Silencing circular RNAPTPN12 promoted the growth of keloid fibroblasts by activating Wnt signaling pathway via targeting microRNA-21-5p

References

• Tan S, Khumalo N, Bayat A. Understanding keloid pathobiology from a quasi-neoplastic perspective: less of a scar and more of a chronic inflammatory disease with cancer-like tendencies. Front Immunol. 2019;10:1810.
   PubMed Web of Science ®Google Scholar
• Ud-Din S, Bayat A. Keloid scarring or disease: unresolved quasi-neoplastic tendencies in the human skin. Wound Repair Regen. 2020;28(3):422–426.
   PubMed Web of Science ®Google Scholar
• Lee S, Kim SK, Park H, et al. Contribution of Autophagy-Notch1-mediated NLRP3 inflammasome activation to chronic inflammation and fibrosis in keloid fibroblasts. Int J Mol Sci. 2020;21(21):8050.
   PubMed Web of Science ®Google Scholar
• Ekstein SF, Wyles SP, Moran SL, et al. Keloids: a review of therapeutic management. Int J Dermatol. 2021;60(6):661–671.
   PubMed Web of Science ®Google Scholar
• Bijlard E, Verduijn GM, Harmeling JX, et al. Optimal high-dose-rate brachytherapy fractionation scheme after keloid excision: a retrospective multicenter comparison of recurrence rates and complications. Int J Radiat Oncol Biol Phys. 2018;100(3):679–686.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Yu K, Liu O, et al. Expression profile and bioinformatics analyses of circular RNAs in keloid and normal dermal fibroblasts. Exp Cell Res. 2020;388(1):111799.
   PubMed Web of Science ®Google Scholar
• Lin Z, Long F, Zhao M, et al. The role of circular RNAs in hematological malignancies. Genomics. 2020;112(6):4000–4008.
   PubMed Web of Science ®Google Scholar
• Yang D, Li M, Du N. Effects of the circ_101238/miR-138-5p/CDK6 axis on proliferation and apoptosis keloid fibroblasts. Exp Ther Med. 2020;20(3):1995–2002.
   PubMed Web of Science ®Google Scholar
• Wang B, Yin L, Zhang HM, et al. circNRIP1 facilitates keloid progression via FXR1‑mediated upregulation of miR‑503‑3p and miR‑503‑5p. Int J Mol Med. 2021;47(5):70.
   PubMed Web of Science ®Google Scholar
• Song M, Zhao G, Sun H, et al. circPTPN12/miR-21-5 p/Np63alpha pathway contributes to human endometrial fibrosis. Elife. 2021;10. DOI:10.7554/eLife.65735.
   Web of Science ®Google Scholar
• Zhang ZY, Gao XH, Ma MY, et al. CircRNA_101237 promotes NSCLC progression via the miRNA-490-3p/MAPK1 axis. Sci Rep. 2020;10(1):9024.
   PubMed Web of Science ®Google Scholar
• Zhang J, Liu Y, Shi G. The circRNA-miRNA-mRNA regulatory network in systemic lupus erythematosus. Clin Rheumatol. 2021;40(1):331–339.
   PubMed Web of Science ®Google Scholar
• Li Q, Li B, Li Q, et al. Exosomal miR-21-5p derived from gastric cancer promotes peritoneal metastasis via mesothelial-to-mesenchymal transition. Cell Death Dis. 2018;9(9):854.
   PubMedGoogle Scholar
• Nasci VL, Chuppa S, Griswold L, et al. miR-21-5p regulates mitochondrial respiration and lipid content in H9C2 cells. Am J Physiol Heart Circ Physiol. 2019;316(3):H710–H721.
   PubMed Web of Science ®Google Scholar
• Zhang X, Li X, Li B, et al. miR-21-5p protects hippocampal neurons of epileptic rats via inhibiting STAT3 expression. Adv Clin Exp Med. 2020;29(7):793–801.
   PubMed Web of Science ®Google Scholar
• Yan L, Wang LZ, Xiao R, et al. Inhibition of microRNA-21-5p reduces keloid fibroblast autophagy and migration by targeting PTEN after electron beam irradiation. Lab Invest. 2020;100(3):387–399.
