Bioinformatics and in-silico findings reveal medical features and pharmacological targets of biochanin A against colorectal cancer and COVID-19

References

• Di Cosimo S, Tagliaferri B, Generali D, et al. Baseline characteristics and outcomes of cancer patients infected with SARS-CoV-2 in the Lombardy Region, Italy (AIOM-L Corona): a multicenter, observational, ambispective, cohort study. Cancers (Basel). 2021;13(6):1324.
   PubMed Web of Science ®Google Scholar
• Siegel RL, Miller KD, Goding Sauer A, et al. Colorectal cancer statistics, 2020. CA Cancer J Clin. 2020;70(3):145–164.
   PubMed Web of Science ®Google Scholar
• Whittaker TM, Abdelrazek MEG, Fitzpatrick AJ, et al. Delay to elective colorectal cancer surgery and implications for survival: a systematic review and meta-analysis. Colorectal Dis. 2021;23:1699–1711.
   PubMed Web of Science ®Google Scholar
• Ren X, Chen B, Hong Y, et al. The challenges in colorectal cancer management during COVID-19 epidemic. Ann Transl Med. 2020;8(7):498.
   PubMed Web of Science ®Google Scholar
• Abd Ghani MF, Othman R, Nordin N. Molecular docking study of naturally derived flavonoids with antiapoptotic BCL-2 and BCL-XL proteins toward ovarian cancer treatment. J Pharm Bioallied Sci. 2020;12(6):676–680.
   Google Scholar
• Xiao Y, Gong Q, Wang W, et al. The combination of biochanin A and SB590885 potentiates the inhibition of tumour progression in hepatocellular carcinoma. Cancer Cell Int. 2020;20(1):371.
   PubMed Web of Science ®Google Scholar
• Xue Z, Li A, Zhang X, et al. Amelioration of PM2.5-induced lung toxicity in rats by nutritional supplementation with biochanin A. Ecotoxicol Environ Saf. 2020;202:110878.
   PubMed Web of Science ®Google Scholar
• Puthli A, Tiwari R, Mishra KP. Biochanin A enhances the radiotoxicity in colon tumor cells in vitro. J Environ Pathol Toxicol Oncol. 2013;32(3):189–203.
   PubMed Web of Science ®Google Scholar
• Hu X, Qin H, Li Y, et al. Biochanin A protect against lipopolysaccharide-induced acute lung injury in mice by regulating TLR4/NF-κB and PPAR-γ pathway. Microb Pathog. 2020;138:103846.
   PubMed Web of Science ®Google Scholar
• Ko WC, Lin LH, Shen HY, et al. Biochanin a, a phytoestrogenic isoflavone with selective inhibition of phosphodiesterase 4, suppresses ovalbumin-induced airway hyperresponsiveness. Evid Based Complement Alternat Med. 2011;2011:635058.
   PubMed Web of Science ®Google Scholar
• Stelzer G, Rosen N, Plaschkes I, et al. The genecards suite: from gene data mining to disease genome sequence analyses. Curr Protoc Bioinformatics. 2016;54:1.30.1–1.30.33.
   PubMedGoogle Scholar
• Su M, Guo C, Liu M, et al. Therapeutic targets of vitamin C on liver injury and associated biological mechanisms: a study of network pharmacology. Int Immunopharmacol. 2019;66:383–387.
   PubMed Web of Science ®Google Scholar
• Ru J, Li P, Wang J, et al. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. J Cheminform. 2014;6(1):13.
   PubMed Web of Science ®Google Scholar
• Daina A, Michielin O, Zoete V. SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules. Nucleic Acids Res. 2019;47(W1):W357–W364.
   PubMed Web of Science ®Google Scholar
• Nickel J, Gohlke BO, Erehman J, et al. SuperPred: update on drug classification and target prediction. Nucleic Acids Res. 2014;42:W26–31.
   PubMed Web of Science ®Google Scholar
• Yao ZJ, Dong J, Che YJ, et al. TargetNet: a web service for predicting potential drug-target interaction profiling via multi-target SAR models. J Comput Aided Mol Des. 2016;30:413–424.
