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Research Paper

Kukoamine A attenuates lipopolysaccharide-induced apoptosis, extracellular matrix degradation, and inflammation in nucleus pulposus cells by activating the P13K/Akt pathway

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Pages 8772-8784 | Received 07 Dec 2021, Accepted 05 Mar 2022, Published online: 25 Mar 2022

References

  • Wang Y, Che M, Xin J, et al. The role of IL-1beta and TNF-alpha in intervertebral disc degeneration. Biomed Pharmacother. 2020;131:110660.
  • Che Z, Xueqin J, Zhang Z. LncRNA OIP5-AS1 accelerates intervertebral disc degeneration by targeting miR-25-3p. Bioengineered. 2021;12:11201–11212.
  • Risbud MV, Shapiro IM. Role of cytokines in intervertebral disc degeneration: pain and disc content. Nat Rev Rheumatol. 2014;10:44–56.
  • Schwarzer AC, Aprill CN, Derby R, et al. The prevalence and clinical features of internal disc disruption in patients with chronic low back pain. Spine (Phila Pa 1976). 1995;20:1878–1883.
  • Koes BW, van Tulder MW, Peul WC. Diagnosis and treatment of sciatica. BMJ. 2007;334:1313–1317.
  • Clouet J, Vinatier C, Merceron C, et al. The intervertebral disc: from pathophysiology to tissue engineering. Joint Bone Spine. 2009;76:614–618.
  • Urban JP, Roberts S. Degeneration of the intervertebral disc. Arthritis Res Ther. 2003;5:120–130.
  • Hadjipavlou AG, Tzermiadianos MN, Bogduk N, et al. The pathophysiology of disc degeneration: a critical review. J Bone Joint Surg Br. 2008;90:1261–1270.
  • Molinos M, Almeida CR, Caldeira J, et al. Inflammation in intervertebral disc degeneration and regeneration. J R Soc Interface. 2015;12:20141191.
  • Vergroesen PP, Kingma I, Emanuel KS, et al. Mechanics and biology in intervertebral disc degeneration: a vicious circle. Osteoarthritis Cartilage. 2015;23:1057–1070.
  • Zhu C, Jiang W, Cheng Q, et al. Hemeoxygenase-1 suppresses IL-1beta-induced apoptosis through the NF-kappaB pathway in human degenerative nucleus pulposus cells. Cell Physiol Biochem. 2018;46:644–653.
  • Hughes SP, Freemont AJ, Hukins DW, et al. The pathogenesis of degeneration of the intervertebral disc and emerging therapies in the management of back pain. J Bone Joint Surg Br. 2012;94:1298–1304.
  • Li G, Zhou F, Chen Y, et al. Kukoamine A attenuates insulin resistance and fatty liver through downregulation of Srebp-1c. Biomed Pharmacother. 2017;89:536–543.
  • Hu X-L, Gao L-Y, Niu Y-X, et al. Neuroprotection by Kukoamine A against oxidative stress may involve N-methyl-D-aspartate receptors. Biochim Biophys Acta. 2015;1850(2):287–298.
  • Zhang Y, Cheng Z, Wang C, et al. Neuroprotective effects of kukoamine a against radiation-induced rat brain injury through inhibition of oxidative stress and neuronal apoptosis. Neurochem Res. 2016;41:2549–2558.
  • Uko NE, Guner OF, Matesic DF, et al. Akt pathway inhibitors. Curr Top Med Chem. 2020;20:883–900.
  • Bao L, Yan Y, Xu C, et al. MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways. Cancer Lett. 2013;337:226–236.
  • Ouyang ZH, Wang WJ, Yan YG, et al. The PI3K/Akt pathway: a critical player in intervertebral disc degeneration. Oncotarget. 2017;8:57870–57881.
  • Tan Y, Yao X, Dai Z, et al. Bone morphogenetic protein 2 alleviated intervertebral disc degeneration through mediating the degradation of ECM and apoptosis of nucleus pulposus cells via the PI3K/Akt pathway. Int J Mol Med. 2019;43:583–592.
  • Liu W, Niu F, Sha H, et al. Apelin-13/APJ system delays intervertebral disc degeneration by activating the PI3K/AKT signaling pathway. Eur Rev Med Pharmacol Sci. 2020;24:2820–2828.
