Identification of a novel circular RNA circZNF652/miR-486-5p/SERPINE1 signaling cascade that regulates cancer aggressiveness in glioblastoma (GBM)

References

• Li L, Zhu X, Qian Y, et al. Chimeric Antigen Receptor T-Cell therapy in glioblastoma: current and future. Front Immunol. 2020;11:594271.
   PubMed Web of Science ®Google Scholar
• Stupp R, Brada M, van Den Bent MJ, et al. High-grade glioma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2014;25(Suppl 3):iii93–101.
   PubMed Web of Science ®Google Scholar
• Delgado-López PD, Corrales-García EM. Survival in glioblastoma: a review on the impact of treatment modalities. Clin Transl Oncol. 2016;18(11):1062–1071.
   PubMed Web of Science ®Google Scholar
• Chistiakov DA, Chekhonin VP. Circulating tumor cells and their advances to promote cancer metastasis and relapse, with focus on glioblastoma multiforme. Exp Mol Pathol. 2018;105(2):166–174.
   PubMed Web of Science ®Google Scholar
• Goodall GJ, Wickramasinghe VO. RNA in cancer. Nat Rev Cancer. 2020; 211: 22–36.
   PubMed Web of Science ®Google Scholar
• Guo Z, Xie M, Zou Y, et al. Circular RNA Hsa_circ_0006766 targets microRNA miR-4739 to regulate osteogenic differentiation of human bone marrow mesenchymal stem cells. Bioengineered. 2021;12(1):5679–5687.
   PubMed Web of Science ®Google Scholar
• Gao C, Wen Y, Jiang F, et al. Circular RNA circ_0008274 upregulates granulin to promote the progression of hepatocellular carcinoma via sponging microRNA −140-3p. Bioengineered. 2021;12(1):1890–1901.
   PubMed Web of Science ®Google Scholar
• Wang J, Huang K, Shi L, et al. CircPVT1 promoted the progression of breast cancer by regulating MiR-29a-3p-Mediated AGR2-HIF-1α Pathway. Cancer Manag Res. 2020;12:11477–11490.
   PubMed Web of Science ®Google Scholar
• Xu P, Wang, L, Xie, X, Hu, F, Yang, Q, Hu, R, Jiang, L, Ding, F, Mei, J, Liu, J, et al. Hsa_circ_0001869 promotes NSCLC progression via sponging miR-638 and enhancing FOSL2 expression. Aging (Albany NY). 2020; 12(23):23836–23848.
   PubMedGoogle Scholar
• Wu Z, Zheng M, Zhang Y, et al. Hsa_circ_0043278 functions as competitive endogenous RNA to enhance glioblastoma multiforme progression by sponging miR-638. Aging (Albany NY). 2020;12(21):21114–21128.
   PubMedGoogle Scholar
• Lou J, Hao Y, Lin K, et al. Circular RNA CDR1as disrupts the p53/MDM2 complex to inhibit Gliomagenesis. Mol Cancer. 2020;19(1):138.
   PubMed Web of Science ®Google Scholar
• Guo J, Duan H, Li Y, et al. A novel circular RNA circ-ZNF652 promotes hepatocellular carcinoma metastasis through inducing snail-mediated epithelial-mesenchymal transition by sponging miR-203/miR-502-5p. Biochem Biophys Res Commun. 2019;513(4):812–819.
   PubMed Web of Science ®Google Scholar
• Mishra S, Yadav T, Rani V. Exploring miRNA based approaches in cancer diagnostics and therapeutics. Crit Rev Oncol Hematol. 2016;98:12–23.
   PubMed Web of Science ®Google Scholar
• Guo Y, Shi W, Fang R. miR‑18a‑5p promotes melanoma cell proliferation and inhibits apoptosis and autophagy by targeting EPHA7 signaling. Mol Med Rep. 2021;23(1):1.
   PubMed Web of Science ®Google Scholar
• Wang H, Pan J, Yu L, et al. MicroRNA-16 inhibits glioblastoma growth in orthotopic model by targeting cyclin D1 and WIP1. Onco Targets Ther. 2020;13:10807–10816.
   PubMed Web of Science ®Google Scholar
• Cui D, Wang K, Liu Y, et al. MicroRNA-623 inhibits epithelial-mesenchymal transition to attenuate glioma proliferation by targeting TRIM44. Onco Targets Ther. 2020;13:9291–9303.
   PubMed Web of Science ®Google Scholar
• Salimian J, Baradaran B, Azimzadeh Jamalkandi S, et al. MiR-486-5p enhances cisplatin sensitivity of human muscle-invasive bladder cancer cells by induction of apoptosis and down-regulation of metastatic genes. Urol Oncol. 2020;38(9):738.e9–738.e21.
