Mesenchymal stem cells inhibited the apoptosis of alveolar epithelial cells caused by ARDS through CXCL12/CXCR4 axis

References

• Fan E, Brodie D, Slutsky A. Acute respiratory distress syndrome: advances in diagnosis and treatment. Jama. 2018;319(7):698–710.
   PubMed Web of Science ®Google Scholar
• Rezoagli E, Fumagalli R, Bellani G. Definition and epidemiology of acute respiratory distress syndrome. Ann Transl Med. 2017;5(14):282.
   PubMed Web of Science ®Google Scholar
• Matthay MA, Zemans RL, Zimmerman GA, et al. Acute respiratory distress syndrome. Nat Rev Dis Primers. 2019;5(1):1–22.
   PubMed Web of Science ®Google Scholar
• Thompson BT, Chambers RC, Liu KD. Acute respiratory distress syndrome. N Engl J Med. 2017;377(6):562–572.
   PubMed Web of Science ®Google Scholar
• Beitler JR, Thompson BT, Baron RM, et al. Advancing precision medicine for acute respiratory distress syndrome. Lancet Respir Med. 2022;10(1):107–120.
   PubMed Web of Science ®Google Scholar
• Naji A, Favier B, Deschaseaux F, et al. Mesenchymal stem/stromal cell function in modulating cell death. Stem Cell Res Ther. 2019;10(1):56.
   PubMed Web of Science ®Google Scholar
• Moll G, Hoogduijn MJ, Ankrum JA. Safety, efficacy and mechanisms of action of mesenchymal stem cell therapies. Front Immunol. 2020;11:11.
   PubMed Web of Science ®Google Scholar
• Woodworth TG, Furst DE. Safety and feasibility of umbilical cord mesenchymal stem cells in treatment-refractory systemic lupus erythematosus nephritis: time for a double-blind placebo-controlled trial to determine efficacy. Arthritis Res Ther. 2014;16(4):113.
   PubMed Web of Science ®Google Scholar
• Bhonde RR, Sheshadri P, Sharma S, et al. Making surrogate β-cells from mesenchymal stromal cells: perspectives and future endeavors. Int J Biochem Cell Biol. 2014;46:90–102.
   PubMed Web of Science ®Google Scholar
• Ghannam S, Bouffi C, Djouad F, et al. Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications. Stem Cell Res Ther. 2010;1(1):2.
   PubMed Web of Science ®Google Scholar
• Dorronsoro A, Fernández-Rueda J, Fechter K, et al. Human mesenchymal stromal cell-mediated immunoregulation: mechanisms of action and clinical applications. Bone Marrow Res. 2013;2013:203643.
   PubMedGoogle Scholar
• Xu L, Gong Y, Wang B, et al. Randomized trial of autologous bone marrow mesenchymal stem cells transplantation for hepatitis B virus cirrhosis: regulation of Treg/Th17 cells. J Gastroenterol Hepatol. 2014;29(8):1620–1628.
   PubMed Web of Science ®Google Scholar
• Simonson OE, Mougiakakos D, Heldring N, et al. In vivo effects of mesenchymal stromal cells in two patients with severe acute respiratory distress syndrome. Stem Cells Transl Med. 2015;4(10):1199–1213.
   PubMed Web of Science ®Google Scholar
• Jackson MV, Morrison TJ, Doherty DF, et al. Mitochondrial transfer via tunneling nanotubes is an important mechanism by which mesenchymal stem cells enhance macrophage phagocytosis in the in vitro and in vivo models of ARDS. Stem Cells. 2016;34(8):2210–2223.
   PubMed Web of Science ®Google Scholar
• Wang X, Jiang B, Sun H, et al. Noninvasive application of mesenchymal stem cell spheres derived from hESC accelerates wound healing in a CXCL12-CXCR4 axis-dependent manner. Theranostics. 2019;9(21):6112.
   PubMed Web of Science ®Google Scholar
• Ding J, Cui X, Liu Q. Emerging role of HMGB1 in lung diseases: friend or foe. J Cell Mol Med. 2017;21(6):1046–1057.
