microRNA-211-5p predicts the progression of postmenopausal osteoporosis and attenuates osteogenesis by targeting dual specific phosphatase 6

References

• Li J, Chen X, Lu L, et al. The relationship between bone marrow adipose tissue and bone metabolism in postmenopausal osteoporosis. Cytokine Growth Factor Rev. 2020Apr; 52: 88–98 Epub 2020 Feb 10. PMID: 32081538
   PubMed Web of Science ®Google Scholar
• Sözen T, Özışık L, Başaran NÇ. An overview and management of osteoporosis. Eur J Rheumatol. 2017Mar;4(1):46–56. Epub 2016 Dec 30. PMID: 28293453; PMCID: PMC5335887.
   PubMed Web of Science ®Google Scholar
• Correia de Sousa M, Gjorgjieva M, Dolicka D, et al. Deciphering miRNAs’ action through miRNA editing. Int J Mol Sci. 2019Dec11;20(24):6249. PMID: 31835747; PMCID: PMC6941098.
   PubMed Web of Science ®Google Scholar
• Ji Y, Ji J, Yin H, et al. Exosomes derived from microRNA-129-5p-modified tumor cells selectively enhanced suppressive effect in malignant behaviors of homologous colon cancer cells. Bioengineered. 2021Nov15;12(2):12148–12156. Epub ahead of print. PMID: 34775889.
   PubMed Web of Science ®Google Scholar
• Lou X, Wang D, Gu Z, et al. Mechanism of microRNA regulating the progress of atherosclerosis in apoE-deficient mice. Bioengineered. 2021Dec;12(2):10994–11006. PMID: 34775883.
   PubMed Web of Science ®Google Scholar
• Mei L, Li M, Zhang T. MicroRNA miR-874-3p inhibits osteoporosis by targeting leptin (LEP). Bioengineered. 2021 Nov 24. Epub ahead of print. PMID: 34818977. 10.1080/21655979.2021.2009618
   Google Scholar
• Li Z, Zhang W, Huang Y. MiRNA-133a is involved in the regulation of postmenopausal osteoporosis through promoting osteoclast differentiation. Acta Biochim Biophys Sin (Shanghai). 2018Mar1;50(3):273–280. PMID: 29425279.
   PubMed Web of Science ®Google Scholar
• Chen R, Qiu H, Tong Y, et al. MiRNA-19a-3p alleviates the progression of osteoporosis by targeting HDAC4 to promote the osteogenic differentiation of hMSCs. Biochem Biophys Res Commun. 2019Aug27;516(3):666–672. Epub 2019 Jun 24. PMID: 31248594.
   PubMed Web of Science ®Google Scholar
• Xu F, Gao F. Liuwei Dihuang pill cures postmenopausal osteoporosis with kidney-Yin deficiency: potential therapeutic targets identified based on gene expression profiling. Medicine (Baltimore). 2018Aug;97(31):e11659. PMID: 30075554; PMCID: PMC6081159.
   PubMed Web of Science ®Google Scholar
• Higa T, Takahashi H, Higa-Nakamine S, et al. Up-regulation of DUSP5 and DUSP6 by gonadotropin-releasing hormone in cultured hypothalamic neurons, GT1-7 cells. Biomed Res. 2018;39(3):149–158. PMID: 29899190.
   PubMed Web of Science ®Google Scholar
• James NE, Beffa L, Oliver MT, et al.Inhibition of DUSP6 sensitizes ovarian cancer cells to chemotherapeutic agents via regulation of ERK signaling response genes.Oncotarget.2019May21;10:3315–3327. PMID: 31164954; PMCID: PMC653436136
   PubMedGoogle Scholar
• Zhang F, Tang B, Zhang Z, et al. DUSP6 Inhibitor (E/Z)-BCI hydrochloride attenuates lipopolysaccharide-induced inflammatory responses in murine macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB Pathway. Inflammation. 2019Apr;42(2):672–681. PMID: 30506106.
   PubMed Web of Science ®Google Scholar
• Hsu WC, Chen MY, Hsu SC, et al. DUSP6 mediates T cell receptor-engaged glycolysis and restrains TFH cell differentiation. Proc Natl Acad Sci U S A. 2018Aug21;115(34):E8027–E8036. Epub 2018 Aug 7. PMID: 30087184; PMCID: PMC6112722.
