References
- Hammen C. Risk factors for depression: an autobiographical review. Annu Rev Clin Psychol. 2018;14:1–28.
- Ting EY, Yang AC, Tsai SJ. Role of interleukin-6 in depressive disorder. Int J Mol Sci. 2020;21:6.
- O’Rourke MC, Jamil RT, Siddiqui W. Suicide Screening and Prevention. In: StatPearls. Treasure Island (FL); 2021.PMID: 30285348. Treasure Island (FL): StatPearls Publishing.
- Park C, Rosenblat JD, Brietzke E, et al. Stress, epigenetics and depression: a systematic review. Neurosci Biobehav Rev. 2019;102:139–152.
- Yrondi A, Brauge D, LeMen J, et al. Depression and sports-related concussion: a systematic review. Presse Med. 2017;46(10):890–902.
- Menard C, Hodes GE, Russo SJ. Pathogenesis of depression: insights from human and rodent studies. Neuroscience. 2016;321:138–162.
- Zhang L, Wei W. Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony. Pharmacol Ther. 2020;207:107452.
- Yin D, Liu YY, Wang TX, et al. Paeoniflorin exerts analgesic and hypnotic effects via adenosine A1 receptors in a mouse neuropathic pain model. Psychopharmacology (Berl). 2016;233(2):281–293.
- Zhang JW, Li LX, Wu WZ, et al. Anti-tumor effects of paeoniflorin on epithelial-to-mesenchymal transition in human colorectal cancer cells. Med Sci Monit. 2018;24:6405–6413.
- Ma X, Zhang W, Jiang Y, et al. Paeoniflorin, a natural product with multiple targets in liver diseases-a mini review. Front Pharmacol. 2020;11:531.
- She Y, Shao L, Zhang Y, et al. Neuroprotective effect of glycosides in Buyang Huanwu Decoction on pyroptosis following cerebral ischemia-reperfusion injury in rats. J Ethnopharmacol. 2019;242:112051.
- Li H, Jiao Y, Xie M. Paeoniflorin ameliorates atherosclerosis by suppressing TLR4-mediated NF-kappaB activation. Inflammation. 2017;40(6):2042–2051.
- Ji Y, Dou YN, Zhao QW, et al. Paeoniflorin suppresses TGF-β mediated epithelial-mesenchymal transition in pulmonary fibrosis through a Smad-dependent pathway. Acta Pharmacologica Sinica. 2016;37(6):794-804.
- Li YC, Qiao JY, Wang BY, et al. Paeoniflorin ameliorates fructose-induced insulin resistance and hepatic steatosis by activating LKB1/AMPK and AKT pathways. Nutrients. 2018;10:8.
- Hu PF, Chen WP, Bao JP, et al. Paeoniflorin inhibits IL-1beta-induced chondrocyte apoptosis by regulating the Bax/Bcl-2/caspase-3 signaling pathway. Mol Med Rep. 2018;17(4):6194–6200.
- Yu G, Wang Z, Zeng S, et al. Paeoniflorin inhibits hepatocyte growth factor- (HGF-) induced migration and invasion and actin rearrangement via suppression of c-Met-mediated RhoA/ROCK signaling in glioblastoma. Biomed Res Int. 2019;2019:9053295.
- Zhu J, Zhang X, Gao W, et al. lncRNA/circRNAmiRNAmRNA ceRNA network in lumbar intervertebral disc degeneration. Mol Med Rep. 2019;20(4):3160–3174.
- Mao QQ, Ip SP, Ko KM, et al. Effects of peony glycosides on mice exposed to chronic unpredictable stress: further evidence for antidepressant-like activity. J Ethnopharmacol. 2009;124(2):316–320.
- Shen J, Liu L, Zhang F, et al. LncRNA TapSAKI promotes inflammation injury in HK-2 cells and urine derived sepsis-induced kidney injury. J Pharm Pharmacol. 2019;71(5):839–848.
- Li YC, Zheng XX, Xia SZ, et al. Paeoniflorin ameliorates depressive-like behavior in prenatally stressed offspring by restoring the HPA axis- and glucocorticoid receptor- associated dysfunction. J Affect Disord. 2020;274:471–481.
- Lin S, Li Q, Jiang S, et al. Crocetin ameliorates chronic restraint stress-induced depression-like behaviors in mice by regulating MEK/ERK pathways and gut microbiota. J Ethnopharmacol. 2020;268:113608.
- Qiu FM, Zhong XM, Mao QQ, et al. Antidepressant-like effects of paeoniflorin on the behavioural, biochemical, and neurochemical patterns of rats exposed to chronic unpredictable stress. Neurosci Lett. 2013;541:209–213.
- Lin S, Li Q, Jiang S, et al. Crocetin ameliorates chronic restraint stress-induced depression-like behaviors in mice by regulating MEK/ERK pathways and gut microbiota. J Ethnopharmacol. 2021;268:113608.
- Chen JJ, Shen JX, Yu ZH, et al. The Antidepressant Effects of Resveratrol are Accompanied by the Attenuation of Dendrite/Dendritic Spine Loss and the Upregulation of BDNF/p-cofilin1 Levels in Chronic Restraint Mice. Neurochem Res. 2021;46(3):660–674.
- Chen Y, Zhou H, An Y, et al. Combined effects of olfactory dysfunction and chronic stress on anxiety- and depressive- like behaviors in mice. Neurosci Lett. 2019;692:143–149.
- Jiang B, Wang W, Wang F, et al. The stability of NR2B in the nucleus accumbens controls behavioral and synaptic adaptations to chronic stress. Biol Psychiatry. 2013;74(2):145–155.
