Cell membrane breakage and triggering T cell infiltration are involved in human telomerase reverse transcriptase (hTERT) promoter-driven novel peptide KK-64 for liver cancer gene therapy

References

• Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA Cancer J Clin. 2018;68(6):394–424.
   PubMed Web of Science ®Google Scholar
• Burroughs A, Hochhauser D, Meyer T. Systemic treatment and liver transplantation for hepatocellular carcinoma: two ends of the therapeutic spectrum [J]. Lancet Oncol. 2004;5(7):409–418.
   PubMed Web of Science ®Google Scholar
• Johnson PJ. Hepatocellular carcinoma: is current therapy really altering outcome? [J]. Gut. 2002;51(4):459–462.
   PubMed Web of Science ®Google Scholar
• Palmer DH, Hussain SA, Johnson PJ. Systemic therapies for hepatocellular carcinoma [J]. Expert Opin Investig Drugs. 2004;13(12):1555–1568.
   PubMed Web of Science ®Google Scholar
• Powers JP, Hancock RE. The relationship between peptide structure and antibacterial activity [J]. Peptides. 2003;24(11):1681–1691.
   PubMed Web of Science ®Google Scholar
• He JF, Jin DX, Luo XG, et al. LHH1, a novel antimicrobial peptide with anti-cancer cell activity identified from lactobacillus casei HZ1 [J]. AMB Express. 2020;10(1):204.
   PubMed Web of Science ®Google Scholar
• Soliman C, Eastwood S, Truong VK, et al. The membrane effects of melittin on gastric and colorectal cancer [J] PLoS One . 2019;14(10):e0224028.
   PubMed Web of Science ®Google Scholar
• Chen WH, Chen JX, Cheng H, et al. A new anti-cancer strategy of damaging mitochondria by pro-apoptotic peptide functionalized gold nanoparticles [J]. Chem Commun (Camb). 2013;49(57):6403–6405.
   PubMed Web of Science ®Google Scholar
• Heulot M, Chevalier N, Puyal J, et al. The TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner [J]. Oncotarget. 2016;7(39):64342–64359.
   PubMedGoogle Scholar
• Wu D, Gao Y, Qi Y, et al. Peptide-based cancer therapy: opportunity and challenge [J]. Cancer Lett. 2014;351(1):13–22.
   PubMed Web of Science ®Google Scholar
• Hilchie AL, Doucette CD, Pinto DM, et al. Pleurocidin-family cationic antimicrobial peptides are cytolytic for breast carcinoma cells and prevent growth of tumor xenografts [J]. Breast Cancer Res. 2011;13(5):R102.
   PubMed Web of Science ®Google Scholar
• Huang W, Seo J, Willingham SB, et al. Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity [J]. PLoS One. 2014;9(2):e90397.
   PubMed Web of Science ®Google Scholar
• Rady I, Siddiqui IA, Rady M, et al. Melittin, a major peptide component of bee venom, and its conjugates in cancer therapy [J]. Cancer Lett. 2017;402:16–31.
   PubMed Web of Science ®Google Scholar
• Friedmann T, Roblin R. Gene therapy for human genetic disease? [J]. Science. 1972;178(4061):648–649.
   PubMedGoogle Scholar
• Dunbar CE, High KA, Joung JK, et al. Gene therapy comes of age [J]. Science. 2018;359(6372 eaan4672).
   PubMed Web of Science ®Google Scholar
• Ginn SL, Amaya AK, Alexander IE, et al. Gene therapy clinical trials worldwide to 2017: an update [J]. J Gene Med. 2018;20(5):e3015.
   PubMed Web of Science ®Google Scholar
• Zafir-Lavie I, Sherbo S, Goltsman H, et al. Successful intracranial delivery of trastuzumab by gene-therapy for treatment of HER2-positive breast cancer brain metastases [J]. J Control Release. 2018;291:80–89.
   PubMed Web of Science ®Google Scholar
• Lou B, Jin R, Cheng J, et al. A hierarchical assembly strategy to engineer dextran-enveloped polyurethane nanopolyplexes for robust ovarian cancer gene therapy [J]. Acta Biomater. 2018;78:260–273.
