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Research Paper

Targeting Forkhead box O1-aquaporin 5 axis mitigates neuropathic pain in a CCI rat model through inhibiting astrocytic and microglial activation

, , , , & ORCID Icon
Pages 8567-8580 | Received 05 Jan 2022, Accepted 02 Mar 2022, Published online: 24 Mar 2022

References

  • Szok D, Tajti J, Nyári A, et al. Therapeutic approaches for peripheral and central neuropathic pain. Behav Neurol. 2019;2019:8685954.
  • Jensen TS, Finnerup NB. Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms. Lancet Neurol. 2014;13(9):924–935.
  • Gilron I, Baron R, Jensen T. Neuropathic pain: principles of diagnosis and treatment. Mayo Clin Proc. 2015;90(4):532–545.
  • Peng S, Li W, Hou N, et al. A review of FoxO1-regulated metabolic diseases and related drug discoveries. Cells. 2020;9(1):184.
  • Liu D, Wan L, Gong H, et al. Sevoflurane promotes the apoptosis of laryngeal squamous cell carcinoma in-vitro and inhibits its malignant progression via miR-26a/FOXO1 axis. Bioengineered. 2021Dec;12(1):6364–6376. PMID: 34511023.
  • Li M, Liao H, Wu J, et al. Long noncoding RNA matrilineal expression gene 3 inhibits hepatocellular carcinoma progression by targeting microRNA-5195-3p and regulating the expression of forkhead box O1. Bioengineered. 2021Dec;12(2):12880–12890. PMID: 34895065.
  • Han C, Guo L, Sheng Y, et al. FoxO1 regulates TLR4/MyD88/MD2-NF-κB inflammatory signalling in mucosal barrier injury of inflammatory bowel disease. J Cell Mol Med. 2020;24(6):3712–3723.
  • Guo LT, Wang SQ, Su J, et al. Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway. J Neuroinflammation. 2019;16(1):95.
  • Dong H, Zhang X, Dai X, et al. Lithium ameliorates lipopolysaccharide-induced microglial activation via inhibition of toll-like receptor 4 expression by activating the PI3K/Akt/FoxO1 pathway. J Neuroinflammation. 2014;11:140.
  • Li X, Liu H, Yang Y. Magnesium sulfate attenuates brain edema by lowering AQP4 expression and inhibits glia-mediated neuroinflammation in a rodent model of eclampsia. Behav Brain Res. 2019;364:403–412.
  • Wu TT, Su FJ, Feng YQ, et al. Mesenchymal stem cells alleviate AQP-4-dependent glymphatic dysfunction and improve brain distribution of antisense oligonucleotides in BACHD mice. Stem Cells. 2020;38(2):218–230.
  • Lan YL, Zhao J, Ma T, et al. The potential roles of aquaporin 4 in Alzheimer’s disease. Mol Neurobiol. 2016;53(8):5300–5309.
  • Lan YL, Zou S, Chen JJ, et al. The neuroprotective effect of the association of Aquaporin-4/Glutamate transporter-1 against Alzheimer’s disease. Neural Plast. 2016;2016:4626593.
  • Han G, Ma L, Guo Y, et al. Hyperbaric oxygen therapy palliates lipopolysaccharide-induced acute lung injury in rats by upregulating AQP1 and AQP5 expression. Exp Lung Res. 2015;41(8):444–449.
  • Rana S, Shahzad M, Shabbir A. Pistacia integerrima ameliorates airway inflammation by attenuation of TNF-α, IL-4, and IL-5 expression levels, and pulmonary edema by elevation of AQP1 and AQP5 expression levels in mouse model of ovalbumin-induced allergic asthma. Phytomedicine. 2016;23(8):838–845.
  • Lv CM, Wu HM, Wu L, et al. Sevoflurane modulates AQPs (1,5) expression and endoplasmic reticulum stress in mice lung with allergic airway inflammation. Biosci Rep. 2019;39(11):BSR20193282.
  • Lee SM, Lee SW, Kang M, et al. FoxO1 as a regulator of Aquaporin 5 expression in the salivary gland. J Dent Res. 2021;100(11):1281–1288.
  • Gomes C, Ferreira R, George J, et al. Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia. J Neuroinflammation. 2013 Jan 30;10:16. PMID: 23363775.
  • Li J, Zhao Y, Shi J, et al. Histone deacetylase 6 interference protects mice against experimental stroke-induced brain injury via activating Nrf2/HO-1 pathway. Anim Cells Syst (Seoul). 2019 Apr 18;23(3):192–199. PMID: 31231583.
  • Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain. 1988;33(1):87–107.
  • Yang H, Wu L, Deng H, et al. Anti-inflammatory protein TSG-6 secreted by bone marrow mesenchymal stem cells attenuates neuropathic pain by inhibiting the TLR2/MyD88/NF-κB signaling pathway in spinal microglia. J Neuroinflammation. 2020;17(1):154.