  • Yang Y, Gao L, Niu Y, et al. Kukoamine A protects against NMDA-induced neurotoxicity accompanied with down-regulation of GluN2B-Containing NMDA receptors and phosphorylation of PI3K/Akt/GSK-3beta signaling pathway in cultured primary cortical neurons. Neurochem Res. 2020;45:2703–2711.
  • Zhang Y, Yang J, Zhou X, et al. Knockdown of miR-222 inhibits inflammation and the apoptosis of LPS-stimulated human intervertebral disc nucleus pulposus cells. Int J Mol Med. 2019;44:1357–1365.
  • Liu Y, Zheng J, Chen Y, et al. Shikonin protects against lipopolysaccharide-induced inflammation and apoptosis in human nucleus pulposus cells through the nuclear factor-kappa B pathway. Food Sci Nutr. 2021;9:5583–5589.
  • Zhang Y, He F, Chen Z, et al. Melatonin modulates IL-1β-induced extracellular matrix remodeling in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration and inflammation. Aging (Albany NY). 2019;11:10499–10512.
  • Zhu X, Liu S, Cao Z, et al. Higenamine mitigates interleukin-1β-induced human nucleus pulposus cell apoptosis by ROS-mediated PI3K/Akt signaling. Mol Cell Biochem. 2021;476:3889–3897.
  • Priyadarshani P, Li Y, Yao L. Advances in biological therapy for nucleus pulposus regeneration. Osteoarthritis Cartilage. 2016;24:206–212.
  • Urban JP, Smith S, Fairbank JC. Nutrition of the intervertebral disc. Spine (Phila Pa 1976). 2004;29:2700–2709.
  • Wang D, Hu Z, Hao J, et al. SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway. Age (Dordr). 2013;35:1741–1753.
  • Liu J, Jiang X, Zhang Q, et al. Neuroprotective effects of Kukoamine A against cerebral ischemia via antioxidant and inactivation of apoptosis pathway. Neurochem Int. 2017;107:191–197.
  • Hu X, Song Q, Li X, et al. Neuroprotective effects of Kukoamine A on neurotoxin-induced Parkinson’s model through apoptosis inhibition and autophagy enhancement. Neuropharmacology. 2017;117:352–363.
  • Zhong H, Zhou Z, Guo L, et al. The miR-623/CXCL12 axis inhibits LPS-induced nucleus pulposus cell apoptosis and senescence. Mech Ageing Dev. 2021;194:111417.
  • Bibby SR, Jones DA, Lee RB, et al. The pathophysiology of the intervertebral disc. Joint Bone Spine. 2001;68:537–542.
  • Weiler C, Nerlich AG, Zipperer J, et al. 2002 SSE award competition in basic science: expression of major matrix metalloproteinases is associated with intervertebral disc degradation and resorption. Eur Spine J. 2002;11:308–320.
  • Vo NV, Hartman RA, Yurube T, et al. Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration. Spine J. 2013;13:331–341.
  • Roughley PJ, Melching LI, Heathfield TF, et al. The structure and degradation of aggrecan in human intervertebral disc. Eur Spine J. 2006;15(Suppl 3):S326–332.
  • Antoniou J, Steffen T, Nelson F, et al. The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration. J Clin Invest. 1996;98:996–1003.
  • Menon VP, Sudheer AR. Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol. 2007;595:105–125.
  • Carter DR, Wong M. Modelling cartilage mechanobiology. Philos Trans R Soc Lond B Biol Sci. 2003;358:1461–1471.
  • Holguin N, Uzer G, Chiang FP, et al. Brief daily exposure to low-intensity vibration mitigates the degradation of the intervertebral disc in a frequency-specific manner. J Appl Physiol. 2011;111:1846–1853. (1985).
  • Burke JG, Rw GW, Conhyea D, et al. Human nucleus pulposis can respond to a pro-inflammatory stimulus. Spine (Phila Pa 1976). 2003;28:2685–2693.
  • Sun X, Chen L, He Z. PI3K/Akt-Nrf2 and anti-inflammation effect of macrolides in chronic obstructive pulmonary disease. Curr Drug Metab. 2019;20:301–304.
  • Cheng CC, Uchiyama Y, Hiyama A, et al. PI3K/AKT regulates aggrecan gene expression by modulating Sox9 expression and activity in nucleus pulposus cells of the intervertebral disc. J Cell Physiol. 2009;221:668–676.