Inhibition of translocator protein 18 kDa suppressed the progression of glioma via the ELAV-like RNA-binding protein 1/MAPK-activated protein kinase 3 axis

References

• Babu D, Mudiraj A, Yadav N, et al. Rabeprazole has efficacy per se and reduces resistance to temozolomide in glioma via EMT inhibition. Cellular Oncology. 2021;44(4):889–905.
   Web of Science ®Google Scholar
• Ren P, Wang J, Li L, et al. Identification of key genes involved in the recurrence of glioblastoma multiforme using weighted gene co-expression network analysis and differential expression analysis. Bioengineered. 2021;12(1):3188–3200.
   PubMed Web of Science ®Google Scholar
• Holland EC. Glioblastoma multiforme: the terminator. Proc Natl Acad Sci U S A. 2000;97(12):6242–6244.
   PubMed Web of Science ®Google Scholar
• Veenman L, Gavish M, Kugler W. Apoptosis induction by erucylphosphohomocholine via the 18 kDa mitochondrial translocator protein: implications for cancer treatment. Anticancer Agents Med Chem. 2014;14(4):559–577
   Google Scholar
• Papadopoulos V, Baraldi M, Guilarte TR, et al. Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci. 2006;27(8):402–409.
   PubMed Web of Science ®Google Scholar
• Ren P, Ma L, Wang J-Y, et al. Anxiolytic and Anti-depressive Like Effects of Translocator Protein (18 kDa) Ligand YL-IPA08 in a Rat Model of Postpartum Depression. Neurochem Res. 2020;45(8):1746–1757.
   PubMed Web of Science ®Google Scholar
• Bouyer G, Cueff A, Egée S, et al. Erythrocyte peripheral type benzodiazepine receptor/voltage-dependent anion channels are upregulated by Plasmodium falciparum. Blood. 2011;118(8):2305–2312.
   PubMed Web of Science ®Google Scholar
• Scarf AM, Kassiou M. The translocator protein. J Nucl Med. 2011;52(5):677–680.
   PubMed Web of Science ®Google Scholar
• Cai L, Kirchleitner SV, Zhao D, et al. Glioblastoma exhibits inter-individual heterogeneity of TSPO and LAT1 expression in neoplastic and parenchymal cells. Int J Mol Sci. 2020;21(2):612.
   PubMed Web of Science ®Google Scholar
• Yasin N, Veenman L, Singh S, et al. Classical and novel TSPO ligands for the mitochondrial TSPO can modulate nuclear gene expression: implications for mitochondrial retrograde signaling. Int J Mol Sci. 2017;18(4):786.
   PubMed Web of Science ®Google Scholar
• Veenman L, Papadopoulos V, Gavish M. Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response. Curr Pharm Des. 2007;13(23):2385–2405.
   PubMed Web of Science ®Google Scholar
• Hinman MN, Lou H. Diverse molecular functions of Hu proteins. Cell Mol Life Sci. 2008;65(20):3168–3181.
   PubMed Web of Science ®Google Scholar
• Wang W, Fan J, Yang X, et al. AMP-activated kinase regulates cytoplasmic HuR. Mol Cell Biol. 2002;22(10):3425–3436.
   PubMed Web of Science ®Google Scholar
• Wang J, Hjelmeland AB, Nabors LB, et al. Anti-cancer effects of the HuR inhibitor, MS-444, in malignant glioma cells. Cancer Biol Ther. 2019;20(7):979–988.
   PubMed Web of Science ®Google Scholar
• Uren PJ, Vo DT, de Araujo PR, et al. RNA-binding protein Musashi1 is a central regulator of adhesion pathways in glioblastoma. Mol Cell Biol. 2015;35(17):2965–2978.
   PubMed Web of Science ®Google Scholar
• Velasco MX, Kosti A, Penalva LOF, et al. The diverse roles of RNA-binding proteins in glioma development. Adv Exp Med Biol. 2019;1157:29–39.
   PubMed Web of Science ®Google Scholar
• Guo Y-J, Pan -W-W, Liu S-B, et al. ERK/MAPK signalling pathway and tumorigenesis. Exp Ther Med. 2020;19(3):1997–2007.
   PubMed Web of Science ®Google Scholar
• Wei Y, An Z, Zou Z, et al. The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation. eLife. 2015;4:e05289.
   PubMed Web of Science ®Google Scholar
• Chen X, Hao A, Li X, et al. Activation of JNK and p38 MAPK mediated by ZDHHC17 drives glioblastoma multiforme development and malignant progression. Theranostics. 2020;10(3):998–1015.
