DNA methyltransferase 3 beta mediates the methylation of the microRNA-34a promoter and enhances chondrocyte viability in osteoarthritis

References

• Grassel S, Zaucke F, Madry H. Osteoarthritis: novel molecular mechanisms increase our understanding of the disease pathology. J Clin Med. 2021;10:1938.
   PubMed Web of Science ®Google Scholar
• Goldring MB, Otero M. Inflammation in osteoarthritis. Curr Opin Rheumatol. 2011;23:471–478.
   PubMed Web of Science ®Google Scholar
• Peng Z, Sun H, Bunpetch V, et al. The regulation of cartilage extracellular matrix homeostasis in joint cartilage degeneration and regeneration. Biomaterials. 2021;268:120555.
   PubMed Web of Science ®Google Scholar
• Rahmati M, Nalesso G, Mobasheri A, et al. Aging and osteoarthritis: central role of the extracellular matrix. Ageing Res Rev. 2017;40:20–30.
   PubMed Web of Science ®Google Scholar
• Swingler TE, Niu L, Smith P, et al. The function of microRNAs in cartilage and osteoarthritis. Clin Exp Rheumatol. 2019;37(Suppl 120):40–47.
   PubMed Web of Science ®Google Scholar
• Xie F, Liu YL, Chen XY, et al. Role of MicroRNA, LncRNA, and exosomes in the progression of osteoarthritis: a review of recent literature. Orthop Surg. 2020;12:708–716.
   PubMed Web of Science ®Google Scholar
• Li XJ, Ren ZJ, Tang JH. MicroRNA-34a: a potential therapeutic target in human cancer. Cell Death Dis. 2014;5:e1327.
   PubMed Web of Science ®Google Scholar
• Endisha H, Datta P, Sharma A, et al. MicroRNA-34a-5p promotes joint destruction during osteoarthritis. Arthritis Rheumatol. 2021;73:426–439.
   PubMedGoogle Scholar
• Yan S, Wang M, Zhao J, et al. MicroRNA-34a affects chondrocyte apoptosis and proliferation by targeting the SIRT1/p53 signaling pathway during the pathogenesis of osteoarthritis. Int J Mol Med. 2016;38:201–209.
   PubMed Web of Science ®Google Scholar
• Visconti VV, Cariati I, Fittipaldi S, et al. DNA methylation signatures of bone metabolism in osteoporosis and osteoarthritis aging-related diseases: an updated review. Int J Mol Sci. 2021;22:4244.
   Web of Science ®Google Scholar
• Johnson AA, Akman K, Calimport SR, et al. The role of DNA methylation in aging, rejuvenation, and age-related disease. Rejuvenation Res. 2012;15:483–494.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Chen M, O’Keefe RJ, et al. Epigenetic and therapeutic implications of dnmt3b in temporomandibular joint osteoarthritis. Am J Transl Res. 2019;11:1736–1747.
   PubMed Web of Science ®Google Scholar
• Dou P, He Y, Yu B, et al. Downregulation of microRNA-29b by DNMT3B decelerates chondrocyte apoptosis and the progression of osteoarthritis via PTHLH/CDK4/RUNX2 axis. Aging (Albany NY). 2020;13:7676–7690.
   PubMedGoogle Scholar
• Jiang L, Zhou X, Xu K, et al. miR-7/EGFR/MEGF9 axis regulates cartilage degradation in osteoarthritis via PI3K/AKT/mTOR signaling pathway. Bioengineered. 2021;12:8622–8634.
   PubMed Web of Science ®Google Scholar
• Tang Y, Li Y, Xin D, et al. Icariin alleviates osteoarthritis by regulating autophagy of chondrocytes by mediating PI3K/AKT/mTOR signaling. Bioengineered. 2021;12:2984–2999.
   PubMed Web of Science ®Google Scholar
• Mankin HJ, Johnson ME, Lippiello L. Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. III. Distribution and metabolism of amino sugar-containing macromolecules. J Bone Joint Surg Am. 1981;63:131–139.
   PubMed Web of Science ®Google Scholar
• Musumeci G, Castrogiovanni P, Trovato FM, et al. Biomarkers of chondrocyte apoptosis and autophagy in osteoarthritis. Int J Mol Sci. 2015;16:20560–20575.
   PubMed Web of Science ®Google Scholar
• Xu B, Li YY, Ma J, et al. Roles of microRNA and signaling pathway in osteoarthritis pathogenesis. J Zhejiang Univ Sci B. 2016;17:200–208.
