Crosstalk of pyroptosis, ferroptosis, and mitochondrial aldehyde dehydrogenase 2-related mechanisms in sepsis-induced lung injury in a mouse model

References

• Papafilippou L, Claxton A, Dark P, et al. Nanotools for sepsis diagnosis and treatment. Adv Healthc Mater. 2021;10(1):2001378.
   Web of Science ®Google Scholar
• Lee W, Chen Y, Chu Y, et al. Comparison of glutathione peroxidase-3 protein expression and enzyme bioactivity in normal subjects and patients with sepsis. Clin Chim Acta. 2019;489:177–182.
   PubMed Web of Science ®Google Scholar
• Bai Y, Meng L, Han L, et al. Lipid storage and lipophagy regulates ferroptosis. Biochem Biophys Res Commun. 2019;508(4):997–1003.
   PubMed Web of Science ®Google Scholar
• Li J, Cao F, Yin H, et al. Ferroptosis: past, present and future. Cell Death Dis. 2020;11(2):88.
   PubMed Web of Science ®Google Scholar
• Fei W, Chen D, Tang H, et al. Targeted GSH-exhausting and hydroxyl radical self-producing manganese-silica nanomissiles for MRI guided ferroptotic cancer therapy. Nanoscale. 2020;12(32):16738–16754.
   PubMed Web of Science ®Google Scholar
• Xiao Z, Kong B, Fang J, et al. Ferrostatin-1 alleviates lipopolysaccharide-induced cardiac dysfunction. Bioengineered. 2021;12(2):9367–9376.
   PubMed Web of Science ®Google Scholar
• Liu P, Feng Y, Li H, et al. Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis. Cell Mol Biol Lett. 2020;25(10). DOI:10.1186/s11658-020-00205-0.
   Google Scholar
• Zhou B, Zhang J, Liu X, et al. Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis. Cell Res. 2018;28(12):1171–1185.
   PubMed Web of Science ®Google Scholar
• Wang C, Yuan W, Hu A, et al. Dexmedetomidine alleviated sepsisinduced myocardial ferroptosis and septic heart injury. Mol Med Rep. 2020;22(1):175–184.
   PubMed Web of Science ®Google Scholar
• Wang W, Cao Z, and Liang H, et al. Effect of low-dose ethanol on NLRP3 inflammasome in diabetes-induced lung injury. Exp Anim. 2021;70(3):364–371.
   PubMed Web of Science ®Google Scholar
• Ji W, Wan T, Zhang F, et al. Aldehyde dehydrogenase 2 protects against lipopolysaccharide-induced myocardial injury by suppressing mitophagy. Front Pharmacol. 2021;12(641058). DOI:10.3389/fphar.2021.641058.
   Google Scholar
• Xu Y, Yuan Q, Cao S, et al. Aldehyde dehydrogenase 2 inhibited oxidized LDL-induced NLRP3 inflammasome priming and activation via attenuating oxidative stress. Biochem Biophys Res Commun. 2020;529(4):998–1004.
   PubMed Web of Science ®Google Scholar
• Cao R, Fang D, Wang J, et al. Aldh2 overexpression alleviates high glucose-induced cardiotoxicity by inhibiting nlrp3 inflammasome activation. J Diabetes Res. 2019;2019:4857921.
   PubMed Web of Science ®Google Scholar
• Zhang B, Zheng F, Liu A, et al. Activation of CB2 receptor inhibits pyroptosis and subsequently ameliorates cecal ligation and puncture-induced sepsis. Int Immunopharmacol. 2021;99:108038.
   PubMed Web of Science ®Google Scholar
• Li N, Wang W, Zhou H, et al. Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury. Free Radical Bio Med. 2020;160:303–318.
   PubMed Web of Science ®Google Scholar
• Rittirsch D, Huber-Lang MS, Flierl MA, et al. Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc. 2009;4(1):31–36.
   PubMed Web of Science ®Google Scholar
• Xu K, Wu C, Tong S, et al. The selective Nlrp3 inflammasome inibitor Mcc950 attenuates lung ischemia-reperfusion injury. Biochem Biophys Res Commun. 2018;503(4):3031–3037.