   PubMed Web of Science ®Google Scholar
• Li C, Zheng X, Li W, et al. Serum miR-486-5p as a diagnostic marker in cervical cancer: with investigation of potential mechanisms. BMC Cancer. 2018;18(1):61.
   PubMed Web of Science ®Google Scholar
• Qi C, Lei L, Hu J, et al. Thrombospondin-1 is a prognostic biomarker and is correlated with tumor immune microenvironment in glioblastoma. Oncol Lett. 2021;21(1):22.
   PubMed Web of Science ®Google Scholar
• Liu W, Xu W, Li C, et al. Network pharmacological systems study of Huang-Lian-Tang in the treatment of glioblastoma multiforme. Oncol Lett. 2021;21(1):18.
   PubMed Web of Science ®Google Scholar
• Du WW, Zhang C, Yang W, et al. Identifying and Characterizing circRNA-Protein Interaction. Theranostics. 2017;7(17):4183–4191.
   PubMed Web of Science ®Google Scholar
• Chen LL, Yang L. Regulation of circRNA biogenesis. RNA Biol. 2015;12(4):381–388.
   PubMed Web of Science ®Google Scholar
• Aufiero S, van Den Hoogenhof MMG, Reckman YJ, et al. Cardiac circRNAs arise mainly from constitutive exons rather than alternatively spliced exons. Rna. 2018;24(6):815–827.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Lin X, Geng X, et al. Advances in circular RNAs and their role in glioma (Review). Int J Oncol. 2020;57(1):67–79.
   PubMed Web of Science ®Google Scholar
• Wang R, Zhang S, Chen X, et al. CircNT5E Acts as a Sponge of miR-422a to promote glioblastoma tumorigenesis. Cancer Res. 2018;78(17):4812–4825.
   PubMed Web of Science ®Google Scholar
• Zhou JX, Chen, KF, Hu, S, Dong, JR, Wang, HX, Su, X, Wang, YH, and Chu, JS . Up-regulation of circular RNA hsa_circ_01844 induces apoptosis and suppresses proliferation and migration of glioblastoma cells. Chin Med J (Engl). 2020;134(1): 81–87.
   PubMed Web of Science ®Google Scholar
• Wang R, Zhang S, Chen X, et al. Correction to: EIF4A3-induced circular RNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes glioblastoma multiforme cell tumorigenesis. Mol Cancer. 2020;19(1):153.
   PubMed Web of Science ®Google Scholar
• Lin X, Feng D, Li P, et al. LncRNA LINC00857 regulates the progression and glycolysis in ovarian cancer by modulating the Hippo signaling pathway. Cancer Med. 2020;9(21):8122–8132.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Han G, Cao Y, et al. Solasonine inhibits gastric cancer proliferation and enhances chemosensitivity through microRNA-486-5p. Am J Transl Res. 2020;12(7):3522–3530.
   PubMed Web of Science ®Google Scholar
• Zheng X, Xu K, Zhu L, et al. MiR-486-5p act as a biomarker in endometrial carcinoma: promotes cell proliferation, migration, invasion by targeting MARK1. Onco Targets Ther. 2020;13:4843–4853.
   PubMed Web of Science ®Google Scholar
• Zhang Q, Lei L, Jing D. Knockdown of SERPINE1 reverses resistance of triple‑negative breast cancer to paclitaxel via suppression of VEGFA. Oncol Rep. 2020;44(5):1875–1884.
   PubMed Web of Science ®Google Scholar
• Yang JD, Ma L, Zhu Z. SERPINE1 as a cancer-promoting gene in gastric adenocarcinoma: facilitates tumour cell proliferation, migration, and invasion by regulating EMT. J Chemother. 2019;31(7–8):408–418.
   PubMed Web of Science ®Google Scholar
• Li X, Dong P, Wei W, et al. Overexpression of CEP72 Promotes Bladder Urothelial Carcinoma Cell Aggressi-veness via Epigenetic CREB-Mediated Induction of SERPINE1. Am J Pathol. 2019;189(6):1284–1297.
   PubMed Web of Science ®Google Scholar
• Seker F, Cingoz A, Sur-Erdem İ, et al. Identification of SERPINE1 as a regulator of glioblastoma cell dispersal with transcriptome profiling. Cancers (Basel). 2019;11(11):11.
   Web of Science ®Google Scholar
• Vachher M, Arora K, Burman A, et al. NAMPT, GRN, and SERPINE1 signature as predictor of disease progression and survival in gliomas. J Cell Biochem. 2020;121(4):3010–3023.
   PubMed Web of Science ®Google Scholar