Synergetic protective effect of berberine and ginsenoside Rb1 against tumor necrosis factor alpha−induced inflammation in adipocytes

References

• Bluher M. Obesity: global epidemiology and pathogenesis. Nat Rev Endocrinol. 2019;15(5):288–298.
   PubMed Web of Science ®Google Scholar
• Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988;37(12):1595–1607.
   PubMed Web of Science ®Google Scholar
• Bochud M, Marquant F, Marques-Vidal PM, et al. Association between C-reactive protein and adiposity in women. J Clin Endocrinol Metab. 2009;94(10):3969–3977.
   PubMed Web of Science ®Google Scholar
• Welsh P, Polisecki E, Robertson M, et al. Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach. J Clin Endocrinol Metab. 2010;95(1):93–99.
   PubMed Web of Science ®Google Scholar
• Zou K, Li Z, Zhang Y, et al. Advances in the study of berberine and its derivatives: a focus on anti-inflammatory and anti-tumor effects in the digestive system. Acta Pharmacol Sin. 2017;38(2):157–167.
   PubMed Web of Science ®Google Scholar
• Sun SF, Zhao TT, Zhang HJ, et al. Renoprotective effect of berberine on type 2 diabetic nephropathy in rats. Clin Exp Pharmacol Physiol. 2015;42(6):662–670.
   PubMed Web of Science ®Google Scholar
• Choi BH, Kim YH, Ahn IS, et al. The inhibition of inflammatory molecule expression on 3T3-L1 adipocytes by berberine is not mediated by leptin signaling. Nutr Res Pract. 2009;3(2):84–88.
   PubMed Web of Science ®Google Scholar
• Ilyas Z, Perna S, Al-Thawadi S, et al. The effect of Berberine on weight loss in order to prevent obesity: a systematic review. Biomed Pharmacother. 2020;127:110137.
   PubMed Web of Science ®Google Scholar
• Lan TH, Xu DP, Huang MT, et al. Ginsenoside Rb1 prevents homocysteine-induced EPC dysfunction via VEGF/p38MAPK and SDF-1/CXCR4 activation. Sci Rep. 2017;7(1):13061.
   PubMedGoogle Scholar
• Liu DH, Chen YM, Liu Y, et al. Ginsenoside Rb1 reverses H2O2-induced senescence in human umbilical endothelial cells: involvement of eNOS pathway. J Cardiovasc Pharmacol. 2012;59(3):222–230.
   PubMed Web of Science ®Google Scholar
• Lu JM, Weakley SM, Yang Z, et al. Ginsenoside Rb1 directly scavenges hydroxyl radical and hypochlorous acid. Curr Pharm Des. 2012;18(38):6339–6347.
   PubMed Web of Science ®Google Scholar
• Lin N, Cai DL, Jin D, et al. Ginseng panaxoside Rb1 reduces body weight in diet-induced obese mice. Cell Biochem Biophys. 2014;68(1):189–194.
   PubMed Web of Science ®Google Scholar
• Yu X, Ye L, Zhang H, et al. Ginsenoside Rb1 ameliorates liver fat accumulation by upregulating perilipin expression in adipose tissue of db/db obese mice. J Ginseng Res. 2015;39(3):199–205.
   PubMed Web of Science ®Google Scholar
• Cheng AW, Tan X, Sun JY, et al. Catechin attenuates TNF-alpha induced inflammatory response via AMPK-SIRT1 pathway in 3T3-L1 adipocytes. PloS One. 2019;14(5):e0217090.
   PubMed Web of Science ®Google Scholar
• Yang H, Lv H, Li H, et al. Oridonin protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-kappaB pathways. Cell Commun Signal. 2019;17(1):62.
   PubMedGoogle Scholar
• Duangjai A, Nuengchamnong N, Suphrom N, et al. Potential of coffee fruit extract and quinic acid on adipogenesis and lipolysis in 3T3-L1 Adipocytes. Kobe J Med Sci. 2018;64:E84–E92.
   PubMedGoogle Scholar
• Ma Y, Ren Y, Dai ZJ, et al. IL-6, IL-8 and TNF-alpha levels correlate with disease stage in breast cancer patients. Adv Clin Exp Med. 2017;26(3):421–426.
