Bone marrow mesenchymal stem cells-derived exosomes suppress miRNA-5189-3p to increase fibroblast-like synoviocyte apoptosis via the BATF2/JAK2/STAT3 signaling pathway

References

• Garcia-Montoya L, Gul H, Emery P. Recent advances in ankylosing spondylitis: understanding the disease and management. F1000Res. 2018;7:1512.
   Google Scholar
• Bond D. Ankylosing spondylitis: diagnosis and management. Nurs Stand. 2013;28(16):52–59. quiz 60.
   PubMedGoogle Scholar
• Zhang D, Liu W, Yang H, et al. Clinical review of ankylosing spondylitis treated with acupuncture and medicine. Zhongguo Zhen Jiu. 2016;36(8):893–896.
   PubMedGoogle Scholar
• Dai J, Su Y, Zhong S, et al. Exosomes: key players in cancer and potential therapeutic strategy. Signal Transduct Target Ther. 2020;5(1):145.
   PubMed Web of Science ®Google Scholar
• Hessvik NP, Llorente A. Current knowledge on exosome biogenesis and release. Cell Mol Life Sci. 2018;75(2):193–208.
   PubMed Web of Science ®Google Scholar
• Xia Q, Wang Q, Li J, et al. miR-125a-5p-abundant exosomes derived from mesenchymal stem cells suppress chondrocyte degeneration via targeting E2F2 in traumatic osteoarthritis. Bioengineered. 2021;12(2):11225–11238.
   PubMed Web of Science ®Google Scholar
• Liang L, Zhao L, Wang Y, et al. Treatment for hepatocellular carcinoma is enhanced when norcantharidin is encapsulated in exosomes derived from bone marrow mesenchymal stem cells. Mol Pharm. 2021;18(3):1003–1013.
   PubMedGoogle Scholar
• Gu J, Jin ZS, Wang CM, et al. Bone marrow mesenchymal stem cell-derived exosomes improves spinal cord function after injury in rats by activating autophagy. Drug Des Devel Ther. 2020;14:1621–1631.
   PubMed Web of Science ®Google Scholar
• Zuo R, Liu M, Wang Y, et al. BM-MSC-derived exosomes alleviate radiation-induced bone loss by restoring the function of recipient BM-MSCs and activating wnt/beta-catenin signaling. Stem Cell Res Ther. 2019;10(1):30.
   PubMedGoogle Scholar
• Song JE, Kim JS, Shin JH, et al. Role of synovial exosomes in osteoclast differentiation in inflammatory arthritis. Cells. 2021;10(1):120.
   PubMed Web of Science ®Google Scholar
• Cai Y, Yu X, Hu S, et al. A brief review on the mechanisms of miRNA regulation. Genomics Proteomics Bioinformatics. 2009;7(4):147–154.
   PubMedGoogle Scholar
• Mohammadi H, Hemmatzadeh M, Babaie F, et al. MicroRNA implications in the etiopathogenesis of ankylosing spondylitis. J Cell Physiol. 2018;233(8):5564–5573.
   PubMed Web of Science ®Google Scholar
• Liu Z, Huang F, Luo G, et al. miR-214 stimulated by IL-17A regulates bone loss in patients with ankylosing spondylitis. Rheumatology. 2020;59(5):1159–1169. Oxford.
   PubMed Web of Science ®Google Scholar
• Park MC, Kwon OC, Lee SW, et al. MiR-451 suppresses inflammatory responses in ankylosing spondylitis by targeting macrophage migration inhibitory factor. Clin Exp Rheumatol. 2020;38(2):275–281.
   PubMed Web of Science ®Google Scholar
• Fotoh DS, Noreldin RI, Rizk MS, et al. miRNA-451a and miRNA-125a expression levels in ankylosing spondylitis: impact on disease diagnosis, prognosis, and outcomes. J Immunol Res. 2020;2020:2180913.
   PubMed Web of Science ®Google Scholar
• Pan Q, Zhao J, Li M, et al. Exosomal miRNAs are potential diagnostic biomarkers between malignant and benign thyroid nodules based on next-generation sequencing. Carcinogenesis. 2020;41(1):18–24.
   PubMed Web of Science ®Google Scholar
• Aviña-Zubieta JA, Chan J, De Vera M, et al. Risk of venous thromboembolism in ankylosing spondylitis: a general population-based study. Ann Rheum Dis. 2019;78(4):480–485.
   PubMed Web of Science ®Google Scholar
• Lu J, Fang Q, Ge X. Role and mechanism of mir-5189-3p in deep vein thrombosis of lower extremities. Ann Vasc Surg. 2021;77:288–295.
   PubMed Web of Science ®Google Scholar
• Jo S, Wang SE, Lee YL, et al. IL-17A induces osteoblast differentiation by activating JAK2/STAT3 in ankylosing spondylitis. Arthritis Res Ther. 2018;20(1):115.
   PubMedGoogle Scholar
• Zou YC, Yan LM, Gao YP, et al. miR-21 may act as a potential mediator between inflammation and abnormal bone formation in ankylosing spondylitis based on TNF-α concentration-dependent manner through the JAK2/STAT3 pathway. Dose-response. 2020;18(1):1559325819901239. a publication of International Hormesis Society.
   Web of Science ®Google Scholar
• Gu G, Huo Y, Xu G, et al. MicroRNA-204-GSDMD interaction regulates pyroptosis of fibroblast-like synoviocytes in ankylosing spondylitis. Int Immunopharmacol. 2021;91:107227.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods. 2001;25(4):402–408.
   PubMed Web of Science ®Google Scholar
• Ruutu M, Thomas G, Steck R, et al. β-glucan triggers spondylarthritis and crohn’s disease-like ileitis in SKG mice. Arthritis Rheumatism. 2012;64(7):2211–2222.
