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Bioengineered Volume 12, 2021 - Issue 2
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Research Paper

Effect of miRNA-200a on radiosensitivity of osteosarcoma cells by targeting Bone morphogenetic protein receptor 2

Xian TaoDepartment of Orthopedics, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, Jiangsu, ChinaCorrespondence[email protected]
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Jiansheng ChengView further author information
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Xinghua WangDepartment of Orthopedics, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, Jiangsu, ChinaView further author information
Pages 12625-12635 | Received 11 Sep 2021, Accepted 22 Nov 2021, Published online: 13 Dec 2021

References

  • Chen EL, Yoo CH, Gutkin PM, et al. Outcomes for pediatric patients with osteosarcoma treated with palliative radiotherapy. Pediatr Blood Cancer. 2020;67(1):e27967.
  • PosthumaDeBoer J, Würdinger T, Graat HC, et al. WEE1 inhibition sensitizes osteosarcoma to radiotherapy. BMC Cancer. 2011;11(1):156.
  • Reda El Sayed S, Cristante J, Guyon L, et al. MicroRNA Therapeutics in Cancer: current Advances and Challenges. Cancers (Basel). 2021;13(11):2680.
  • Wang J, Liu S, Shi J, et al. The role of miRNA in the diagnosis, prognosis, and treatment of osteosarcoma. Cancer Biother Radiopharm. 2019;34(10):605–613.
  • Wang Q. Expression of miR-200a in osteosarcoma and its clinical significance[D]. Zhengzhou University, 2008.
  • Greither T, Vorwerk F, Kappler M, et al. Salivary miR-93 and miR-200a as post-radiotherapy biomarkers in head and neck squamous cell carcinoma[J]. Oncol Rep. 2017;38(2):1268–1275.
  • Du M, Wang J, Chen H, et al. MicroRNA‑200a suppresses migration and invasion and enhances the radiosensitivity of NSCLC cells by inhibiting the HGF/c‑Met signaling pathway. Oncol Rep. 2019;41(3):1497–1508.
  • Chen X, Zhang Y. BMP-2 and miR-29c in osteosarcoma tissues on proliferation and invasion of osteosarcoma cells. Oncol Lett. 2019;17(6):5389–5394.
  • Jin X, Jin X, Kim LJY, et al. Inhibition of ID1-BMPR2 intrinsic signaling sensitizes glioma stem cells to differentiation therapy[J]. Clin Cancer Res. 2017;24(2):383–394.
  • Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 2008;3(6):1101–1108.
  • Lin J, Redies C. Histological evidence: housekeeping genes beta-actin and GAPDH are of limited value for normalization of gene expression. Dev Genes Evol. 2012;222(6):369–376.
  • Weichert H, Blechschmidt I, Schröder S, et al. The MTT-assay as a rapid test for cell proliferation and cell killing: application to human peripheral blood lymphocytes (PBL). Allerg Immunol (Leipz). 1991;37(3–4):139–144.
  • Iménez-Díaz MB, Mulet T, Gómez V, et al. Quantitative measurement of Plasmodium-infected erythrocytes in murine models of malaria by flow cytometry using bidimensional assessment of SYTO-16 fluorescence. Cytometry A. 2009;75(3):225–235.
  • Tishler RB, Geard CR. Correlation of sensitizer enhancement ratio with bromodeoxyuridine concentration and exposure time in human cervical carcinoma cells treated with low dose rate irradiation. Int J Radiat Oncol Biol Phys. 1992;22(3):495–498.
  • Beillard E, Ong SC, Giannakakis A, et al. miR-Sens–a retroviral dual-luciferase reporter to detect microRNA activity in primary cells. RNA. 2012;18(5):1091–1100.
  • Kim TK. T test as a parametric statistic. Korean J Anesthesiol. 2015;68(6):540–546.
  • Mishra P, Singh U, Pandey CM, et al. Application of student’s t-test, analysis of variance, and covariance. Ann Card Anaesth. 2019;22(4):407–411.
  • Anderson PM, Wiseman GA, Erlandson L, et al. Gemcitabine radiosensitization after high-dose samarium for osteoblastic osteosarcoma[J]. Clin Cancer Res. 2005;11(19):6895–6900.
  • Dai N, Qing Y, Cun Y, et al. miR-513a-5p regulates radiosensitivity of osteosarcoma by targeting human apurinic/apyrimidinic endonuclease. Oncotarget. 2016;9(39):25414–25426.
  • Sun Q, Liu T, Yuan Y, et al. MiR-200c inhibits autophagy and enhances radiosensitivity in breast cancer cells by targeting UBQLN1[J]. Int J Cancer. 2015;136(5):1003–1012.
  • Cortez MA, Valdecanas D, Zhang X, et al. Therapeutic delivery of miR-200c enhances radiosensitivity in lung cancer[J]. Mol Ther. 2014;22(8):1494–1503.
  • Shiiba M, Uzawa K, Tanzawa H. MicroRNAs in head and neck squamous cell carcinoma (HNSCC) and oral squamous cell carcinoma (OSCC)[J]. Cancers (Basel). 2010;2(2):653–669.
  • Yang J, Wang Y. Long-chain non-coding LSAMP-AS3 targets modulation of Mir-200a invasion and proliferation of osteosarcoma Via MAPK pathway[J]. Int J Clin Exp Med. 2017;10(12):16328–16335.
  • Hiepen C, Jatzlau J, Hildebrandt S, et al. BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics. PLoS Biol. 2019;17(12):e3000557.
  • Wang S, Ren T, Jiao G, et al. BMPR2 promotes invasion and metastasis via the RhoA-ROCK-LIMK2 pathway in human osteosarcoma cells[J]. Oncotarget. 2017;8(35):58625–58641.
  • Jiao G, Guo W, Ren T, et al. BMPR2 inhibition induced apoptosis and autophagy via destabilization of XIAP in human chondrosarcoma cells[J]. Cell Death Dis. 2014;5(12):e1571.
  • Owens P, Pickup MW, Novitskiy SV, et al. Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators[J]. Proc Natl Acad Sci USA. 2012;109(8):2814–2819.

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