   PubMed Web of Science ®Google Scholar
• Yin Z, Zhu W, Wu Q, et al. Glycyrrhizic acid suppresses osteoclast differentiation and postmenopausal osteoporosis by modulating the NF-κB, ERK, and JNK signaling pathways. Eur J Pharmacol. 2019Sep15;859:172550. Epub 2019 Jul 16. PMID: 31323222.
   PubMed Web of Science ®Google Scholar
• Wang Y, Han X, Zang T, et al. miR-29b enhances the proliferation and migration of bone marrow mesenchymal stem cells in rats with castration-induced osteoporosis through the PI3K/AKT and TGF-β/Smad signaling pathways. Exp Ther Med. 2020Oct;20(4):3185–3195. Epub 2020 Jul 24. PMID: 32855687; PMCID: PMC7444379.
   PubMed Web of Science ®Google Scholar
• Zhou P, Li Y, Di R, et al. H19 and Foxc2 synergistically promotes osteogenic differentiation of BMSCs via Wnt-β-catenin pathway. J Cell Physiol. 2019Aug;234(8):13799–13806. Epub 2019 Jan 11. PMID: 30633332.
   PubMed Web of Science ®Google Scholar
• Peng Z, Lu S, Lou Z, et al. Exosomes from bone marrow mesenchymal stem cells promoted osteogenic differentiation by delivering miR-196a that targeted Dickkopf-1 to activate Wnt/β-catenin pathway. Bioengineered. 2021 Nov 1. Epub ahead of print. PMID: 34720039. 10.1080/21655979.2021.1996015
   Google Scholar
• Liu Z, Yang J. Uncarboxylated osteocalcin promotes osteogenic differentiation of mouse bone marrow-derived mesenchymal stem cells by activating the ERK-Smad/β-catenin signalling pathways. Cell Biochem Funct. 2020Jan;38(1):87–96. Epub 2019 Oct 31. PMID: 31674048.
   PubMed Web of Science ®Google Scholar
• Zhu J, Wang H, Liu H. Osteoclastic miR-301-b knockout reduces ovariectomy (OVX)-induced bone loss by regulating CYDR/NF-κB signaling pathway. Biochem Biophys Res Commun. 2020Aug13;529(1):35–42. Epub 2020 Jun 5. PMID: 32560816.
   PubMed Web of Science ®Google Scholar
• Wang T, Zhang C, Wu C, et al. miR-765 inhibits the osteogenic differentiation of human bone marrow mesenchymal stem cells by targeting BMP6 via regulating the BMP6/Smad1/5/9 signaling pathway. Stem Cell Res Ther. 2020;11(1):62.
   PubMed Web of Science ®Google Scholar
• Wang B, Wu W, Xu K, et al. MicroRNA-223-3p is involved in fracture healing by regulating fibroblast growth factor receptor 2. Bioengineered. 2021Nov9;12(2):12040–12048. Epub ahead of print. PMID: 34753389.
   PubMed Web of Science ®Google Scholar
• Yin CM, Suen WC, Lin S, et al. Dysregulation of both miR-140-3p and miR-140-5p in synovial fluid correlate with osteoarthritis severity. Bone Joint Res. 2017Nov;6(11):612–618. PMID: 29092816; PMCID: PMC5717073.
   PubMed Web of Science ®Google Scholar
• Forman JP, Curhan GC, Taylor EN. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension among young women. Hypertension. 2008Nov;52(5):828–832. Epub 2008 Oct 6. PMID: 18838623; PMCID: PMC2747298.
   PubMed Web of Science ®Google Scholar
• Sun Y, Chen R, Zhu D, et al. Osteoking improves OP rat by enhancing HSP90-β expression. Int J Mol Med. 2020May;45(5):1543–1553. Epub 2020 Mar 6. PMID: 32323753; PMCID: PMC7138285.
   PubMed Web of Science ®Google Scholar
• Rocha-Martins M, Njaine B, Silveira MS. Avoiding pitfalls of internal controls: validation of reference genes for analysis by qRT-PCR and Western blot throughout rat retinal development. PLoS One. 2012;7(8):e43028. Epub 2012 Aug 20. PMID: 22916200; PMCID: PMC3423434.
   PubMed Web of Science ®Google Scholar
• Li ZH, Hu H, Zhang XY, et al. MiR-291a-3p regulates the BMSCs differentiation via targeting DKK1 in dexamethasone-induced osteoporosis. Kaohsiung J Med Sci. 2020Jan;36(1):35–42. Epub 2019 Nov 15. PMID: 31729834.
