Methylation recognition protein YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) regulates the proliferation, migration and invasion of osteosarcoma by regulating m6A level of CCR4-NOT transcription complex subunit 7 (CNOT7)

References

• Wagner ER, Luther G, Zhu G, et al. Defective osteogenic differentiation in the development of osteosarcoma. Sarcoma. 2011;2011:325238.
   PubMedGoogle Scholar
• Tiram G, Segal E, Krivitsky A, et al. Identification of Dormancy-Associated MicroRNAs for the design of osteosarcoma-targeted dendritic polyglycerol nanopolyplexes. ACS Nano. 2016;10(2):2028–2045.
   PubMed Web of Science ®Google Scholar
• Marina N, Gebhardt M, Teot L, et al. Biology and therapeutic advances for pediatric osteosarcoma. Oncologist. 2004;9(4):422–441.
   PubMed Web of Science ®Google Scholar
• Wagle S, Park SH, Kim KM, et al. DBC1/CCAR2 is involved in the stabilization of androgen receptor and the progression of osteosarcoma. Sci Rep. 2015;5(1):13144.
   PubMed Web of Science ®Google Scholar
• Duchman KR, Gao Y, Miller BJ. Prognostic factors for survival in patients with high-grade osteosarcoma using the Surveillance, Epidemiology, and End Results (SEER) program database. Cancer Epidemiol. 2015;39(4):593–599.
   PubMed Web of Science ®Google Scholar
• Gill J, Ahluwalia MK, Geller D, et al. New targets and approaches in osteosarcoma. Pharmacol Ther. 2013;137(1):89–99.
   PubMed Web of Science ®Google Scholar
• Desrosiers R, Friderici K, Rottman F. Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells. Proc Natl Acad Sci U S A. 1974;71(10):3971–3975.
   PubMed Web of Science ®Google Scholar
• Meyer KD, Saletore Y, Zumbo P, et al. Comprehensive analysis of mRNA methylation reveals enrichment in 3’ UTRs and near stop codons. Cell. 2012;149(7):1635–1646.
   PubMed Web of Science ®Google Scholar
• He L, Li H, Wu A, et al. Functions of N6-methyladenosine and its role in cancer. Mol Cancer. 2019;18(1):176.
   PubMed Web of Science ®Google Scholar
• Shi H, Wei J, He C. Where, when, and how: context-dependent functions of RNA methylation writers, readers, and erasers. Mol Cell. 2019;74(4):640–650.
   PubMed Web of Science ®Google Scholar
• Xia T, Wu X, Cao M, et al. The RNA m6A methyltransferase METTL3 promotes pancreatic cancer cell proliferation and invasion. Pathol Res Pract. 2019;215(11):152666.
   PubMed Web of Science ®Google Scholar
• Zhang L, Wan Y, and Zhang Z, et al. FTO demethylates m6A modifications in HOXB13 mRNA and promotes endometrial cancer metastasis by activating the WNT signalling pathway. RNA Biol. 2020;18(9):1265–1278.
   Web of Science ®Google Scholar
• Yang X, Zhang S, He C, et al. METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST. Mol Cancer. 2020;19(1):46.
   PubMed Web of Science ®Google Scholar
• Shen S, Yao T, Xu Y, et al. CircECE1 activates energy metabolism in osteosarcoma by stabilizing c-Myc. Mol Cancer. 2020;19(1):151.
   PubMed Web of Science ®Google Scholar
• Chen J, Liu G, Wu Y, et al. CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of beta-catenin/LEF1 complex via effects on chromatin remodeling. Mol Cancer. 2019;18(1):150.
   PubMed Web of Science ®Google Scholar
• Yuan Y, Yan G, He M, et al. ALKBH5 suppresses tumor progression via an m(6) A-dependentepigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma. Cell Death Dis. 2021;12(1):60.
   PubMed Web of Science ®Google Scholar
• Huo FC, Zhu ZM, Zhu WT, et al. METTL3-mediated m(6)A methylation of SPHK2 promotes gastric cancer progression by targeting KLF2. Oncogene. 2021;40(16):2968–2981.
   PubMed Web of Science ®Google Scholar
• Lin S, Choe J, Du P, et al. The m(6)A methyltransferase METTL3 promotes translation in human cancer cells. Mol Cell. 2016;62(3):335–345.
   PubMed Web of Science ®Google Scholar
• Mao W, Wang K, Xu B, et al. ciRS-7 is a prognostic biomarker and potential gene therapy target for renal cell carcinoma. Mol Cancer. 2021;20(1):142.
   PubMed Web of Science ®Google Scholar
• Li Y, Zhang X, Cai J, et al. The pathological tissue expression pattern and clinical significance of m6A-regulatory genes in non-small cell lung cancer. J Gene Med. 2021;e3397. doi:10.1002/jgm.3397.