   PubMed Web of Science ®Google Scholar
• Janssens R, Struyf S, Proost P. The unique structural and functional features of CXCL12. Cell Mol Immunol. 2018;15(4):299–311.
   PubMed Web of Science ®Google Scholar
• García-Cuesta EM, Santiago CA, Vallejo J, et al. The role of the CXCL12/CXCR4/ACKR3 axis in autoimmune diseases. Front Endocrinol (Lausanne). 2019;10:585.
   PubMed Web of Science ®Google Scholar
• Cheng KT, Xiong S, Ye Z, et al. Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury. J Clin Invest. 2017;127(11):4124–4135.
   PubMed Web of Science ®Google Scholar
• Pooladanda V, Thatikonda S, Bale S, et al. Nimbolide protects against endotoxin-induced acute respiratory distress syndrome by inhibiting TNF-α mediated NF-κB and HDAC-3 nuclear translocation. Cell Death Dis. 2019;10(2):1–17.
   Web of Science ®Google Scholar
• Ooppachai C, Limtrakul Dejkriengkraikul P, Yodkeeree S. Dicentrine potentiates TNF-α-induced apoptosis and suppresses invasion of A549 lung adenocarcinoma cells via modulation of NF-κB and AP-1 activation. Molecules. 2019;24(22):4100.
   PubMed Web of Science ®Google Scholar
• Patel MN, Carroll RG, Galván-Peña S, et al. Inflammasome priming in sterile inflammatory disease. Trends Mol Med. 2017;23(2):165–180.
   PubMed Web of Science ®Google Scholar
• Toussaint I. Alternative methods for killing laboratory animals: summary of a published advisory report by the Netherlands national Committee for the protection of animals used for scientific purposes and for education (NCad). Lab Anim. 2017;51(2):222–223.
   PubMed Web of Science ®Google Scholar
• Ding Q, Liu G, Zeng Y, et al. Glycogen synthase kinase‑3β inhibitor reduces LPS‑induced acute lung injury in mice. Mol Med Rep. 2017;16(5):6715–6721.
   PubMed Web of Science ®Google Scholar
• Islam D, Huang Y, Fanelli V, et al. Identification and modulation of microenvironment is crucial for effective mesenchymal stromal cell therapy in acute lung injury. Am J Respir Crit Care Med. 2019;199(10):1214–1224.
   PubMed Web of Science ®Google Scholar
• Su W, Wan Q, Huang J, et al. Culture medium from TNF-α–stimulated mesenchymal stem cells attenuates allergic conjunctivitis through multiple antiallergic mechanisms. J Allergy Clin Immunol. 2015;136(2):423–432. e8.
   PubMed Web of Science ®Google Scholar
• S J L, Lee RH, Gregory CA. Mechanisms of mesenchymal stem/stromal cell function. Stem Cell Res Ther. 2016;7(1):125.
   PubMed Web of Science ®Google Scholar
• Zhong Z, Umemura A, Sanchez-Lopez E, et al. NF-κB restricts inflammasome activation via elimination of damaged mitochondria. Cell. 2016;164(5):896–910.
   PubMed Web of Science ®Google Scholar
• Liu D, Perfettini JL, Brenner C. Mitochondrial regulation of cell death mitochondrial biology and experimental therapeutics. Cham: Springer; 2018. p. 75–90.
   Google Scholar
• Hong Duck M. Bcl-2 family proteins as regulators of cancer cell invasion and metastasis: a review focusing on mitochondrial respiration and reactive oxygen species. Oncotarget. 2016;7(5):5193.
   PubMedGoogle Scholar
• Ramierz MLG, Salvesen GS. A primer on caspase mechanisms Seminars in cell & developmental biology. Vol. 82. La Jolla, CA: Academic Press; 2018. p. 79–85.
   Google Scholar
• Fritsch M, Günther SD, Schwarzer R, et al. Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis. Nature. 2019;575(7784):683–687.
   PubMed Web of Science ®Google Scholar
• Huang X, Feng Y, Xiong G, et al. Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosis. Cell Biosci. 2019;9(1):31.
