Human umbilical vein endothelial cells derived-exosomes promote osteosarcoma cell stemness by activating Notch signaling pathway

References

• Xu N, Kang Y, Wang W, et al. The prognostic role of CD133 expression in patients with osteosarcoma. Clin Exp Med. 2020;20(2):261–267.
   PubMed Web of Science ®Google Scholar
• Sadykova LR, Ntekim AI, Muyangwa-Semenova M, et al. Epidemiology and risk factors of osteosarcoma. Cancer Invest. 2020;38(5):259–269.
   PubMed Web of Science ®Google Scholar
• Brown HK, Tellez-Gabriel M, Heymann D. Cancer stem cells in osteosarcoma. Cancer Lett. 2017;386:189–195.
   PubMed Web of Science ®Google Scholar
• Das M, Law S. Role of tumor microenvironment in cancer stem cell chemoresistance and recurrence. Int J Biochem Cell Biol. 2018;103:115–124.
   PubMed Web of Science ®Google Scholar
• Chouaib S, Kieda C, Benlalam H, et al. Endothelial cells as key determinants of the tumor microenvironment: interaction with tumor cells, extracellular matrix and immune killer cells. Crit Rev Immunol. 2010;30(6):529–545.
   PubMed Web of Science ®Google Scholar
• Wang R, Bhattacharya R, Ye X, et al. Endothelial cells activate the cancer stem cell-associated NANOGP8 pathway in colorectal cancer cells in a paracrine fashion. Mol Oncol. 2017;11(8):1023–1034.
   PubMed Web of Science ®Google Scholar
• Wang R, Bhattacharya R, Ye X, et al. Endothelial cells promote colorectal cancer cell survival by activating the HER3-AKT pathway in a paracrine fashion. Mol Cancer Res. 2019;17(1):20–29.
   PubMed Web of Science ®Google Scholar
• Lu J, Ye X, Fan F, et al. Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1. Cancer Cell. 2013;23(2):171–185.
   PubMed Web of Science ®Google Scholar
• Yan GN, Yang L, Lv YF, et al. Endothelial cells promote stem-like phenotype of glioma cells through activating the hedgehog pathway. J Pathol. 2014;234(1):11–22.
   PubMed Web of Science ®Google Scholar
• Fessler E, Borovski T, Medema JP. Endothelial cells induce cancer stem cell features in differentiated glioblastoma cells via bFGF. Mol Cancer. 2015;14(1):157.
   PubMed Web of Science ®Google Scholar
• Wei Y, Shi D, Liang Z, et al. IL-17A secreted from lymphatic endothelial cells promotes tumorigenesis by upregulation of PD-L1 in hepatoma stem cells. J Hepatol. 2019;71(6):1206–1215.
   PubMed Web of Science ®Google Scholar
• Xu ZH, Miao ZW, Jiang QZ, et al. Brain microvascular endothelial cell exosome-mediated S100A16 up-regulation confers small-cell lung cancer cell survival in brain. FASEB J. 2019;33(2):1742–1757.
   PubMed Web of Science ®Google Scholar
• Zeng Y, Yao X, Liu X, et al. Anti-angiogenesis triggers exosomes release from endothelial cells to promote tumor vasculogenesis. J Extracell Vesicles. 2019;8(1):1629865.
   PubMed Web of Science ®Google Scholar
• Yu L, Fan Z, Fang S, et al. Cisplatin selects for stem-like cells in osteosarcoma by activating Notch signaling. Oncotarget. 2016;7(22):33055–33068.
   PubMedGoogle Scholar
• Trajkovic K, Hsu C, Chiantia S, et al. Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science (New York, NY). 2008;319(5867):1244–1247.
   Google Scholar
• Wang H, Zang C, Liu X, et al. The role of Notch receptors in transcriptional regulation. J Cell Physiol. 2015;230(5):982–988.
   PubMed Web of Science ®Google Scholar
• Yan Z, Dutta S, Liu Z, et al. A label-free platform for identification of exosomes from different Sources. ACS Sens. 2019;4(2):488–497.
   PubMed Web of Science ®Google Scholar
• Yu L, Fan Z, Fang S, et al. Cisplatin selects for stem-like cells in osteosarcoma by activating Notch signaling. Oncotarget. 2016;7(22):33055–33068.
   PubMedGoogle Scholar
• Cai J, Qiao B, Gao N, et al. Oral squamous cell carcinoma-derived exosomes promote M2 subtype macrophage polarization mediated by exosome-enclosed miR-29a-3p. Am J Physiol Cell Physiol. 2019;316(5):C731–C740.