   PubMed Web of Science ®Google Scholar
• Yan L, Cao R, Liu Y, et al. MiR-21-5p links epithelial-mesenchymal transition phenotype with stem-like cell signatures via AKT Signaling in keloid keratinocytes. Sci Rep. 2016;6:28281.
   PubMed Web of Science ®Google Scholar
• Zhou J, Qie S, Fang H, et al. MiR-487a-3p suppresses the malignant development of pancreatic cancer by targeting SMAD7. Exp Mol Pathol. 2020;116:104489.
   PubMed Web of Science ®Google Scholar
• Kleerekooper I, Herbert MK, Kuiperij HB, et al. CSF levels of glutamine synthetase and GFAP to explore astrocytic damage in seronegative NMOSD. J Neurol Neurosurg Psychiatry. 2020;91(6):605–611.
   PubMed Web of Science ®Google Scholar
• Li Q, Fang L, Chen J, et al. Exosomale microRNA-21 Promotes Keloid Fibroblast Proliferation and Collagen Production by inhibiting Smad7. J Burn Care Res. 2021;42(6):1266–1274.
   PubMed Web of Science ®Google Scholar
• Li X, Wu X. MiR-21-5p promotes the progression of non-small-cell lung cancer by regulating the expression of SMAD7. Onco Targets Ther. 2018;11:8445–8454.
   PubMed Web of Science ®Google Scholar
• Zhang J, Liu N, Wu X, et al. Identification of differentially expressed circular RNAs in keloid and normal skin tissue by high-throughput sequencing. Dermatol Ther. 2021;34(2):e14745.
   PubMed Web of Science ®Google Scholar
• Odorisio T, Di Salvio M, Orecchia A, et al. Monozygotic twins discordant for recessive dystrophic epidermolysis bullosa phenotype highlight the role of TGF-beta signalling in modifying disease severity. Hum Mol Genet. 2014;23(15):3907–3922.
   PubMed Web of Science ®Google Scholar
• Frost JR, Mendez M, Soriano AM, et al. Adenovirus 5 E1A-Mediated suppression of p53 via FUBP1. J Virol. 2018;92(14). DOI:10.1128/JVI.00439-18
   Web of Science ®Google Scholar
• Shao Y, Song Y, Xu S, et al. Expression profile of circular RNAs in oral squamous cell carcinoma. Front Oncol. 2020;10:533616.
   PubMed Web of Science ®Google Scholar
• Zambon AC, Zhang L, Minovitsky S, et al. Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase A. Proc Natl Acad Sci U S A. 2005;102(24):8561–8566.
   PubMed Web of Science ®Google Scholar
• Jiao Y, Wang X, Zhang J, et al. Inhibiting function of human fetal dermal mesenchymal stem cells on bioactivities of keloid fibroblasts. Stem Cell Res Ther. 2017;8(1):170.
   PubMedGoogle Scholar
• Han W, Xu Y, Feng X, et al. NQO-induced DNA-less cell formation is associated with chromatin protein degradation and dependent on A0A1-ATPase in sulfolobus. Front Microbiol. 2017;8:1480.
   PubMed Web of Science ®Google Scholar
• Wei Y, Zhang F, Zhang T, et al. LDLRAD2 overexpression predicts poor prognosis and promotes metastasis by activating Wnt/beta-catenin/EMT signaling cascade in gastric cancer. Aging (Albany NY). 2019;11(20):8951–8968.
   PubMedGoogle Scholar
• Sun Y, Qin B. Long noncoding RNA MALAT1 regulates HDAC4-mediated proliferation and apoptosis via decoying of miR-140-5p in osteosarcoma cells. Cancer Med. 2018;7(9):4584–4597.
   PubMed Web of Science ®Google Scholar
• Sun Y, Yang Z, Zheng B, et al. A novel regulatory mechanism of smooth muscle alpha-actin expression by NRG-1/circACTA2/miR-548f-5p axis. Circ Res. 2017;121(6):628–635.
