Cancer-associated fibroblast exosomes promote chemoresistance to cisplatin in hepatocellular carcinoma through circZFR targeting signal transducers and activators of transcription (STAT3)/ nuclear factor -kappa B (NF-κB) pathway

References

• Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Ca-Cancer J Clin. 2018;68(6):394–424.
   PubMed Web of Science ®Google Scholar
• How CW, Ong YS, Low SS, et al. How far have we explored fungi to fight cancer? Semin Cancer Biol. 2021. DOI:10.1016/j.semcancer.2021.03.009
   PubMed Web of Science ®Google Scholar
• Chi HC, Chen SL, Cheng YH, et al. Chemotherapy resistance and metastasis-promoting effects of thyroid hormone in hepatocarcinoma cells are mediated by suppression of FoxO1 and Bim pathway. Cell Death Dis. 2016;7(8):e2324–e2324.
   PubMedGoogle Scholar
• Zhou ZJ, Xin HY, Li J, et al. Intratumoral plasmacytoid dendritic cells as a poor prognostic factor for hepatocellular carcinoma following curative resection. Cancer Immunol Immun. 2019;68(8):1223–1233.
   PubMed Web of Science ®Google Scholar
• Xi SJ, Cai WQ, Wang QQ, et al. Role of circular RNAs in gastrointestinal tumors and drug resistance. World J Clin Cases. 2021;9(34):10400–10417.
   PubMed Web of Science ®Google Scholar
• Liu Y, Ao X, Yu W, et al. Biogenesis, functions, and clinical implications of circular RNAs in non-small cell lung cancer. Mol Ther Nucleic Acids. 2022;27:50–72.
   PubMedGoogle Scholar
• Gao C, Wen Y, Jiang F, et al. Circular RNA circ_0008274 upregulates granulin to promote the progression of hepatocellular carcinoma via sponging microRNA −140-3p. Bioengineered. 2021;12(1):1890–1901.
   PubMed Web of Science ®Google Scholar
• Wang F, Xie Z, Zhang N, et al. Has_circ_0008583 modulates hepatocellular carcinoma progression through the miR-1301-3p/METTL3 pathway. Bioengineered. 2022;13(1):1185–1197.
   PubMed Web of Science ®Google Scholar
• Han D, Li J, Wang H, et al. Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression. Hepatology. 2017;66(4):1151–1164.
   PubMed Web of Science ®Google Scholar
• Liu Z, Yu Y, Huang Z, et al. CircRNA-5692 inhibits the progression of hepatocellular carcinoma by sponging miR-328-5p to enhance DAB2IP expression. Cell Death Dis. 2019;10(12):900.
   PubMed Web of Science ®Google Scholar
• Yao Z, Xu R, Yuan L, et al. Circ_0001955 facilitates hepatocellular carcinoma (HCC) tumorigenesis by sponging miR-516a-5p to release TRAF6 and MAPK11. Cell Death Dis. 2019;10(12):945.
   PubMed Web of Science ®Google Scholar
• Guan Y, Zhang Y, Hao L, et al. CircRNA_102272 promotes cisplatin-resistance in hepatocellular carcinoma by decreasing MiR-326 targeting of RUNX2. Cancer Manag Res. 2020;12:12527–12534.
   PubMed Web of Science ®Google Scholar
• Luo Y, Fu Y, Huang R, et al. CircRNA_101505 sensitizes hepatocellular carcinoma cells to cisplatin by sponging miR-103 and promotes oxidored-nitro domain-containing protein 1 expression. Cell Death Discov. 2019;5(1):121.
   PubMed Web of Science ®Google Scholar
• Xu J, Ji L, Liang Y, et al. CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1. Signal Transduct Target Ther. 2020;5(1):298.
   PubMed Web of Science ®Google Scholar
• Tan A, Li Q, Chen L. CircZFR promotes hepatocellular carcinoma progression through regulating miR-3619-5p/CTNNB1 axis and activating Wnt/β-catenin pathway. Arch Biochem Biophys. 2019;661:196–202.
   PubMed Web of Science ®Google Scholar
• Yang X, Liu L, Zou H, et al. circZFR promotes cell proliferation and migration by regulating miR-511/AKT1 axis in hepatocellular carcinoma. Dig Liver Dis. 2019;51(10):1446–1455.
   PubMedGoogle Scholar
• Li H, Liu F, Qin W. Circ_0072083 interference enhances growth-inhibiting effects of cisplatin in non-small-cell lung cancer cells via miR-545-3p/CBLL1 axis. Cancer Cell Int. 2020;20(1):78.