   PubMed Web of Science ®Google Scholar
• Hsiao WC, Sung SY, Chung LWK, et al. Osteonectin promoter-mediated suicide gene therapy of prostate cancer [J]. Methods Mol Biol. 2019;1895:27–42.
   PubMedGoogle Scholar
• Lei L, Chen C, Zhao J, et al. Targeted expression of miR-7 operated by TTF-1 promoter inhibited the growth of human lung cancer through the NDUFA4 pathway [J]. Mol Ther Nucleic Acids. 2017;6:183–197.
   PubMedGoogle Scholar
• Li Z, Ding Q, Li Y, et al. Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant [J]. Cancer Lett. 2006;236(1):58–63.
   PubMed Web of Science ®Google Scholar
• Shay JW. Role of telomeres and telomerase in aging and cancer [J]. Cancer Discov. 2016;6(6):584–593.
   PubMed Web of Science ®Google Scholar
• Jafari-Gharabaghlou D, Pilehvar-Soltanahmadi Y, Dadashpour M, et al. Combination of metformin and phenformin synergistically inhibits proliferation and hTERT expression in human breast cancer cells [J]. Iran J Basic Med Sci. 2018;21(11):1167–1173.
   PubMed Web of Science ®Google Scholar
• Chatran M, Pilehvar-Soltanahmadi Y, Dadashpour M, et al. Synergistic anti-proliferative effects of metformin and silibinin combination on T47D breast cancer cells via hTERT and cyclin D1 inhibition [J]. Drug Res (Stuttg). 2018;68(12):710–716.
   PubMed Web of Science ®Google Scholar
• Koga S, Hirohata S, Kondo Y, et al. FADD gene therapy using the human telomerase catalytic subunit (hTERT) gene promoter to restrict induction of apoptosis to tumors in vitro and in vivo [J]. Anticancer Res. 2001;21(3b):1937–1943.
   PubMed Web of Science ®Google Scholar
• Komata T, Kondo Y, Kanzawa T, et al. Caspase-8 gene therapy using the human telomerase reverse transcriptase promoter for malignant glioma cells [J]. Hum Gene Ther. 2002;13(9):1015–1025.
   PubMed Web of Science ®Google Scholar
• Wang X, Zhou P, Sun X, et al. Modification of the hTERT promoter by heat shock elements enhances the efficiency and specificity of cancer targeted gene therapy [J]. Int J Hyperthermia. 2016;32(3):244–253.
   PubMed Web of Science ®Google Scholar
• Han Y, Lu M, Zhou J. Buforin IIb induces androgen-independent prostate cancer cells apoptosis though p53 pathway in vitro [J]. Toxicon. 2019;168:16–21.
   PubMed Web of Science ®Google Scholar
• Shin SY, Kang JH, Jang SY, et al. Effects of the hinge region of cecropin A(1-8)-magainin 2 (1-12),a synthetic antimicrobial peptide, on liposomes, bacterial and tumor cells [J]. Biochim Biophys Acta. 2000;1463(2):209–218.
   PubMed Web of Science ®Google Scholar
• Swithenbank L, Cox P, Harris LG. Temporin A and bombinin H2 antimicrobial peptides exhibit selective cytotoxicity to lung cancer cells [J] Scientifica. 2020;2020:3526286.
   PubMed Web of Science ®Google Scholar
• Liu H, Tu M, Cheng S, et al. An anticoagulant peptide from beta-casein: identification, structure and molecular mechanism [J]. Food Funct. 2019;10(2):886–892.
   PubMed Web of Science ®Google Scholar
• Zhou C, Ma J, Lu Y, et al. TERT promoter regulating melittin expression induces apoptosis and G(0)/G(1) cell cycle arrest in esophageal carcinoma cells [J]. Oncol Lett. 2021;21(1):16.
   PubMed Web of Science ®Google Scholar
• Chang M, Wu M, Li H. Antitumor activities of novel glycyrrhetinic acid-modified curcumin-loaded cationic liposomes in vitro and in H22 tumor-bearing mice [J]. Drug Deliv. 2018;25(1):1984–1995.
