1,393
Views
2
CrossRef citations to date
0
Altmetric
Research Paper

Gene expression profiling reveals candidate biomarkers and probable molecular mechanisms in chronic stress

, , , , , & ORCID Icon show all
Pages 6048-6060 | Received 26 Oct 2021, Accepted 07 Feb 2022, Published online: 19 Feb 2022

References

  • Yao BC, Meng LB, Hao ML, et al. Chronic stress: a critical risk factor for atherosclerosis. J Int Med Res. 2019;47(4):1429–1440.
  • Ilich JZ, Gilman JC, Cvijetic S, et al. Chronic stress contributes to osteosarcopenic adiposity via inflammation and immune modulation: the case for more precise nutritional investigation. Nutrients. 2020;12(4):989.
  • Salleh MR. Life event, stress and illness. Malays J Med Sci. 2008;15(4):9–18.
  • Li N, Zhang RX, Xie XJ, et al. Autophagy in chronic stress induced atherosclerosis. Clin Chim Acta. 2020;503:70–75.
  • Dai S, Mo Y, Wang Y, et al. Chronic stress promotes cancer development. Front Oncol. 2020;10:1492.
  • Lowery-Gionta EG, Crowley NA, Bukalo O, et al. Chronic stress dysregulates amygdalar output to the prefrontal cortex. Neuropharmacology. 2018;139:68–75.
  • Saeedi M, Rashidy-Pour A. Association between chronic stress and Alzheimer’s disease: therapeutic effects of Saffron. Biomed Pharmacothe. 2021;133:110995.
  • Rajpoot A, Garg K, Saini V, et al. Psychological morbidity in interstitial lung disease: a study from India. Monaldi Arch Chest Dis. 2020;90(4). DOI:10.4081/monaldi.2020.1434
  • Kumar V. Pulmonary innate immune response determines the outcome of inflammation during pneumonia and sepsis-associated acute lung injury. Front Immunol. 2020;11:1722.
  • López-Lois B, González-Barcala FJ, Facal D. Application of mindfulness techniques in patients with asthma or COPD. J Asthma. 2021;58(9):1237–1246.
  • Picaza Gorrochategi M, Eiguren Munitis A, Dosil Santamaria M, et al. Anxiety, and depression in people aged over 60 in the COVID-19 outbreak in a sample collected in northern spain. Am J Geriatr Psychiatry. 2020;28(9):993–998.
  • Taylor WD, Blackford JU. Mental health treatment for front-line clinicians during and after the coronavirus disease 2019 (COVID-19) pandemic: a plea to the medical community. Ann Intern Med. 2020;173(7):574–575.
  • Jackson M. The stress of life: a modern complaint? Lancet. 2014;383(9914):300–301.
  • Zhang L, Pan J, Chen W, et al. Chronic stress-induced immune dysregulation in cancer: implications for initiation, progression, metastasis, and treatment. Am J Cancer Res. 2020;10(5):1294–1307.
  • Reiche EM, Morimoto HK, Nunes SM. Stress and depression-induced immune dysfunction: implications for the development and progression of cancer. Int Rev Psychiatry. 2005;17(6):515–527.
  • Chen H, Liu D, Guo L, et al. Chronic psychological stress promotes lung metastatic colonization of circulating breast cancer cells by decorating a pre-metastatic niche through activating β-adrenergic signaling. J Pathol. 2018;244(1):49–60.
  • Rosenne E, Sorski L, Shaashua L, et al. In vivo suppression of NK cell cytotoxicity by stress and surgery: glucocorticoids have a minor role compared to catecholamines and prostaglandins. Brain Behav Immun. 2014;37:207–219.
  • Lee S, Suh GY, Ryter SW, et al. Regulation and function of the nucleotide binding domain leucine-rich repeat-containing receptor, pyrin domain-containing-3 inflammasome in lung disease. Am J Respir Cell Mol Biol. 2016;54(2):151–160.
