MicroRNA miR-18a-3p promotes osteoporosis and possibly contributes to spinal fracture by inhibiting the glutamate AMPA receptor subunit 1 gene (GRIA1)

References

• Ensrud KE, Kats AM, Boyd CM, et al. Association of disease definition, comorbidity burden, and prognosis with hip fracture probability among late-life women. JAMA Intern Med. 2019;179(8):1095–1103.
   PubMed Web of Science ®Google Scholar
• Briggs AM, Greig AM, Wark JD. The vertebral fracture cascade in osteoporosis: a review of aetiopathogenesis. Osteoporos Int. 2007;18(5):575–584.
   PubMed Web of Science ®Google Scholar
• Fuggle NR, Curtis EM, Ward KA, et al. Fracture prediction, imaging and screening in osteoporosis. Nat Rev Endocrinol. 2019;15(9):535–547.
   PubMed Web of Science ®Google Scholar
• Ensrud KE, Crandall CJ. Osteoporosis. Ann Intern Med. 2017;167(3):Itc17–itc32.
   PubMed Web of Science ®Google Scholar
• Sekiya I, Larson BL, Vuoristo JT, et al. Adipogenic differentiation of human adult stem cells from bone marrow stroma (MSCs). J Bone Miner Res. 2004;19(2):256–264.
   PubMed Web of Science ®Google Scholar
• Arinzeh TL. Mesenchymal stem cells for bone repair: preclinical studies and potential orthopedic applications. Foot Ankle Clin. 2005;10(4):651–65, viii.
   PubMedGoogle Scholar
• Scheideler M, Elabd C, Zaragosi LE, et al. Comparative transcriptomics of human multipotent stem cells during adipogenesis and osteoblastogenesis. BMC Genomics. 2008;9:340.
   PubMed Web of Science ®Google Scholar
• Mandourah AY, Ranganath L, Barraclough R, et al. Circulating microRNAs as potential diagnostic biomarkers for osteoporosis. Sci Rep. 2018;8(1):8421.
   PubMedGoogle Scholar
• Hackl M, Heilmeier U, Weilner S, et al. Circulating microRNAs as novel biomarkers for bone diseases - complex signatures for multifactorial diseases? Mol Cell Endocrinol. 2016;432:83–95.
   PubMed Web of Science ®Google Scholar
• Yu J, Xiao M, Ren G. Long non-coding RNA XIST promotes osteoporosis by inhibiting the differentiation of bone marrow mesenchymal stem cell by sponging miR-29b-3p that suppresses nicotinamide N-methyltransferase. Bioengineered. 2021;12(1):6057–6069.
   PubMed Web of Science ®Google Scholar
• Ma J, Lin X, Chen C, et al. Circulating miR-181c-5p and miR-497-5p are potential biomarkers for prognosis and diagnosis of osteoporosis. J Clin Endocrinol Metab. 2020;105:5.
   Web of Science ®Google Scholar
• Feng L, Xia B, Tian BF, et al. MiR-152 influences osteoporosis through regulation of osteoblast differentiation by targeting RICTOR. Pharm Biol. 2019;57(1):586–594.
   PubMed Web of Science ®Google Scholar
• Gutschner T, Diederichs S. The hallmarks of cancer: a long non-coding RNA point of view. RNA Biol. 2012;9(6):703–719.
   PubMed Web of Science ®Google Scholar
• Li M, Xie Z, Wang P, et al. The long noncoding RNA GAS5 negatively regulates the adipogenic differentiation of MSCs by modulating the miR-18a/CTGF axis as a ceRNA. Cell Death Dis. 2018;9(5):554.
   PubMed Web of Science ®Google Scholar
• Wang L, Dong J, Ma J, et al. By inhibiting ADCY5, miR-18a-3p promotes osteoporosis and possibly contributes to spinal fracture. Biochem Biophys Res Commun. 2021;550:49–55.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25(4):402–408.
   PubMed Web of Science ®Google Scholar
• Fu Y, Hu X, Gao Y, et al. LncRNA ROR/miR-145-5p axis modulates the osteoblasts proliferation and apoptosis in osteoporosis. Bioengineered. 2021;12(1):7714–7723.
