Imperatorin alleviated NLR family pyrin domain-containing 3 inflammasome cascade-induced synovial fibrosis and synovitis in rats with knee osteoarthritis

References

• Prieto-Alhambra D, Judge A, Javaid MK, et al. Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints. Ann Rheum Dis. 2014;73:1659–1664.
   PubMed Web of Science ®Google Scholar
• Hunter DJ, Schofeld D, Callander E. The individual and socioeconomic impact of osteoarthritis. Nat Rev Rheumatol. 2014;10:437–441.
   PubMed Web of Science ®Google Scholar
• Lafyatis R, Thompson NL, Remmers EF, et al. Transforming growth factor-beta production by synovial tissues from rheumatoid patients and streptococcal cell wall arthritic rats. Studies on secretion by synovial fibroblast-like cells and immunohistologic localization. J Immunol. 1989;143:1142–1148.
   PubMed Web of Science ®Google Scholar
• Leask A, Abraham DJ. TGF-beta signaling and the fibrotic response. FASEB J. 2004;18:816–827.
   PubMed Web of Science ®Google Scholar
• Remst DF, Blom AB, Vitters EL, et al. Gene expression analysis of murine and human osteoarthritis synovium reveals elevation of transforming growth factor β-responsive genes in osteoarthritis-related fibrosis. Arthritis Rheumatol. 2014;66:647–656.
   PubMed Web of Science ®Google Scholar
• Ferrara N, Gerber HP. The role of vascular endothelial growth factor in angiogenesis. Acta Haematol. 2001;106:148–156.
   PubMed Web of Science ®Google Scholar
• Bonnet CS, Walsh DA. Osteoarthritis, angiogenesis and inflammation. Rheumatology. 2005;44:7–16.
   PubMed Web of Science ®Google Scholar
• Felson DT. Identifying different osteoarthritis phenotypes through epidemiology. Osteoarthr Cartil. 2010;18:601–604.
   PubMed Web of Science ®Google Scholar
• Hunter DJ, Bierma-Zeinstra S. Osteoarthritis. Lancet. 2019;393:1745–1759.
   PubMed Web of Science ®Google Scholar
• Cramer T, Yamanishi Y, Clausen BE, et al. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell. 2003;112:645–657.
   PubMed Web of Science ®Google Scholar
• Zhang L, Huang Z, Xing R, et al. Increased HIF-1α in knee osteoarthritis aggravate synovial fibrosis via fibroblast-like synoviocyte pyroptosis. Oxid Med Cell Longev. 2019;2019:6326517.
   PubMed Web of Science ®Google Scholar
• McAllister MJ, Chemaly M, Eakin AJ, et al. NLRP3 as a potentially novel biomarker for the management of osteoarthritis. Osteoarthr Cartil. 2018;26:612–619.
   PubMed Web of Science ®Google Scholar
• Li Y, Zheng JY, Liu JQ, et al. Succinate/NLRP3 inflammasome induces synovial fibroblast activation: therapeutical effects of clematichinenoside AR on arthritis. Front Immunol. 2016;7:532.
   PubMed Web of Science ®Google Scholar
• Zhang L, Xing R, Huang Z, et al. Inhibition of synovial macrophage pyroptosis alleviates synovitis and fibrosis in knee osteoarthritis. Mediators Inflamm. 2019;2019:2165918.
   PubMed Web of Science ®Google Scholar
• Mi C, Ma J, Wang KS, et al. Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1α via the mTOR/p70S6K/4E-BP1 and MAPK pathways. J Ethnopharmacol. 2017;203:27–38.
   PubMed Web of Science ®Google Scholar
• Rosselli S, Maggio A, Bellone G, et al. Antibacterial and anticoagulant activities of coumarins isolated from the flowers of Magydaris tomentosa. Planta Med. 2007;73:116–120.
   PubMed Web of Science ®Google Scholar
• Chowdhury AA, Gawali NB, Shinde P, et al. Imperatorin ameliorates lipopolysaccharide induced memory deficit by mitigating proinflammatory cytokines, oxidative stress and modulating brain-derived neurotropic factor. Cytokine. 2018;110:78–86.
   PubMed Web of Science ®Google Scholar
• Wu P, Huang Z, Shan J, et al. Interventional effects of the direct application of “Sanse powder” on knee osteoarthritis in rats as determined from lipidomics via UPLC-Q-Exactive Orbitrap MS. Chin Med. 2020;15:9.
   PubMed Web of Science ®Google Scholar
• Oh HA, Kim HM, Jeong HJ. Distinct effects of imperatorin on allergic rhinitis: imperatorin inhibits caspase-1 activity in vivo and in vitro. J Pharmacol Exp Ther. 2011;339:72–81.
