Circular RNA circFLNA inhibits the development of bladder carcinoma through microRNA miR-216a-3p/BTG2 axis

References

• Antoni S, Ferlay J, Soerjomataram I, et al. Bladder cancer incidence and mortality: a global overview and recent trends. Eur Urol. 2017;71(1):96–108.
   PubMed Web of Science ®Google Scholar
• Fu DXX, Wei Z, Yi X, et al. NRP-1 silencing suppresses bladder cancer cell line proliferation both in vitro and in vivo. Anal Quant Cytopathol Histopathol. 2018;40:277–283.
   Web of Science ®Google Scholar
• Bladder cancer: diagnosis and management of bladder cancer: © NICE. Bladder cancer: diagnosis and management of bladder cancer. BJU Int. 2015;2017(120):755–765.
   Google Scholar
• Fankhauser CD, Mostafid H. Prevention of bladder cancer incidence and recurrence: nutrition and lifestyle. Curr Opin Urol. 2018;28(1):88–92.
   PubMed Web of Science ®Google Scholar
• Dong L, Zieren RC, Wang Y, et al. Recent advances in extracellular vesicle research for urological cancers: from technology to application. Biochim Biophys Acta Rev Cancer. 2019;1871:342–360.
   PubMed Web of Science ®Google Scholar
• Marqueen KE, Waingankar N, Sfakianos JP, et al. Early mortality in patients with muscle-invasive bladder cancer undergoing cystectomy in the United States. JNCI Cancer Spectr. 2018;2. pky075.
   PubMed Web of Science ®Google Scholar
• Wang H, Niu X, Mao F, et al. Hsa_circRNA_100146 Acts as a Sponge of miR-149-5p in Promoting Bladder Cancer Progression via Regulating RNF2. Onco Targets Ther. 2020;13:11007–11017.
   PubMed Web of Science ®Google Scholar
• Dong W, Bi J, Liu H, et al. Circular RNA ACVR2A suppresses bladder cancer cells proliferation and metastasis through miR-626/EYA4 axis. Mol Cancer. 2019;18(1):95.
   PubMedGoogle Scholar
• Wang JX, Liu Y, Jia XJ, et al. Upregulation of circFLNA contributes to laryngeal squamous cell carcinoma migration by circFLNA-miR-486-3p-FLNA axis. Cancer Cell Int. 2019;19:196.
   PubMed Web of Science ®Google Scholar
• Qu J, Yang J, Chen M, et al. CircFLNA ACTS AS A SPONGE of miR-646 to facilitate the proliferation, metastasis, glycolysis, and apoptosis inhibition of gastric cancer by targeting PFKFB2. Cancer Manag Res. 2020;12:8093–8103.
   PubMed Web of Science ®Google Scholar
• Ma C, Wang X, Yang F, et al. Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit. Mol Cancer. 2020;19(1):157.
   PubMed Web of Science ®Google Scholar
• Jemal, A, Siegel, R, Ward, E, Murray, T, Xu, J, and Thun, MJ, et al. Cancer statistics, 2007. CA Cancer J Clin. 2007;57(1):43–66.
   Google Scholar
• Stenzl A, Cowan NC, De Santis M, et al. Treatment of muscle-invasive and metastatic bladder cancer: update of the EAU guidelines. Eur Urol. 2011;59(6):1009–1018.
   PubMed Web of Science ®Google Scholar
• Travis LB, Curtis RE, Glimelius B, et al. Bladder and kidney cancer following cyclophosphamide therapy for non-Hodgkin’s lymphoma. J Natl Cancer Inst. 1995;87:524–530.
   PubMed Web of Science ®Google Scholar
• Czene K, Lichtenstein P, Hemminki K. Environmental and heritable causes of cancer among 9.6 million individuals in the Swedish family-cancer database. Int J Cancer. 2002;99:260–266.
   PubMed Web of Science ®Google Scholar
• Lu Q, Liu T, Feng H, et al. Circular RNA circSLC8A1 acts as a sponge of miR-130b/miR-494 in suppressing bladder cancer progression via regulating PTEN. Mol Cancer. 2019;18(1):111.
   PubMed Web of Science ®Google Scholar
• Jeck WR, Sorrentino JA, Wang K, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats. Rna. 2013;19(2):141–157.