   PubMed Web of Science ®Google Scholar
• Yugawa K, Yoshizumi T, Mano Y, et al. Cancer-associated fibroblasts promote hepatocellular carcinoma progression through downregulation of exosomal miR-150-3p. Eur J Surg Oncol. 2020;47(2):384–393.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Li X, Sun W, et al. Loss of exosomal miR-320a from cancer-associated fibroblasts contributes to HCC proliferation and metastasis. Cancer Lett. 2017;397:33–42.
   PubMed Web of Science ®Google Scholar
• Li C, Teixeira AF, Zhu HJ, et al. Cancer associated-fibroblast-derived exosomes in cancer progression. Mol Cancer. 2021;20(1):154.
   PubMed Web of Science ®Google Scholar
• Fang Y, Zhou W, Rong Y, et al. Exosomal miRNA-106b from cancer-associated fibroblast promotes gemcitabine resistance in pancreatic cancer. Exp Cell Res. 2019;383(1):111543.
   PubMed Web of Science ®Google Scholar
• Hu JL, Wang W, Lan XL, et al. CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer. Mol Cancer. 2019;18(1):91.
   PubMed Web of Science ®Google Scholar
• Qin X, Guo H, Wang X, et al. Exosomal miR-196a derived from cancer-associated fibroblasts confers cisplatin resistance in head and neck cancer through targeting CDKN1B and ING5. Genome Biol. 2019;20(1):12.
   PubMed Web of Science ®Google Scholar
• Zhang H, Deng T, Liu R, et al. CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer. Mol Cancer. 2020;19(1):43.
   PubMed Web of Science ®Google Scholar
• Dundon WG, Settypalli TBK, Spiegel K, et al. Comparison of eleven in vitro diagnostic assays for the detection of SARS-CoV-2 RNA. J Virol Methods. 2021;295:114200.
   PubMed Web of Science ®Google Scholar
• Su P, Mao F, Zhang J, et al. Circular RNA UBR1 promotes the proliferation, migration, and invasion but represses apoptosis of lung cancer cells via modulating microRNA-545-5p/SSFA2 axis. Bioengineered. 2021;12(2):12135–12147.
   PubMed Web of Science ®Google Scholar
• Zhao B, Song X, Guan H. CircACAP2 promotes breast cancer proliferation and metastasis by targeting miR-29a/b-3p-COL5A1 axis. Life Sci. 2020;244:117179.
   PubMed Web of Science ®Google Scholar
• Mao Y, He JX, Zhu M, et al. Circ0001320 inhibits lung cancer cell growth and invasion by regulating TNFAIP1 and TPM1 expression through sponging miR-558. Hum Cell. 2021;34(2):468–477.
   PubMed Web of Science ®Google Scholar
• Ji Y, Ji J, Yin H, et al. Exosomes derived from microRNA-129-5p-modified tumor cells selectively enhanced suppressive effect in malignant behaviors of homologous colon cancer cells. Bioengineered. 2021;12(2):12148–12156.
   PubMed Web of Science ®Google Scholar
• Zhang J, Wu L, Lian C, et al. Nitidine chloride possesses anticancer property in lung cancer cells through activating Hippo signaling pathway. Cell Death Discov. 2020;6(1):91.
   PubMed Web of Science ®Google Scholar
• Long L, Hu Y, Long T, et al. Tumor-associated macrophages induced spheroid formation by CCL18-ZEB1-M-CSF feedback loop to promote transcoelomic metastasis of ovarian cancer. J Immunother Cancer. 2021;9(12):e003973.
   PubMed Web of Science ®Google Scholar
• Guan H, Sun C, Gu Y, et al. Circular RNA circ_0003028 contributes to tumorigenesis by regulating GOT2 via miR-1298-5p in non-small cell lung cancer. Bioengineered. 2021;12(1):2326–2340.
   PubMed Web of Science ®Google Scholar
• Zhou XD. Recurrence and metastasis of hepatocellular carcinoma: progress and prospects. Hepatobiliary Pancreat Dis Int. 2002;1(1):35–41.
   PubMedGoogle Scholar
• Boucher E, Corbinais S, Brissot P, et al. Treatment of hepatocellular carcinoma (HCC) with systemic chemotherapy combining epirubicin, cisplatinum and infusional 5-fluorouracil (ECF regimen). Cancer Chemother Pharmacol. 2002;50(4):305–308.
   PubMed Web of Science ®Google Scholar
• Li YY, Tao YW, Gao S, et al. Cancer-associated fibroblasts contribute to oral cancer cells proliferation and metastasis via exosome-mediated paracrine miR-34a-5p. EBioMedicine. 2018;36:209–220.
   PubMed Web of Science ®Google Scholar
• Wang H, Wei H, Wang J, et al. MicroRNA-181d-5p-containing exosomes derived from CAFs Promote EMT by regulating CDX2/HOXA5 in breast cancer. Mol Ther Nucleic Acids. 2020;19:654–667.
