A high bile acid environment promotes apoptosis and inhibits migration in pancreatic cancer

References

• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70:7e30.
   Web of Science ®Google Scholar
• Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology. 2013;144(6):1252–1261.
   PubMed Web of Science ®Google Scholar
• Winter JM, Maitra A, Yeo CJ. Genetics and pathology of pancreatic cancer. HPB (Oxford). 2006;8(5):324–336. PMID: 18333084.
   PubMedGoogle Scholar
• Bernstein H, Bernstein C, Payne CM, et al. Bile acids as carcinogens in human gastrointestinal cancers. Mutat Res. 2005;589(1):47–65. PMID: 15652226.
   PubMed Web of Science ®Google Scholar
• Nagathihalli NS, Beesetty Y, Lee W, et al. Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-α: impact on gastrointestinal cancers driven by secondary bile acids. Cancer Res. 2014;74(7):2062–2072.
   PubMed Web of Science ®Google Scholar
• De aguiar vallim T, Tarling EJ, Edwards PA. Pleiotropic roles of bile acids in metabolism. Cell Metab. 2013;17(5):657–669.
   PubMed Web of Science ®Google Scholar
• Ridlon JM, Harris SC, Bhowmik S, et al. Consequences of bile salt biotransformations by intestinal bacteria. Gut Microbes. 2016;7(1):22e39].
   Web of Science ®Google Scholar
• Feng H-Y, Chen Y-C. Role of bile acids in carcinogenesis of pancreatic cancer: an old topic with new perspective. World J Gastroenterol. 2016;22(33):7463–7477.
   PubMed Web of Science ®Google Scholar
• Yee S-B, Song YS, Jeong SH, et al. A novel chenodeoxycholic derivative HS-1200 enhances radiation-induced apoptosis in MCF-7 cells. Oncol Rep. 2007;17(4):919–923. PMID: 17342337.
   PubMed Web of Science ®Google Scholar
• Shrader HR, Miller AM, Tomanek-Chalkley A, et al. Effect of bacterial contamination in bile on pancreatic cancer cell survival. Surgery. 2021;169(3):617–622.
   PubMed Web of Science ®Google Scholar
• Hong X, Li Z-X, Hou J, et al. Effects of ER-resident and secreted AGR2 on cell proliferation, migration, invasion, and survival in PANC-1 pancreatic cancer cells. BMC Cancer. 2021;21(1):33.
   PubMed Web of Science ®Google Scholar
• Joshi S, Cruz E, Rachagani S, et al. Bile acids-mediated overexpression of MUC4 via FAK-dependent c-Jun activation in pancreatic cancer. Mol Oncol. 2016;10(7):1063–1077.
   PubMed Web of Science ®Google Scholar
• Xu X, Chen B, Zhu S, et al. Hyperglycemia promotes Snail-induced epithelial–mesenchymal transition of gastric cancer via activating ENO1 expression. Cancer Cell Int. 2019;19(1):344.
   PubMed Web of Science ®Google Scholar
• Uibo R, Kisand K, Yang C-Y, et al. Primary biliary cirrhosis: a multi-faced interactive disease involving genetics, environment and the immune response. APMIS. 2012;120(11):857–871.
   PubMed Web of Science ®Google Scholar
• Arin MJ. The molecular basis of human keratin disorders [J]. Hum Genet. 2009;125(4):355–357.
   PubMed Web of Science ®Google Scholar
• Zhang B, Hu M, Zhang P, et al. BAFF promotes regulatory T-cell apoptosis and blocks cytokine production by activating B cells in primary biliary cirrhosis[J]. Braz J Med Biol Res. 2013;46(5):433–439.
   PubMed Web of Science ®Google Scholar
• Flores A, Mayo MJ. Primary biliary cirrhosis in 2014 [J]. Curr Opin Gastroenterol. 2014;30(3):245–252.
   PubMed Web of Science ®Google Scholar
• Momah N, Lindor KD. Primary biliary cirrhosis in adults [J]. Expert Rev Gastroenterol Hepatol. 2014;8(4):427–433.
   PubMed Web of Science ®Google Scholar
• Rong G-H, Yang G-X, Ando Y, et al. Human intrahepatic biliary epithelial cells engulf blebs from their apoptotic peers [J]. Clin Exp Immunol. 2013;172(1):95–103.
   PubMed Web of Science ®Google Scholar
• Berg PA. The role of the innate immune recognition system in the pathogenesis of primary biliary cirrhosis: a conceptual view [J]. Liver International. 2011;31(7):920–931.
   PubMed Web of Science ®Google Scholar
• Costarelli V. Bile acids as possible human carcinogens: new tricks from an old dog. International Journal of Food Sciences and Nutrition. 2009;60(sup6):116–125.
   PubMed Web of Science ®Google Scholar
• Adachi T, Tajima Y, Kuroki T, et al. Bile-reflux into the pancreatic ducts is associated with the devel-opment of intraductal papillary carcinoma in hamsters. J Surg Res. 2006. 136(1):106–111.
   PubMed Web of Science ®Google Scholar
• Ajouz H, Mukherji D, Shamseddine A. Secondary bile acids: an underrecognized cause of colon cancer. World Journal of Surgical Oncology. 2014;12(1):164–169.
   PubMedGoogle Scholar
• Chiang JYL. Bile acids: regulation of synthesis. J Lipid Res. 2009. 50(10):1955–1966.
   PubMed Web of Science ®Google Scholar
• Perez MJ, Briz O. Bile-acid-induced cell injury and protection. World J Gastroenterol. 2009;15(14):1677–1689.
   PubMed Web of Science ®Google Scholar
• Kockerling F. (2018). Antibiotic prophylaxis in laparoendoscopic hernia surgery. Int J Abdom Wall Hernia Surg, 1(1), 9. doi: 10.4103/ijawhs.ijawhs_4_18
   Google Scholar
• Bilgiç Ç, Keske S, and Sobutay, E, et al. Surgical site infections after pancreaticoduodenectomy: preoperative biliary system interventions and antimicrobial prophylaxis.Int. J Infect Dis. 2020;95:148e152.
   Web of Science ®Google Scholar
• Sano S, Sugiura T, Kawamura I, et al. Third-generation cephalosporin for antimicrobial prophylaxis in pancreatoduodenectomy in patients with internal preoperative biliary drainage. Surgery. 2019;165:559e564.
   Web of Science ®Google Scholar
• Urdaneta V, Casadesús J. Interactions between bacteria and bile salts in the gastrointestinal and hepatobiliary tracts.Front Med (Lausanne). Frontiers in Medicine. 2017;4:163.
   PubMed Web of Science ®Google Scholar
• Rees DO, Crick PJ, Jenkins GJ, et al. Comparison of the composition of bile acids in bile of patients with adenocarcinoma of the pancreas and benign disease. J Steroid Biochem Mol Biol. 2017;174:290–295.
   PubMed Web of Science ®Google Scholar
• Nha L, Sund M, Vinci A. Prognostic and predictive markers in pancreatic ade-nocarcinoma, Dig. Liver Dis. 2016. 48(3):223–230.
   Google Scholar