GTP-binding protein Di-RAS3 diminishes the migration and invasion of non-small cell lung cancer by inhibiting the RAS/extracellular-regulated kinase pathway

References

• Khan H. Medicinal plants in light of history: recognized therapeutic modality. J Evid Based Complementary Altern Med. 2014;19:216–219.
   PubMedGoogle Scholar
• Salehi M, Movahedpour A, Tayarani A, et al. Therapeutic potentials of curcumin in the treatment of non-small-cell lung carcinoma. Phytother Res. 2020;34:2557–2576.
   PubMed Web of Science ®Google Scholar
• Nagano T, Tachihara M, Nishimura Y. Molecular mechanisms and targeted therapies including immunotherapy for non-small cell lung cancer. Curr Cancer Drug Targets. 2019;19:595–630.
   PubMed Web of Science ®Google Scholar
• Arbour KC, Riely GJ. Systemic therapy for locally advanced and metastatic non-small cell lung cancer: a review. Jama. 2019;322:764–774.
   PubMed Web of Science ®Google Scholar
• Kim KC, Baek SH, Lee C. Curcumin-induced downregulation of Axl receptor tyrosine kinase inhibits cell proliferation and circumvents chemoresistance in non-small lung cancer cells. Int J Oncol. 2015;47:2296–2303.
   PubMed Web of Science ®Google Scholar
• Tunc D, Dere E, Karakas D, et al. Cytotoxic and apoptotic effects of the combination of palladium (II) 5,5-diethylbarbiturate complex with bis(2-pyridylmethyl)amine and curcumin on non small lung cancer cell lines. Bioorg Med Chem. 2017;25:1717–1723.
   PubMed Web of Science ®Google Scholar
• Wang L, Hoque A, Luo RZ, et al. Loss of the expression of the tumor suppressor gene ARHI is associated with progression of breast cancer. Clin Cancer Res off J Am Assoc Cancer Res. 2003;9:3660–3666.
   PubMed Web of Science ®Google Scholar
• Nishimoto A, Yu Y, Lu Z, et al. A Ras homologue member I directly inhibits signal transducers and activators of transcription 3 translocation and activity in human breast and ovarian cancer cells. Cancer Res. 2005;65:6701–6710.
   PubMed Web of Science ®Google Scholar
• Zhao X, Li J, Zhuo J, et al. Reexpression of ARHI inhibits tumor growth and angiogenesis and impairs the mTOR/VEGF pathway in hepatocellular carcinoma. Biochem Biophys Res Commun. 2010;403:417–421.
   PubMed Web of Science ®Google Scholar
• Washington MN, Suh G, Orozco AF, et al. ARHI (DIRAS3)-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts. Cell Death Dis. 2015;6:e1836.
   PubMed Web of Science ®Google Scholar
• Lu Z, Bast RC Jr. The tumor suppressor gene ARHI (DIRAS3) inhibits ovarian cancer cell migration through multiple mechanisms. Cell Adh Migr. 2013;7:232–236.
   PubMed Web of Science ®Google Scholar
• Zou CF, Jia L, Jin H, et al. Re-expression of ARHI (DIRAS3) induces autophagy in breast cancer cells and enhances the inhibitory effect of paclitaxel. BMC Cancer. 2011;11:22.
   PubMed Web of Science ®Google Scholar
• Tang HL, Hu YQ, Qin XP, et al. Aplasia ras homolog member I is downregulated in gastric cancer and silencing its expression promotes cell growth in vitro. J Gastroenterol Hepatol. 2012;27:1395–1404.
   PubMed Web of Science ®Google Scholar
• Wang W, Bu XM, Wang J, et al. The expression of ARHI in pT2a and pT2b stage gastric cancer and its clinical significance. Oncol Rep. 2012;27:1953–1959.
   PubMed Web of Science ®Google Scholar
• Field JK, Liloglou T, Warrak S, et al. Methylation discriminators in NSCLC identified by a microarray based approach. Int J Oncol. 2005;27:105–111.
   PubMed Web of Science ®Google Scholar
• Wu X, Liang L, Dong L, et al. Effect of ARHI on lung cancer cell proliferation, apoptosis and invasion in vitro. Mol Biol Rep. 2013;40:2671–2678.
   PubMed Web of Science ®Google Scholar
• Luo RZ, Fang X, Marquez R, et al. ARHI is a Ras-related small G-protein with a novel N-terminal extension that inhibits growth of ovarian and breast cancers. Oncogene. 2003;22:2897–2909.
   PubMed Web of Science ®Google Scholar
• Liu F, Yang X, Geng M, et al. Targeting ERK, an achilles’ heel of the MAPK pathway, in cancer therapy. Acta Pharm Sin B. 2018;8:552–562.
   PubMed Web of Science ®Google Scholar
• Roberts PJ, Der CJ. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene. 2007;26:3291–3310.
   PubMed Web of Science ®Google Scholar
• Chou YT, Lin HH, Lien YC, et al. EGFR promotes lung tumorigenesis by activating miR-7 through a Ras/ERK/Myc pathway that targets the Ets2 transcriptional repressor ERF. Cancer Res. 2010;70:8822–8831.
