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Research Paper

1α,25(OH)2D3(VD3) promotes Raddeanin A-induced anti-proliferative effects on HeLa cell apoptosis and autophagy through negative regulation of HPV18E6-E7/PD-L1/VDR axis

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Pages 357-369 | Received 12 Sep 2021, Accepted 05 Nov 2021, Published online: 03 Jan 2022

References

  • Workowski KA, Bolan GA; Centers for Disease C, Prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015;64(RR–03):1–137.
  • Zhou C, Tuong ZK, Frazer IH. Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System. Front Oncol. 2019;9:682.
  • Sasagawa T, Takagi H, Makinoda S. Immune responses against human papillomavirus (HPV) infection and evasion of host defense in cervical cancer. J Infect Chemother. 2012;18(6):807–815.
  • Lieblong BJ, Montgomery BEE, Su LJ, et al. Natural history of human papillomavirus and vaccinations in men: a literature review. Health Sci Rep 2019;2(5):e118.
  • Ju X, Zhang H, Zhou Z, et al. Regulation of PD-L1 expression in cancer and clinical implications in immunotherapy. Am J Cancer Res. 2020;10(1):1–11.
  • Chang DY, Song SH, You S, et al. Programmed death-1 (PD-1)-dependent functional impairment of CD4(+) T cells in recurrent genital papilloma. Clin Exp Med 2014;14(3):305–313.
  • Yu WY, Berger TG, North JP, et al. Expression of programmed cell death ligand 1 and programmed cell death 1 in cutaneous warts. J Am Acad Dermatol. 2019;81(5):1127–1133.
  • Gough ME, Graviss EA, May EE. The dynamic immunomodulatory effects of vitamin D3 during Mycobacterium infection. Innate Immun. 2017;23(6):506–523.
  • Grudet C, Wolkowitz OM, Mellon SH, et al. Vitamin D and inflammation in major depressive disorder. J Affect Disord. 2020;267:33–41.
  • Patel D, Druck A, Hoppensteadt D, et al. Relationship Between 25-Hydroxyvitamin D , Renin, and Collagen Remodeling Biomarkers in Atrial Fibrillation. Clin Appl Thromb Hemost 2020;26:1076029619899702.
  • Deuster E, Jeschke U, Ye Y, et al. Vitamin D and VDR in Gynecological Cancers-A Systematic Review. Int J Mol Sci. 2017;18(11):11.
  • Ghanbari A, Le Gresley A, Naughton D, et al. Biological activities of Ficus carica latex for potential therapeutics in Human Papillomavirus (HPV) related cervical cancers. Sci Rep. 2019;9(1):1013.
  • Van de Wall S, Nijman HW, Daemen T. HPV-specific immunotherapy: key role for immunomodulators. Anticancer Agents Med Chem. 2014;14(2):265–279.
  • How CW, Ong YS, Low SS, et al. How far have we explored fungi to fight cancer? Semin Cancer Biol 2021. DOI:10.1016/j.semcancer.2021.03.009
  • Noman E, Al-Shaibani MM, Bakhrebah MA, et al. Potential of Anti-Cancer Activity of Secondary Metabolic Products from Marine Fungi. J Fungi (Basel). 2021;7(6). DOI:10.3390/jof7060436
  • Zhang D, Lei T, Lv C, et al. Pharmacokinetic studies of active triterpenoid saponins and the total secondary saponin from Anemone raddeana Regel. J Chromatogr B Analyt Technol Biomed Life Sci 2017;1044-1045:54–62.
  • Naz I, Ramchandani S, Khan MR, et al. Anticancer Potential of Raddeanin A, a Natural Triterpenoid Isolated from Anemone raddeana Regel. Molecules 2020;25(5):1035.
  • Qian S, Chen QL, Guan JL, et al. Synthesis and biological evaluation of Raddeanin A, a triterpene saponin isolated from Anemone raddeana. Chem Pharm Bull (Tokyo). 2014;62(8):779–785.
  • Guan YD, Jiang SL, Yu P, et al. Suppression of eEF-2K-mediated autophagy enhances the cytotoxicity of raddeanin A against human breast cancer cells in vitro. Acta Pharmacol Sin. 2018;39(4):642–648.
  • Meng C, Teng Y, Jiang X. Raddeanin A Induces Apoptosis and Cycle Arrest in Human HCT116 Cells through PI3K/AKT Pathway Regulation In Vitro and In Vivo. Evid Based Complement Alternat Med. 2019;2019:7457105.
  • Shen X, Li L, He Y, et al. Raddeanin A inhibits proliferation, invasion, migration and promotes apoptosis of cervical cancer cells via regulating miR-224-3p/Slit2/Robo1 signaling pathway. Aging 2021;13(5):7166–7179. eng
  • Liu X, Xie S, Zhang J, et al. Long Noncoding RNA XIST Contributes to Cervical Cancer Development Through Targeting miR-889-3p/SIX1 Axis. Cancer Biother Radiopharm 2020;35(9):640–649.
  • Zhao W, Geng D, Li S, et al. LncRNA HOTAIR influences cell growth, migration, invasion, and apoptosis via the miR-20a-5p/HMGA2 axis in breast cancer. Cancer Med. 2018;7(3):842–855.
