Long non-coding RNA MIR4435-2HG/microRNA-125a-5p axis is involved in myocardial ischemic injuries

References

• World Health Organization. WHO | cardiovascular diseases (CVDs). 2017 May 17. Available from: http://wwwwhoint/mediacentre/factsheets/fs317/en/
   Google Scholar
• Neri M, Riezzo I, Pascale N, et al. Ischemia/reperfusion injury following acute myocardial infarction: a critical issue for clinicians and forensic pathologists. Mediators Inflamm. 2017;2017:7018393.
   PubMed Web of Science ®Google Scholar
• Gerczuk PZ, Kloner RA. An update on cardioprotection: a review of the latest adjunctive therapies to limit myocardial infarction size in clinical trials. J Am Coll Cardiol. 2012 Mar 13;59(11):969–978.
   PubMed Web of Science ®Google Scholar
• Wernly JA. Ischemia, reperfusion, and the role of surgery in the treatment of cardiogenic shock secondary to acute myocardial infarction: an interpretative review. J Surg Res. 2004 Mar;117(1):6–21.
   PubMed Web of Science ®Google Scholar
• Li SY, Li ZX, He ZG, et al. Quantitative proteomics reveal the alterations in the spinal cord after myocardial ischemiareperfusion injury in rats. Int J Mol Med. 2019 Nov;44(5):1877–1887.
   PubMed Web of Science ®Google Scholar
• Lazou A, Iliodromitis EK, Cieslak D, et al. Ischemic but not mechanical preconditioning attenuates ischemia/reperfusion induced myocardial apoptosis in anaesthetized rabbits: the role of Bcl-2 family proteins and ERK1/2. Apoptosis. 2006 Dec;11(12):2195–2204.
   PubMed Web of Science ®Google Scholar
• McCully JD, Wakiyama H, Hsieh YJ, et al. Differential contribution of necrosis and apoptosis in myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2004 May;286(5):H1923–35.
   PubMed Web of Science ®Google Scholar
• Krol J, Loedige I, Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet. 2010 Sep;11(9):597–610.
   PubMed Web of Science ®Google Scholar
• Karbasforooshan H, Roohbakhsh A, Karimi G. SIRT1 and microRNAs: the role in breast, lung and prostate cancers. Exp Cell Res. 2018 Jun 1;367(1):1–6.
   PubMed Web of Science ®Google Scholar
• Young RS, Ponting CP. Identification and function of long non-coding RNAs. Essays Biochem. 2013;54:113–126.
   PubMed Web of Science ®Google Scholar
• Kaikkonen MU, Lam MT, Glass CK. Non-coding RNAs as regulators of gene expression and epigenetics. Cardiovasc Res. 2011 Jun 1;90(3):430–440.
   PubMed Web of Science ®Google Scholar
• Djebali S, Davis CA, Merkel A, et al. Landscape of transcription in human cells. Nature. 2012 Sep 6;489(7414):101–108.
   PubMed Web of Science ®Google Scholar
• Klattenhoff CA, Scheuermann JC, Surface LE, et al. Braveheart, a long noncoding RNA required for cardiovascular lineage commitment. Cell. 2013 Jan 31;152(3):570–583.
   PubMed Web of Science ®Google Scholar
• Ju C, Zhou R, Sun J, et al. LncRNA SNHG5 promotes the progression of osteosarcoma by sponging the miR-212-3p/SGK3 axis. Cancer Cell Int. 2018;18:141.
   PubMed Web of Science ®Google Scholar
• Wang GK, Zhu JQ, Zhang JT, et al. Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. Eur Heart J. 2010 Mar;31(6):659–666.
   PubMed Web of Science ®Google Scholar
• Wang X, Yuan B, Cheng B, et al. Crocin alleviates myocardial ischemia/reperfusion-induced endoplasmic reticulum stress via regulation of miR-34a/Sirt1/Nrf2 pathway. Shock. 2019;51(1):123–130.
   PubMed Web of Science ®Google Scholar
• Huarte M. The emerging role of lncRNAs in cancer. Nat Med. 2015 Nov;21(11):1253–1261.
   PubMed Web of Science ®Google Scholar
• Uchida S, Dimmeler S. Long noncoding RNAs in cardiovascular diseases. Circ Res. 2015 Feb 13;116(4):737–750.
   PubMed Web of Science ®Google Scholar
• Briggs JA, Wolvetang EJ, Mattick JS, et al. Mechanisms of long non-coding RNAs in mammalian nervous system development, plasticity, disease, and evolution. Neuron. 2015 Dec 2;88(5):861–877.
   PubMed Web of Science ®Google Scholar
• Lee JT. Epigenetic regulation by long noncoding RNAs. Science. 2012 Dec 14;338(6113):1435–1439.
   PubMed Web of Science ®Google Scholar
• Zhang S, Li C, Liu J, et al. Fusobacterium nucleatum promotes epithelial-mesenchymal transiton through regulation of the lncRNA MIR4435-2HG/miR-296-5p/Akt2/SNAI1 signaling pathway. FEBS J. 2020 Jan 29;287(18):4032–4047.
   PubMed Web of Science ®Google Scholar
• Xu H, Zhang B, Yang Y, et al. LncRNA MIR4435-2HG potentiates the proliferation and invasion of glioblastoma cells via modulating miR-1224-5p/TGFBR2 axis. J Cell Mol Med 2020 Jun;24(11):6362-6372.
