Apcin inhibits the growth and invasion of glioblastoma cells and improves glioma sensitivity to temozolomide

References

• Ostrom QT, Gittleman H, Truitt G, et al. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2011-2015. Neuro Oncol. 2018;20:iv1–iv86.
   PubMed Web of Science ®Google Scholar
• Hegi ME, Diserens AC, Gorlia T, et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med. 2005;352:997–1003.
   PubMed Web of Science ®Google Scholar
• Hotchkiss KM, Sampson JH. Temozolomide treatment outcomes and immunotherapy efficacy in brain tumor. J Neurooncol. 2021;151:55–62.
   PubMed Web of Science ®Google Scholar
• Kapanidou M, Curtis NL, Bolanos-Garcia VM. Cdc20: at the crossroads between chromosome segregation and mitotic exit. Trends Biochem Sci. 2017;42:193–205.
   PubMed Web of Science ®Google Scholar
• Wan L, Tan M, Yang J, et al. APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction. Dev Cell. 2014;29:377–391.
   PubMed Web of Science ®Google Scholar
• Cheng L, Huang YZ, Chen WX, et al. Cell division cycle proteinising prognostic biomarker of breast cancer. Biosci Rep. 2020;;40(5).
   Web of Science ®Google Scholar
• Wang S, Chen B, Zhu Z, et al. CDC20 overexpression leads to poor prognosis in solid tumors: a system review and meta-analysis. Medicine (Baltimore). 2018;97:e13832.
   PubMed Web of Science ®Google Scholar
• Zheng JH, Viacava Follis A, Kriwacki RW, et al. Discoveries and controversies in BCL-2 protein-mediated apoptosis. FEBS J. 2016;283:2690–2700.
   PubMed Web of Science ®Google Scholar
• Wiener Z, Band AM, Kallio P, et al. Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-β. Proc Natl Acad Sci U S A. 2014;111:E2229–36.
   PubMed Web of Science ®Google Scholar
• Billard C. BH3 mimetics: status of the field and new developments. Mol Cancer Ther. 2013;12:1691–1700.
   PubMed Web of Science ®Google Scholar
• Sackton KL, Dimova N, Zeng X, et al. Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature. 2014;514:646–649.
   PubMed Web of Science ®Google Scholar
• de Lange J, Faramarz A, Oostra AB, et al. Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function. Nat Commun. 2015;6:8399.
   PubMed Web of Science ®Google Scholar
• Song C, Lowe VJ, Lee S. Inhibition of Cdc20 suppresses the metastasis in triple negative breast cancer (TNBC). Breast Cancer. 2021;(5):1073-1086.
   Web of Science ®Google Scholar
• Gao Y, Zhang B, Wang Y, et al. Cdc20 inhibitor apcin inhibits the growth and invasion of osteosarcoma cells. Oncol Rep. 2018;40:841–848.
   PubMed Web of Science ®Google Scholar
• Cheng J, Lou Y, Jiang K. Downregulation of long non-coding RNA LINC00460 inhibits the proliferation, migration and invasion, and promotes apoptosis of pancreatic cancer cells via modulation of the miR-320b/ARF1 axis. Bioengineered. 2021;12:96–107.
   PubMed Web of Science ®Google Scholar
• Liu HJ, Hu HM, Li GZ, et al. Ferroptosis-related gene signature predicts glioma cell death and glioma patient progression. Front Cell Dev Biol. 2020;8:538.
   PubMed Web of Science ®Google Scholar
• Tan AC, Ashley DM, López GY, et al. Management of glioblastoma: state of the art and future directions. CA Cancer J Clin. 2020;70:299–312.
   PubMed Web of Science ®Google Scholar
• Lee SY. Temozolomide resistance in glioblastoma multiforme. Genes Dis. 2016;3:198–210.
   PubMed Web of Science ®Google Scholar
• Ding Y, Yu S, Bao Z, et al. CDC20 with malignant progression and poor prognosis of astrocytoma revealed by analysis on gene expression. J Neurooncol. 2017;133:87–95.
   PubMed Web of Science ®Google Scholar
• Wang J, Zhou F, Li Y, et al. Cdc20 overexpression is involved in temozolomide-resistant glioma cells with epithelial-mesenchymal transition. Cell Cycle (Georgetown, Tex). 2017;16:2355–2365.
   PubMed Web of Science ®Google Scholar
• Gayyed MF, El-Maqsoud NM, Tawfiek ER, et al. A comprehensive analysis of CDC20 overexpression in common malignant tumors from multiple organs: its correlation with tumor grade and stage. Tumour Biol. 2016;37:749–762.
   PubMedGoogle Scholar
• Shang G, Ma X, Lv G. Cell division cycle 20 promotes cell proliferation and invasion and inhibits apoptosis in osteosarcoma cells. Cell Cycle (Georgetown, Tex). 2018;17:43–52.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Xue YB, Li H, et al. Inhibition of cell survival by curcumin is associated with downregulation of cell division cycle 20 (Cdc20) in pancreatic cancer cells. Nutrients. 2017;9(2):109.
   Web of Science ®Google Scholar
• Jeong S, Jung S, Park GS, et al. Piperine synergistically enhances the effect of temozolomide against temozolomide-resistant human glioma cell lines. Bioengineered. 2020;11:791–800.
   PubMed Web of Science ®Google Scholar
• Verma R, Peters NR, D’Onofrio M, et al. Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain. Science (New York, NY). 2004;306:117–120.
   Google Scholar
• Wu F, Dai X, Gan W, et al. Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation. Cancer Lett. 2017;385:207–214.
   PubMed Web of Science ®Google Scholar
• Guo C, Kong F, Lv Y, et al. CDC20 inhibitor Apcin inhibits embryo implantation in vivo and in vitro. Cell Biochem Funct. 2020;38:810–816.
   PubMed Web of Science ®Google Scholar
• Shukla S, Saxena S, Singh BK, et al. BH3-only protein BIM: an emerging target in chemotherapy. Eur J Cell Biol. 2017;96:728–738.
   PubMed Web of Science ®Google Scholar
• Lohmann C, Muschaweckh A, Kirschnek S, et al. Induction of tumor cell apoptosis or necrosis by conditional expression of cell death proteins: analysis of cell death pathways and in vitro immune stimulatory potential. J Immunol. 2009;182:4538–4546.
   PubMed Web of Science ®Google Scholar
• Gambichler T, Rooms I, Scholl L, et al. BH3-only protein Bim predicts advanced stage of cutaneous melanoma. J Eur Acad Dermatol Venereol JEADV. 2016;30:1926–1929.
   PubMed Web of Science ®Google Scholar
• Savry A, Carre M, Berges R, et al. Bcl-2-enhanced efficacy of microtubule-targeting chemotherapy through Bim overexpression: implications for cancer treatment. Neoplasia (New York, NY). 2013;15:49–60.
   PubMed Web of Science ®Google Scholar