   PubMed Web of Science ®Google Scholar
• Qiu J, Huang G, Na N, et al. MicroRNA-214-5p/TGF-β/Smad2 signaling alters adipogenic differentiation of bone marrow stem cells in postmenopausal osteoporosis. Mol Med Rep. 2018May;17(5):6301–6310. Epub 2018 Mar 9. PMID: 29532880; PMCID: PMC5928609.
   PubMed Web of Science ®Google Scholar
• Noh JY, Yang Y, Jung H. Molecular mechanisms and emerging therapeutics for osteoporosis. Int J Mol Sci. 2020Oct15;21(20):E7623. PMID: 33076329.
   PubMed Web of Science ®Google Scholar
• Anupama DS, Norohna JA, Acharya KK, et al. Effect of exercise on bone mineral density and quality of life among postmenopausal women with osteoporosis without fracture: a systematic review. Int J Orthop Trauma Nurs. 2020Jul; 39: 100796 Epub ahead of print. PMID: 33041224
   PubMed Web of Science ®Google Scholar
• Ma W, Dou Q, Ha X. Let-7a-5p inhibits BMSCs osteogenesis in postmenopausal osteoporosis mice. Biochem Biophys Res Commun. 2019Feb26;510(1):53–58. Epub 2019 Jan 16. PMID: 30660362.
   PubMed Web of Science ®Google Scholar
• Fu Y, Xu Y, Chen S, et al. MiR-151a-3p promotes postmenopausal osteoporosis by targeting SOCS5 and activating JAK2/STAT3 signaling. Rejuvenation Res. 2020Aug;23(4):313–323. Epub 2019 Sep 23. PMID: 31411118.
   PubMed Web of Science ®Google Scholar
• Wang WW, Yang L, Wu J, et al. The function of miR-218 and miR-618 in postmenopausal osteoporosis. Eur Rev Med Pharmacol Sci. 2017Dec;21(24):5534–5541. PMID: 29271983.
   PubMed Web of Science ®Google Scholar
• Li LY, Wang XL, Wang GS, et al. MiR-373 promotes the osteogenic differentiation of BMSCs from the estrogen deficiency induced osteoporosis. Eur Rev Med Pharmacol Sci. 2019Sep;23(17):7247–7255. PMID: 31539111.
   PubMed Web of Science ®Google Scholar
• Wang L, Shen YF, Shi ZM, et al. Overexpression miR-211-5p hinders the proliferation, migration, and invasion of thyroid tumor cells by downregulating SOX11. J Clin Lab Anal. 2018Mar;32(3):e22293. Epub 2017 Jul 13. PMID: 28703321; PMCID: PMC6817049.
   PubMed Web of Science ®Google Scholar
• Quan J, Pan X, He T, et al. Tumor suppressor miR-211-5p is associated with cellular migration, proliferation and apoptosis in renal cell carcinoma. Exp Ther Med. 2018Apr;15(4):4019–4028. Epub 2018 Feb 28. PMID: 29581751; PMCID: PMC5863605.
   PubMed Web of Science ®Google Scholar
• Peng Z, Li M, Tan X, et al. miR-211-5p alleviates focal cerebral ischemia-reperfusion injury in rats by down-regulating the expression of COX2. Biochem Pharmacol. 2020Jul; 177: 113983 Epub 2020 Apr 18. PMID: 32311346
   PubMed Web of Science ®Google Scholar
• Liu H, Luo J. miR-211-5p contributes to chondrocyte differentiation by suppressing Fibulin-4 expression to play a role in osteoarthritis. J Biochem. 2019Dec1;166(6):495–502. PMID: 31396630.
   PubMed Web of Science ®Google Scholar
• Gong ZM, Tang ZY, Sun XL. LncRNA PRNCR1 regulates osteogenic differentiation in osteolysis after hip replacement by targeting miR-211-5p. Biosci Rep. 2018May11;BSR20180042. 10.1042/BSR20180042 Epub ahead of print. PMID: 29752342
   PubMedGoogle Scholar
• Lane JM, Russell L, Khan SN. Osteoporosis. Clin Orthop Relat Res. 2000Mar; 372: 139–150 PMID: 10738423
   Google Scholar
• Ghorbaninejad M, Khademi-Shirvan M, Hosseini S, et al. Epidrugs: novel epigenetic regulators that open a new window for targeting osteoblast differentiation. Stem Cell Res Ther. 2020Oct28;11(1):456. PMID: 33115508.
