Elevated expression of NFE2L3 promotes the development of gastric cancer through epithelial-mesenchymal transformation

References

• Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians. 2021;71(3):209–249.
   PubMed Web of Science ®Google Scholar
• Smyth EC, Nilsson M, Grabsch HI, et al. Gastric cancer. Lancet. 2020;396(10251):635–648.
   PubMed Web of Science ®Google Scholar
• Bang YJ, Kim YW, Yang HK, et al. Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial. Lancet. 2012;379(9813):315–321.
   PubMed Web of Science ®Google Scholar
• Cunningham D, Allum WH, Stenning SP, et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med. 2006;355(1):11–20.
   PubMed Web of Science ®Google Scholar
• Kobayashi A, Ito E, Toki T, et al. Molecular cloning and functional characterization of a new Cap’n’ collar family transcription factor Nrf3. J Biol Chem. 1999;274(10):6443–6452.
   PubMed Web of Science ®Google Scholar
• Chevillard G, Blank V. NFE2L3 (NRF3): the Cinderella of the Cap’n’Collar transcription factors. Cell Mol Life Sci. 2011;68(20):3337–3348.
   PubMed Web of Science ®Google Scholar
• Derjuga A, Gourley TS, Holm TM, et al. Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus. Mol Cell Biol. 2004;24(8):3286–3294.
   PubMed Web of Science ®Google Scholar
• Baird L, Yamamoto M. The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway. Mol Cell Biol. 2020;40(13):13.
   Web of Science ®Google Scholar
• Chowdhury I, Mo Y, Gao L, et al. Oxidant stress stimulates expression of the human peroxiredoxin 6 gene by a transcriptional mechanism involving an antioxidant response element. Free Radic Biol Med. 2009;46(2):146–153.
   PubMed Web of Science ®Google Scholar
• Igarashi K, Sun J. The heme-Bach1 pathway in the regulation of oxidative stress response and erythroid differentiation. Antioxid Redox Signal. 2006;8(1–2):107–118.
   PubMed Web of Science ®Google Scholar
• Kokot A, Metze D, Mouchet N, et al. Alpha-melanocyte-stimulating hormone counteracts the suppressive effect of UVB on Nrf2 and Nrf-dependent gene expression in human skin. Endocrinology. 2009;150(7):3197–3206.
   PubMed Web of Science ®Google Scholar
• Chevillard G, Paquet M, Blank V. Nfe2l3 (Nrf3) deficiency predisposes mice to T-cell lymphoblastic lymphoma. Blood. 2011;117(6):2005–2008.
   PubMed Web of Science ®Google Scholar
• Sun J, Zheng Z, Chen Q, et al. NRF3 suppresses breast cancer cell metastasis and cell proliferation and is a favorable predictor of survival in breast cancer. Onco Targets Ther. 2019;12:3019–3030.
   PubMed Web of Science ®Google Scholar
• Wang H, Zhan M, Yang R, et al. Elevated expression of NFE2L3 predicts the poor prognosis of pancreatic cancer patients. Cell Cycle. 2018;17(17):2164–2174.
   PubMed Web of Science ®Google Scholar
• Ren Y, Wang Y, Hao S, et al. NFE2L3 promotes malignant behavior and EMT of human hepatocellular carcinoma (HepG2) cells via Wnt/betacatenin pathway. J Cancer. 2020;11(23):6939–6949.
   PubMed Web of Science ®Google Scholar
• Yu MM, Feng YH, Zheng L, et al. Short hairpin RNA-mediated knockdown of nuclear factor erythroid 2-like 3 exhibits tumor-suppressing effects in hepatocellular carcinoma cells. World J Gastroenterol. 2019;25(10):1210–1223.
   PubMed Web of Science ®Google Scholar
• Zhang L, Hu DL, Tang B, et al. NFE2L3 inhibition induces cell cycle arrest at the G0/G1 phase in colorectal cancer cells through downregulating CCND1 and pRb1-ser807/811. Dis Markers. 2019;2019:2829798.
   PubMed Web of Science ®Google Scholar
• Shah SP, Lam WL, Ng RT, et al. Modeling recurrent DNA copy number alterations in array CGH data. Bioinformatics. 2007;23(13):i450–8.
   PubMed Web of Science ®Google Scholar
• Huang RJ, Epplein M, Hamashima C, et al. An approach to the primary and secondary prevention of gastric cancer in the United States. Clin Gastroenterol Hepatol. 2021. DOI:10.1016/j.cgh.2021.09.039.
   Google Scholar
• Chen D, Cao G, Liu Q. A-kinase-interacting protein 1 facilitates growth and metastasis of gastric cancer cells via Slug-induced epithelial-mesenchymal transition. J Cell Mol Med. 2019;23(6):4434–4442.
   PubMed Web of Science ®Google Scholar
• Stampfel G, Kazmar T, Frank O, et al. Transcriptional regulators form diverse groups with context-dependent regulatory functions. Nature. 2015;528(7580):147–151.
   PubMed Web of Science ®Google Scholar
• Reiter F, Wienerroither S, Stark A. Combinatorial function of transcription factors and cofactors. Curr Opin Genet Dev. 2017;43:73–81.
   PubMed Web of Science ®Google Scholar
• Dawson MA, Kouzarides T. Cancer epigenetics: from mechanism to therapy. Cell. 2012;150(1):12–27.
   PubMed Web of Science ®Google Scholar
• Chio IIC, Tuveson DA. ROS in cancer: the burning question. Trends Mol Med. 2017;23(5):411–429.
   PubMed Web of Science ®Google Scholar
• Liou GY, Storz P. Reactive oxygen species in cancer. Free Radic Res. 2010;44(5):479–496.
   PubMed Web of Science ®Google Scholar
• Moody L, Chen H, Pan YX. Considerations for feature selection using gene pairs and applications in large-scale dataset integration, novel oncogene discovery, and interpretable cancer screening. BMC Med Genomics. 2020;13(Suppl 10):148.
   PubMedGoogle Scholar
• Maehara Y, Hasuda S, Koga T, et al. Postoperative outcome and sites of recurrence in patients following curative resection of gastric cancer. Br J Surg. 2000;87(3):353–357.
   PubMed Web of Science ®Google Scholar
• Gurzu S, Silveanu C, Fetyko A, et al. Systematic review of the old and new concepts in the epithelial-mesenchymal transition of colorectal cancer. World J Gastroenterol. 2016;22(30):6764–6775.
   PubMed Web of Science ®Google Scholar
• Aiello NM, Kang Y. Context-dependent EMT programs in cancer metastasis. J Exp Med. 2019;216(5):1016–1026.
   PubMed Web of Science ®Google Scholar
• Peng JM, Bera R, Chiou CY, et al. Actin cytoskeleton remodeling drives epithelial-mesenchymal transition for hepatoma invasion and metastasis in mice. Hepatology. 2018;67(6):2226–2243.
   PubMed Web of Science ®Google Scholar
• Friedmann Angeli JP, Meierjohann S. NRF2-dependent stress defense in tumor antioxidant control and immune evasion. Pigment Cell Melanoma Res. 2021;34(2):268–279.
   PubMed Web of Science ®Google Scholar
• Ju Q, Li X, Zhang H, et al. NFE2L2 is a potential prognostic biomarker and is correlated with immune infiltration in brain lower grade glioma: a pan-cancer analysis. Oxid Med Cell Longev. 2020;2020:3580719.
   PubMed Web of Science ®Google Scholar