Ferrostatin-1 alleviates lipopolysaccharide-induced cardiac dysfunction

References

• Hotchkiss RS, Monneret G, Payen D. Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol. 2013;13(12):862–874.
   PubMed Web of Science ®Google Scholar
• Landesberg G, Gilon D, Meroz Y, et al. Diastolic dysfunction and mortality in severe sepsis and septic shock. Eur Heart J. 2012;33(7):895–903.
   PubMed Web of Science ®Google Scholar
• Zanotti-Cavazzoni SL, Hollenberg SM. Cardiac dysfunction in severe sepsis and septic shock. Curr Opin Crit Care. 2009;15(5):392–397.
   PubMed Web of Science ®Google Scholar
• Oh BM, Lee SJ, Park GL, et al. Erastin inhibits septic shock and inflammatory gene expression via suppression of the NF-kappaB pathway. J Clin Med. 2019;8(12). DOI:10.3390/jcm8122210
   Web of Science ®Google Scholar
• Wang C, Yuan W, Hu A, et al. Dexmedetomidine alleviated sepsisinduced myocardial ferroptosis and septic heart injury. Mol Med Rep. 2020;22(1):175–184.
   PubMed Web of Science ®Google Scholar
• Ravingerova T, Kindernay L, Bartekova M, et al. The molecular mechanisms of iron metabolism and its role in cardiac dysfunction and cardioprotection. Int J Mol Sci. 2020;21(21):7889.
   PubMed Web of Science ®Google Scholar
• Li N, Wang W, Zhou H, et al. Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury. Free Radic Biol Med. 2020;160:303–318.
   PubMed Web of Science ®Google Scholar
• Tang D, Chen X, Kang R, et al. Ferroptosis: molecular mechanisms and health implications. Cell Res. 2020;31(2):107–125.
   PubMed Web of Science ®Google Scholar
• Han C, Liu Y, Dai R, et al. Ferroptosis and its potential role in human diseases. Front Pharmacol. 2020;11:239.
   PubMed Web of Science ®Google Scholar
• Yang WS, SriRamaratnam R, Welsch ME, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156(1–2):317–331.
   PubMed Web of Science ®Google Scholar
• Liu QJ, Wu J, Zhang XF, et al. Iron homeostasis and disorders revisited in the sepsis. Free Radical Bio Med. 2021;165:1–13.
   PubMed Web of Science ®Google Scholar
• Sun Y, Chen P, Zhai B, et al. The emerging role of ferroptosis in inflammation. Biomed Pharmacother. 2020;127:110108.
   PubMed Web of Science ®Google Scholar
• Yang Y, Lv J, Jiang S, et al. The emerging role of toll-like receptor 4 in myocardial inflammation. Cell Death Dis. 2016;7(5):e2234–e2234.
   PubMed Web of Science ®Google Scholar
• Xu X, Rui S, Chen C, et al. Protective effects of astragalus polysaccharide nanoparticles on septic cardiac dysfunction through inhibition of TLR4/NF-kappaB signaling pathway. Int J Biol Macromol. 2020;153:977–985.
   PubMed Web of Science ®Google Scholar
• Miotto G, Rossetto M, Di Paolo ML, et al. Insight into the mechanism of ferroptosis inhibition by ferrostatin-1. Redox Biol. 2020;28:101328.
   PubMed Web of Science ®Google Scholar
• Martin-Sanchez D, Ruiz-Andres O, Poveda J, et al. Ferroptosis, but not necroptosis, is important in nephrotoxic folic acid-induced AKI. J Am Soc Nephrol. 2017;28(1):218–229.
   PubMed Web of Science ®Google Scholar
• Yamada N, Karasawa T, Wakiya T, et al. Iron overload as a risk factor for hepatic ischemia-reperfusion injury in liver transplantation: potential role of ferroptosis. Am J Transplant. 2020;20(6):1606–1618.
   PubMed Web of Science ®Google Scholar
• Li WJ, Feng GS, Gauthier JM, et al. Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation. J Clin Invest. 2019;129(6):2293–2304.
   PubMed Web of Science ®Google Scholar
• Li C, Wan W, Ye T, et al. Pinocembrin alleviates lipopolysaccharide-induced myocardial injury and cardiac dysfunction in rats by inhibiting p38/JNK MAPK pathway. Life Sci. 2021;277:119418.