   PubMed Web of Science ®Google Scholar
• Yu L, Hu M, Cui X, et al. M1 macrophage-derived exosomes aggravate bone loss in postmenopausal osteoporosis via a microRNA-98/DUSP1/JNK axis. Cell Biol Int. 2021Dec;45(12):2452–2463. Epub 2021 Aug 30. PMID: 34431160.
   PubMed Web of Science ®Google Scholar
• Liu X, Liu X, Du Y, et al. DUSP5 promotes osteogenic differentiation through SCP1/2-dependent phosphorylation of SMAD1. Stem Cells. 2021Oct;39(10):1395–1409. Epub 2021 Jul 10. PMID: 34169608; PMCID: PMC8518947.
   PubMed Web of Science ®Google Scholar
• Lei H, He M, He X, et al. METTL3 induces bone marrow mesenchymal stem cells osteogenic differentiation and migration through facilitating M1 macrophage differentiation. Am J Transl Res. 2021 May 15;13(5):4376–4388. PMID: 34150020; PMCID: PMC8205672.
   PubMed Web of Science ®Google Scholar
• Ma R, Ma L, Weng W, et al. DUSP6 SUMOylation protects cells from oxidative damage via direct regulation of Drp1 dephosphorylation. Sci Adv. 2020Mar25;6(13):eaaz0361. PMID: 32232156; PMCID: PMC7096176.
   PubMed Web of Science ®Google Scholar
• Mendell AL, MacLusky NJ. The testosterone metabolite 3α-androstanediol inhibits oxidative stress-induced ERK phosphorylation and neurotoxicity in SH-SY5Y cells through an MKP3/DUSP6-dependent mechanism. Neurosci Lett. 2019Mar23;696:60–66. Epub 2018 Dec 12. PMID: 30552945.
   PubMed Web of Science ®Google Scholar
• Ma J, Yu X, Guo L, et al. DUSP6, a tumor suppressor, is involved in differentiation and apoptosis in esophageal squamous cell carcinoma. Oncol Lett. 2013Dec;6(6):1624–1630. Epub 2013 Oct 7. PMID: 24260056; PMCID: PMC3834198.
   PubMed Web of Science ®Google Scholar
• Wang HT, Song YQ, Ren YW, et al. Dual specificity phosphatase 6 (DUSP6) polymorphism predicts prognosis of inoperable non-small cell lung cancer after chemoradiotherapy. Clin Lab. 2016;62(3):301–310. PMID: 27156317.
   PubMed Web of Science ®Google Scholar
• Ramkissoon A, Chaney KE, Milewski D, et al. Targeted inhibition of the dual specificity phosphatases DUSP1 and DUSP6 suppress MPNST growth via JNK. Clin Cancer Res. 2019Jul1;25(13):4117–4127. Epub 2019 Apr 1. PMID: 30936125; PMCID: PMC6606396.
   PubMed Web of Science ®Google Scholar
• Zhang B, Yuan P, Xu G, et al. DUSP6 expression is associated with osteoporosis through the regulation of osteoclast differentiation via ERK2/Smad2 signaling. Cell Death Dis. 2021Sep2;12(9):825. PMID: 34475393; PMCID: PMC8413376.
   PubMed Web of Science ®Google Scholar
• Wang H, Li C, Li J, et al. Naringin enhances osteogenic differentiation through the activation of ERK signaling in human bone marrow mesenchymal stem cells. Iran J Basic Med Sci. 2017Apr;20(4):408–414. PMID: 28804610; PMCID: PMC5425923.
   PubMed Web of Science ®Google Scholar
• Cao J, Wei Y, Lian J, et al. Notch signaling pathway promotes osteogenic differentiation of mesenchymal stem cells by enhancing BMP9/Smad signaling. Int J Mol Med. 2017Aug;40(2):378–388. Epub 2017 Jun 22. PMID: 28656211; PMCID: PMC5504972.
   PubMed Web of Science ®Google Scholar
• Gong YY, Peng MY, Yin DQ, et al. Long non-coding RNA H19 promotes the osteogenic differentiation of rat ectomesenchymal stem cells via Wnt/β-catenin signaling pathway. Eur Rev Med Pharmacol Sci. 2018Dec;22(24):8805–8813. PMID: 30575922.
   PubMed Web of Science ®Google Scholar