  • Antoniuk S, Bijata M, Ponimaskin E, et al. Chronic unpredictable mild stress for modeling depression in rodents: meta-analysis of model reliability. Neurosci Biobehav Rev. 2019;99:101–116.
  • Zhu YL, Li SL, Zhu CY, et al. Metabolomics analysis of the antidepressant prescription danzhi xiaoyao powder in a rat model of chronic unpredictable mild stress (CUMS). J Ethnopharmacol. 2020;260:112832.
  • Zheng J, Cai W, Lu X, et al. Chronic stress accelerates the process of gastric precancerous lesions in rats. J Cancer. 2021;12(14):4121–4133.
  • Wei L, Li Y, Tang W, et al. Chronic unpredictable mild stress in rats induces colonic inflammation. Front Physiol. 2019;10:1228.
  • Liu L, Dong Y, and Shan X, et al. Anti-Depressive Effectiveness of Baicalin In Vitro and In Vivo. Molecules. 2019;24(2):326.
  • Song AQ, Gao B, Fan JJ, et al. NLRP1 inflammasome contributes to chronic stress-induced depressive-like behaviors in mice. J Neuroinflammation. 2020;17(1):178.
  • Huang HJ, Chen XR, Han QQ, et al. The protective effects of Ghrelin/GHSR on hippocampal neurogenesis in CUMS mice. Neuropharmacology. 2019;155:31–43.
  • Huang HJ, Zhu XC, Han QQ, et al. Ghrelin alleviates anxiety- and depression-like behaviors induced by chronic unpredictable mild stress in rodents. Behav Brain Res. 2017;326:33–43.
  • Liu MY, Yin CY, Zhu LJ, et al. Sucrose preference test for measurement of stress-induced anhedonia in mice. Nat Protoc. 2018;13(7):1686–1698.
  • Bolger AM, Lohse M, Usadel B. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics. 2014;30(15):2114–2120.
  • Kim D, Langmead B, Salzberg SL. HISAT: a fast spliced aligner with low memory requirements. Nat Methods. 2015;12(4):357–360.
  • Anders S, Pyl PT, Huber W. HTSeq–a Python framework to work with high-throughput sequencing data. Bioinformatics. 2015;31(2):166–169.
  • Anders S, Huber W. Differential expression analysis for sequence count data. Genome Biol. 2010;11(10):R106.
  • Dennis G Jr., Sherman BT, Hosack DA, et al. DAVID: database for annotation, visualization, and integrated discovery. Genome Biol. 2003;4(5):3.
  • Szklarczyk D, Franceschini A, Wyder S, et al. STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 2015;43(D1):D447–52.
  • Shannon P, Markiel A, Ozier O, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13(11):2498–2504.
  • Luo L, Zhou WH, Cai JJ, et al. Gene expression profiling identifies downregulation of the neurotrophin-MAPK signaling pathway in female diabetic peripheral neuropathy patients. J Diabetes Res. 2017;2017:8103904.
  • Yaribeygi H, Panahi Y, Sahraei H, et al. The impact of stress on body function: a review. EXCLI J. 2017;16:1057–1072.
  • Pan J, Ju D, Wang Q, et al. Dexamethasone inhibits the antigen presentation of dendritic cells in MHC class II pathway. Immunol Lett. 2001;76(3):153–161.
  • Borroto A, Abia D, Alarcón B. Crammed signaling motifs in the T-cell receptor. Immunol Lett. 2014;161(1):113–117.
  • Call ME, Wucherpfennig KW. Molecular mechanisms for the assembly of the T cell receptor-CD3 complex. Mol Immunol. 2004;40(18):1295–1305.
  • Le Deist F, Hivroz C, Partiseti M, et al. T cell activation deficiencies. Clini immunol immunopathol. 1995;76(3):S163–4.
  • Benonisson H, Altıntaş I, Sluijter M, et al. CD3-Bispecific antibody therapy turns solid tumors into inflammatory sites but does not install protective memory. Mol Cancer Ther. 2019;18(2):312–322.