   PubMed Web of Science ®Google Scholar
• Lin X, Bai D, Wei Z, et al. Curcumin attenuates oxidative stress in RAW264.7 cells by increasing the activity of antioxidant enzymes and activating the Nrf2-Keap1 pathway. PloS One. 2019;14:e0216711.
   PubMed Web of Science ®Google Scholar
• Deb DK, Chen Y, Zhang Z, et al. 1,25-Dihydroxyvitamin D3 suppresses high glucose-induced angiotensinogen expression in kidney cells by blocking the NF-κB pathway. Am J Physiol Renal Physiol. 2009;296(5):F1212–8.
   PubMed Web of Science ®Google Scholar
• Liu MF, Du CK, Su XY. Forskolin induced remodeling of lipid droplets in rat adipocytes. Sheng Li Xue Bao. 2019;71:379–387.
   PubMedGoogle Scholar
• Guo Y, Zhu X, Sun X. COTI-2 induces cell apoptosis in pediatric acute lymphoblastic leukemia via upregulation of miR-203. Bioengineered. 2020;11(1):201–208.
   PubMed Web of Science ®Google Scholar
• Huang J, Zhou L, Wu H, et al. Triptolide inhibits osteoclast formation, bone resorption, RANKL-mediated NF-B activation and titanium particle-induced osteolysis in a mouse model. Mol Cell Endocrinol. 2015;399:346–353.
   PubMed Web of Science ®Google Scholar
• Mayoral LP, Andrade GM, Mayoral EP, et al. Obesity subtypes, related biomarkers & heterogeneity. Indian J Med Res. 2020;151(1):11–21.
   PubMed Web of Science ®Google Scholar
• Poston L, Caleyachetty R, Cnattingius S, et al. Preconceptional and maternal obesity: epidemiology and health consequences. Lancet Diabetes Endocrinol. 2016;4(12):1025–1036.
   PubMed Web of Science ®Google Scholar
• Kuroda M, Sakaue H. Adipocyte death and chronic inflammation in obesity. J Med Invest. 2017;64(3.4):193–196.
   PubMed Web of Science ®Google Scholar
• Karalis KP, Giannogonas P, Kodela E, et al. Mechanisms of obesity and related pathology: linking immune responses to metabolic stress. FEBS J. 2009;276(20):5747–5754.
   PubMed Web of Science ®Google Scholar
• Xia W, Zhou Y, Wang L, et al. Tauroursodeoxycholic acid inhibits TNF-alpha-induced lipolysis in 3T3-L1 adipocytes via the IRE-JNK-perilipin-A signaling pathway. Mol Med Rep. 2017;15(4):1753–1758.
   PubMed Web of Science ®Google Scholar
• Wu D, Xi QY, Cheng X, et al. miR-146a-5p inhibits TNF-alphainduced adipogenesis via targeting insulin receptor in primary porcine adipocytes. J Lipid Res. 2016;57(8):1360–1372.
   PubMed Web of Science ®Google Scholar
• Choi BH, Ahn IS, Kim YH, et al. Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte. Exp Mol Med. 2006;38(6):599–605.
   PubMed Web of Science ®Google Scholar
• Baker RG, Hayden MS, Ghosh S. NF-kappaB, inflammation, and metabolic disease. Cell Metab. 2011;13(1):11–22.
   PubMed Web of Science ®Google Scholar
• Suganami T, Tanimoto-Koyama K, Nishida J, et al. Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler Thromb Vasc Biol. 2007;27(1):84–91.
   PubMed Web of Science ®Google Scholar
• Contreras-Nunez E, Blancas-Flores G, Cruz M, et al. Participation of the IKK-alpha/beta complex in the inhibition of the TNF-alpha/NF-kappaB pathway by glycine: possible involvement of a membrane receptor specific to adipocytes. Biomed Pharmacother. 2018;102:120–131.
   PubMed Web of Science ®Google Scholar
• Wu L, Luo Z, Liu Y, et al. Aspirin inhibits RANKL-induced osteoclast differentiation in dendritic cells by suppressing NF-kappaB and NFATc1 activation. Stem Cell Res Ther. 2019;10(1):375.
   PubMed Web of Science ®Google Scholar