   PubMed Web of Science ®Google Scholar
• Lu Z, Yang H, Sutton MN, et al. ARHI (DIRAS3) induces autophagy in ovarian cancer cells by downregulating the epidermal growth factor receptor, inhibiting PI3K and Ras/MAP signaling and activating the FOXo3a-mediated induction of Rab7. Cell Death Differ. 2014;21:1275–1289.
   PubMed Web of Science ®Google Scholar
• Dorard C, Vucak G, Baccarini M. Deciphering the RAS/ERK pathway in vivo. Biochem Soc Trans. 2017;45:27–36.
   PubMed Web of Science ®Google Scholar
• Wei CH, Wu G, Cai Q, et al. MicroRNA-330-3p promotes cell invasion and metastasis in non-small cell lung cancer through GRIA3 by activating MAPK/ERK signaling pathway. J Hematol Oncol. 2017;10:125.
   PubMed Web of Science ®Google Scholar
• Qiu J, Li X, He Y, et al. Distinct subgroup of the Ras family member 3 (DIRAS3) expression impairs metastasis and induces autophagy of gastric cancer cells in mice. J Cancer Res Clin Oncol. 2018;144:1869–1886.
   PubMed Web of Science ®Google Scholar
• Kumar EA, Tsao D, Radhakrishnan A, et al. Building cells for quantitative, live-cell analyses of collective motor protein functions. Methods Cell Biol. 2015;128:69–82.
   PubMed Web of Science ®Google Scholar
• Sheppard KE, Cullinane C, Hannan KM, et al. Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors. Eur J Cancer. 2013;49:3936–3944.
   PubMed Web of Science ®Google Scholar
• Jessen WJ, Miller SJ, Jousma E, et al. MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors. J Clin Invest. 2013;123:340–347.
   PubMed Web of Science ®Google Scholar
• Zhao H, Wang J, Kong X, et al. CD47 promotes tumor invasion and metastasis in non-small cell lung cancer. Sci Rep. 2016;6:29719.
   PubMed Web of Science ®Google Scholar
• Li J, Tan Q, Yan M, et al. miRNA-200c inhibits invasion and metastasis of human non-small cell lung cancer by directly targeting ubiquitin specific peptidase 25. Mol Cancer. 2014;13:166.
   PubMed Web of Science ®Google Scholar
• Shi M, Cao M, Song J, et al. PinX1 inhibits the invasion and metastasis of human breast cancer via suppressing NF-kappaB/MMP-9 signaling pathway. Mol Cancer. 2015;14:66.
   PubMed Web of Science ®Google Scholar
• Badgwell DB, Lu Z, Le K, et al. The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways. Oncogene. 2012;31:68–79.
   PubMed Web of Science ®Google Scholar
• Xiang S, Dauchy RT, Hoffman AE, et al. Epigenetic inhibition of the tumor suppressor ARHI by light at night-induced circadian melatonin disruption mediates STAT3-driven paclitaxel resistance in breast cancer. J Pineal Res. 2019;67:e12586.
   PubMed Web of Science ®Google Scholar
• Li L, Gao P, Li Y, et al. JMJD2A-dependent silencing of Sp1 in advanced breast cancer promotes metastasis by downregulation of DIRAS3. Breast Cancer Res Treat. 2014;147:487–500.
   PubMed Web of Science ®Google Scholar
• Uekita T, Fujii S, Miyazawa Y, et al. Oncogenic Ras/ERK signaling activates CDCP1 to promote tumor invasion and metastasis. Mol Cancer Res. 2014;12:1449–1459.
   PubMed Web of Science ®Google Scholar
• Wu D, Zhao B, Qi X, et al. Nogo-B receptor promotes epithelial-mesenchymal transition in non-small cell lung cancer cells through the Ras/ERK/Snail1 pathway. Cancer Lett. 2018;418:135–146.
   PubMed Web of Science ®Google Scholar
• Lu Z, Baquero MT, Yang H, et al. DIRAS3 regulates the autophagosome initiation complex in dormant ovarian cancer cells. Autophagy. 2014;10:1071–1092.
   PubMed Web of Science ®Google Scholar
• Chen J, Shi S, Yang W. Over-expression of ARHI decreases tumor growth, migration, and invasion in human glioma. Med Oncol. 2014;31:846.
   PubMed Web of Science ®Google Scholar
• Ouyang J, Pan X, Hu Z. The role of aplysia ras homolog I in colon cancer cell invasion and adhesion. Exp Ther Med. 2017;14:5193–5199.
   PubMed Web of Science ®Google Scholar
• Li D, Wu LJ, Tashiro S, et al. Oridonin-induced A431 cell apoptosis partially through blockage of the Ras/Raf/ERK signal pathway. J Pharmacol Sci. 2007;103:56–66.
   PubMed Web of Science ®Google Scholar
• Shan X, Miao Y, Fan R, et al. Suppression of Grb2 expression improved hepatic steatosis, oxidative stress, and apoptosis induced by palmitic acid in vitro partly through insulin signaling alteration. Vitro Cell Dev Biol Anim. 2013;49:576–582.
   PubMed Web of Science ®Google Scholar
• Swanton C, Govindan R, Longo DL. Clinical implications of genomic discoveries in lung cancer. N Engl J Med. 2016;374:1864–1873.
   PubMed Web of Science ®Google Scholar
• Cancer Genome Atlas Research N. Comprehensive molecular profiling of lung adenocarcinoma. Nature. 2014;511:543–550.
   PubMed Web of Science ®Google Scholar