2,252
Views
7
CrossRef citations to date
0
Altmetric
Research paper

Remifentanil attenuates sepsis-induced intestinal injury by inducing autophagy

, , , &
Pages 9575-9584 | Received 30 Jun 2021, Accepted 21 Oct 2021, Published online: 11 Dec 2021

References

  • Chen J, Xia H, Zhang L, Wang D, Tao X, et al. Protective effects of melatonin on sepsis-induced liver injury and dysregulation of gluconeogenesis in rats through activating SIRT1/STAT3 pathway. Biomed Pharmacother. 2019;117:109150.
  • Liu S, Xie J, Zhao B, et al. Yin W and Li J. ADAR1 prevents small intestinal injury from inflammation in a murine model of sepsis. Cytokine. 2018;104:30–37.
  • Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med. 2003;348(2):138–150.
  • Zou Z, Liu B, Zeng L, et al. Cx43 inhibition attenuates sepsis-induced intestinal injury via downregulating ROS transfer and the activation of the JNK1/Sirt1/FoxO3a signaling pathway. Mediators Inflamm. 2019;2019:7854389.
  • Meng M. Klingensmith NJ and coopersmith CM. New insights into the gut as the driver of critical illness and organ failure. Curr Opin Crit Care. 2017;23(2):143–148.
  • Mittal R, Coopersmith CM. Redefining the gut as the motor of critical illness. Trends Mol Med. 2014;20(4):214–223.
  • Damsteegt EL, Hassan Z, Hewawasam NV, et al. Role for somatostatin in the survival of mouse pancreatic beta cells. Cell Physiol Biochem. 2019;52:486–502.
  • Chen S, He Y, Hu Z,Lv C, Jin G, et al. Heparanase mediates intestinal inflammation and injury in a mouse model of sepsis. J Histochem Cytochem. 2017;65(4):241–249.
  • Wang YM, Ji R, Chen WW, Chen Y, Chen EZ, et al. Paclitaxel alleviated sepsis-induced acute lung injury by activating MUC1 and suppressing TLR-4/NF-κB pathway. Drug Des Devel Ther. 2019;13:3391–3404.
  • Godwin SA, Burton JH, Gerardo CJ, et al. Clinical policy: procedural sedation and analgesia in the emergency department. Ann Emerg Med. 2014;63(247–258):e218.
  • Chollat C, Lecointre M, Leuillier M, Jegou S, Tourrel F, et al. Beneficial effects of remifentanil against excitotoxic brain damage in newborn mice. Front Neurol. 2019;10:407.
  • Wu X, Guo L and Ye G. Remifentanil ameliorates lung injury in neonate rats with acute respiratory distress by down-regulating TIMP1 expression. Am J Transl Res. 2020;12:6325–6334.
  • Hofbauer R, Frass M, Gmeiner B, Wagner O, Kaye AD, et al. Effects of remifentanil on neutrophil adhesion, transmigration, and intercellular adhesion molecule expression. Acta Anaesthesiol Scand. 2000;44(10):1232–1237.
  • Lewinska A, Adamczyk-Grochala J, Bloniarz D, Widenka K, Wnuk M, et al. Remifentanil preconditioning protects against hypoxia-induced senescence and necroptosis in human cardiac myocytes in vitro. Aging (Albany NY). 2020;12(14):13924–13938.
  • Kwon JY, Park BS, Kim YH, Yoon JY, Yoon JU, et al. Remifentanil protects human keratinocytes against hypoxia-reoxygenation injury through activation of autophagy. PLoS One. 2015;10(1):e0116982.
  • Ke H, Mou X and Xia Q. Remifentanil repairs cartilage damage and reduces the degradation of cartilage matrix in post-traumatic osteoarthritis, and inhibits IL-1β-induced apoptosis of articular chondrocytes via inhibition of PI3K/AKT/NF-κB phosphorylation. Ann Transl Med. 2020;8(22):1487.
  • Hu CA, Hou Y, Yi D, Kong X, Yin Y, et al. Autophagy and tight junction proteins in the intestine and intestinal diseases. Anim Nutr. 2015;1(3):123–127.