   PubMed Web of Science ®Google Scholar
• Liu Z, Guo F, Wang Y, et al. BATMAN-TCM: a bioinformatics analysis tool for molecular mechANism of Traditional Chinese Medicine. Sci Rep. 2016;6:21146.
   PubMed Web of Science ®Google Scholar
• Wishart DS, Feunang YD, Guo AC, et al. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018;46:D1074–D1082.
   PubMed Web of Science ®Google Scholar
• Wu K, Wei P, Liu M, et al. To reveal pharmacological targets and molecular mechanisms of curcumol against interstitial cystitis. J Adv Res. 2019;20:43–50.
   PubMed Web of Science ®Google Scholar
• Szklarczyk D, Franceschini A, Wyder S, et al. STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 2015;43:D447–52.
   PubMed Web of Science ®Google Scholar
• Shannon P, Markiel A, Ozier O, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13:2498–2504.
   PubMed Web of Science ®Google Scholar
• Elfiky AA. Natural products may interfere with SARS-CoV-2 attachment to the host cell. J Biomol Struct Dyn. 2020;1–10.
   Web of Science ®Google Scholar
• Fiscon G, Paci P. SWIMmeR: an R-based software to unveiling crucial nodes in complex biological networks. Bioinformatics. 2021;btab657. DOI:10.1093/bioinformatics/btab657
   Web of Science ®Google Scholar
• Vaninov N. In the eye of the COVID-19 cytokine storm. Nat Rev Immunol. 2020;20(5):277.
   PubMedGoogle Scholar
• Waldner MJ, Foersch S, Neurath MF. Interleukin-6–a key regulator of colorectal cancer development. Int J Biol Sci. 2012;8:1248–1253.
   PubMed Web of Science ®Google Scholar
• Islam ABMMK, Khan MA, Ahmed R, et al. Transcriptome of nasopharyngeal samples from COVID-19 patients and a comparative analysis with other SARS-CoV-2 infection models reveal disparate host responses against SARS-CoV-2. J Transl Med. 2021;19(1):32.
   PubMed Web of Science ®Google Scholar
• Peter AE, Sandeep BV, Rao BG, et al. Calming the Storm: natural Immunosuppressants as Adjuvants to Target the Cytokine Storm in COVID-19. Front Pharmacol. 2021;11:583777.
   PubMed Web of Science ®Google Scholar
• Solimani F, Meier K, Ghoreschi K. Janus kinase signaling as risk factor and therapeutic target for severe SARS-CoV-2 infection. Eur J Immunol. 2021;51(5):1071–1075.
   PubMed Web of Science ®Google Scholar
• Paniri A, Akhavan-Niaki H. Emerging role of IL-6 and NLRP3 inflammasome as potential therapeutic targets to combat COVID-19: role of lncRNAs in cytokine storm modulation. Life Sci. 2020;257:118114.
   PubMed Web of Science ®Google Scholar
• Pullamsetti SS, Seeger W, Savai R. Classical IL-6 signaling: a promising therapeutic target for pulmonary arterial hypertension. J Clin Invest. 2018;128(5):1720–1723.
   PubMed Web of Science ®Google Scholar
• Ji H, Lu L, Huang J, et al. IL1A polymorphisms is a risk factor for colorectal cancer in Chinese Han population: a case control study. BMC Cancer. 2019;19(1):181.
   PubMedGoogle Scholar
• Dimberg J, Shamoun L, Landerholm K, et al. Genetic variants of the IL2 gene related to risk and survival in patients with colorectal cancer. Anticancer Res. 2019;39:4933–4940.
   PubMed Web of Science ®Google Scholar
• Jia X, Liu B, Ye M, et al. Silica induces cell cycle changes through PI-3K/AP-1 pathway in human embryo lung fibroblast cells. Cell Biochem Funct. 2010;28(7):613–619.