  • Iizuka A, Nonomura C, Ashizawa T, et al. A T-cell-engaging B7-H4/CD3-bispecific Fab-scFv antibody targets human breast cancer. Clin Cancer Res off J Am Assoc Cancer Res. 2019;25(9):2925–2934.
  • Banerjee A, Herring CA, Chen B, et al. Succinate produced by intestinal microbes promotes specification of tuft cells to suppress ileal inflammation. Gastroenterology. 2020;159(6):2101–15.e5.
  • Kakleas K, Soldatou A, Karachaliou F, et al. Associated autoimmune diseases in children and adolescents with type 1 diabetes mellitus (T1DM). Autoimmun Rev. 2015;14(9):781–797.
  • Vlasakakis G, Napolitano A, Barnard R, et al. Target engagement and cellular fate of otelixizumab: a repeat dose escalation study of an anti-CD3ε mAb in new-onset type 1 diabetes mellitus patients. Br J Clin Pharmacol. 2019;85(4):704–714.
  • Liu Y, Wu Y, Zhang P, et al. CXCL12 and CD3E as indicators for tumor microenvironment modulation in bladder cancer and their correlations with immune infiltration and molecular subtypes. Front Oncol. 2021;11:636870.
  • Feng X, Zhao C, Li L, et al. iNKT cells with high PLZF expression are recruited into the lung via CCL21-CCR7 signaling to facilitate the development of asthma tolerance in mice. Eur J Immunol. 2021;51(2):414–432.
  • Parkinson N, Rodgers N, Head Fourman M, et al. Dynamic data-driven meta-analysis for prioritisation of host genes implicated in COVID-19. Sci Rep. 2020;10(1):22303.
  • Irving BA, Weiss A. The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways. Cell. 1991;64(5):891–901.
  • Takeuchi T, Suzuki K, Kondo T, et al. CD3 ζ defects in systemic lupus erythematosus. Ann Rheum Dis. 2012;71(Suppl 2):i78–81.
  • Baniyash M. TCR zeta-chain downregulation: curtailing an excessive inflammatory immune response. Nat Rev Immunol. 2004;4(9):675–687.
  • Grundy S, Plumb J, Lea S, et al. Down regulation of T cell receptor expression in COPD pulmonary CD8 cells. PloS one. 2013;8(8):e71629.
  • Lahdenperä AI, Fälth-Magnusson K, Högberg L, et al. Expression pattern of T-helper 17 cell signaling pathway and mucosal inflammation in celiac disease. Scand J Gastroenterol. 2014;49(2):145–156.
  • Gorman CL, Russell AI, Zhang Z, et al. Polymorphisms in the CD3Z gene influence TCRzeta expression in systemic lupus erythematosus patients and healthy controls. J Immunol. 2008;180(2):1060–1070.
  • Radstake TR, Gorlova O, Rueda B, et al. Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. Nat Genet. 2010;42(5):426–429.
  • Eldor R, Klieger Y, Sade-Feldman M, et al. CD247, a novel T cell-derived diagnostic and prognostic biomarker for detecting disease progression and severity in patients with type 2 diabetes. Diabetes Care. 2015;38(1):113–118.
  • Ardini-Poleske ME, Clark RF, Ansong C, et al. LungMAP: the molecular atlas of lung development program. Am J Physiol Lung Cell Mol Physiol. 2017;313(5):L733–l40.
  • Wang A, Chiou J, Poirion OB, et al. Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes. eLife. 2020;9: DOI:10.7554/eLife.62522.
  • Li Y, Chen S, Li X, et al. CD247, a potential t cell-derived disease severity and prognostic biomarker in patients with idiopathic pulmonary fibrosis. Front Immunol. 2021;12:762594.
  • Zeng X, Feng J, Yang Y, et al. Screening of key genes of sepsis and septic shock using bioinformatics analysis. J Inflamm Res. 2021;14:829–841.