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Bioengineered Volume 12, 2021 - Issue 2
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Research Paper

Knockdown of lysine (K)-specific demethylase 2B KDM2B inhibits glycolysis and induces autophagy in lung squamous cell carcinoma cells by regulating the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway

Zhonghai XieDepartment of Thoracic Surgery, Huzhou Central Hospital, Huzhou, Zhejiang Province, ChinaView further author information
,
Hongwei LiDepartment of Thoracic Surgery, Huzhou Central Hospital, Huzhou, Zhejiang Province, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-6293-1017View further author information
ORCID Icon &
Jin ZangDepartment of Thoracic Surgery, Huzhou Central Hospital, Huzhou, Zhejiang Province, ChinaView further author information
Pages 12227-12235 | Received 28 Sep 2021, Accepted 09 Nov 2021, Published online: 07 Dec 2021

References

  • Socinski MA, Obasaju C, Gandara D, et al. Current and emergent therapy options for advanced squamous cell lung cancer. J Thorac Oncol. 2018;13(2):165–183.
  • Filipits M. New developments in the treatment of squamous cell lung cancer. Curr Opin Oncol. 2014;26(2):152–158.
  • Kim HS, Mitsudomi T, Soo RA, et al. Personalized therapy on the horizon for squamous cell carcinoma of the lung. Lung Cancer. 2013;80(3):249–255.
  • Huang G, Zhang J, Gong L, et al. A glycolysis-based three-gene signature predicts survival in patients with lung squamous cell carcinoma. BMC Cancer. 2021;21(1):626.
  • Zhu J, Wang M, Hu D. Development of an autophagy-related gene prognostic signature in lung adenocarcinoma and lung squamous cell carcinoma. PeerJ. 2020;8:e8288.
  • Beck JT, Ismail A, Tolomeo C. Targeting the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway: an emerging treatment strategy for squamous cell lung carcinoma. Cancer Treat Rev. 2014;40(8):980–989.
  • Yan M, Yang X, Wang H, et al. The critical role of histone lysine demethylase KDM2B in cancer. Am J Transl Res. 2018;10(8):2222–2233.
  • Zheng Q, Fan H, Meng Z, et al. Histone demethylase KDM2B promotes triple negative breast cancer proliferation by suppressing p15INK4B, p16INK4A, and p57KIP2 transcription. Acta Biochim Biophys Sin (Shanghai). 2018;50(9):897–904.
  • Blackledge NP, Farcas AM, Kondo T, et al. Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation. Cell. 2014;157(6):1445–1459.
  • World Medical A. World medical association declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310(20):2191–2194.
  • Kumar P, Nagarajan A, Uchil PD. Analysis of cell viability by the MTT assay. Cold Spring Harb Protoc. 2018 Jun 1;2018(6). doi:10.1101/pdb.prot095505. PMID: 29858338.
  • Kajiwara Y, Panchabhai S, Levin VA. A new preclinical 3-dimensional agarose colony formation assay. Technol Cancer Res Treat. 2008;7(4):329–334.
  • Jozefczuk J, Adjaye J. Quantitative real-time PCR-based analysis of gene expression. Methods Enzymol. 2011;500:99–109.
  • Kurien BT, Scofield RH. Western blotting. Methods. 2006;38(4):283–293.
  • Duerr JS. Immunohistochemistry. WormBook. 2006;1–61. DOI:10.1895/wormbook.1.105.1
  • Chu Y, Chang Y, Lu W, et al. Regulation of autophagy by glycolysis in cancer. Cancer Manag Res. 2020;12:13259–13271.
  • Lau H-C, Shen Y, Huang Q, et al. Glycolysis related gene expression signature in predicting prognosis of laryngeal squamous cell carcinoma. Bioengineered. 2021 Dec;12(1):8738-8752.
  • Dias HF, Kühtreiber WM, Nelson KJ, et al. Epigenetic changes related to glucose metabolism in type 1 diabetes after BCG vaccinations: a vital role for KDM2B. Vaccine. 2021. DOI:10.1016/j.vaccine.2021.04.011
  • Liu Z, Wang F, Ma H, et al. Amentoflavone induces cell cycle arrest, apoptosis, and autophagy in BV-2 cells. Front Biosci-Landmark. 2020;25(5):798–816.
  • Poillet-Perez L, White E. Role of tumor and host autophagy in cancer metabolism. Genes Dev. 2019;33(11–12):610–619.
  • Kawaguchi M, Aoki S, Hirao T, et al. Autophagy is an important metabolic pathway to determine leukemia cell survival following suppression of the glycolytic pathway. Biochem Biophys Res Commun. 2016;474(1):188–192.
  • Markham A. Alpelisib: first global approval. Drugs. 2019;79(11):1249–1253.
  • Hasskarl J. Everolimus. Recent Results Cancer Res. 2018;211:101–123.

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