C1q/tumor necrosis factor-related protein-3 (CTRP3) activated by forkhead box O4 (FOXO4) down-regulation protects retinal pericytes against high glucose-induced oxidative damage through nuclear factor erythroid 2-related factor 2 (Nrf2)/Nuclear factor-kappaB (NF-κB) signaling

References

• Henriques J, Vaz-Pereira S, Nascimento J, et al. [Diabetic eye disease]. Acta Med Port. 2015;28(1):107–113.
   PubMed Web of Science ®Google Scholar
• Lightman S, Towler HM. Diabetic retinopathy. Clin Cornerstone. 2003;5(2):12–21.
   PubMedGoogle Scholar
• Moreno A, Lozano M, Salinas P. Diabetic retinopathy. Nutr Hosp. 2013;28 Suppl 2:53–56.
   PubMed Web of Science ®Google Scholar
• Terasaki H. Multimodal approaches for the analysis of retinal functional disorders-focusing on retinal detachment. Nippon Ganka Gakkai Zasshi. 2017;121(3):185–231.
   PubMedGoogle Scholar
• Motiejūnaite R, Kazlauskas A. Pericytes and ocular diseases. Exp Eye Res. 2008;86(2):171–177.
   PubMed Web of Science ®Google Scholar
• Pfister F, Przybyt, E, Harmsen , MC, et al. Pericytes in the eye. Pflugers Arch. 2013;465(6):789–796.
   PubMed Web of Science ®Google Scholar
• Trost A, Bruckner , D, Rivera , FJ, et al. Pericytes in the retina. Adv Exp Med Biol. 2019;1122:1–26.
   PubMed Web of Science ®Google Scholar
• Zhang CL, Wu LL, Li L. [Research progress of complement-C1q/tumor necrosis factor-related protein 3]. Sheng Li Xue Bao. 2017;69(5):666–676.
   PubMedGoogle Scholar
• Gao J, Qian T, Wang W. CTRP3 activates the AMPK/SIRT1-PGC-1α pathway to protect mitochondrial biogenesis and functions in cerebral ischemic stroke. Neurochem Res. 2020;45(12):3045–3058.
   PubMed Web of Science ®Google Scholar
• Lv C, He Y, Wei M, et al. CTRP3 ameliorates cerulein-induced severe acute pancreatitis in mice via SIRT1/NF-κB/p53 axis. Biosci Rep. 2020;40(10). DOI:10.1042/BSR20200092.
   Google Scholar
• Xia L, Huijuan , Z, Qiang , S, et al. Protective role of CTRP3 and CTRP9 in the development of gestational diabetes mellitus. Clin Lab. 2020;66(11). DOI:10.7754/Clin.Lab.2020.200247.
   Web of Science ®Google Scholar
• Zhang J, He J. CTRP3 inhibits high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells. Artif Cells Nanomed Biotechnol. 2019;47(1):3758–3764.
   PubMed Web of Science ®Google Scholar
• Yan Z, Zhao J, Gan L, et al. CTRP3 is a novel biomarker for diabetic retinopathy and inhibits HGHL-induced VCAM-1 expression in an AMPK-dependent manner. PLoS One. 2017;12(6):e0178253.
   PubMed Web of Science ®Google Scholar
• Link W. Introduction to FOXO biology. Methods Mol Biol. 2019;1890:1–9.
   PubMedGoogle Scholar
• Yu L, Zhang W, Huang C, et al. FoxO4 promotes myocardial ischemia-reperfusion injury: the role of oxidative stress-induced apoptosis. Am J Transl Res. 2018;10(9):2890–2900.
   PubMed Web of Science ®Google Scholar
• Bian L, Zhi X, Ma L, et al. Hsa_circRNA_103809 regulated the cell proliferation and migration in colorectal cancer via miR-532-3p/FOXO4 axis. Biochem Biophys Res Commun. 2018;505(2):346–352.
   PubMed Web of Science ®Google Scholar
• Wang XH, Jiang Z-H, Yang H-M, et al. Hypoxia-induced FOXO4/LDHA axis modulates gastric cancer cell glycolysis and progression. Clin Transl Med. 2021;11(1):e279.