   PubMed Web of Science ®Google Scholar
• Varghese F, Bukhari AB, Malhotra R, et al. IHC Profiler: an open source plugin for the quantitative evaluation and automated scoring of immunohistochemistry images of human tissue samples [J]. PLoS One. 2014;9(5):e96801.
   PubMed Web of Science ®Google Scholar
• Seyed Jafari SM, Hunger RE. IHC optical density score: a new practical method for quantitative immunohistochemistry image analysis [J]. Appl Immunohistochem Mol Morphol. 2017;25(1):e12–e13.
   PubMedGoogle Scholar
• Pistritto G, Trisciuoglio D, Ceci C, et al. Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies [J]. Aging (Albany NY). 2016;8(4):603–619.
   PubMedGoogle Scholar
• van der Leun AM, Thommen DS. CD8(+) T cell states in human cancer: insights from single-cell analysis [J]. Nat Rev Cancer. 2020;20(4):218–232.
   PubMed Web of Science ®Google Scholar
• Leader B, Baca QJ, Golan DE. Protein therapeutics: a summary and pharmacological classification [J]. Nat Rev Drug Discov. 2008;7(1):21–39.
   PubMed Web of Science ®Google Scholar
• Qi GB, Gao YJ, Wang L, et al. Self-assembled peptide-based nanomaterials for biomedical imaging and therapy [J]. Adv Mater. 2018;30(22):e1703444.
   PubMed Web of Science ®Google Scholar
• Hilchie AL, Hoskin DW, Power Coombs MR. Anticancer activities of natural and synthetic peptides [J]. Adv Exp Med Biol. 2019;1117:131–147.
   PubMed Web of Science ®Google Scholar
• Vlieghe P, Lisowski V, Martinez J, et al. Synthetic therapeutic peptides: science and market [J]. Drug Discov Today. 2010;15(1–2):40–56.
   PubMed Web of Science ®Google Scholar
• O’Connor S, Szwej E, Nikodinovic-Runic J, et al. The anti-cancer activity of a cationic anti-microbial peptide derived from monomers of polyhydroxyalkanoate [J]. Biomaterials. 2013;34(11):2710–2718.
   PubMed Web of Science ®Google Scholar
• Assaf AM, Haddadin RN, Aldouri NA, et al. Anti-cancer, anti-inflammatory and anti-microbial activities of plant extracts used against hematological tumors in traditional medicine of Jordan [J]. J Ethnopharmacol. 2013;145(3):728–736.
   PubMed Web of Science ®Google Scholar
• Nguyen LT, Haney EF, Vogel HJ. The expanding scope of antimicrobial peptide structures and their modes of action [J]. Trends Biotechnol. 2011;29(9):464–472.
   PubMed Web of Science ®Google Scholar
• Hoskin DW, Ramamoorthy A. Studies on anticancer activities of antimicrobial peptides [J]. Biochim Biophys Acta. 2008;1778(2):357–375.
   PubMed Web of Science ®Google Scholar
• Xie X, Kong Y, Tang H, et al. Targeted BikDD expression kills androgen-dependent and castration-resistant prostate cancer cells [J]. Mol Cancer Ther. 2014;13(7):1813–1825.
   PubMed Web of Science ®Google Scholar
• Xie X, Hsu Jennifer L, Choi M-G, et al. A novel hTERT promoter–driven E1A therapeutic for ovarian cancer [J]. Mol Cancer Ther. 2009;8(8):2375–2382.
   PubMed Web of Science ®Google Scholar
• Gu J, Fang B. Telomerase promoter-driven cancer gene therapy [J]. Cancer Biol Ther. 2003;2(4 Suppl 1):S64–70.
   PubMed Web of Science ®Google Scholar
• Kalinichenko SV, Shepelev MV, Vikhreva PN, et al. A novel hybrid promoter ARE-hTERT for Cancer gene therapy [J]. Acta Naturae. 2017;9(4):66–73.
   PubMed Web of Science ®Google Scholar
• Chakrabarty AM, Bernardes N, Fialho AM. Bacterial proteins and peptides in cancer therapy: today and tomorrow [J]. Bioengineered. 2014;5(4):234–242.
   PubMed Web of Science ®Google Scholar