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Research Paper

Stigmasterol alleviates interleukin-1beta-induced chondrocyte injury by down-regulatingsterol regulatory element binding transcription factor 2 to regulateferroptosis

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Pages 9332-9340 | Received 16 Aug 2021, Accepted 27 Oct 2021, Published online: 22 Nov 2021

References

  • He M, Zhong X, Li Z, et al. Progress in the treatment of knee osteoarthritis with high tibial osteotomy: a systematic review. Syst Rev. 2021;10(1):56.
  • Shi D, Dai J, Xu Z, et al. Update on basic and clinical aspects of osteoarthritis. Ann Transl Med. 2015;3(10):142.
  • Cen X, Huang XQ, Sun WT, et al. Long noncoding RNAs: a new regulatory code in osteoarthritis. Am J Transl Res. 2017;9(11):4747–4755.
  • Murata K, Yoshitomi H, Tanida S, et al. Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis. Arthritis Res Ther. 2010;12(3):R86.
  • Bian Q, Wang YJ, Liu SF, et al. Osteoarthritis: genetic factors, animal models, mechanisms, and therapies. Front Biosci (Elite Ed). 2012;4:74–100.
  • Yao X, Sun K, Yu S, et al. Chondrocyte ferroptosis contribute to the progression of osteoarthritis. J Orthop Translat. 2021;27:33–43.
  • Kim D, Lee D, Oh D, et al. A mixture containing fermented achyranthes japonica nakai ameliorates osteoarthritis in knee joints of monoiodoacetate-injected rats. J Med Food. 2020;23(8):811–817.
  • Antwi AO, Obiri DD, Osafo N, et al. Stigmasterol inhibits lipopolysaccharide-induced innate immune responses in murine models. Int Immunopharmacol. 2017;53:105–113.
  • Antwi AO, Obiri DD, Osafo N. Stigmasterol modulates allergic airway inflammation in guinea pig model of ovalbumin-induced asthma. Mediators Inflamm. 2017;2017:2953930.
  • Qiu XM, Jin CT, Wang W. Association between single nucleotide polymorphisms of sterol regulatory element binding protein-2 gene and risk of knee osteoarthritis in a Chinese Han population. J Int Med Res. 2014;42(2):320–328.
  • Tashkandi M, Ali F, Alsaqer S, et al. Lysyl oxidase-like 2 protects against progressive and aging related knee joint osteoarthritis in mice. Int J Mol Sci. 2019;20:19.
  • Jun Z, Xinmeng J, Yue L, et al. Jumonji domain containing-3 (JMJD3) inhibition attenuates IL-1beta-induced chondrocytes damage in vitro and protects osteoarthritis cartilage in vivo. Inflamm Res. 2020;69(7):657–666.
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25(4):402–408.
  • Yang C, Yu L, Li W, et al. Disruption of cholesterol homeostasis by plant sterols. J Clin Invest. 2004;114(6):813–822.
  • Hong X, Roh W, Sullivan RJ, et al. The lipogenic regulator SREBP2 induces transferrin in circulating melanoma cells and suppresses ferroptosis. Cancer Discov. 2021;11(3):678–695.
  • Lefebvre P, Staels B. SREBF2-embedded mir33 links the nuclear bile acid receptor FXR to cholesterol and lipoprotein metabolism. Arterioscler Thromb Vasc Biol. 2015;35(4):748–749.
  • Chen B, Chen Z, Liu M, et al. Inhibition of neuronal ferroptosis in the acute phase of intracerebral hemorrhage shows long-term cerebroprotective effects. Brain Res Bull. 2019;153:122–132.
  • Xie BS, Wang YQ, Lin Y, et al. Inhibition of ferroptosis attenuates tissue damage and improves long-term outcomes after traumatic brain injury in mice. CNS Neurosci Ther. 2019;25(4):465–475.
  • Stockwell BR, Friedmann Angeli JP, Bayir H, et al. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell. 2017;171(2):273–285.
  • Han C, Liu Y, Dai R, et al. Ferroptosis and its potential role in human diseases. Front Pharmacol. 2020;11:239.
  • Bolduc JA, Collins JA, Loeser RF. Reactive oxygen species, aging and articular cartilage homeostasis. Free Radic Biol Med. 2019;132:73–82.
  • Peng Z, Sun H, Bunpetch V, et al. The regulation of cartilage extracellular matrix homeostasis in joint cartilage degeneration and regeneration. Biomaterials 2021;268:120555.
  • Vilaca-Faria H, Marote A, Lages I, et al. Fractionating stem cells secretome for Parkinson’s disease modeling: is it the whole better than the sum of its parts? Biochimie 2021;189:87–98.
  • Matsuzaki T, Alvarez-Garcia O, Mokuda S, et al. FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis. Sci Transl Med. 2018;10:428.
  • Sun K, Luo J, Jing X, et al. Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis. Aging (Albany NY). 2019;11(22):10513–10531.
  • Wang BW, Jiang Y, Yao ZL, et al. Aucubin protects chondrocytes against IL-1beta-induced apoptosis in vitro and inhibits osteoarthritis in mice model. Drug Des Devel Ther. 2019;13:3529–3538.
  • Zhang L, Xing R, Huang Z, et al. Inhibition of synovial macrophage pyroptosis alleviates synovitis and fibrosis in knee osteoarthritis. Mediators Inflammation. 2019;2019:2165918.
  • Chen WP, Yu C, Hu PF, et al. Stigmasterol blocks cartilage degradation in rabbit model of osteoarthritis. Acta Biochim Pol. 2012;59(4):537–541.
  • Ahmad Khan M, Sarwar A, Rahat R, et al. Stigmasterol protects rats from collagen induced arthritis by inhibiting proinflammatory cytokines. Int Immunopharmacol. 2020;85:106642.
  • Kostopoulou F, Gkretsi V, Malizos KN, et al. Central role of SREBP-2 in the pathogenesis of osteoarthritis. PLoS One. 2012;7(5):e35753.