  • Papadaki C, Monastirioti A, Rounis K, et al. Circulating MicroRNAs Regulating DNA Damage Response and Responsiveness to Cisplatin in the Prognosis of Patients with Non-Small Cell Lung Cancer Treated with First-Line Platinum Chemotherapy. Cancers (Basel). 2020;12(5):1282.
  • Zhou C, Yi C, Yi Y, et al. LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/beta-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes. Mol Cancer. 2020;19(1):118.
  • Viry E, Paggetti J, Baginska J, et al. Autophagy: an adaptive metabolic response to stress shaping the antitumor immunity. Biochem Pharmacol. 2014;92(1):31–42.
  • Yang Y, Klionsky DJ. Autophagy and disease: unanswered questions. Cell Death Differ. 2020;27(3):858–871.
  • Egawa N, Egawa K, Griffin H, et al. Human Papillomaviruses; Epithelial Tropisms, and the Development of Neoplasia. Viruses 2015;7(7):3863–3890.
  • James CD, Prabhakar AT, Otoa R, et al. SAMHD1 Regulates Human Papillomavirus 16-Induced Cell Proliferation and Viral Replication during Differentiation of Keratinocytes. mSphere 2019;4(4). DOI:10.1128/mSphere.00448-19
  • Kaczanowski S. Apoptosis: its origin, history, maintenance and the medical implications for cancer and aging. Phys Biol 2016;13(3):031001.
  • Brentnall M, Rodriguez-Menocal L, De Guevara RL, et al. Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis. BMC Cell Biol. 2013;14(1):32.
  • Zheng JH, Viacava Follis A, Kriwacki RW, et al. Discoveries and controversies in BCL-2 protein-mediated apoptosis. FEBS J. 2016;283(14):2690–2700.
  • Jan R, Chaudhry GE. Understanding Apoptosis and Apoptotic Pathways Targeted Cancer Therapeutics. Adv Pharm Bull 2019;9(2):205–218.
  • Levy JMM, Towers CG, Thorburn A. Targeting autophagy in cancer. Nat Rev Cancer. 2017;17(9):528–542.
  • Menzies FM, Fleming A, Caricasole A, et al. Autophagy and Neurodegeneration: pathogenic Mechanisms and Therapeutic Opportunities. Neuron 2017;93(5):1015–1034.
  • Vega-rubin-de-celis S. The Role of Beclin 1-Dependent Autophagy in Cancer. Biology (Basel). 2019;9(1). DOI:10.3390/biology9010004
  • Strickley JD, Messerschmidt JL, Awad ME, et al. Immunity to commensal papillomaviruses protects against skin cancer. Nature 2019;575(7783):519–522.
  • Dermani FK, Samadi P, Rahmani G, et al. PD-1/PD-L1 immune checkpoint: potential target for cancer therapy. J Cell Physiol. 2019;234(2):1313–1325.
  • Han Y, Liu D, Li L. PD-1/PD-L1 pathway: current researches in cancer. Am J Cancer Res. 2020;10(3):727–742.
  • Liu C, Lu J, Tian H, et al. Increased expression of PDL1 by the human papillomavirus 16 E7 oncoprotein inhibits anticancer immunity. Mol Med Rep. 2017;15(3):1063–1070.
  • Tang H, Zhou X, Ye Y, et al. The different role of PD-L1 in head and neck squamous cell carcinomas: a meta-analysis. Pathol Res Pract. 2020;216(1):152768.
  • Wang Y, Li G. PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives. Front Med 2019;13(4):438–450.
  • Zhang L, Zhao Y, Tu Q, et al. The role of programmed cell death ligand-1/ programmed cell death-1 (PD-L1/PD-1) in HPV-induced cervical cancer and potential for their use in blockade therapy. Curr Med Chem. 2021;28(5):893-909. doi:10.2174/0929867327666200128105459.
  • Lei GS, Zhang C, Cheng BH, et al. Mechanisms of Action of Vitamin D as Supplemental Therapy for Pneumocystis Pneumonia. Antimicrob Agents Chemother. 2017;61(10). DOI:10.1128/AAC.01226-17
  • Mohanty S, Kamolvit W, Hertting O, et al. Vitamin D strengthens the bladder epithelial barrier by inducing tight junction proteins during E. coli urinary tract infection Cell Tissue Res. 2020;380(3):669–673.
  • Ozgu E, Yilmaz N, Baser E, et al. Could 25-OH vitamin D deficiency be a reason for HPV infection persistence in cervical premalignant lesions? J Exp Ther Oncol 2016;11(3):177–180.
  • Shim J, Perez A, Symanski E, et al. Association Between Serum 25-Hydroxyvitamin D Level and Human Papillomavirus Cervicovaginal Infection in Women in the United States. J Infect Dis. 2016;213(12):1886–1892.
  • Mun MJ, Kim TH, Hwang JY, et al. Vitamin D receptor gene polymorphisms and the risk for female reproductive cancers: a meta-analysis. Maturitas 2015;81(2):256–265.
  • Munetsuna E, Kawanami R, Nishikawa M, et al. Anti-proliferative activity of 25-hydroxyvitamin D3 in human prostate cells. Mol Cell Endocrinol. 2014;382(2):960–970.