   PubMed Web of Science ®Google Scholar
• Intuyod K, Chomwong S, Thongpon P, et al. Expression of FOXO4 inhibits cholangiocarcinoma cell proliferation in vitro via induction of G(0)/G(1) arrest. Anticancer Res. 2020;40(12):6899–6905.
   PubMed Web of Science ®Google Scholar
• Wardyn JD, Ponsford AH, Sanderson CM. Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways. Biochem Soc Trans. 2015;43(4):621–626.
   PubMed Web of Science ®Google Scholar
• Wang W, Zhao H, Chen B. DJ-1 protects retinal pericytes against high glucose-induced oxidative stress through the Nrf2 signaling pathway. Sci Rep. 2020;10(1):2477.
   PubMed Web of Science ®Google Scholar
• Yun JH. Interleukin-1β induces pericyte apoptosis via the NF-κB pathway in diabetic retinopathy. Biochem Biophys Res Commun. 2021;546:46–53.
   PubMed Web of Science ®Google Scholar
• Kim J, Kim C-S, Sohn E, et al. KIOM-79 protects AGE-induced retinal pericyte apoptosis via inhibition of NF-kappaB activation in vitro and in vivo. PLoS One. 2012;7(8):e43591.
   PubMed Web of Science ®Google Scholar
• Roy S, Kim D, Lim R. Cell-cell communication in diabetic retinopathy. Vision Res. 2017;139:115–122.
   PubMed Web of Science ®Google Scholar
• Gan J, Huang M, Lan G, et al. High glucose induces the loss of retinal pericytes partly via NLRP3-Caspase-1-GSDMD-mediated pyroptosis. Biomed Res Int. 2020;2020:4510628.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25(4):402–408.
   PubMed Web of Science ®Google Scholar
• Chen X, Xu M, Xu X, et al. METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer. Mol Cancer. 2020;19(1):106.
   PubMed Web of Science ®Google Scholar
• Yao J, Xu G, Zhu L, et al. circGFRA1 enhances NSCLC progression by sponging miR-188-3p. Onco Targets Ther. 2020;13:549–558.
   PubMed Web of Science ®Google Scholar
• Fornes O, Castro-Mondragon JA, Khan A, et al. JASPAR 2020: update of the open-access database of transcription factor binding profiles. Nucleic Acids Res. 2020;48(D1):D87–D92.
   PubMed Web of Science ®Google Scholar
• Kang Q, Yang C. Oxidative stress and diabetic retinopathy: molecular mechanisms, pathogenetic role and therapeutic implications. Redox Biol. 2020;37:101799.
   PubMed Web of Science ®Google Scholar
• Beltramo E, Porta M. Pericyte loss in diabetic retinopathy: mechanisms and consequences. Curr Med Chem. 2013;20(26):3218–3225.
   PubMed Web of Science ®Google Scholar
• Arboleda-Velasquez JF, Valdez CN, Marko CK, et al. From pathobiology to the targeting of pericytes for the treatment of diabetic retinopathy. Curr Diab Rep. 2015;15(2):573.
   PubMed Web of Science ®Google Scholar
• Cai X, McGinnis JF. Diabetic retinopathy: animal models, therapies, and perspectives. J Diabetes Res. 2016;2016:3789217.
   PubMed Web of Science ®Google Scholar
• Sies H. Oxidative stress: a concept in redox biology and medicine. Redox Biol. 2015;4:180–183.
   PubMed Web of Science ®Google Scholar
• Calderon GD, Juarez OH, Hernandez GE, et al. Oxidative stress and diabetic retinopathy: development and treatment. Eye (Lond). 2017;31(8):1122–1130.
   PubMed Web of Science ®Google Scholar
• Becer E, Çırakoğlu A. Association of the Ala16Val MnSOD gene polymorphism with plasma leptin levels and oxidative stress biomarkers in obese patients. Gene. 2015;568(1):35–39.
