Naringenin alleviates myocardial ischemia/reperfusion injury by regulating the nuclear factor-erythroid factor 2-related factor 2 (Nrf2) /System xc-/ glutathione peroxidase 4 (GPX4) axis to inhibit ferroptosis

References

• Mao ZJ, Lin H, Hou JW, et al. A meta-analysis of resveratrol protects against myocardial ischemia/reperfusion injury: evidence from small animal studies and insight into molecular mechanisms. Oxid Med Cell Longev. 2019;2019:5793867. PubMed PMID: 31182995; PubMed Central PMCID: PMCPMC6512035.
   PubMed Web of Science ®Google Scholar
• Gupta SC, Kunnumakkara AB, Aggarwal S, et al. Inflammation, a double-edge sword for cancer and other age-related diseases. Front Immunol. 2018;9:2160. PubMed PMID: 30319623; PubMed Central PMCID: PMCPMC6170639.
   PubMed Web of Science ®Google Scholar
• Salehi B, Fokou PVT, Sharifi-Rad M, et al. The therapeutic potential of naringenin: a review of clinical trials. Pharmaceuticals (Basel). 2019;12(1). PubMed PMID: 30634637; PubMed Central PMCID: PMCPMC6469163. DOI:10.3390/ph12010011.
   PubMedGoogle Scholar
• Testai L, Calderone V. Nutraceutical value of citrus flavanones and their implications in cardiovascular disease. Nutrients. 2017;9(5):502. PubMed PMID: 28509871; PubMed Central PMCID: PMCPMC5452232.
   PubMed Web of Science ®Google Scholar
• Li F, Zhan Z, Qian J, et al. Naringin attenuates rat myocardial ischemia/reperfusion injury via PI3K/Akt pathway-mediated inhibition of apoptosis, oxidative stress and autophagy. Exp Ther Med. 2021;22(2):811. PubMed PMID: 34131434; PubMed Central PMCID: PMCPMC8193209.
   PubMed Web of Science ®Google Scholar
• Rani N, Bharti S, Manchanda M, et al. Regulation of heat shock proteins 27 and 70, p-Akt/p-eNOS and MAPKs by Naringin Dampens myocardial injury and dysfunction in vivo after ischemia/reperfusion. PLoS One. 2013;8(12):e82577. PubMed PMID: 24324809; PubMed Central PMCID: PMCPMC3855773.
   PubMed Web of Science ®Google Scholar
• Bakar E, Ulucam E, Cerkezkayabekir A, et al. Investigation of the effects of naringin on intestinal ischemia reperfusion model at the ultrastructural and biochemical level. Biomed Pharmacother. 2019;109:345–350. PubMed PMID: 30399568.
   PubMed Web of Science ®Google Scholar
• Cerkezkayabekir A, Sanal F, Bakar E, et al. Naringin protects viscera from ischemia/reperfusion injury by regulating the nitric oxide level in a rat model. Biotech Histochem. 2017;92(4):252–263. PubMed PMID: 28426254.
   PubMed Web of Science ®Google Scholar
• Li J, Cao F, Yin HL, et al. Ferroptosis: past, present and future. Cell Death Dis. 2020;11(2):88. PubMed PMID: 32015325; PubMed Central PMCID: PMCPMC6997353.
   PubMed Web of Science ®Google Scholar
• Li W, Li W, Leng Y, et al. Ferroptosis is involved in diabetes myocardial ischemia/reperfusion injury through endoplasmic reticulum stress. DNA Cell Biol. 2020;39(2):210–225. PubMed PMID: 31809190.
   PubMed Web of Science ®Google Scholar
• Kobayashi M, Suhara T, Baba Y, et al. Pathological roles of iron in cardiovascular disease. Curr Drug Targets. 2018;19(9):1068–1076. PubMed PMID: 29874997; PubMed Central PMCID: PMCPMC6469984.
   PubMed Web of Science ®Google Scholar
• Chtourou Y, Fetoui H, Gdoura R. Protective effects of naringenin on iron-overload-induced cerebral cortex neurotoxicity correlated with oxidative stress. Biol Trace Elem Res. 2014;158(3):376–383. PubMed PMID: 24682942.
   PubMed Web of Science ®Google Scholar
• Cheng IF, Breen K. On the ability of four flavonoids, baicilein, luteolin, naringenin, and quercetin, to suppress the Fenton reaction of the iron-ATP complex. Biometals. 2000;13(1):77–83. PubMed PMID: 10831228.
   PubMed Web of Science ®Google Scholar
• Yu LM, Dong X, Xue XD, et al. Naringenin improves mitochondrial function and reduces cardiac damage following ischemia-reperfusion injury: the role of the AMPK-SIRT3 signaling pathway. Food Funct. 2019;10(5):2752–2765. PubMed PMID: 31041965.