   Web of Science ®Google Scholar
• Dong X, Yang Z, Yang H, et al. Long non-coding RNA MIR4435-2HG promotes colorectal cancer proliferation and metastasis through miR-206/YAP1 axis. Front Oncol. 2020;10:160.
   PubMed Web of Science ®Google Scholar
• Yang M, He X, Huang X, et al. LncRNA MIR4435-2HG-mediated upregulation of TGF-beta1 promotes migration and proliferation of nonsmall cell lung cancer cells. Environ Toxicol. 2020 May;35(5):582–590.
   PubMed Web of Science ®Google Scholar
• Zhang H, Meng H, Huang X, et al. lncRNA MIR4435-2HG promotes cancer cell migration and invasion in prostate carcinoma by upregulating TGF-beta1. Oncol Lett. 2019 Oct;18(4):4016–4021.
   PubMed Web of Science ®Google Scholar
• Khalyfa A, Kheirandish-Gozal L, Bhattacharjee R, et al. Circulating microRNAs as potential biomarkers of endothelial dysfunction in obese children. Chest. 2016 Mar;149(3):786–800.
   PubMed Web of Science ®Google Scholar
• Hendgen-Cotta UB, Messiha D, Esfeld S, et al. Inorganic nitrite modulates miRNA signatures in acute myocardial in vivo ischemia/reperfusion. Free Radic Res. 2017 Jan;51(1):91–102.
   PubMed Web of Science ®Google Scholar
• Morita M, Prudent J, Basu K, et al. mTOR controls mitochondrial dynamics and cell survival via MTFP1. Mol Cell. 2017 Sep 21;67(6):922–935 e5.
   PubMed Web of Science ®Google Scholar
• Aung LHH, Li R, Prabhakar BS, et al. Knockdown of Mtfp1 can minimize doxorubicin cardiotoxicity by inhibiting Dnm1l-mediated mitochondrial fission. J Cell Mol Med. 2017 Dec;21(12):3394–3404.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zeng Y, Wang M, et al. Cardiac-specific overexpression of E3 ligase Nrdp1 increases ischemia and reperfusion-induced cardiac injury. Basic Res Cardiol. 2011 May;106(3):371–383.
   PubMed Web of Science ®Google Scholar
• Li S, Wang X, Wang T, et al. Identification of the regulatory role of lncRNA HCG18 in myasthenia gravis by integrated bioinformatics and experimental analyses. J Transl Med. 2021 Nov 18;19(1):468.
   PubMed Web of Science ®Google Scholar
• Xin L, Wu Y, Liu C, et al. Exosome-mediated transfer of lncRNA HCG18 promotes M2 macrophage polarization in gastric cancer. Mol Immunol. 2021 Dec;140:196–205.
   PubMed Web of Science ®Google Scholar
• Clement T, Salone V, Rederstorff M. Dual luciferase gene reporter assays to study miRNA function. Methods Mol Biol. 2015;1296:187–198.
   PubMedGoogle Scholar
• Bugger H, Pfeil K. Mitochondrial ROS in myocardial ischemia reperfusion and remodeling. Biochim Biophys Acta Mol Basis Dis. 2020 Mar 12;1866(7):165768.
   PubMed Web of Science ®Google Scholar
• Garcia-Dorado D, Ruiz-Meana M, Inserte J, et al. Calcium-mediated cell death during myocardial reperfusion. Cardiovasc Res. 2012 May 1;94(2):168–180.
   PubMed Web of Science ®Google Scholar
• Chouchani ET, Pell VR, Gaude E, et al. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature. 2014 Nov 20;515(7527):431–435.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Sinovas A, Abdallah Y, Piper HM, et al. Reperfusion injury as a therapeutic challenge in patients with acute myocardial infarction. Heart Fail Rev. 2007 Dec;12(3–4):207–216.
   PubMed Web of Science ®Google Scholar
• Harisseh R, Abrial M, Chiari P, et al. A modified calcium retention capacity assay clarifies the roles of extra- and intracellular calcium pools in mitochondrial permeability transition pore opening. J Biol Chem. 2019 Oct 18;294(42):15282–15292.
   PubMed Web of Science ®Google Scholar
• Whelan RS, Kaplinskiy V, Kitsis RN. Cell death in the pathogenesis of heart disease: mechanisms and significance. Annu Rev Physiol. 2010;72:19–44.
   PubMed Web of Science ®Google Scholar
• Holly TA, Drincic A, Byun Y, et al. Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo. J Mol Cell Cardiol. 1999 Sep;31(9):1709–1715.
   PubMed Web of Science ®Google Scholar
• Beermann J, Piccoli MT, Viereck J, et al. Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches. Physiol Rev. 2016 Oct;96(4):1297–1325.
   PubMed Web of Science ®Google Scholar
• Zhang J, Gao C, Meng M, et al. Long noncoding RNA MHRT protects cardiomyocytes against H2O2-induced apoptosis. Biomol Ther (Seoul). 2016 Jan;24(1):19–24.
   PubMed Web of Science ®Google Scholar
• Yan Y, Zhang B, Liu N, et al. Circulating long noncoding RNA UCA1 as a novel biomarker of acute myocardial infarction. Biomed Res Int. 2016;2016:8079372.
   PubMed Web of Science ®Google Scholar
• Xia Q, Wang Q, Lin F, et al. miR-125a-5p-abundant exosomes derived from mesenchymal stem cells suppress chondrocyte degeneration via targeting E2F2 in traumatic osteoarthritis. Bioengineered. 2021 Dec;12(2):11225–11238.
   PubMed Web of Science ®Google Scholar