   PubMed Web of Science ®Google Scholar
• Cui J, Placzek WJ. PTBP1 enhances miR-101-guided AGO2 targeting to MCL1 and promotes miR-101-induced apoptosis. Cell Death Dis. 2018;9:552.
   PubMed Web of Science ®Google Scholar
• Gu Y, Zhao S, Wan J, et al. Hsa-miRNA-125b may induce apoptosis of HTR8/SVneo cells by targeting MCL1. Reprod Biol. 2019;19:368–373.
   PubMed Web of Science ®Google Scholar
• Li C, Zhang Y, Zhao W, et al. miR-153-3p regulates progression of ovarian carcinoma in vitro and in vivo by targeting MCL1 gene. J Cell Biochem. 2019;120:19147–19158.
   PubMed Web of Science ®Google Scholar
• Ma Y, Chai N, Jiang Q, et al. DNA methyltransferase mediates the hypermethylation of the microRNA 34a promoter and enhances the resistance of patient-derived pancreatic cancer cells to molecular targeting agents. Pharmacol Res. 2020;160:105071.
   PubMed Web of Science ®Google Scholar
• Kim D, Song J, Kim S, et al. MicroRNA-34a regulates migration of chondroblast and IL-1beta-induced degeneration of chondrocytes by targeting EphA5. Biochem Biophys Res Commun. 2011;415:551–557.
   PubMed Web of Science ®Google Scholar
• Abouheif MM, Nakasa T, Shibuya H, et al. Silencing microRNA-34a inhibits chondrocyte apoptosis in a rat osteoarthritis model in vitro. Rheumatology (Oxford). 2010;49:2054–2060.
   PubMed Web of Science ®Google Scholar
• Liu W, Zhang Y, Feng X, et al. Inhibition of microRNA-34a prevents IL-1beta-induced extracellular matrix degradation in nucleus pulposus by increasing GDF5 expression. Exp Biol Med (Maywood). 2016;241:1924–1932.
   PubMed Web of Science ®Google Scholar
• Cheleschi S, Tenti S, Mondanelli N, et al. MicroRNA-34a and MicroRNA-181a mediate visfatin-induced apoptosis and oxidative stress via NF-kappaB pathway in human osteoarthritic chondrocytes. Cells. 2019;8. DOI:10.3390/cells8080874.
   PubMed Web of Science ®Google Scholar
• Izumi S, Saito A, Kanemoto S, et al. The endoplasmic reticulum stress transducer BBF2H7 suppresses apoptosis by activating the ATF5-MCL1 pathway in growth plate cartilage. J Biol Chem. 2012;287:36190–36200.
   PubMed Web of Science ®Google Scholar
• Shen J, Wang C, Li D, et al. DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism. JCI Insight. 2017;2. DOI:10.1172/jci.insight.93612.
   Web of Science ®Google Scholar
• Wang C, Abu-Amer Y, O’Keefe RJ, et al. Loss of Dnmt3b in chondrocytes leads to delayed endochondral ossification and fracture repair. J Bone Miner Res. 2018;33:283–297.
   PubMed Web of Science ®Google Scholar
• Xu T, Wang C, Shen J, et al. Ablation of Dnmt3b in chondrocytes suppresses cell maturation during embryonic development. J Cell Biochem. 2018;119:5852–5863.
   PubMed Web of Science ®Google Scholar
• Sun K, Luo J, Guo J, et al. The PI3K/AKT/mTOR signaling pathway in osteoarthritis: a narrative review. Osteoarthritis Cartilage. 2020;28:400–409.
   PubMed Web of Science ®Google Scholar
• Zhang W, Hsu P, Zhong B, et al. MiR-34a enhances chondrocyte apoptosis, senescence and facilitates development of osteoarthritis by targeting DLL1 and regulating PI3K/AKT pathway. Cell Physiol Biochem. 2018;48:1304–1316.
   PubMedGoogle Scholar
• Wu DM, Hong XW, Wen X, et al. MCL1 gene silencing promotes senescence and apoptosis of glioma cells via inhibition of the PI3K/Akt signaling pathway. IUBMB Life. 2019;71:81–92.
   PubMed Web of Science ®Google Scholar
• Liu B, Sun W, Gao W, et al. microRNA-451a promoter methylation regulated by DNMT3B expedites bladder cancer development via the EPHA2/PI3K/AKT axis. BMC Cancer. 2020;20:1019.
   PubMed Web of Science ®Google Scholar