Matrine Combined with Mammalian Target of Rapamycin Inhibitor Enhances Anti-Tumor Efficacy of dendritic cell Vaccines in hepatocellular carcinoma

References

• Plumas J. Harnessing dendritic cells for innovative therapeutic cancer vaccines. Curr Opin Oncol. 2021 Dec 20. DOI:10.1097/CCO.0000000000000815
   Web of Science ®Google Scholar
• Sukhbaatar N, Hengstschläger M, Weichhart T. mTOR-mediated regulation of dendritic cell differentiation and function. Trends Immunol. 2016;37(11):778–789.
   PubMed Web of Science ®Google Scholar
• How CW, Ong YS, Low SS, et al. How far have we explored fungi to fight cancer? Semin Cancer Biol. 2021 Mar 15;S1044-579X(21): 00059–6.
   Google Scholar
• Tan KL, Chia WC, How CW, et al. Benchtop isolation and characterisation of small extracellular vesicles from human mesenchymal stem cells. Mol Biotechnol. 2021 Sep;63(9):780–791.
   PubMed Web of Science ®Google Scholar
• Sharma MD, Pacholczyk R, Shi H, et al. Inhibition of the BTK-IDO-mTOR axis promotes differentiation of monocyte-lineage dendritic cells and enhances anti-tumor T cell immunity. Immunity. 2021 Oct 12;54(10):2354–2371.
   PubMed Web of Science ®Google Scholar
• Looi QH, Foo JB, Lim MT, et al. How far have we reached in development of effective influenza vaccine? Int Rev Immunol. 2018;37(5):266–276.
   PubMed Web of Science ®Google Scholar
• Huang H, Du T, Xu G, et al. Matrine suppresses invasion of castration-resistant prostate cancer cells by downregulating MMP-2/9 via NF-κB signaling pathway. Int J Oncol. 2017;50(2):640–648.
   PubMed Web of Science ®Google Scholar
• Gu YY, Chen MH, May BH, et al. Matrine induces apoptosis in multiple colorectal cancer cell lines in vitro and inhibits tumour growth with minimum side effects in vivo via Bcl-2 and caspase-3. Phytomedicine. 2018;51:214–225.
   PubMed Web of Science ®Google Scholar
• Guo S, Chen Y, Pang C, et al. Matrine is a novel inhibitor of the TMEM16A chloride channel with anti lung adenocarcinoma effects. J Cell Physiol. 2019;234(6):8698–8708.
   PubMed Web of Science ®Google Scholar
• Teh YM, Mualif SA, Lim SK. A comprehensive insight into autophagy and its potential signaling pathways as a therapeutic target in podocyte injury. Int J Biochem Cell Biol. 2021 Dec;30:106153.
   Google Scholar
• Chen J, Guo Q, Chen Q, et al. Interleukin 10 inhibits oxidative stress-induced autophagosome formation in hepatic stellate cells by activating the mTOR-STAT3 pathway. Exp Cell Res. 2021 Dec;30:113001.
   Google Scholar
• Wei C, Liu X, Wang Q, et al. Identification of hypoxia signature to assess the tumor immune microenvironment and predict prognosis in patients with ovarian cancer. Int J Endocrinol. 2021 Dec 14;2021:4156187.
   PubMed Web of Science ®Google Scholar
• Hersant J, Ramondou P, Douillet D, et al. Comparison between conventional duplex ultrasonography and the dual-gate Doppler mode for hemodynamic measurements of the carotid arteries. Ultrasonography. 2021 Nov 10. DOI:10.14366/usg.21175
   PubMed Web of Science ®Google Scholar
• Han Y, Yu C, Yu Y. Astragalus polysaccharide alleviates alveolar bone destruction by regulating local osteoclastogenesis during periodontitis. J Appl Biomed. 2021 May;19(2):97–104.
   PubMed Web of Science ®Google Scholar
• Fujii SI, Yamasaki S, Hanada K, et al. Cancer immunotherapy using artificial adjuvant vector cells to deliver NY-ESO-1 antigen to dendritic cells in situ. Cancer Sci. 2021 Dec 31. DOI:10.1111/cas.15259
   Web of Science ®Google Scholar
• Matsoukas J, Deraos G, Kelaidonis K, et al. Myelin peptide-mannan conjugate multiple sclerosis vaccines: conjugation efficacy and stability of vaccine ingredient. Vaccines (Basel). 2021 Dec 8;9(12):1456.
   PubMed Web of Science ®Google Scholar
• Young ID, Nepogodiev SA, Black IM, et al. Lipopolysaccharide associated with β-2,6 fructan mediates TLR4-dependent immunomodulatory activity in vitro. Carbohydr Polym. 2022 Feb 1;277:118606.
