2,014
Views
3
CrossRef citations to date
0
Altmetric
Research Paper

Aryl hydrocarbon receptor is a prognostic biomarker and is correlated with immune responses in cervical cancer

, , &
Pages 11922-11935 | Received 29 Jul 2021, Accepted 11 Nov 2021, Published online: 25 Dec 2021

References

  • Lu DJ, King B, Sandler HM, et al. Paid parental leave policies among U.S. news & world report 2020-2021 best hospitals and best hospitals for cancer[J]. JAMA Network Open. 2021;4(5):e218518.
  • Suzuki T, Hidaka T, Kumagai Y, et al. Environmental pollutants and the immune response[J]. Nat Immunol. 2020;21(12):1486–1495.
  • Paris A, Tardif N, Galibert MD, et al. AhR and cancer: from gene profiling to targeted therapy[J]. Int J Mol Sci. 2021;22(2):752.
  • Takenaka MC, Gabriely G, Rothhammer V, et al. Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39[J]. Nat Neurosci. 2019;22(5):729–740.
  • Harms KL, Zhao L, Johnson B, et al. Virus-positive merkel cell carcinoma is an independent prognostic group with distinct predictive biomarkers[J]. Clin Cancer Res. 2021;27(9):2494–2504.
  • Feng Q, Wei H, Morihara J, et al. Th2 type inflammation promotes the gradual progression of HPV-infected cervical cells to cervical carcinoma[J]. Gynecol Oncol. 2012;127(2):412–419.
  • Trikha P, Lee DA. The role of AhR in transcriptional regulation of immune cell development and function[J]. Biochim Biophys Acta Rev Cancer. 2020;1873(1):188335.
  • Murray IA, Patterson AD, Perdew GH. Aryl hydrocarbon receptor ligands in cancer: friend and foe[J]. Nat Rev Cancer. 2014;14(12):801–814.
  • Funatake CJ, Marshall NB, Kerkvliet NI. 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters the differentiation of alloreactive CD8+ T cells toward a regulatory T cell phenotype by a mechanism that is dependent on aryl hydrocarbon receptor in CD4+ T cells[J]. J Immunotoxicol. 2008;5(1):81–91.
  • Li J, Bhattacharya S, Zhou J, et al. Aryl hydrocarbon receptor activation suppresses EBF1 and PAX5 and impairs human B lymphopoiesis[J]. J Immunol. 2017;199(10):3504–3515.
  • Wagage S, John B, Krock BL, et al. The aryl hydrocarbon receptor promotes IL-10 production by NK cells[J]. J Immunol. 2014;192(4):1661–1670.
  • Goudot C, Coillard A, Villani AC, et al. Aryl hydrocarbon receptor controls monocyte differentiation into dendritic cells versus macrophages[J]. Immunity. 2017;47(3):582–596.
  • Mei J, Xing Y, Lv J, et al. Construction of an immune-related gene signature for prediction of prognosis in patients with cervical cancer[J]. Int Immunopharmacol. 2020;88:106882.
  • Wang J, Li Z, Gao A, et al. The prognostic landscape of tumor-infiltrating immune cells in cervical cancer[J]. Biomed Pharmacother. 2019;120:109444.
  • Vasaikar SV, Straub P, Wang J, et al. LinkedOmics: analyzing multi-omics data within and across 32 cancer types[J]. Nucleic Acids Res. 2018;46(D1):D956–D963.
  • Szklarczyk D, Franceschini A, Wyder S, et al. STRING v10: protein-protein interaction networks, integrated over the tree of life[J]. Nucleic Acids Res. 2015 Database issue;43:D447–D452.
  • Li T, Fan J, Wang B, et al. TIMER: a web server for comprehensive analysis of tumor-infiltrating immune cells[J]. Cancer Res. 2017;77(21):e108–e110.
  • Ru B, Wong CN, Tong Y, et al. TISIDB: an integrated repository portal for tumor-immune system interactions[J]. Bioinformatics. 2019;35(20):4200–4202.
  • Lanczky A, Nagy A, Bottai G, et al. miRpower: a web-tool to validate survival-associated miRNAs utilizing expression data from 2178 breast cancer patients[J]. Breast Cancer Res Treat. 2016;160(3):439–446.
  • Lu DJ, King B, Sandler HM, et al. Paid parental leave policies among U.S. news & world report 2020-2021 best hospitals and best hospitals for cancer[J]. JAMA Network Open. 2021;4(5):e218518.
  • Gardner AB, Charo LM, Mann AK, et al. Ovarian, uterine, and cervical cancer patients with distant metastases at diagnosis: most common locations and outcomes[J]. Clin Exp Metastasis. 2020;37(1):107–113.
  • Zhang Y, Guo X, Wang G, et al. Real-World study of the incidence, risk factors, and prognostic factors associated with bone metastases in women with uterine cervical cancer using Surveillance, Epidemiology, and End Results (SEER) data analysis[J]. Med Sci Monit. 2018;24:6387–6397.