- Li J, Huang S, Huang W, et al. Paeoniflorin ameliorates interferon-alpha-induced neuroinflammation and depressive-like behaviors in mice. Oncotarget. 2017;8(5):8264–8282.
- Zhong X, Li G, Qiu F, et al. Paeoniflorin Ameliorates Chronic Stress-Induced Depression-Like Behaviors and Neuronal Damages in Rats via Activation of the ERK-CREB Pathway. Front Psychiatry. 2018;9:772.
- Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 2008;3(6):1101–1108.
- Liang Z, Xu J, Ma Z, et al. MiR-187 suppresses non-small-cell lung cancer cell proliferation by targeting FGF9. Bioengineered. 2020;11(1):70–80.
- Zhang N, Liu JF. MicroRNA (MiR)-301a-3p regulates the proliferation of esophageal squamous cells via targeting PTEN. Bioengineered. 2020;11(1):972–983.
- Li X, Sanford LD, Zong Q, et al. Prevalence of depression or depressive symptoms in patients with narcolepsy: a systematic review and meta-analysis. Neuropsychol Rev. 2021;31(1):89-102.
- Englbrecht M, Alten R, Aringer M, et al. New insights into the prevalence of depressive symptoms and depression in rheumatoid arthritis - Implications from the prospective multicenter VADERA II study. PLoS One. 2019;14(5):e0217412.
- Rotenstein LS, Ramos MA, Torre M, et al. Prevalence of depression, depressive symptoms, and suicidal ideation among medical students: a systematic review and meta-analysis. JAMA. 2016;316(21):2214–2236.
- Mu DZ, Xue M, Xu JJ, et al. Antidepression and prokinetic effects of paeoniflorin on rats in the forced swimming test via polypharmacology. Evid Based Complement Alternat Med. 2020;2020:2153571.
- Wu SH, Wu DG, Chen YW. Chemical constituents and bioactivities of plants from the genus Paeonia. Chem Biodivers. 2010;7(1):90–104.
- Xiang Y, Zhang Q, Wei S, et al. Paeoniflorin: a monoterpene glycoside from plants of Paeoniaceae family with diverse anticancer activities. J Pharm Pharmacol. 2020;72(4):483–495.
- Zhou YX, Gong XH, Zhang H, et al. A review on the pharmacokinetics of paeoniflorin and its anti-inflammatory and immunomodulatory effects. Biomed Pharmacother. 2020;130:110505.
- Xin Q, Yuan R, Shi W, et al. A review for the anti-inflammatory effects of paeoniflorin in inflammatory disorders. Life Sci. 2019;237:116925.
- Bai H, Chen S, Yuan T, et al. Paeoniflorin ameliorates neuropathic pain-induced depression-like behaviors in mice by inhibiting hippocampal neuroinflammation activated via TLR4/NF-kappaB pathway. Korean J Physiol Pharmacol. 2021;25(3):217–225.
- Zhou D, Zhang S, Hu L, et al. Inhibition of apoptosis signal-regulating kinase by paeoniflorin attenuates neuroinflammation and ameliorates neuropathic pain. J Neuroinflammation. 2019;16(1):83.
- Hu MZ, Wang AR, Zhao ZY, et al. Antidepressant-like effects of paeoniflorin on post-stroke depression in a rat model. Neurol Res. 2019;41(5):446–455.
- Tian DD, Wang M, Liu A, et al. Antidepressant effect of paeoniflorin is through inhibiting pyroptosis CASP-11/GSDMD pathway. Mol Neurobiol. 2021;58(2):761–776.
- Kortam MA, Ali BM, Fathy N. The deleterious effect of stress-induced depression on rat liver: protective role of resveratrol and dimethyl fumarate via inhibiting the MAPK/ERK/JNK pathway. J Biochem Mol Toxicol. 2021;35(1):e22627.
- Wang JQ, The ML. ERK pathway: molecular mechanisms and treatment of depression. Mol Neurobiol. 2019;56(9):6197–6205.
- Wang JQ, Fibuch EE, Mao L. Regulation of mitogen-activated protein kinases by glutamate receptors. J Neurochem. 2007;100(1):1–11.
- Hu PF, Sun FF, Jiang LF, et al. Paeoniflorin inhibits IL-1beta-induced MMP secretion via the NF-kappaB pathway in chondrocytes. Exp Ther Med. 2018;16(2):1513–1519.
- Liu X, Chen K, Zhuang Y, et al. Paeoniflorin improves pressure overload-induced cardiac remodeling by modulating the MAPK signaling pathway in spontaneously hypertensive rats. Biomed Pharmacother. 2019;111:695–704.
- Lang UE, Borgwardt S. Molecular mechanisms of depression: perspectives on new treatment strategies. Cell Physiol Biochem. 2013;31(6):761–777.
- Yuan S, Jiang X, Zhou X, et al. Inosine alleviates depression-like behavior and increases the activity of the ERK-CREB signaling in adolescent male rats. Neuroreport. 2018;29(14):1223–1229.
- Li SY, Rong PJ, Gao GJ, et al. [Auricular electroacupuncture improves depression possibly by promoting hippocampal Raf/ERK/RSK/CREB signaling in chronic unpredictable mild stress induced depression rats]. Zhen Ci Yan Jiu. 2019;44(8):554–559.
- Liu W, Wang P, Shang C, et al. Endophilin-1 regulates blood-brain barrier permeability by controlling ZO-1 and occludin expression via the EGFR-ERK1/2 pathway. Brain Res. 2014;1573:17–26.