   PubMed Web of Science ®Google Scholar
• Martin-Sanchez D, Ruiz-Andres O, Poveda J, et al. Ferroptosis, but not Necroptosis, is important in nephrotoxic folic acid-induced AKI. J Am Soc Nephrol. 2017;28(1):218–229.
   PubMed Web of Science ®Google Scholar
• Zhang R, Liu B, Fan X, et al. Aldehyde dehydrogenase 2 protects against post-cardiac arrest myocardial dysfunction through a novel mechanism of suppressing mitochondrial reactive oxygen species production. Front Pharmacol. 2020;11:373.
   PubMed Web of Science ®Google Scholar
• Zhang W, Li J, Yao H, et al. Restoring microRNA-499-5p protects sepsis-induced lung injury mice via targeting Sox6. Nanoscale Res Lett. 2021 21; 16(1): 89.
   PubMed Web of Science ®Google Scholar
• Zhou H, Li F, Niu JY, et al. Ferroptosis was involved in the oleic acid-induced acute lung injury in mice. Sheng Li Xue Bao. 2019;71(5):689–697.
   PubMedGoogle Scholar
• Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the global burden of disease study. Lancet. 2020;395(10219):200–211.
   PubMed Web of Science ®Google Scholar
• Hu JJ, Liu X, Xia S, et al. FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation. Nat Immunol. 2020;21(7):736–745.
   PubMed Web of Science ®Google Scholar
• Swanson KV, Deng M, Ting JPY. The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat Rev Immunol. 2019;19(8):477–489.
   PubMed Web of Science ®Google Scholar
• Dang X, Du G, Hu W, et al. Peroxisome proliferator-activated receptor gamma coactivator-1alpha/HSF1 axis effectively alleviates lipopolysaccharide-induced acute lung injury via suppressing oxidative stress and inflammatory response. J Cell Biochem. 2019;120(1):544–551.
   PubMed Web of Science ®Google Scholar
• Cao C, Yin C, Shou S, et al. Ulinastatin protects against LPS-induced acute lung injury by attenuating TLR4/NF-kappaB pathway activation and reducing inflammatory mediators. Shock. 2018;50(5):595–605.
   PubMed Web of Science ®Google Scholar
• Tang D, Kang R, Berghe TV, et al. The molecular machinery of regulated cell death. Cell Res. 2019;29(5):347–364.
   PubMed Web of Science ®Google Scholar
• Chen B, Chen Z, Liu M, et al. Inhibition of neuronal ferroptosis in the acute phase of intracerebral hemorrhage shows long-term cerebroprotective effects. Brain Res Bull. 2019;153:122–132.
   PubMed Web of Science ®Google Scholar
• Sun YB, Zhao H, Mu DL, et al. Dexmedetomidine inhibits astrocyte pyroptosis and subsequently protects the brain in in vitro and in vivo models of sepsis. Cell Death Dis. 2019;10(3):167.
   PubMed Web of Science ®Google Scholar
• Liu X, Wang D, Zhang X, et al. Effect and mechanism of phospholipid scramblase 4 (PLSCR4) on lipopolysaccharide (LPS)-induced injury to human pulmonary microvascular endothelial cells. Ann Transl Med. 2021;9(2):159.
   PubMed Web of Science ®Google Scholar
• Han F, Li S, Yang Y, et al. Interleukin-6 promotes ferroptosis in bronchial epithelial cells by inducing reactive oxygen species-dependent lipid peroxidation and disrupting iron homeostasis. Bioengineered. 2021;12(1):5279–5288.
   PubMed Web of Science ®Google Scholar
• Chu J, Liu CX, Song R, et al. Ferrostatin-1 protects HT-22 cells from oxidative toxicity. Neural Regen Res. 2020;15(3):528–536.
   PubMed Web of Science ®Google Scholar
• Sidramagowda Patil S, Hernández-Cuervo H, Fukumoto J, et al. Alda-1 attenuates hyperoxia-induced acute lung injury in mice. Front Pharmacol. 2021;11:597942.
   PubMed Web of Science ®Google Scholar
• Hu JF, Wang HX, Li HH, et al. Inhibition of ALDH2 expression aggravates renal injury in a rat sepsis syndrome model. Exp Ther Med. 2017;14(3):2249–2254.
   PubMed Web of Science ®Google Scholar