Type IIA topoisomerase (TOP2A) triggers epithelial-mesenchymal transition and facilitates HCC progression by regulating Snail expression

References

• Yu LX, Schwabe RF. The gut microbiome and liver cancer: mechanisms and clinical translation. Nat Rev Gastroenterol Hepatol. 2017;14(9):527–539.
   PubMed Web of Science ®Google Scholar
• Nitiss JL. DNA topoisomerase II and its growing repertoire of biological functions. Nat Rev Cancer. 2009;9(5):327–337.
   PubMed Web of Science ®Google Scholar
• Thakurela S, Garding A, Jung J, et al. Gene regulation and priming by topoisomerase IIα in embryonic stem cells. Nat Commun. 2013;4(1):1–13.
   Google Scholar
• Vos SM, Tretter EM, Schmidt BH, et al. All tangled up: how cells direct, manage and exploit topoisomerase function. Nat Rev Mol Cell Biol. 2011;12(12):827–841.
   PubMed Web of Science ®Google Scholar
• Wang JC. Cellular roles of DNA topoisomerases: a molecular perspective. Nat Rev Mol Cell Biol. 2002;3(6):430–440.
   PubMed Web of Science ®Google Scholar
• Heestand GM, Schwaederle M, Gatalica Z, et al. Topoisomerase expression and amplification in solid tumours: analysis of 24,262 patients. Eur J Cancer. 2017;83:80–87.
   PubMed Web of Science ®Google Scholar
• Hooks KB, Audoux J, Fazli H, et al. New insights into diagnosis and therapeutic options for proliferative hepatoblastoma. Hepatology. 2018;68(1):89–102.
   PubMed Web of Science ®Google Scholar
• Kolberg M, Høland M, Lind GE, et al. Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours–A prognostic test after surgical resection. Mol Oncol. 2015;9(6):1129–1139.
   PubMed Web of Science ®Google Scholar
• Pei YF, Yin XM, Liu XQ. TOP2A induces malignant character of pancreatic cancer through activating β-catenin signaling pathway. BBA - Mol Basis Dis. 2018;1864(1):197–207.
   PubMed Web of Science ®Google Scholar
• Zhang R, Xu J, Zhao J, et al. Proliferation and invasion of colon cancer cells are suppressed by knockdown of TOP2A. J Cell Biochem. 2018;119(9):7256–7263.
   PubMed Web of Science ®Google Scholar
• Sun L, Wang Y, Yuan H, et al. CPA4 is a novel diagnostic and prognostic marker for human non-small-cell lung cancer. J Cancer. 2016;7(10):1197.
   PubMed Web of Science ®Google Scholar
• Li W, Li S, Yang J, et al. ITGBL1 promotes EMT, invasion and migration by activating NF-κB signaling pathway in prostate cancer. Onco Targets and therapy. 2019;12:3753.
   PubMed Web of Science ®Google Scholar
• Dong Y, Wu Z, He M, et al. ADAM9 mediates the interleukin-6-induced Epithelial–Mesenchymal transition and metastasis through ROS production in hepatoma cells. Cancer Lett. 2018;421:1–14.
   PubMed Web of Science ®Google Scholar
• Tarpgaard LS, Qvortrup C, Nygård SB, et al. A phase II study of Epirubicin in oxaliplatin-resistant patients with metastatic colorectal cancer and TOP2A gene amplification. BMC Cancer. 2016;16(1):1–5.
   Google Scholar
• Guo W, Sun S, Guo L, et al. Elevated TOP2A and UBE2C expressions correlate with poor prognosis in patients with surgically resected lung adenocarcinoma: a study based on immunohistochemical analysis and bioinformatics. J Cancer Res Clin Oncol. 2020;146(4):821–841.
   PubMed Web of Science ®Google Scholar
• Kou F, Sun H, Wu L, et al. TOP2A promotes lung adenocarcinoma cells’ malignant progression and predicts poor prognosis in lung adenocarcinoma. J Cancer. 2020;11(9):2496.
   PubMed Web of Science ®Google Scholar
• Schaefer-Klein J, Murphy SJ, Johnson SH, et al. Topoisomerase 2 alpha cooperates with androgen receptor to contribute to prostate cancer progression. PLoS One. 2015;10(11):e0142327.
   PubMed Web of Science ®Google Scholar
• Chen G, Yu M, Cao J, et al. Identification of candidate biomarkers correlated with poor prognosis of breast cancer based on bioinformatics analysis. Bioengineered. 2021;12(1):5149–5161.
   PubMed Web of Science ®Google Scholar
• Wong N, Yeo W, Wong WL, et al. TOP2A overexpression in hepatocellular carcinoma correlates with early age onset, shorter patients survival and chemoresistance. Int J Cancer. 2009;124(3):644–652.
   PubMed Web of Science ®Google Scholar
• Raja R, Pandey A, Kumar P. Epithelial to mesenchymal plasticity: role in cancer progression. Front Biosci (Landmark Ed). 2020;25(4):838–873.
   PubMedGoogle Scholar
• Poh ME, Liam CK, Mun KS, et al. Epithelial‐to‐mesenchymal transition (EMT) to sarcoma in recurrent lung adenosquamous carcinoma following adjuvant chemotherapy. Thorac Cancer. 2019;10(9):1841–1845.
   PubMed Web of Science ®Google Scholar
• Tulchinsky E, Demidov O, Kriajevska M, et al. EMT: a mechanism for escape from EGFR-targeted therapy in lung cancer. BBA -Rev Cancer. 2019;1871:29–39.
   PubMed Web of Science ®Google Scholar
• Bronte G, Bravaccini S, Bronte E, et al. Epithelial‐to‐mesenchymal transition in the context of epidermal growth factor receptor inhibition in non‐small‐cell lung cancer. Biol Rev. 2018;93(4):1735–1746.
   PubMed Web of Science ®Google Scholar
• Lento W, Congdon K, Voermans C, et al. Wnt signaling in normal and malignant hematopoiesis. Cold Spring Harb Perspect Biol. 2013;5(2):a008011.
   PubMed Web of Science ®Google Scholar
• Cano A, Pérez-Moreno MA, Rodrigo I, et al. The transcription factor snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol. 2000;2(2):76–83.
   PubMed Web of Science ®Google Scholar
• Giannelli G, Koudelkova P, Dituri F, et al. Role of epithelial to mesenchymal transition in hepatocellular carcinoma. J Hepatol. 2016;65(4):798–808.
   PubMed Web of Science ®Google Scholar
• Luo W, Liu X, Sun W, et al. Toosendanin, a natural product, inhibited TGF‐β1‐induced epithelial‐mesenchymal transition through ERK/Snail pathway. Phytother Res. 2018;32(10):2009–2020.
   PubMed Web of Science ®Google Scholar
• Song S, Qiu D, Luo F, et al. Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells. J Mol Endocrinol. 2018;61(3):101–113.
   PubMed Web of Science ®Google Scholar
• Wang M, Zhang L, Liu Z, et al. AGO1 may influence the prognosis of hepatocellular carcinoma through TGF-β pathway. Cell Death Dis. 2018;9(1):1–12.
   PubMedGoogle Scholar
• Gonzalez DM, Medici D. Signaling mechanisms of the epithelial-mesenchymal transition. Sci Signal. 2014;7(344):re8–re.
   PubMed Web of Science ®Google Scholar
• Xu W, Yang Z, Lu N. A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition. Cell Adh Migr. 2015;9(4):317–324.
   PubMed Web of Science ®Google Scholar