   PubMed Web of Science ®Google Scholar
• Chen Z, Wang H, Xia Y, et al. Therapeutic potential of mesenchymal cell-derived miRNA-150-5p-expressing exosomes in rheumatoid arthritis mediated by the modulation of MMP14 and VEGF. J Iimmunol. 2018;201(8):2472–2482. Baltimore, Md: 1950.
   PubMed Web of Science ®Google Scholar
• Lee YJ, Kim MJ, Jo S, et al. Clonorchis sinensis-derived protein attenuates inflammation and new bone formation in ankylosing spondylitis. Front Immunol. 2021;12:615369.
   PubMed Web of Science ®Google Scholar
• Benham H, Rehaume LM, Hasnain SZ, et al. Interleukin-23 mediates the intestinal response to microbial β-1,3-glucan and the development of spondyloarthritis pathology in SKG mice. Arthritis Rheumatol. 2014;66(7):1755–1767. Hoboken, NJ.
   PubMed Web of Science ®Google Scholar
• Paraskevopoulou MD, Vlachos IS, Karagkouni D, et al. DIANA-lncbase v2: indexing microRNA targets on non-coding transcripts. Nucleic Acids Res. 2016;44(D1):D231–8.
   PubMed Web of Science ®Google Scholar
• Yang X, Yang J, Lei P, et al. LncRNA MALAT1 shuttled by bone marrow-derived mesenchymal stem cells-secreted exosomes alleviates osteoporosis through mediating microRNA-34c/SATB2 axis. Aging ( Albany NY). 2019;11(20):8777–8791.
   PubMedGoogle Scholar
• Li X, Zheng Y, Hou L, et al. Exosomes derived from maxillary BMSCs enhanced the osteogenesis in iliac BMSCs. Oral Dis. 2020;26(1):131–144.
   PubMed Web of Science ®Google Scholar
• Li J, Ding Z, Li Y, et al. BMSCs-derived exosomes ameliorate pain via abrogation of aberrant nerve invasion in subchondral bone in lumbar facet joint osteoarthritis. J Orthop Res. 2020;38(3):670–679.
   PubMed Web of Science ®Google Scholar
• Shi Y, Kang X, Wang Y, et al. Exosomes derived from Bone Marrow Stromal Cells (BMSCs) enhance tendon-bone healing by regulating macrophage polarization. Med Sci Monit. 2020;26:e923328.
   PubMed Web of Science ®Google Scholar
• Ranganathan V, Gracey E, Brown MA, et al. Pathogenesis of ankylosing spondylitis - recent advances and future directions. Nat Rev Rheumatol. 2017;13(6):359–367.
   PubMed Web of Science ®Google Scholar
• Meng Q, Qiu B. Exosomal microrna-320a derived from mesenchymal stem cells regulates rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing CXCL9 expression. Front Physiol. 2020;11:441.
   PubMed Web of Science ®Google Scholar
• Su Y, Liu Y, Ma C, et al. Mesenchymal stem cell-originated exosomal lncRNA HAND2-AS1 impairs rheumatoid arthritis fibroblast-like synoviocyte activation through miR-143-3p/TNFAIP3/NF-kappaB pathway. J Orthop Surg Res. 2021;16(1):116.
   PubMed Web of Science ®Google Scholar
• Qin X, Zhu B, Jiang T, et al. miR-17-5p regulates heterotopic ossification by targeting ankh in ankylosing spondylitis. Mol Ther Nucleic Acids. 2019;18:696–707.
   PubMedGoogle Scholar
• Ma S, Wang DD, Ma CY, et.al. microRNA-96 promotes osteoblast differentiation and bone formation in ankylosing spondylitis mice through activating the wnt signaling pathway by binding to SOST. J Cell Biochem. 2019;120(9):15429–15442.
   PubMed Web of Science ®Google Scholar
• Yang W, Zhao S, Wu B, et al. BATF2 inhibits chemotherapy resistance by suppressing AP-1 in vincristine-resistant gastric cancer cells. Cancer Chemother Pharmacol. 2019;84(6):1279–1288.
   PubMed Web of Science ®Google Scholar
• Liu Z, Wei P, Yang Y, et al. BATF2 deficiency promotes progression in human colorectal cancer via activation of HGF/MET signaling: a potential rationale for combining MET inhibitors with IFNs. Clin Cancer Res off J Am Assoc Cancer Res. 2015;21(7):1752–1763.
   PubMed Web of Science ®Google Scholar
• Feng X, Yang Q, Wang C, et al. Punicalagin exerts protective effects against ankylosing spondylitis by regulating NF-kappaB-TH17/JAK2/STAT3 signaling and oxidative stress. Biomed Res Int. 2020;2020:4918239.
   PubMed Web of Science ®Google Scholar
• Kanemaru H, Yamane F, Tanaka H, et al. BATF2 activates DUSP2 gene expression and up-regulates NF-κB activity via phospho-STAT3 dephosphorylation. Int Immunol. 2018;30(6):255–265.
   PubMed Web of Science ®Google Scholar
• Ghoreschi K, Laurence A, O’Shea JJ. Janus kinases in immune cell signaling. Immunol Rev. 2009;228(1):273–287.
   PubMed Web of Science ®Google Scholar
• Li J. JAK-STAT and bone metabolism. JAKSTAT. 2013;2(3):e23930.
   PubMedGoogle Scholar
• van der Heijde D, Deodhar A, Wei JC, et al. Tofacitinib in patients with ankylosing spondylitis: a phase II, 16-week, randomised, placebo-controlled, dose-ranging study. Ann Rheum Dis. 2017;76(8):1340–1347.
   PubMed Web of Science ®Google Scholar