   PubMedGoogle Scholar
• Yang K, Zhang J, Bao C. Exosomal circEIF3K from cancer-associated fibroblast promotes colorectal cancer (CRC) progression via miR-214/PD-L1 axis. BMC Cancer. 2021;21(1):933.
   PubMed Web of Science ®Google Scholar
• Zhang J, Gu C, Song Q, et al. Identifying cancer-associated fibroblasts as emerging targets for hepatocellular carcinoma. Cell Biosci. 2020;10(1):127.
   PubMed Web of Science ®Google Scholar
• Chen Z, Wang F, Xiong Y, et al. CircZFR functions as a sponge of miR-578 to promote breast cancer progression by regulating HIF1A expression. Cancer Cell Int. 2020;20(1):400.
   PubMed Web of Science ®Google Scholar
• Liu T, Liu S, Xu Y, et al. Circular RNA-ZFR inhibited cell proliferation and promoted apoptosis in gastric cancer by sponging miR-130a/miR-107 and modulating PTEN. Cancer Res Treat. 2018;50(4):1396–1417.
   PubMed Web of Science ®Google Scholar
• Wang M, Gao Y, Liu J. Silencing circZFR inhibits the proliferation, migration and invasion of human renal carcinoma cells by regulating miR-206. Onco Targets Ther. 2019;12:7537–7550.
   PubMed Web of Science ®Google Scholar
• Wang S, Fu S, Chen Q, et al. Prognostic role of circular RNAs expression in bladder carcinoma: a meta-analysis. Genet Test Mol Biomarkers. 2020;24(11):692–700.
   PubMed Web of Science ®Google Scholar
• Zhang WY, Liu QH, Wang TJ, et al. CircZFR serves as a prognostic marker to promote bladder cancer progression by regulating miR-377/ZEB2 signaling. Biosci Rep. 2019;39(12). DOI:10.1042/BSR20192779
   Google Scholar
• Bian L, Zhi X, Ma L, et al. Hsa_circRNA_103809 regulated the cell proliferation and migration in colorectal cancer via miR-532-3p/FOXO4 axis. Biochem Biophys Res Commun. 2018;505(2):346–352.
   PubMed Web of Science ®Google Scholar
• Huang L, Jian Z, Gao Y, et al. RPN2 promotes metastasis of hepatocellular carcinoma cell and inhibits autophagy via STAT3 and NF-κB pathways. Aging (Albany NY). 2019;11(17):6674–6690.
   PubMedGoogle Scholar
• Meng F, Zhang S, Song R, et al. NCAPG2 overexpression promotes hepatocellular carcinoma proliferation and metastasis through activating the STAT3 and NF-κB/miR-188-3p pathways. EBioMedicine. 2019;44:237–249.
   PubMed Web of Science ®Google Scholar
• Zhou Q, Tian W, and Jiang Z, et al. A positive feedback loop of AKR1C3-mediated activation of NF-κB and STAT3 facilitates proliferation and metastasis in hepatocellular carcinoma. Cancer Res. 2021;81(5): 1361–1374.
   Web of Science ®Google Scholar
• Quail DF, Joyce JA. Microenvironmental regulation of tumor progression and metastasis. Nat Med. 2013;19(11):1423–1437.
   PubMed Web of Science ®Google Scholar
• Swartz MA, Iida N, Roberts EW, et al. Tumor microenvironment complexity: emerging roles in cancer therapy. Cancer Res. 2012;72(10):2473–2480.
   PubMed Web of Science ®Google Scholar
• Khawar IA, Park JK, Jung ES, et al. Three dimensional mixed-cell spheroids mimic stroma-mediated chemoresistance and invasive migration in hepatocellular carcinoma. Neoplasia. 2018;20(8):800–812.
   PubMed Web of Science ®Google Scholar
• Li Y, Wang R, Xiong S, et al. Cancer-associated fibroblasts promote the stemness of CD24(+) liver cells via paracrine signaling. J Mol Med (Berl). 2019;97(2):243–255.
   PubMed Web of Science ®Google Scholar
• Peng H, Xue R, Ju Z, et al. Cancer-associated fibroblasts enhance the chemoresistance of CD73(+) hepatocellular carcinoma cancer cells via HGF-Met-ERK1/2 pathway. Ann Transl Med. 2020;8(14):856.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Ren H, Dai B, et al. Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts. J Exp Clin Cancer Res. 2018;37(1):324.
   PubMed Web of Science ®Google Scholar
• Song Q, Su J, Miller LD, et al. scLM: automatic detection of consensus gene clusters across multiple single-cell datasets. Genomics Proteomics Bioinformatics. 2021;19(2):330–341.
   PubMed Web of Science ®Google Scholar