   PubMed Web of Science ®Google Scholar
• Dai M, Sui B, Xue Y, et al. Cartilage repair in degenerative osteoarthritis mediated by squid type II collagen via immunomodulating activation of M2 macrophages, inhibiting apoptosis and hypertrophy of chondrocytes. Biomaterials. 2018;180:91–103.
   PubMed Web of Science ®Google Scholar
• Guo C, Fu R, Wang S, et al. NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis. Clin Exp Immunol. 2018;194:231–243.
   PubMed Web of Science ®Google Scholar
• Wang Q, Ye C, Sun S, et al. Curcumin attenuates collagen-induced rat arthritis via anti-inflammatory and apoptotic effects. Int Immunopharmacol. 2019;72:292–300.
   PubMed Web of Science ®Google Scholar
• Estakhri F, Panjehshahin MR, Tanideh N, et al. The effect of kaempferol and apigenin on allogenic synovial membrane-derived stem cells therapy in knee osteoarthritic male rats. Knee. 2020;27:817–832.
   PubMedGoogle Scholar
• Yang G, Li S, Yuan L, et al. Effect of nobiletin on the MAPK/NF-κB signaling pathway in the synovial membrane of rats with arthritis induced by collagen. Food Funct. 2017;8:4668–4674.
   PubMedGoogle Scholar
• Mao T, He C, Wu H, et al. Silencing lncRNA HOTAIR declines synovial inflammation and synoviocyte proliferation and promotes synoviocyte apoptosis in osteoarthritis rats by inhibiting Wnt/β-catenin signaling pathway. Cell Cycle. 2019;18:3189–3205.
   PubMed Web of Science ®Google Scholar
• Li YZ, Chen JH, Tsai CF, et al. Anti-inflammatory property of imperatorin on alveolar macrophages and inflammatory lung injury. J Nat Prod. 2019;82:1002–1008.
   PubMed Web of Science ®Google Scholar
• Scanzello CR, Goldring SR. The role of synovitis in osteoarthritis pathogenesis. Bone. 2012;51:249–257.
   PubMed Web of Science ®Google Scholar
• Qing L, Lei P, Liu H, et al. Expression of hypoxia-inducible factor-1α in synovial fluid and articular cartilage is associated with disease severity in knee osteoarthritis. Exp Ther Med. 2017;13:63–68.
   PubMedGoogle Scholar
• Pufe T, Petersen W, Tillmann B, et al. The splice variants VEGF121 and VEGF189 of the angiogenic peptide vascular endothelial growth factor are expressed in osteoarthritic cartilage. Arthritis Rheum. 2001;44:1082–1088.
   PubMed Web of Science ®Google Scholar
• Gupta N, Sahu A, Prabhakar A, et al. Activation of NLRP3 inflammasome complex potentiates venous thrombosis in response to hypoxia. Proc Natl Acad Sci U S A. 2017;114:4763–4768.
   PubMed Web of Science ®Google Scholar
• Li Y, Liu Y, Wang C, et al. Succinate induces synovial angiogenesis in rheumatoid arthritis through metabolic remodeling and HIF-1α/VEGF axis. Free Radic Biol Med. 2018;126:1–14.
   PubMed Web of Science ®Google Scholar
• Meng XM, Nikolic-Paterson DJ, Lan HY. TGF-β: the master regulator of fibrosis. Nat Rev Nephrol. 2016;12:325–338.
   PubMed Web of Science ®Google Scholar
• Ko JH, Kang YM, Yang JH, et al. Regulation of MMP and TIMP expression in synovial fibroblasts from knee osteoarthritis with flexion contracture using adenovirus-mediated relaxin gene therapy. Knee. 2019;26:317–329.
   PubMedGoogle Scholar
• Remst DF, Blaney Davidson EN, Van der Kraan PM. Unravelling osteoarthritis-related synovial fibrosis: a step closer to solving joint stiffness. Rheumatology. 2015;54:1954–1963.
   PubMedGoogle Scholar
• Sotobayashi D, Kawahata H, Anada N, et al. Therapeutic effect of intra‐articular injection of ribbon‐type decoy oligonucleotides for hypoxia inducible factor‐1 on joint contracture in an immobilized knee animal model. J Gene Med. 2016;18:180–192.
   PubMed Web of Science ®Google Scholar
• Xu J, Feng Z, Chen S, et al. Taxol alleviates collagen-induced arthritis in mice by inhibiting the formation of microvessels. Clin Rheumatol. 2019;38:19–27.
   PubMed Web of Science ®Google Scholar