Ligase family of E3 Ubiquitin Ligases. J Virol. 2016;90(13):6036–6048.
  • Hubner M, Peter M. Cullin-3 and the endocytic system: new functions of ubiquitination for endosome maturation. Cell Logist. 2012;2(3):166–168.
  • Ou CY, Wang CH, Jiang J, et al. Suppression of Hedgehog signaling by Cul3 ligases in proliferation control of retinal precursors. Dev Biol. 2007;308(1):106–119.
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25(4):402–408.
  • Leung A, Stapleton K, Natarajan R. Functional long non-coding RNAs in vascular smooth muscle cells. Curr Top Microbiol Immunol. 2016;394:127–141.
  • Wang P, Song J, Ye D. CRL3s: the BTB-CUL3-RING E3 Ubiquitin Ligases. Adv Exp Med Biol. 2020;1217:211–223.
  • Gao F, Fan Y, Zhou B, et al. The functions and properties of cullin-5, a potential therapeutic target for cancers. Am J Transl Res. 2020;12(2):618–632.
  • Raghavan S, Singh NK, Mani AM, et al. Protease-activated receptor 1 inhibits cholesterol efflux and promotes atherogenesis via cullin 3-mediated degradation of the ABCA1 transporter. J Biol Chem. 2018;293(27):10574–10589.
  • Zhang MJ, Zhou Y, Chen L, et al. SIRT1 improves VSMC functions in atherosclerosis. Prog Biophys Mol Biol. 2016;121(1):11–15.
  • Hyman JM, Firestone AJ, Heine VM, et al. Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc Natl Acad Sci U S A. 2009;106(33):14132–14137.
  • de Boer S, Baran Y, Garcia-Garcia HM, et al. The European Collaborative Project on inflammation and vascular wall remodeling in atherosclerosis - intravascular ultrasound (ATHEROREMO-IVUS) study. EuroIntervention. 2018;14(2):194–203.