   PubMed Web of Science ®Google Scholar
• Garcia-Dominguez M, March-Diaz R, Reyes JC. The PHD domain of plant PIAS proteins mediates sumoylation of bromodomain GTE proteins. J Biol Chem. 2008;283(31):21469–21477.
   PubMed Web of Science ®Google Scholar
• Lee KJ, Kim HA, Kim PH, et al. Ox-LDL suppresses PMA-induced MMP-9 expression and activity through CD36-mediated activation of PPAR-g. Exp Mol Med. 2004;36(6):534–544.
   PubMed Web of Science ®Google Scholar
• Lee HJ, Jang YJ. Recent understandings of biology, prophylaxis and treatment strategies for hypertrophic scars and keloids. Int J Mol Sci. 2018;19(3):711.
   PubMed Web of Science ®Google Scholar
• Berman B, Maderal A, Raphael B. Keloids and hypertrophic scars: pathophysiology, classification, and treatment. Dermatol Surg. 2017;43(Suppl 1):S3–S18.
   PubMedGoogle Scholar
• Naik PP. Review on novel targets and therapies for keloids. Clin Exp Dermatol. 2021. DOI:10.1111/ced.14920
   PubMed Web of Science ®Google Scholar
• Stevenson AW, Deng Z, Allahham A, et al. The epigenetics of keloids. Exp Dermatol. 2021;30(8):1099–1114.
   PubMed Web of Science ®Google Scholar
• Lv W, Liu S, Zhang Q, et al. Circular RNA CircCOL5A1 sponges the MiR-7-5p/Epac1 axis to promote the progression of keloids through regulating PI3K/Akt signaling pathway. Front Cell Dev Biol. 2021;9:626027.
   PubMed Web of Science ®Google Scholar
• Wei C, Zhang R, Cai Q, et al. MicroRNA-330-3p promotes brain metastasis and epithelial-mesenchymal transition via GRIA3 in non-small cell lung cancer. Aging (Albany NY). 2019;11(17):6734–6761.
   PubMedGoogle Scholar
• Wang H, He P, Pan H, et al. Circular RNA circ-4099 is induced by TNF-alpha and regulates ECM synthesis by blocking miR-616-5p inhibition of Sox9 in intervertebral disc degeneration. Exp Mol Med. 2018;50(4):1–14.
   Google Scholar
• Wang D, Xin L, Lin JH, et al. Identifying miRNA-mRNA regulation network of chronic pancreatitis based on the significant functional expression. Medicine (Baltimore). 2017;96(21):e6668.
   PubMed Web of Science ®Google Scholar
• Yang J, Deng P, Qi Y, et al. NEAT1 knockdown inhibits keloid fibroblast progression by miR-196b-5p/FGF2 axis. J Surg Res. 2021;259:261–270.
   PubMed Web of Science ®Google Scholar
• Jin J, Jia Z, Luo X, et al. Long non-coding RNA HOXA11-AS accelerates the progression of keloid formation via miR-124-3p/TGFβR1 axis. Cell Cycle. 2020;19(2):218–232.
   PubMed Web of Science ®Google Scholar
• Xiong DD, Dang YW, Lin P, et al. A circRNA-miRNA-mRNA network identification for exploring underlying pathogenesis and therapy strategy of hepatocellular carcinoma. J Transl Med. 2018;16(1):220.
   PubMed Web of Science ®Google Scholar
• Cardozo ER, Foster R, Karmon AE, et al. MicroRNA 21a-5p overexpression impacts mediators of extracellular matrix formation in uterine leiomyoma. Reprod Biol Endocrinol. 2018;16(1):46.
   PubMedGoogle Scholar
• Shen DW, Li YL, Hou YJ, et al. MicroRNA-543 promotes cell invasion and impedes apoptosis in pituitary adenoma via activating the Wnt/beta-catenin pathway by negative regulation of Smad7. Biosci Biotechnol Biochem. 2019;83(6):1035–1044.
   PubMed Web of Science ®Google Scholar
• Huang N, Li W, Wang X, et al. MicroRNA-17-5p aggravates lipopolysaccharide-induced injury in nasal epithelial cells by targeting Smad7. BMC Cell Biol. 2018;19(1):1.
   PubMedGoogle Scholar