microRNA-378b regulates ethanol-induced hepatic steatosis by targeting CaMKK2 to mediate lipid metabolism

References

• Fuster D, Samet JH. Alcohol use in patients with chronic liver disease. N Engl J Med. 2018;379(13):1251–1261.
   PubMed Web of Science ®Google Scholar
• Axley PD, Richardson CT, Singal AK. Epidemiology of alcohol consumption and societal burden of alcoholism and alcoholic liver disease. Clin Liver Dis. 2019;23(1):39–50.
   PubMed Web of Science ®Google Scholar
• Mitra S, De A, Chowdhury A. Epidemiology of non-alcoholic and alcoholic fatty liver diseases. Transl Gastroenterol Hepatol. 2020;5:16.
   PubMed Web of Science ®Google Scholar
• Gao B, Bataller R. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology. 2011;141(5):1572–1585.
   PubMed Web of Science ®Google Scholar
• Baghy K, Iozzo RV, Kovalszky I. Decorin-TGFβ axis in hepatic fibrosis and cirrhosis. J Histochem Cytochem. 2012;60(4):262–268.
   PubMed Web of Science ®Google Scholar
• Jiang Z, Zhou J, Zhou D, et al. The adiponectin-SIRT1-AMPK pathway in alcoholic fatty liver disease in the rat. Alcohol Clin Exp Res. 2015;39(3):424–433.
   PubMed Web of Science ®Google Scholar
• Singal AK, Bataller R, Ahn J, et al. ACG clinical guideline: alcoholic liver disease. Am J Gastroenterol. 2018;113(2):175–194.
   PubMed Web of Science ®Google Scholar
• Racioppi L, Means AR. Calcium/Calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology. J Biol Chem. 2012;287(38):31658. 10.1074/jbc.R112.356485.
   PubMed Web of Science ®Google Scholar
• Chauhan AS, Liu X, Jing J, et al. STIM2 interacts with AMPK and regulates calcium-induced AMPK activation. FASEB J. 2019;33(2):2957–2970.
   PubMed Web of Science ®Google Scholar
• Wang Q, Liu S, Zhai A, et al. AMPK-mediated regulation of lipid metabolism by phosphorylation. Biol Pharm Bull. 2018;41(7):985–993. 10.1248/bpb.b17-00724.
   Web of Science ®Google Scholar
• Garcia D, Shaw RJ. AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance. Mol Cell. 2017;66(6):789–800.
   PubMed Web of Science ®Google Scholar
• Li Y, Xu S, Mihaylova MM, et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 2011;13(4):376–388.
   PubMed Web of Science ®Google Scholar
• Jadeja RN, Chu X, Wood C, et al. M3 muscarinic receptor activation reduces hepatocyte lipid accumulation via CaMKKβ/AMPK pathway. Biochem Pharmacol. 2019;169:113613. 10.1016/j.bcp.2019.08.015.
   PubMed Web of Science ®Google Scholar
• Liu W, Cao H, Ye C, et al. Hepatic miR-378 targets p110α and controls glucose and lipid homeostasis by modulating hepatic insulin signaling. Nat Commun. 2014;5(1):5684.
   PubMedGoogle Scholar
• Eichner LJ, Perry MC, Dufour CR, et al. miR-378(*) mediates metabolic shift in breast cancer cells via the PGC-1β/ERRγ transcriptional pathway. Cell Metab. 2010;12(4):352–361.
   PubMed Web of Science ®Google Scholar
• Carrer M, Liu N, Grueter CE, et al. Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378*. Proc Natl Acad Sci U S A. 2012;109(38):15330–15335.
   PubMed Web of Science ®Google Scholar
• Yang Z, Cappello T, Wang L. Emerging role of microRNAs in lipid metabolism. Acta Pharm Sin B. 2015;5(2):145–150.
   PubMed Web of Science ®Google Scholar
• Li YY, Zhong YJ, Cheng Q, et al. miR-378b regulates insulin sensitivity by targeting insulin receptor and p110α in alcohol-induced hepatic steatosis. Front Pharmacol. 2020;11:717.
   PubMed Web of Science ®Google Scholar
• Ghosh Dastidar S, Warner JB, Warner DR, et al. Rodent models of alcoholic liver disease: role of binge ethanol administration. Biomolecules. 2018;8(1):3.
   PubMed Web of Science ®Google Scholar
• Mingozzi F, High KA. Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges. Nat Rev Genet. 2011;12(5):341–355.
   PubMed Web of Science ®Google Scholar
• Li C, Li L, Yang CF, et al. Hepatoprotective effects of Methyl ferulic acid on alcohol-induced liver oxidative injury in mice by inhibiting the NOX4/ROS-MAPK pathway. Biochem Biophys Res Commun. 2017;493(1):277–285.
   PubMed Web of Science ®Google Scholar
• Cheng Q, Li YW, Yang CF, et al. Methyl ferulic acid attenuates ethanol-induced hepatic steatosis by regulating AMPK and FoxO1 pathways in rats and L-02 cells. Chem Biol Interact. 2018;291:180–189.
   PubMed Web of Science ®Google Scholar
• Li L, Zhong Y, Ma Z, et al. Methyl ferulic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway. Int J Oncol. 2018;53(1):225–236.
   PubMed Web of Science ®Google Scholar
• Toppo E, Darvin SS, Esakkimuthu S, et al. Effect of two andrographolide derivatives on cellular and rodent models of non-alcoholic fatty liver disease. Biomed Pharmacother. 2017;95:402–411.
   PubMed Web of Science ®Google Scholar
• Yang C, Li L, Ma Z, et al. Hepatoprotective effect of methyl ferulic acid against carbon tetrachloride-induced acute liver injury in rats. Exp Ther Med. 2018;15(3):2228–2238.
   PubMed Web of Science ®Google Scholar
• Wang K. Molecular mechanism of hepatic steatosis: pathophysiological role of autophagy. Expert Rev Mol Med. 2016;18:e14.
   PubMed Web of Science ®Google Scholar
• You M, Arteel GE. Effect of ethanol on lipid metabolism. J Hepatol. 2019;70(2):237–248.
   PubMed Web of Science ®Google Scholar
• Lu YL, Jing W, Feng LS, et al. Effects of hypoxic exercise training on microRNA expression and lipid metabolism in obese rat livers. J Zhejiang Univ Sci B. 2014;15(9):820–829.
   PubMed Web of Science ®Google Scholar
• Su M, Niu Y, Dang Q, et al. Circulating microRNA profiles based on direct S-Poly(T)Plus assay for detection of coronary heart disease. J Cell Mol Med. 2020;24(11):5984–5997.
   PubMed Web of Science ®Google Scholar
• Li C, Gao S, Chen S, et al. Differential expression of microRNAs in luteinising hormone-treated mouse TM3 Leydig cells. Andrologia. 2018;50(1):e12824.
   Web of Science ®Google Scholar
• Hawley SA, Pan DA, Mustard KJ, et al. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab. 2005;2(1):9–19.
   PubMed Web of Science ®Google Scholar
• Wang XL, Zhang T, Wang J, et al. MiR-378b promotes differentiation of keratinocytes through NKX3.1. PloS One. 2015;10(8):e0136049.
   PubMed Web of Science ®Google Scholar
• Shah AU, Cao Y, Siddique N, et al. miR29a and miR378b influence CpG-stimulated dendritic cells and regulate cGAS/STING pathway. Vaccines (Basel). 2019;7(4):197.
   Web of Science ®Google Scholar