   PubMed Web of Science ®Google Scholar
• Pandey V, Bhaskara VK, Babu PP. Implications of mitogen-activated protein kinase signaling in glioma. J Neurosci Res. 2016;94(2):114–127.
   PubMed Web of Science ®Google Scholar
• Daniel P, Filiz G, Brown DV, et al. Selective CREB-dependent cyclin expression mediated by the PI3K and MAPK pathways supports glioma cell proliferation. Oncogenesis. 2014;3(6):e108.
   PubMedGoogle Scholar
• Zhou P, Li B, Liu F, et al. The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer. Mol Cancer. 2017;16(1):52.
   PubMed Web of Science ®Google Scholar
• Colquhoun A. Cell biology-metabolic crosstalk in glioma. Int J Biochem Cell Biol. 2017;89:171–181.
   PubMed Web of Science ®Google Scholar
• Zinnhardt B, Roncaroli F, Foray C, et al. Imaging of the glioma microenvironment by TSPO PET. Eur J Nucl Med Mol Imaging. 2021;49(1):174–185.
   PubMed Web of Science ®Google Scholar
• Ammer L-M, Vollmann-Zwerenz A, Ruf V, et al. The role of translocator protein TSPO in hallmarks of glioblastoma. Cancers (Basel). 2020;12(10):2973.
   PubMed Web of Science ®Google Scholar
• Rechichi M, Salvetti A, Chelli B, et al. TSPO over-expression increases motility, transmigration and proliferation properties of C6 rat glioma cells. Biochim Biophys Acta. 2008;1782(2):118–125.
   PubMed Web of Science ®Google Scholar
• Gao Z-W, Huang -Y-Y, Zhang J-Q, et al. Paeoniflorin elicits the anti-proliferative effects on glioma cell via targeting translocator protein 18 KDa. J Pharmacol Sci. 2021;145(1):115–121.
   PubMed Web of Science ®Google Scholar
• Reichardt LF. Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci. 2006;361(1473):1545–1564.
   PubMed Web of Science ®Google Scholar
• Finkbeiner S, Tavazoie SF, Maloratsky A, et al. CREB: a major mediator of neuronal neurotrophin responses. Neuron. 1997;19(5):1031–1047.
   PubMed Web of Science ®Google Scholar
• Zhao N, Zhang J, Zhao L, et al. Long noncoding RNA NONHSAT079852.2 Contributes to GBM Recurrence by Functioning as a ceRNA for has-mir-10401-3p to Facilitate HSPA1A Upregulation. Front Oncol. 2021;11:636632.
   PubMed Web of Science ®Google Scholar
• McCubrey JA, Steelman LS, Chappell WH, et al. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta. 2007;1773(8):1263–1284.
   PubMed Web of Science ®Google Scholar
• Cai Q-H, Tang Y, Fan S-H, et al. In vivo effects of dexmedetomidine on immune function and tumor growth in rats with ovarian cancer through inhibiting the p38MAPK/NF-κB signaling pathway. Biomed Pharmacother. 2017;95:1830–1837.
   PubMed Web of Science ®Google Scholar
• Denkert C, Koch I, Berger S, et al. Cytokine-suppressive anti-inflammatory drugs (CSAIDs) inhibit invasion and MMP-1 production of ovarian carcinoma cells. Cancer Lett. 2003;195(1):101–109.
   PubMed Web of Science ®Google Scholar
• Wu L-P, Gong Z-F, Wang H, et al. TSPO ligands prevent the proliferation of vascular smooth muscle cells and attenuate neointima formation through AMPK activation. Acta Pharmacol Sin. 2020;41(1):34–46.
   PubMed Web of Science ®Google Scholar
• Li X-M, Meng J, Li LT, et al. Effect of ZBD-2 on chronic pain, depressive-like behaviors, and recovery of motor function following spinal cord injury in mice. Behav Brain Res. 2017;322(A):92–99.
   PubMedGoogle Scholar
• Wu M, Tong CWS, Yan W, et al. The RNA binding protein HuR: a promising drug target for anticancer therapy. Curr Cancer Drug Targets. 2019;19(5):382–399.
   PubMed Web of Science ®Google Scholar
• Srikantan S. HuR function in disease. Front Biosci (Landmark Ed). 2012;17(1):189–205.
   PubMed Web of Science ®Google Scholar