   PubMed Web of Science ®Google Scholar
• Zhou YJ, Guo YJ, Yang XL, et al. Anti-cervical cancer role of matrine, oxymatrine and Sophora flavescens alkaloid gels and its mechanism. J Cancer. 2018;9(8):1357–1364.
   PubMed Web of Science ®Google Scholar
• Singh S, Almuhanna Y, Alshahrani MY, et al. Carbohydrates from Pseudomonas aeruginosa biofilms interact with immune C-type lectins and interfere with their receptor function. NPJ Biofilms Microbiomes. 2021 Dec 8;7(1):87.
   PubMed Web of Science ®Google Scholar
• Choi E, Yang J, Ji GE, et al. The effect of probiotic supplementation on systemic inflammation in dialysis patients. Kidney Res Clin Pract. 2021 Nov 18;41(1):89–101.
   PubMed Web of Science ®Google Scholar
• Thiago AP, Mariana PP, Aline AO, et al. Human dendritic cells: their heterogeneity and clinical application potential in cancer immunotherapy. Front Immunol. 2019;9:3176.
   PubMed Web of Science ®Google Scholar
• Wang H, Chen H, Liu S, et al. Costimulation of γδTCR and TLR7/8 promotes Vδ2 T-cell antitumor activity by modulating mTOR pathway and APC function. J Immunother Cancer. 2021 Dec;9(12):e003339.
   PubMed Web of Science ®Google Scholar
• Martín-Sánchez A, González-Pardo H, Alegre-Zurano L, et al. Early-life stress induces emotional and molecular alterations in female mice that are partially reversed by cannabidiol. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Dec;29:110508.
   Google Scholar
• Faitot F, Artzner T, Michard B, et al., Study Group OBOTSLTS. Immunosuppression in patients with grade 3 acute-on-chronic liver failure at transplantation: a practice analysis study. Clin Transplant. 2022Jan;2:e14580.
   Google Scholar
• Tang G, Li S, Zhang C, et al. Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management. Acta Pharm Sin B. 2021 Sep;11(9):2749–2767.
   PubMed Web of Science ®Google Scholar
• Aboulgheit A, Karbasiafshar C, Sabra M, et al. Extracellular vesicles improve diastolic function and substructure in normal and high-fat diet models of chronic myocardial ischemia. J Thorac Cardiovasc Surg. 2021 Oct 13;S0022-5223(21): 01420–3.
   Google Scholar
• Lynn J, Park M, Ogunwale C, et al. A tale of two diseases: Exploring mechanisms linking diabetes mellitus with alzheimer’s disease. J Alzheimers Dis. 2021 Nov 21. DOI:10.3233/JAD-210612
   Web of Science ®Google Scholar
• Zhan L, Zhang J, Zhang J, et al. LC3 and NLRC5 interaction inhibits NLRC5-mediated MHC class I antigen presentation pathway in endometrial cancer. Cancer Lett. 2021 Dec 30;S0304-3835(21): 00648–0.
   Google Scholar
• Wu D, Shao K, Zhou Q, et al. Autophagy and ubiquitin-mediated proteolytic degradation of PML/rarα fusion protein in matrine-induced differentiation sensitivity recovery of ATRA-resistant APL (NB4-LR1) cells: in vitro and in vivo studies. Cell Physiol Biochem. 2018;48(6):2286–2301.
   PubMedGoogle Scholar
• Ma K, Huang MY, Guo YX, et al. Matrine-induced autophagy counteracts cell apoptosis via the ERK signaling pathway in osteosarcoma cells. Oncol Lett. 2016;12(3):1854–1860.
   PubMed Web of Science ®Google Scholar
• Ke Y, Hu TX, Huo JF, et al. Synthesis and in vitro biological evaluation of novel derivatives of Flexicaulin A condensation with amino acid trifluoroacetate. Eur J Med Chem. 2019 Nov 15;182:111645.
   PubMed Web of Science ®Google Scholar
• Zhang X, Ming Y, Fu X, et al. PI3K/AKT/p53 pathway inhibits infectious spleen and kidney necrosis virus infection by regulating autophagy and immune responses. Fish Shellfish Immunol. 2021 Dec 28;120:648–657.
   PubMed Web of Science ®Google Scholar
• Zittlau KI, Terradas AL, Nalpas N, et al. Temporal analysis of protein ubiquitylation and phosphorylation during parkin-dependent mitophagy. Mol Cell Proteomics. 2021 Dec;30:100191.
   Google Scholar