   PubMed Web of Science ®Google Scholar
• Noutsios GT, Thorenoor N, Zhang X, et al. Major effect of oxidative stress on the male, but not female, SP-A1 type II cell miRNome. Front Immunol. 2019;10:1514.
   PubMed Web of Science ®Google Scholar
• Katoh M. Multi‑layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β‑catenin signaling activation (Review). Int J Mol Med. 2018;42(2):713–725.
   PubMed Web of Science ®Google Scholar
• Garcia-Lezana T, Lopez-Canovas JL, Villanueva A. Signaling pathways in hepatocellular carcinoma. Adv Cancer Res. 2021;149:63–101.
   PubMed Web of Science ®Google Scholar
• Muroni MR, Ribback S, Sotgiu G, et al. Prognostic impact of membranous/nuclear epidermal growth factor receptor localization in clear cell renal cell carcinoma. Int J Mol Sci. 2021;22(16):8747.
   PubMed Web of Science ®Google Scholar
• Toeda Y, Kasamatsu A, Koike K, et al. FBLIM1 enhances oral cancer malignancy via modulation of the epidermal growth factor receptor pathway. Mol Carcinog. 2018;57(12):1690–1697.
   PubMed Web of Science ®Google Scholar
• Câmara AB, Brandão IA. the main receptors involved with COVID-19: a systematic review and meta-analysis. Curr Med Chem. 2021;28(34):7157–7184.
   PubMed Web of Science ®Google Scholar
• Qin X, Huang C, Wu K, et al. Anti-coronavirus disease 2019 (COVID-19) targets and mechanisms of puerarin. J Cell Mol Med. 2021;25:677–685.
   PubMed Web of Science ®Google Scholar
• Cui Y, Yang J, Bai Y, et al. ENC1 facilitates colorectal carcinoma tumorigenesis and metastasis via JAK2/STAT5/AKT axis-mediated epithelial mesenchymal transition and stemness. Front Cell Dev Biol. 2021;9:616887.
   PubMed Web of Science ®Google Scholar
• Sanches JGP, Song B, Zhang Q, et al. The role of KDM2B and EZH2 in regulating the stemness in colorectal cancer through the PI3K/AKT pathway. Front Oncol. 2021;11:637298.
   PubMed Web of Science ®Google Scholar
• Gao W, Wen H, Liang L, et al. IL20RA signaling enhances stemness and promotes the formation of an immunosuppressive microenvironment in breast cancer. Theranostics. 2021;11(6):2564–2580.
   PubMed Web of Science ®Google Scholar
• Wu X, Lu Y, Qin X. Combination of Compound Kushen Injection and cisplatin shows synergistic antitumor activity in p53-R273H/P309S mutant colorectal cancer cells through inducing apoptosis. J Ethnopharmacol. 2021;283:114690.
   PubMed Web of Science ®Google Scholar
• Li N, Shi F, Wang X, et al. Silica dust exposure induces pulmonary fibrosis through autophagy signaling. Environ Toxicol. 2021;36:1269–1277.
   PubMed Web of Science ®Google Scholar
• Wang S, Wuniqiemu T, Tang W, et al. Luteolin inhibits autophagy in allergic asthma by activating PI3K/Akt/mTOR signaling and inhibiting Beclin-1-PI3KC3 complex. Int Immunopharmacol. 2021;94:107460.
   PubMed Web of Science ®Google Scholar
• Icard P, Lincet H, Wu Z, et al. The key role of Warburg effect in SARS-CoV-2 replication and associated inflammatory response. Biochimie. 2021;180:169–177.
   PubMed Web of Science ®Google Scholar
• Tao SL, Wang XM, Feng YG, et al. Is the presence of lung injury in COVID-19 an independent risk factor for secondary lung cancer? Med Hypotheses. 2020;143:110074.
   PubMed Web of Science ®Google Scholar
• Banji D, Alqahtani SS, Banji OJF, et al. Calming the inflammatory storm in severe COVID-19 infections: role of biologics- A narrative review. Saudi Pharm J. 2021;29:213–222.
   PubMed Web of Science ®Google Scholar