  • Hou Y, Guo S, Lyu J, et al. Prognostic factors in Asian and white American patients with cervical cancer, considering competing risks[J]. Curr Oncol. 2019;26(3):e277–e285.
  • Bekki K, Vogel H, Li W, et al. The aryl hydrocarbon receptor (AhR) mediates resistance to apoptosis induced in breast cancer cells[J]. Pestic Biochem Physiol. 2015;120:5–13.
  • Formosa R, Borg J, Vassallo J. Aryl hydrocarbon receptor (AHR) is a potential tumour suppressor in pituitary adenomas[J]. Endocr Relat Cancer. 2017;24(8):445–457.
  • Sadik A, Somarribas PL, Ozturk S, et al. IL4I1 Is a metabolic immune checkpoint that activates the AHR and promotes tumor progression[J]. Cell. 2020;182(5):1252–1270.
  • Kubli SP, Bassi C, Roux C, et al. AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer[J]. Proc Natl Acad Sci U S A. 2019;116(9):3604–3613.
  • Jiang Y, Xiao H, Sun L, et al. LMP2A suppresses the role of AHR pathway through ERK signal pathway in EBV-associated gastric cancer[J]. Virus Res. 2021;297:198399.
  • Kociba RJ, Keyes DG, Beyer JE, et al. Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats[J]. Toxicol Appl Pharmacol. 1978;46(2):279–303.
  • Mei J, Xing Y, Lv J, et al. Construction of an immune-related gene signature for prediction of prognosis in patients with cervical cancer[J]. Int Immunopharmacol. 2020;88:106882.
  • Kluxen FM, Hofer N, Kretzschmar G, et al. Cadmium modulates expression of aryl hydrocarbon receptor-associated genes in rat uterus by interaction with the estrogen receptor[J]. Arch Toxicol. 2012;86(4):591–601.
  • Dunlap TL, Howell CE, Mukand N, et al. Red clover Aryl Hydrocarbon Receptor (AhR) and Estrogen Receptor (ER) agonists enhance genotoxic estrogen metabolism[J]. Chem Res Toxicol. 2017;30(11):2084–2092.
  • Esakky P, Hansen DA, Drury AM, et al. Cigarette smoke condensate induces aryl hydrocarbon receptor-dependent changes in gene expression in spermatocytes[J]. Reprod Toxicol. 2012;34(4):665–676.
  • Beischlag TV, Perdew GH. ER alpha-AHR-ARNT protein-protein interactions mediate estradiol-dependent transrepression of dioxin-inducible gene transcription[J]. J Biol Chem. 2005;280(22):21607–21611.
  • Wongpratate M, Ishida W, Phuthong S, et al. Genetic polymorphisms of the human cytochrome P450 1A1 (CYP1A1) and cervical cancer susceptibility among northeast thai women[J]. Asian Pac J Cancer Prev. 2020;21(1):243–248.
  • Stejskalova L, Pavek P. The function of cytochrome P450 1A1 enzyme (CYP1A1) and aryl hydrocarbon receptor (AhR) in the placenta[J]. Curr Pharm Biotechnol. 2011;12(5):715–730.
  • Liu Y, Wu L, Tong R, et al. PD-1/PD-L1 inhibitors in cervical cancer[J]. Front Pharmacol. 2019;10:65.
  • Wardhani LO, Matsushita M, Iwasaki T, et al. Expression of the IDO1/TDO2-AhR pathway in tumor cells or the tumor microenvironment is associated with Merkel cell polyomavirus status and prognosis in merkel cell carcinoma[J]. Hum Pathol. 2019;84:52–61.
  • Ehrlich AK, Pennington JM, Tilton S, et al. AhR activation increases IL-2 production by alloreactive CD4(+) T cells initiating the differentiation of mucosal-homing Tim3(+) Lag3(+) Tr1 cells[J]. Eur J Immunol. 2017;47(11):1989–2001.
  • Zhang X, Liu X, Zhou W, et al. Blockade of IDO-kynurenine-AhR axis ameliorated colitis-associated colon cancer via inhibiting immune tolerance[J]. Cell Mol Gastroenterol Hepatol. 2021;12(4):1179–1199.
  • Androutsopoulos VP, Spyrou I, Ploumidis A, et al. Expression profile of CYP1A1 and CYP1B1 enzymes in colon and bladder tumors[J]. PLoS One. 2013;8(12):e82487.
  • Zhou X, Qiao G, Wang X, et al. CYP1A1 genetic polymorphism is a promising predictor to improve chemotherapy effects in patients with metastatic breast cancer treated with docetaxel plus thiotepa vs. docetaxel plus capecitabine[J]. Cancer Chemother Pharmacol. 2018;81(2):365–372.
  • Chen D, Li Q, Chen H, et al. Estrogen receptor regulates immune defense by suppressing NF-kappaB signaling in the crassostrea hongkongensis[J]. Fish Shellfish Immunol. 2020;106:796–803.
  • Zhao L, Huang S, Mei S, et al. Pharmacological activation of estrogen receptor beta augments innate immunity to suppress cancer metastasis[J]. Proc Natl Acad Sci U S A. 2018;115(16):E3673–E3681.
  • Asaba J, Bandyopadhyay M, Kindy M, et al. Estrogen receptor signal in regulation of B cell activation during diverse immune responses[J]. Int J Biochem Cell Biol. 2015;68:42–47.