   PubMed Web of Science ®Google Scholar
• Shuai W, Kong B, Fu H, et al. MD1 deficiency promotes inflammatory atrial remodelling induced by high-fat diets. Can J Cardiol. 2019;35(2):208–216.
   PubMed Web of Science ®Google Scholar
• Shuai W, Kong B, Yang H, et al. Loss of myeloid differentiation protein 1 promotes atrial fibrillationin heart failure with preserved ejection fraction. ESC Heart Fail. 2020;7(2):626–638.
   PubMed Web of Science ®Google Scholar
• Xiao Z, Kong B, Yang H, et al. Key player in cardiac hypertrophy, emphasizing the role of toll-like receptor 4. Front Cardiovasc Med. 2020;7:579036.
   PubMed Web of Science ®Google Scholar
• Xu XY, Rui SZ, Chen C, et al. Protective effects of astragalus polysaccharide nanoparticles on septic cardiac dysfunction through inhibition of TLR4/NF-kappa B signaling pathway. Int J Biol Macromol. 2020;153:977–985.
   PubMed Web of Science ®Google Scholar
• Li Z, Meng Y, Liu C, et al. Kcnh2 mediates FAK/AKT-FOXO3A pathway to attenuate sepsis-induced cardiac dysfunction. Cell Prolif. 2020;54(2):e12962.
   PubMed Web of Science ®Google Scholar
• Sun LJ, Qiao W, Xiao YJ, et al. Naringin mitigates myocardial strain and the inflammatory response in sepsis-induced myocardial dysfunction through regulation of PI3K/AKT/NF-kappaB pathway. Int Immunopharmacol. 2019;75:105782.
   PubMed Web of Science ®Google Scholar
• Friedmann Angeli JP, Schneider M, Proneth B, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014;16(12):1180–1191.
   PubMed Web of Science ®Google Scholar
• Bai T, Li M, Liu Y, et al. Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell. Free Radic Biol Med. 2020;160:92–102.
   PubMed Web of Science ®Google Scholar
• Huang W, Zhan Y, Zheng Y, et al. Up-regulated ferritin in periodontitis promotes inflammatory cytokine expression in human periodontal ligament cells through transferrin receptor via ERK/P38 MAPK pathways. Clin Sci (Lond). 2019;133(1):135–148.
   PubMed Web of Science ®Google Scholar
• Siegert I, Schodel J, Nairz M, et al. Ferritin-mediated iron sequestration stabilizes hypoxia-inducible factor-1alpha upon LPS activation in the presence of ample oxygen. Cell Rep. 2015;13(10):2048–2055.
   PubMed Web of Science ®Google Scholar
• Bao WD, Pang P, Zhou XT, et al. Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease. Cell Death Differ. 2021;28(5):1548–1562.
   Web of Science ®Google Scholar
• Park E, Chung SW. ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation. Cell Death Dis. 2019;10(11):822.
   PubMedGoogle Scholar
• Proneth B, Conrad M. Ferroptosis and necroinflammation, a yet poorly explored link. Cell Death Differ. 2019;26(1):14–24.
   PubMed Web of Science ®Google Scholar
• Chen X, Xu S, Zhao C, et al. Role of TLR4/NADPH oxidase 4 pathway in promoting cell death through autophagy and ferroptosis during heart failure. Biochem Biophys Res Commun. 2019;516(1):37–43.
   PubMed Web of Science ®Google Scholar
• Zhang M, Zou L, Feng Y, et al. Toll-like receptor 4 is essential to preserving cardiac function and survival in low-grade polymicrobial sepsis. Anesthesiology. 2014;121(6):1270–1280.
   PubMed Web of Science ®Google Scholar
• Lin YM, Badrealam KF, Kuo WW, et al. Nerolidol improves cardiac function in spontaneously hypertensive rats by inhibiting cardiac inflammation and remodelling associated TLR4/ NF-kappaB signalling cascade. Food Chem Toxicol. 2021;147:111837.
   PubMed Web of Science ®Google Scholar
• Sun SC. The non-canonical NF-kappaB pathway in immunity and inflammation. Nat Rev Immunol. 2017;17(9):545–558.
   PubMed Web of Science ®Google Scholar