   PubMed Web of Science ®Google Scholar
• Meng S, Zhou H, Feng Z, et al. CircRNA: functions and properties of a novel potential biomarker for cancer. Mol Cancer. 2017;16(1):94.
   PubMed Web of Science ®Google Scholar
• Sun Y, Ma G, Xiang H, et al. circFLNA promotes glioblastoma proliferation and invasion by negatively regulating miR‑199‑3p expression. Mol Med Rep. 2021;24(5):786.
   PubMed Web of Science ®Google Scholar
• Pan J, Huang G, Yin Z, et al. Circular RNA FLNA acts as a sponge of miR-486-3p in promoting lung cancer progression via regulating XRCC1 and CYP1A1. Cancer Gene Ther. 2021. DOI:10.1038/s41417-021-00293-w.
   Web of Science ®Google Scholar
• Chen X, Han H, Li Y, et al. Upregulation of long noncoding RNA HOTTIP promotes metastasis of esophageal squamous cell carcinoma via induction of EMT. Oncotarget. 2016;7:84480–84485.
   PubMedGoogle Scholar
• Yousef EM, Tahir MR, St-Pierre Y, et al. MMP-9 expression varies according to molecular subtypes of breast cancer. BMC Cancer. 2014;14(1):609.
   PubMedGoogle Scholar
• Hou Q, Han S, Yang L, et al. The Interplay of MicroRNA-34a, LGR4, EMT-associated factors, and MMP2 in regulating uveal melanoma cells. Invest Ophthalmol Vis Sci. 2019;60(13):4503–4510.
   PubMed Web of Science ®Google Scholar
• Ayob AZ, Ramasamy TS. Cancer stem cells as key drivers of tumour progression. J Biomed Sci. 2018;25(1):20.
   PubMedGoogle Scholar
• López-Lázaro M. The stem cell division theory of cancer. Crit Rev Oncol Hematol. 2018;123:95–113.
   PubMed Web of Science ®Google Scholar
• Mitra T, Prasad P, Mukherjee P, et al. Stemness and chemoresistance are imparted to the OC cells through TGFβ1 driven EMT. J Cell Biochem. 2018;119(7):5775–5787.
   PubMed Web of Science ®Google Scholar
• Zhang Q, Zhuang J, Deng Y, et al. miR34a/GOLPH3 axis abrogates urothelial bladder cancer chemoresistance via reduced cancer stemness. Theranostics. 2017;7(19):4777–4790.
   PubMed Web of Science ®Google Scholar
• Aghaalikhani N, Rashtchizadeh N, Shadpour P, et al. Cancer stem cells as a therapeutic target in bladder cancer. J Cell Physiol. 2019;234(4):3197–3206.
   PubMed Web of Science ®Google Scholar
• Zhu F, Qian W, Zhang H, et al. SOX2 is a marker for stem-like tumor cells in bladder cancer. Stem Cell Reports. 2017;9(2):429–437.
   PubMed Web of Science ®Google Scholar
• Buanne P, Corrente G, Micheli L, et al. Cloning of PC3B, a novel member of the PC3/BTG/TOB family of growth inhibitory genes, highly expressed in the olfactory epithelium. Genomics. 2000;68(3):253–263.
   PubMed Web of Science ®Google Scholar
• Mao B, Zhang Z, Wang G. BTG2: a rising star of tumor suppressors (review). Int J Oncol. 2015;46(2):459–464.
   PubMed Web of Science ®Google Scholar
• Takahashi F, Chiba N, Tajima K, et al. Breast tumor progression induced by loss of BTG2 expression is inhibited by targeted therapy with the ErbB/HER inhibitor lapatinib. Oncogene. 2011;30(27):3084–3095.
   PubMed Web of Science ®Google Scholar
• Tsui KH, Chiang KC, Lin YH, et al. BTG2 is a tumor suppressor gene upregulated by p53 and PTEN in human bladder carcinoma cells. Cancer Med. 2018;7:184–195.
   PubMed Web of Science ®Google Scholar
• Devanand P, Kim SI, Choi YW, et al. Inhibition of bladder cancer invasion by Sp1-mediated BTG2 expression via inhibition of DNA methyltransferase 1. FEBS J. 2014;281:5581–5601.
   PubMed Web of Science ®Google Scholar