   PubMed Web of Science ®Google Scholar
• Kim JL, Reader BF, Dumond C, et al. Pegylated-catalase is protective in lung ischemic injury and oxidative stress. Ann Thorac Surg. 2021;111(3):1019–1027.
   PubMed Web of Science ®Google Scholar
• Tsikas D. Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: analytical and biological challenges. Anal Biochem. 2017;524:13–30.
   PubMed Web of Science ®Google Scholar
• Zhang R, Guo C, Liu T, et al. MicroRNA miR-495 regulates the development of Hepatocellular Carcinoma by targeting C1q/tumor necrosis factor-related protein-3 (CTRP3). Bioengineered. 2021;12(1):6902–6912.
   PubMed Web of Science ®Google Scholar
• Hu TY, Li LM, Pan YZ. CTRP3 inhibits high glucose-induced human glomerular mesangial cell dysfunction. J Cell Biochem. 2019;120(4):5729–5736.
   PubMed Web of Science ®Google Scholar
• Wang F, Zhao L, Shan Y, et al. CTRP3 protects against high glucose-induced cell injury in human umbilical vein endothelial cells. Anal Cell Pathol (Amst). 2019;2019:7405602.
   PubMedGoogle Scholar
• Zhu M, Goetsch SC, Wang Z, et al. FoxO4 promotes early inflammatory response upon myocardial infarction via endothelial Arg1. Circ Res. 2015;117(11):967–977.
   PubMed Web of Science ®Google Scholar
• Huang J, Liu, Y, Wang, M, et al. FoxO4 negatively modulates USP10 transcription to aggravate the apoptosis and oxidative stress of hypoxia/reoxygenation-induced cardiomyocytes by regulating the Hippo/YAP pathway. J Bioenerg Biomembr. 2021;53(5):541–551.
   PubMed Web of Science ®Google Scholar
• Coomans de Brachène A, Demoulin JB. FOXO transcription factors in cancer development and therapy. Cell Mol Life Sci. 2016;73(6):1159–1172.
   PubMed Web of Science ®Google Scholar
• Zhang J, Wu, L, Chen, J, et al. Downregulation of MicroRNA 29a/b exacerbated diabetic retinopathy by impairing the function of Müller cells via Forkhead box protein O4. Diab Vasc Dis Res. 2018;15(3):214–222.
   PubMed Web of Science ®Google Scholar
• Zhang L, Dong L, Liu X, et al. α-Melanocyte-stimulating hormone protects retinal vascular endothelial cells from oxidative stress and apoptosis in a rat model of diabetes. PLoS One. 2014;9(4):e93433.
   PubMed Web of Science ®Google Scholar
• Tonelli C, Chio IIC, Tuveson DA. Transcriptional Regulation by Nrf2. Antioxid Redox Signal. 2018;29(17):1727–1745.
   PubMed Web of Science ®Google Scholar
• Sajadimajd S, Khazaei M. Oxidative stress and cancer: the role of Nrf2. Curr Cancer Drug Targets. 2018;18(6):538–557.
   PubMed Web of Science ®Google Scholar
• Napetschnig J, Wu H. Molecular basis of NF-κB signaling. Annu Rev Biophys. 2013;42:443–468.
   PubMed Web of Science ®Google Scholar
• Xiao G, Zhang M, Peng X, et al. Protocatechuic acid attenuates cerebral aneurysm formation and progression by inhibiting TNF-alpha/Nrf-2/NF-kB-mediated inflammatory mechanisms in experimental rats. Open Life Sci. 2021;16(1):128–141.
   PubMed Web of Science ®Google Scholar
• Xiao N, Zhao, Y, He, W, et al. Egg yolk oils exert anti-inflammatory effect via regulating Nrf2/NF-κB pathway. J Ethnopharmacol. 2021;274:114070.
   PubMed Web of Science ®Google Scholar
• Sang L, Kang K, Sun Y, et al. FOXO4 ameliorates alcohol-induced chronic liver injury via inhibiting NF-κB and modulating gut microbiota in C57BL/6J mice. Int Immunopharmacol. 2021;96:107572.
   PubMed Web of Science ®Google Scholar