   PubMed Web of Science ®Google Scholar
• Li S, Qi Y, Hu S, et al. Mesenchymal stem cells-conditioned medium protects PC12 cells against 2, 5-hexanedione-induced apoptosis via inhibiting mitochondria-dependent caspase 3 pathway. Toxicol Ind Health. 2017;33(2):107–118.
   PubMed Web of Science ®Google Scholar
• Li CL, Leng Y, Zhao B, et al. Human iPSC‐MSC‐derived xenografts modulate immune responses by inhibiting the cleavage of caspases. Stem Cells. 2017;35(7):1719–1732.
   PubMed Web of Science ®Google Scholar
• Li L, Wang R, Jia Y, et al. Exosomes derived from mesenchymal stem cells ameliorate renal ischemic-reperfusion injury through inhibiting inflammation and cell apoptosis. Front Med (Lausanne). 2019;6:6.
   PubMed Web of Science ®Google Scholar
• Schneider KS, Groß C J, Dreier RF, et al. The inflammasome drives GSDMD-independent secondary pyroptosis and IL-1 release in the absence of caspase-1 protease activity. Cell Rep. 2017;21(13):3846–3859.
   PubMed Web of Science ®Google Scholar
• Liu Y, Li P, Qiao C, et al. Chitosan hydrogel enhances the therapeutic efficacy of bone marrow–derived mesenchymal stem cells for myocardial infarction by alleviating vascular endothelial cell pyroptosis. J Cardiovasc Pharmacol. 2020;75(1):75–83.
   PubMed Web of Science ®Google Scholar
• Isles HM, Herman KD, Robertson AL, et al. The CXCL12/CXCR4 signaling Axis retains neutrophils at inflammatory sites in zebrafish. Front Immunol. 2019;10:1784.
   PubMed Web of Science ®Google Scholar
• Hammad H, Lambrecht BN. Rbm7 in structural cells: a NEAT way to control fibrosis. Immunity. 2020;52(3):429–431.
   PubMed Web of Science ®Google Scholar
• Li Z, Wang W, Xu H, et al. Effects of altered CXCL12/CXCR4 axis on BMP2/Smad/Runx2/Osterix axis and osteogenic gene expressions during osteogenic differentiation of MSCs. Am J Transl Res. 2017;9(4):1680.
   PubMed Web of Science ®Google Scholar
• Xie L, Zhao L. Role of CXCL12/CXCR4-Mediated Circulating Fibrocytes in Pulmonary Fibrosis. Journal of Biomedicine. 2017;2:134–139.
   Google Scholar
• Zheng XB, He XW, Zhang LJ, et al. Bone marrow-derived CXCR4-overexpressing MSCs display increased homing to intestine and ameliorate colitis-associated tumorigenesis in mice. Gastroenterol Rep (Oxf). 2019;7(2):127–138.
   PubMed Web of Science ®Google Scholar
• Wang M, Lin T, Wang Y, et al. CXCL12 suppresses cisplatin-induced apoptosis through activation of JAK2/STAT3 signaling in human non-small-cell lung cancer cells. Onco Targets Ther. 2017;10:3215.
   PubMed Web of Science ®Google Scholar
• El Agha E, Kramann R, Schneider RK, et al. Mesenchymal stem cells in fibrotic disease. Cell Stem Cell. 2017;21(2):166–177.
   PubMed Web of Science ®Google Scholar
• Ma T, Fu B, Yang X, et al. Adipose mesenchymal stem cell‐derived exosomes promote cell proliferation, migration, and inhibit cell apoptosis via Wnt/β‐catenin signaling in cutaneous wound healing. J Cell Biochem. 2019;120(6):10847–10854.
   PubMed Web of Science ®Google Scholar
• Zhou X, Li T, Chen Y, et al. Mesenchymal stem cell-derived extracellular vesicles promote the in vitro proliferation and migration of breast cancer cells through the activation of the ERK pathway. Int J Oncol. 2019;54(5):1843–1852.
   PubMed Web of Science ®Google Scholar
• Ren S, Chen J, Duscher D, et al. Microvesicles from human adipose stem cells promote wound healing by optimizing cellular functions via AKT and ERK signaling pathways. Stem Cell Res Ther. 2019;10(1):47.
   PubMed Web of Science ®Google Scholar