   PubMed Web of Science ®Google Scholar
• Sun J, Liu M, Wang P, et al. Novel high-selectivity fluorescent probe for detecting alkaline phosphatase activity in marine environment. J Nanosci Nanotechnol. 2020;20(6):3348–3355.
   PubMed Web of Science ®Google Scholar
• Gregory CA, Gunn WG, Peister A, et al. An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction. Anal Biochem. 2004;329(1):77–84.
   PubMed Web of Science ®Google Scholar
• Nomura S, Shouzu A, Taomoto K, et al. Assessment of an ELISA kit for platelet-derived microparticles by joint research at many institutes in Japan. J Atheroscler Thromb. 2009;16(6):878–887.
   PubMed Web of Science ®Google Scholar
• Xu YZ, Kanagaratham C, Jancik S, et al. Promoter deletion analysis using a dual-luciferase reporter system. Methods Mol Biol. 2013;977:79–93.
   PubMedGoogle Scholar
• Xiu B, Chi Y, Liu L, et al. LINC02273 drives breast cancer metastasis by epigenetically increasing AGR2 transcription. Mol Cancer. 2019;18(1):187.
   PubMed Web of Science ®Google Scholar
• Hirano S. Western blot analysis. Methods Mol Biol. 2012;926:87–97.
   PubMedGoogle Scholar
• Yang X, Yang J, Lei P, et al. LncRNA MALAT1 shuttled by bone marrow-derived mesenchymal stem cells-secreted exosomes alleviates osteoporosis through mediating microRNA-34c/SATB2 axis. Aging (Albany NY). 2019;11(20):8777–8791.
   PubMedGoogle Scholar
• Deng L, Hu G, Jin L, et al. Involvement of microRNA-23b in TNF-α-reduced BMSC osteogenic differentiation via targeting runx2. J Bone Miner Metab. 2018;36(6):648–660.
   PubMed Web of Science ®Google Scholar
• Wang C, Zhang Z, Zhang H, et al. Susceptibility genes for osteoporotic fracture in postmenopausal Chinese women. J Bone Miner Res. 2012;27(12):2582–2591.
   PubMed Web of Science ®Google Scholar
• Segovia-Silvestre T, Neutzsky-Wulff AV, Sorensen MG, et al. Advances in osteoclast biology resulting from the study of osteopetrotic mutations. Hum Genet. 2009;124(6):561–577.
   PubMed Web of Science ®Google Scholar
• Ding B, Xu S, Sun X, et al. miR-18a-3p encourages apoptosis of chondrocyte in osteoarthritis via HOXA1 pathway. Curr Mol Pharmacol. 2020;13(4):328–341.
   PubMed Web of Science ®Google Scholar
• Sun K, Lai EC. Adult-specific functions of animal microRNAs. Nat Rev Genet. 2013;14(8):535–548.
   PubMed Web of Science ®Google Scholar
• Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116(2):281–297.
   PubMed Web of Science ®Google Scholar
• Magri C, Gardella R, Barlati SD, et al. Glutamate AMPA receptor subunit 1 gene (GRIA1) and DSM-IV-TR schizophrenia: a pilot case-control association study in an Italian sample. Am J Med Genet B Neuropsychiatr Genet. 2006;141b(3):287–293.
   PubMed Web of Science ®Google Scholar
• Ishiuchi S, Yoshida Y, Sugawara K, et al. Ca2+-permeable AMPA receptors regulate growth of human glioblastoma via Akt activation. J Neurosci. 2007;27(30):7987–8001.
   PubMed Web of Science ®Google Scholar
• Bernardini G, Laschi M, Serchi T, et al. Proteomics and phosphoproteomics provide insights into the mechanism of action of a novel pyrazolo[3,4-d]pyrimidine Src inhibitor in human osteosarcoma. Mol Biosyst. 2014;10(6):1305–1312.
   PubMedGoogle Scholar
• Mi B, Yan C, Xue H, et al. Inhibition of circulating miR-194-5p reverses osteoporosis through Wnt5a/β-catenin-dependent induction of osteogenic differentiation. Mol Ther Nucleic Acids. 2020;21:814–823.
   PubMedGoogle Scholar