MicroRNA miR-124-3p suppresses proliferation and epithelial–mesenchymal transition of hepatocellular carcinoma via ARRDC1 (arrestin domain containing 1)

References

• Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87–108.
   PubMed Web of Science ®Google Scholar
• Chen Q, Shu C, Laurence AD, et al. Effect of Huaier granule on recurrence after curative resection of HCC: a multicentre, randomised clinical trial. Gut. 2018;67(11):2006–2016.
   PubMed Web of Science ®Google Scholar
• Serper M, Taddei TH, Mehta R, et al. Association of provider specialty and multidisciplinary care with hepatocellular carcinoma treatment and mortality. Gastroenterology. 2017;152(8):1954–1964.
   PubMed Web of Science ®Google Scholar
• Kim J, Kang W, Sinn DH, et al. Substantial risk of recurrence even after 5 recurrence-free years in early-stage hepatocellular carcinoma patients. Clin Mol Hepatol. 2020;26(4):516–528.
   PubMed Web of Science ®Google Scholar
• Garzon R, Marcucci G, Croce CM. Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov. 2010;9(10):775–789.
   PubMed Web of Science ®Google Scholar
• Rupaimoole R, Slack FJ. MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov. 2017;16(3):203–222.
   PubMed Web of Science ®Google Scholar
• Li Y, Bai W, Zhang J. MiR-200c-5p suppresses proliferation and metastasis of human hepatocellular carcinoma (HCC) via suppressing MAD2L1. Biomed Pharmacother. 2017;92:1038–1044.
   PubMed Web of Science ®Google Scholar
• Hayes CN, Chayama K. MicroRNAs as biomarkers for liver disease and hepatocellular carcinoma. Int J Mol Sci. 2016;17(3):280.
   PubMed Web of Science ®Google Scholar
• Khare S, Zhang Q, Ibdah JA. Epigenetics of hepatocellular carcinoma: role of microRNA. World J Gastroenterol. 2013;19(33):5439–5445.
   PubMed Web of Science ®Google Scholar
• Ge X, Guo M, Hu T, et al. Increased microglial exosomal miR-124-3p alleviates neurodegeneration and improves cognitive outcome after rmTBI. Mol Ther. 2020;28(2):503–522.
   PubMed Web of Science ®Google Scholar
• Deng D, Luo K, Liu H, et al. p62 acts as an oncogene and is targeted by miR-124-3p in glioma. Cancer Cell Int. 2019;19:280.
   PubMed Web of Science ®Google Scholar
• Margolin-Miller Y, Yanichkin N, Shichrur K, et al. Prognostic relevance of miR-124-3p and its target TP53INP1 in pediatric ependymoma. Genes Chromosomes Cancer. 2017;56(8):639–650.
   PubMed Web of Science ®Google Scholar
• Yan G, Li Y, Zhan L, et al. Decreased miR-124-3p promoted breast cancer proliferation and metastasis by targeting MGAT5. Am J Cancer Res. 2019;9(3):585–596.
   PubMed Web of Science ®Google Scholar
• Yang W, Cui G, Ding M, et al. MicroRNA-124-3p.1 promotes cell proliferation through Axin1-dependent Wnt signaling pathway and predicts a poor prognosis of triple-negative breast cancer. J Clin Lab Anal. 2020;34(7):e23266.
   PubMed Web of Science ®Google Scholar
• Wang H, Mao J, Huang Y, et al. Prognostic roles of miR-124-3p and its target ANXA7 and their effects on cell migration and invasion in hepatocellular carcinoma. Int J Clin Exp Pathol. 2020;13(3):357–370.
   PubMed Web of Science ®Google Scholar
• Dongre A, Weinberg RA. New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. Nat Rev Mol Cell Biol. 2019;20(2):69–84.
   PubMed Web of Science ®Google Scholar
• Du B, Shim JS. Targeting Epithelial-Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer. Molecules. 2016;21(7):965.
   PubMed Web of Science ®Google Scholar
• Xia P, Xu XY. Epithelial-mesenchymal transition and gastric cancer stem cell. Tumour Biol. 2017;39(5):1010428317698373.
   Google Scholar
• Wang R, Yu Z, Chen F, et al. miR-300 regulates the epithelial-mesenchymal transition and invasion of hepatocellular carcinoma by targeting the FAK/PI3K/AKT signaling pathway. Biomed Pharmacother. 2018;103:1632–1642.
   PubMed Web of Science ®Google Scholar
• Zheng L, Xu M, Xu J, et al. ELF3 promotes epithelial-mesenchymal transition by protecting ZEB1 from miR-141-3p-mediated silencing in hepatocellular carcinoma. Cell Death Dis. 2018;9(3):387.
   PubMedGoogle Scholar
• Tian X, Irannejad R, Bowman SL, et al. The α-Arrestin ARRDC3 regulates the endosomal residence time and intracellular signaling of the β2-adrenergic receptor. J Biol Chem. 2016;291(28):14510–14525.