   PubMed Web of Science ®Google Scholar
• Rong D, Wu F, Lu C, et al. m6A modification of circHPS5 and hepatocellular carcinoma progression through HMGA2 expression. Mol Ther Nucleic Acids. 2021;26:637–648.
   PubMedGoogle Scholar
• Liang X, Zhang Z, Wang L, et al. Mechanism of methyltransferase like 3 in epithelial-mesenchymal transition process, invasion, and metastasis in esophageal cancer. Bioengineered. 2021;12(2):10023–10036.
   PubMed Web of Science ®Google Scholar
• Li K, Peng ZY, Gao S, et al. M6A associated TSUC7 inhibition contributed to Erlotinib resistance in lung adenocarcinoma through a notch signaling activation dependent way. J Exp Clin Cancer Res. 2021;40(1):325.
   PubMed Web of Science ®Google Scholar
• Zhou C, Zhang Z, Zhu X, et al. N6-Methyladenosine modification of the TRIM7 positively regulates tumorigenesis and chemoresistance in osteosarcoma through ubiquitination of BRMS1. EBioMedicine. 2020;59:102955.
   PubMed Web of Science ®Google Scholar
• Li J, Rao B, Yang J, et al. Dysregulated m6A-related regulators are associated with tumor metastasis and poor prognosis in osteosarcoma. Front Oncol. 2020;10:769.
   PubMed Web of Science ®Google Scholar
• Isakoff MS, Bielack SS, Meltzer P, et al. Osteosarcoma: current treatment and a collaborative pathway to success. J Clin Oncol. 2015;33(27):3029–3035.
   PubMed Web of Science ®Google Scholar
• Casali PG, Bielack S, Abecassis N, et al. Bone sarcomas: ESMO-PaedCan-EURACAN clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2018;29:iv79–iv95.
   PubMed Web of Science ®Google Scholar
• Fu Y, Dominissini D, Rechavi G, et al. Gene expression regulation mediated through reversible m(6)A RNA methylation. Nat Rev Genet. 2014;15(5):293–306.
   PubMed Web of Science ®Google Scholar
• Deng X, Su R, Weng H, et al. RNA N(6)-methyladenosine modification in cancers: current status and perspectives. Cell Res. 2018;28(5):507–517.
   PubMed Web of Science ®Google Scholar
• Imai Y, Matsuo N, Ogawa S, et al. Cloning of a gene, YT521, for a novel RNA splicing-related protein induced by hypoxia/reoxygenation. Brain Res Mol Brain Res. 1998;53(1–2):33–40.
   PubMedGoogle Scholar
• Stoilov P, Rafalska I, Stamm S. YTH: a new domain in nuclear proteins. Trends Biochem Sci. 2002;27(10):495–497.
   PubMed Web of Science ®Google Scholar
• Wang X, Zhao BS, Roundtree IA, et al. N(6)-methyladenosine modulates messenger RNA translation efficiency. Cell. 2015;161:1388–1399.
   PubMed Web of Science ®Google Scholar
• Liu T, Wei Q, Jin J, et al. The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation. Nucleic Acids Res. 2020;48(7):3816–3831.
   PubMed Web of Science ®Google Scholar
• Pi J, Wang W, Ji M, et al. YTHDF1 promotes gastric carcinogenesis by controlling translation of FZD7. Cancer Res. 2020;81(10):2651–2665.
   PubMed Web of Science ®Google Scholar
• Zhao X, Chen Y, Mao Q, et al. Overexpression of YTHDF1 is associated with poor prognosis in patients with hepatocellular carcinoma. Cancer Biomark. 2018;21(4):859–868.
   PubMed Web of Science ®Google Scholar
• Bartlam M, Yamamoto T. The structural basis for deadenylation by the CCR4-NOT complex. Protein Cell. 2010;1(5):443–452.
   PubMed Web of Science ®Google Scholar
• Chapat C, Kolytcheff C, Le Romancer M, et al. hCAF1/CNOT7 regulates interferon signalling by targeting STAT1. EMBO J. 2013;32(5):688–700.
   PubMed Web of Science ®Google Scholar
• Flanagan J, Healey S, Young J, et al. Analysis of the transcription regulator, CNOT7, as a candidate chromosome 8 tumor suppressor gene in colorectal cancer. Int J Cancer. 2003;106(4):505–509.
   PubMed Web of Science ®Google Scholar
• Miao Y, Lu J, Fan B, et al. MicroRNA-126-5p inhibits the migration of breast cancer cells by directly targeting CNOT7. Technol Cancer Res Treat.2020;19:1533033820977545.
   Web of Science ®Google Scholar
• Yu J,Hu X, Chen X, et al. CNOT7 modulates biological functions of ovarian cancer cells via AKT signaling pathway. Life Sci.2021;268:118996.
   PubMed Web of Science ®Google Scholar