  • Yang Z, Klionsky DJ. Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol. 2010;22:124–131.
  • Mizushima N, Levine B, Cuervo AM and Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature. 2008;451(7182):1069–1075.
  • Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. Cell. 2011;147(4):728–741.
  • Levine B, Kroemer G. Biological functions of autophagy genes: a disease perspective. Cell. 2019;176:11–42.
  • Mann SS, Hammarback JA. Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B. J Biol Chem. 1994;269(15):11492–11497.
  • Kabeya Y, Ohsumi Y and Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 2000;19(21):5720–5728.
  • Shen JT, Li YS, Xia ZQ, Li C, Liu KX, et al. Remifentanil preconditioning protects the small intestine against ischemia/reperfusion injury via intestinal delta- and mu-opioid receptors. Surgery. 2016;159(2):548–559.
  • Yang Y, Li R, Hui J, Li L and Zheng X. β-Carotene attenuates LPS-induced rat intestinal inflammation via modulating autophagy and regulating the JAK2/STAT3 and JNK/p38 MAPK signaling pathways. J Food Biochem. 2021;45(1):e13544.
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25(4):402–408.
  • Wan SX, Shi B, Lou XL, Liang DY, Ma S, et al. Ghrelin protects small intestinal epithelium against sepsis-induced injury by enhancing the autophagy of intestinal epithelial cells. Biomed Pharmacother. 2016;83:1315–1320.
  • Jia J, Gong X, Zhao Y, Zang B, Li G, et al. Autophagy enhancing contributes to the organ protective effect of alpha-lipoic acid in septic rats. Front Immunol. 2019;10:1491.
  • Ross AK, Davis PJ, Dear GGL, et al. Pharmacokinetics of remifentanil in anesthetized pediatric patients undergoing elective surgery or diagnostic procedures. Anesth Analg. 2001;93(6):1393–1401. table of contents.
  • Hungerford JL, O’Brien N, Moore-Clingenpeel M, Leonard JR, Tobias JD, et al. Remifentanil for sedation of children with traumatic brain injury. J Intensive Care Med. 2019;34(7):557–562.
  • Guignard B, Bossard AE, Coste C, Fletcher D, Chauvin M, et al. Acute opioid tolerance: intraoperative remifentanil increases postoperative pain and morphine requirement. Anesthesiology. 2000;93(2):409–417.
  • Yoo S, Nam K and Kim WH. Association between remifentanil and acute kidney injury. J Anesth. 2018;32(2):306.
  • Qu ZJ, Qu ZJ, Zhou HB, Zhang DZ, Wang G, et al. Protective effect of remifentanil on myocardial ischemia-reperfusion injury through Fas apoptosis signaling pathway. Eur Rev Med Pharmacol Sci. 2019;23:5980–5986.
  • Yamoto M, Lee C, Chusilp S, Li B, Pierro A, et al. The role of autophagy in intestinal epithelial injury. Pediatr Surg Int. 2019;35(12):1389–1394.
  • Tanida I, Ueno T and Kominami E. LC3 and autophagy. Methods Mol Biol. 2008;445:77–88.
  • Lei S, Zhang Y, Su W, Xu J, Xia ZY, et al. Remifentanil attenuates lipopolysaccharide-induced oxidative injury by downregulating PKCβ2 activation and inhibiting autophagy in H9C2 cardiomyocytes. Life Sci. 2018;213:109–115.
  • Yoon JY, Baek CW, Woo MN, Yoon JU, Park CH, et al. Remifentanil induces autophagy and prevents hydrogen peroxide-induced apoptosis in Cos-7 cells. J Dent Anesth Pain Med. 2016;16(3):175–184.
  • Kim CH, Jeong SS, Yoon JY, Yu SB, Kim EJ, et al. Remifentanil reduced the effects of hydrogen peroxide-induced oxidative stress in human keratinocytes via autophagy. Connect Tissue Res. 2017;58(6):597–605.