   PubMed Web of Science ®Google Scholar
• Zhang C, Yu Y, Huang Q, et al. SIRT6 regulates the proliferation and apoptosis of hepatocellular carcinoma via the ERK1/2 signaling pathway. Mol Med Rep. 2019;20(2):1575–1582.
   PubMed Web of Science ®Google Scholar
• Wang J, Li Y, Ma Q, et al. miR‑378 in combination with ultrasonic irradiation and SonoVue microbubbles transfection inhibits hepatoma cell growth. Mol Med Rep. 2020;21(6):2493–2501.
   PubMed Web of Science ®Google Scholar
• Hu Z, Luo D, Wang D, et al. IL-17 activates the IL-6/STAT3 signal pathway in the proliferation of hepatitis B virus-related hepatocellular carcinoma. Cell Physiol Biochem. 2017;43(6):2379–2390.
   PubMedGoogle Scholar
• Liu Z, Yu Y, Huang Z, et al. CircRNA-5692 inhibits the progression of hepatocellular carcinoma by sponging miR-328-5p to enhance DAB2IP expression. Cell Death Dis. 2019;10(12):900.
   PubMed Web of Science ®Google Scholar
• Wang J, He H, Jiang Q, et al. CBX6 promotes HCC metastasis via transcription factors Snail/Zeb1-mediated EMT mechanism. Onco Targets Ther. 2020;13:12489–12500.
   PubMed Web of Science ®Google Scholar
• Chen Y, Peng C, Chen J, et al. WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1. Mol Cancer. 2019;18(1):127.
   PubMed Web of Science ®Google Scholar
• Wang L, Long H, Zheng Q, et al. Circular RNA circRHOT1 promotes hepatocellular carcinoma progression by initiation of NR2F6 expression. Mol Cancer. 2019;18(1):119.
   PubMed Web of Science ®Google Scholar
• Chen Z, Xie H, Hu M, et al. Recent progress in treatment of hepatocellular carcinoma. Am J Cancer Res. 2020;10(9):2993–3036.
   PubMed Web of Science ®Google Scholar
• Hai B, Pan X, Du C, et al. LncRNA XIST promotes growth of human chordoma cells by regulating miR-124-3p/iASPP pathway. Onco Targets Ther. 2020;13:4755–4765.
   PubMedGoogle Scholar
• Deng X, Chen Y, Liu Z, et al. MiR-124-3p.1 sensitizes ovarian cancer cells to mitochondrial apoptosis induced by carboplatin. Onco Targets Ther. 2020;13:5375–5386.
   PubMed Web of Science ®Google Scholar
• Feo F, Pascale RM. Multifocal hepatocellular carcinoma: intrahepatic metastasis or multicentric carcinogenesis? Ann Transl Med. 2015;3(1):4.
   PubMedGoogle Scholar
• Wang B, Xia C-Y, Lau W-Y, et al. Determination of clonal origin of recurrent hepatocellular carcinoma for personalized therapy and outcomes evaluation: a new strategy for hepatic surgery. J Am Coll Surg. 2013;217(6):1054–1062.
   PubMed Web of Science ®Google Scholar
• Portolani N, Coniglio A, Ghidoni S, et al. Early and late recurrence after liver resection for hepatocellular carcinoma: prognostic and therapeutic implications. Ann Surg. 2006;243(2):229–235.
   PubMed Web of Science ®Google Scholar
• Tang ZY. Hepatocellular carcinoma–cause, treatment and metastasis. World J Gastroenterol. 2001;7(4):445–454.
   PubMed Web of Science ®Google Scholar
• Saitoh M. Involvement of partial EMT in cancer progression. J Biochem. 2018;164(4):257–264.
   PubMed Web of Science ®Google Scholar
• Giannelli G, Koudelkova P, Dituri F, et al. Role of epithelial to mesenchymal transition in hepatocellular carcinoma. J Hepatol. 2016;65(4):798–808.
   PubMed Web of Science ®Google Scholar
• Chao J, Zhao S, Sun H. Dedifferentiation of hepatocellular carcinoma: molecular mechanisms and therapeutic implications. Am J Transl Res. 2020;12(5):2099–2109.
   PubMed Web of Science ®Google Scholar
• Shukla V, Adiga D, Jishnu PV, et al. Role of miRNA clusters in epithelial to mesenchymal transition in cancer. Front Biosci (Elite Ed). 2020;12:48–78.
   Google Scholar
• Xiao J, Shi Q, Li W, et al. ARRDC1 and ARRDC3 act as tumor suppressors in renal cell carcinoma by facilitating YAP1 degradation. Am J Cancer Res. 2018;8(1):132–143.
   PubMed Web of Science ®Google Scholar
• Hou PP, Luo L-J, Chen H-Z, et al. Ectosomal PKM2 promotes HCC by inducing macrophage differentiation and remodeling the tumor microenvironment. Mol Cell. 2020;78(6):1192–1206.e10.
   PubMed Web of Science ®Google Scholar