   PubMed Web of Science ®Google Scholar
• Hou Y, Wang K, Wan W, et al. Resveratrol provides neuroprotection by regulating the JAK2/STAT3/PI3K/AKT/mTOR pathway after stroke in rats. Genes Dis. 2018;5(3):245–255. PubMed PMID: 30320189; PubMed Central PMCID: PMCPMC6176158.
   PubMed Web of Science ®Google Scholar
• Sen Z, Jie M, Jingzhi Y, et al. Total coumarins from hydrangea paniculata protect against cisplatin-induced acute kidney damage in mice by suppressing renal inflammation and apoptosis. Evid Based Complement Alternat Med. 2017;2017:5350161. PubMed PMID: 28367225; PubMed Central PMCID: PMCPMC5358452.
   PubMed Web of Science ®Google Scholar
• Hirschhorn T, Stockwell BR. The development of the concept of ferroptosis. Free Radic Biol Med. 2019;133:130–143. PubMed PMID: 30268886; PubMed Central PMCID: PMCPMC6368883.
   PubMed Web of Science ®Google Scholar
• Chen J, Yang X, Fang X, et al. [The role of ferroptosis in chronic diseases]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020;49(1):44–57. PubMed PMID: 32621416.
   PubMedGoogle Scholar
• Hassannia B, Vandenabeele P, Vanden Berghe T. Targeting ferroptosis to iron out cancer. Cancer Cell. 2019;35(6):830–849. PubMed PMID: 31105042.
   PubMed Web of Science ®Google Scholar
• Ganguly R, Hasanally D, Stamenkovic A, et al. Alpha linolenic acid decreases apoptosis and oxidized phospholipids in cardiomyocytes during ischemia/reperfusion. Mol Cell Biochem. 2018;437(1–2):163–175. PubMed PMID: 28634855.
   PubMed Web of Science ®Google Scholar
• Ravingerova T, Kindernay L, Bartekova M, et al. The molecular mechanisms of iron metabolism and its role in cardiac dysfunction and cardioprotection. Int J Mol Sci. 2020;21(21):7889. PubMed PMID: 33114290; PubMed Central PMCID: PMCPMC7660609.
   PubMed Web of Science ®Google Scholar
• Shamsi A, Shahwan M, Khan MS, et al. Elucidating the interaction of human ferritin with quercetin and naringenin: implication of natural products in neurodegenerative diseases: molecular docking and dynamics simulation insight. ACS Omega. 2021;6(11):7922–7930. PubMed PMID: 33778303; PubMed Central PMCID: PMCPMC7992174.
   PubMed Web of Science ®Google Scholar
• Sripetchwandee J, Pipatpiboon N, Chattipakorn N, et al. Combined therapy of iron chelator and antioxidant completely restores brain dysfunction induced by iron toxicity. PLoS One. 2014;9(1):e85115. PubMed PMID: 24400127; PubMed Central PMCID: PMCPMC3882264.
   PubMed Web of Science ®Google Scholar
• Chtourou Y, Slima AB, Gdoura R, et al. Naringenin mitigates iron-induced anxiety-like behavioral impairment, mitochondrial dysfunctions, ectonucleotidases and acetylcholinesterase alteration activities in rat hippocampus. Neurochem Res. 2015;40(8):1563–1575. PubMed PMID: 26050208.
   PubMed Web of Science ®Google Scholar
• Imai H, Matsuoka M, Kumagai T, et al. Lipid peroxidation-dependent cell death regulated by GPx4 and ferroptosis. Curr Top Microbiol Immunol. 2017;403:143–170. PubMed PMID: 28204974.
   PubMed Web of Science ®Google Scholar
• Tang Q, Bai L, Zou Z, et al. Ferroptosis is newly characterized form of neuronal cell death in response to arsenite exposure. Neurotoxicology. 2018;67:27–36. PubMed PMID: 29678591.
   PubMed Web of Science ®Google Scholar
• Wang H, Liu C, Zhao Y, et al. Mitochondria regulation in ferroptosis. Eur J Cell Biol. 2020;99(1):151058. PubMed PMID: 31810634.
   PubMed Web of Science ®Google Scholar
• Bersuker K, Hendricks JM, Li Z, et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature. 2019;575(7784):688–692. PubMed PMID: 31634900; PubMed Central PMCID: PMCPMC6883167.
   PubMed Web of Science ®Google Scholar
• Zhou Y. The protective effects of cryptochlorogenic acid on beta-cells function in diabetes in vivo and vitro via inhibition of ferroptosis. Diabetes Metab Syndr Obes. 2020;13:1921–1931. PubMed PMID: 32606852; PubMed Central PMCID: PMCPMC7294720.
   PubMed Web of Science ®Google Scholar
• Amini N, Sarkaki A, Dianat M, et al. Protective effects of naringin and trimetazidine on remote effect of acute renal injury on oxidative stress and myocardial injury through Nrf-2 regulation. Pharmacol Rep. 2019;71(6):1059–1066. PubMed PMID: 31604166.
   PubMed Web of Science ®Google Scholar