   PubMed Web of Science ®Google Scholar
• Sambi M, Samuel V, Qorri B, et al. A triple combination of metformin, acetylsalicylic acid, and oseltamivir phosphate impacts tumour spheroid viability and upends chemoresistance in triple-negative breast cancer. Drug Des Devel Ther. 2020;14:1995–2019.
   PubMed Web of Science ®Google Scholar
• Lin YH, Jewell BE, Gingold J, et al. Osteosarcoma: molecular pathogenesis and iPSC modeling. Trends Mol Med. 2017;23(8):737–755.
   PubMed Web of Science ®Google Scholar
• Dai W, Jin X, Han L, et al. Exosomal lncRNA DOCK9-AS2 derived from cancer stem cell-like cells activated Wnt/β-catenin pathway to aggravate stemness, proliferation, migration, and invasion in papillary thyroid carcinoma. Cell Death Dis. 2020;11(9):743.
   PubMed Web of Science ®Google Scholar
• Lin H, Zhang L, Zhang C, et al. Exosomal MiR-500a-3p promotes cisplatin resistance and stemness via negatively regulating FBXW7 in gastric cancer. J Cell Mol Med. 2020;24(16):8930–8941.
   PubMed Web of Science ®Google Scholar
• Li Y, Li Q, Li D, et al. Exosome carrying PSGR promotes stemness and epithelial-mesenchymal transition of low aggressive prostate cancer cells. Life Sci. 2020;264:118638.
   PubMed Web of Science ®Google Scholar
• Adhikari AS, Agarwal N, Wood BM, et al. CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance. Cancer Res. 2010;70(11):4602–4612.
   PubMed Web of Science ®Google Scholar
• Hr S, Ak H, Balling R, et al. A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor. EMBO J. 1989;8(9):2543–2550.
   PubMed Web of Science ®Google Scholar
• Driessens G, Blanpain C. Long live sox2: sox2 lasts a lifetime. Cell Stem Cell. 2011;9(4):283–284.
   PubMed Web of Science ®Google Scholar
• Previs RA, Coleman RL, Harris AL, et al. Molecular pathways: translational and therapeutic implications of the Notch signaling pathway in cancer. Clin Cancer Res off J Am Assoc Cancer Res. 2015;21(5):955–961.
   PubMed Web of Science ®Google Scholar
• Kranenburg O. Prometastatic NOTCH signaling in colon cancer. Cancer Discov. 2015;5(2):115–117.
   PubMed Web of Science ®Google Scholar
• Hu Y, Su H, Li X, et al. The NOTCH ligand JAGGED2 promotes pancreatic cancer metastasis independent of NOTCH signaling activation. Mol Cancer Ther. 2015;14(1):289–297.
   PubMed Web of Science ®Google Scholar
• Tanaka M, Setoguchi T, Hirotsu M, et al. Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation. Br J Cancer. 2009;100(12):1957–1965.
   PubMed Web of Science ®Google Scholar
• Ren S, Zhang X, Hu Y, et al. Blocking the Notch signal transduction pathway promotes tumor growth in osteosarcoma by affecting polarization of TAM to M2 phenotype. Ann Transl Med. 2020;8(17):1057.
   PubMed Web of Science ®Google Scholar
• Jin H, Luo S, Wang Y, et al. miR-135b stimulates osteosarcoma recurrence and lung metastasis via Notch and Wnt/β-Catenin signaling. Mol Ther Nucleic Acids. 2017;8:111–122.
   PubMedGoogle Scholar
• Nawaz M. Extracellular vesicle-mediated transport of non-coding RNAs between stem cells and cancer cells: implications in tumor progression and therapeutic resistance. Stem Cell Investig. 2017;4(10):83.
   PubMedGoogle Scholar
• Hur Y, Feng S, Wilson K, et al. Embryonic stem cell-derived extracellular vesicles maintain ESC Stemness by activating FAK. Dev Cell. 2021;56(3):277–291.e6.
   PubMed Web of Science ®Google Scholar
• Sun Z, Wang L, Zhou Y, et al. Glioblastoma stem cell-derived exosomes enhance stemness and tumorigenicity of glioma cells by transferring Notch1 protein. Cell Mol Neurobiol. 2020;40(5):767–784.
   PubMed Web of Science ®Google Scholar
• Mu X, Agarwal R, March D, et al. Notch signaling mediates skeletal muscle atrophy in cancer cachexia caused by osteosarcoma. Sarcoma. 2016;2016:3758162.
   PubMedGoogle Scholar