  • Chu Y, Ge W, Wang X. MicroRNA-448 modulates the progression of neuropathic pain by targeting sirtuin 1. Exp Ther Med. 2019Dec;18(6):4665–4672. Epub 2019 Nov 4. PMID: 31807151.
  • Wu J, Wang C, Ding H. LncRNA MALAT1 promotes neuropathic pain progression through the miR 154 5p/AQP9 axis in CCI rat models. Mol Med Rep. 2020Jan;21(1):291–303. Epub 2019 Nov 20. PMID: 31746418.
  • Isami K, Haraguchi K, So K, et al. Involvement of TRPM2 in peripheral nerve injury-induced infiltration of peripheral immune cells into the spinal cord in mouse neuropathic pain model. PLoS One. 2013 Jul 30;8(7):e66410. PMID: 23935822.
  • Zhao Y, Xin Y, Chu H. MC4R is involved in neuropathic pain by regulating JNK signaling pathway after chronic constriction injury. Front Neurosci. 2019 Sep 10;13:919. PMID: 31551683.
  • Yan Z, Deng Y, Zou Y, et al. Analysis of regulatory effect of miR-149-5p on Sphingosine-1-phosphate receptor 2 of pericytes and its neuroprotective molecular mechanism after acute cerebral ischemia reperfusion in rats. Bioengineered. 2021Dec;12(1):3348–3357. PMID: 34224319.
  • Wang T, Zhang J, Li P, et al. NT-4 attenuates neuroinflammation via TrkB/PI3K/FoxO1 pathway after germinal matrix hemorrhage in neonatal rats. J Neuroinflammation. 2020;17(1):158.
  • Donnelly CR, Andriessen AS, Chen G, et al. Central nervous system targets: glial cell mechanisms in chronic pain. Neurotherapeutics. 2020Jul;17(3):846–860. PMID: 32820378.
  • Otto J, Forstenpointner J, Binder A, et al. Pharmakologische Therapie chronischer neuropathischer Schmerzen [Pharmacotherapy of chronic neuropathic pain]. Internist (Berl). 2019;60(7):711–723. German.
  • Ji RR, Donnelly CR, Nedergaard M. Astrocytes in chronic pain and itch. Nat Rev Neurosci. 2019;20(11):667–685.
  • Inoue K, Tsuda M. Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential. Nat Rev Neurosci. 2018;19(3):138–152.
  • Zhao H, Alam A, Chen Q, et al. The role of microglia in the pathobiology of neuropathic pain development: what do we know? Br J Anaesth. 2017;118(4):504–516.
  • Jiang BC, Cao DL, Zhang X, et al. CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5. J Clin Invest. 2016;126(2):745–761.
  • Lee JY, Choi HY, Ju BG, et al. Estrogen alleviates neuropathic pain induced after spinal cord injury by inhibiting microglia and astrocyte activation. Biochim Biophys Acta Mol Basis Dis. 2018;1864(7):2472–2480.
  • Ge Y, Wu F, Sun X, et al. Intrathecal infusion of hydrogen-rich normal saline attenuates neuropathic pain via inhibition of activation of spinal astrocytes and microglia in rats. PLoS One. 2014;9(5):e97436.
  • Doan KV, Kinyua AW, Yang DJ, et al. FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase. Nat Commun. 2016;7:12733.
  • You M, Miao Z, Tian J, et al. Trans-10-hydroxy-2-decenoic acid protects against LPS-induced neuroinflammation through FoxO1-mediated activation of autophagy. Eur J Nutr. 2020;59(7):2875–2892.
  • Zhang XL, Lai RC, Chen ZH, et al. FoxO1 selectively regulates static mechanical pain by interacting with Nav1.7. Pain. 2021;162(2):490–502.
  • Zhang J, Zheng Y, Luo Y, et al. Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2/ TLR4/ NF-κB pathways in BV2 cells. Mol Immunol. 2019Dec; 116: 29–37 Epub 2019 Oct 4. PMID: 31590042.
  • Zhang L, Liu Y, Wang S, et al. Vagus nerve stimulation mediates microglia M1/2 polarization via inhibition of TLR4 pathway after ischemic stroke. Biochem Biophys Res Commun. 2021 Nov 5;577:71–79. Epub 2021 Sep 3. PMID: 34507068.
  • Koh YC, Yang G, Lai CS, et al. Chemopreventive effects of phytochemicals and medicines on M1/M2 polarized macrophage role in inflammation-related diseases. Int J Mol Sci. 2018;19(8):2208.
  • He Y, Gao Y, Zhang Q, et al. IL-4 switches microglia/macrophage M1/M2 polarization and alleviates neurological damage by modulating the JAK1/STAT6 pathway following ICH. Neuroscience. 2020;437:161–171.
  • Xian S, Ding R, Li M, et al. LncRNA NEAT1/miR-128-3p/AQP4 axis regulating spinal cord injury-induced neuropathic pain progression. J Neuroimmunol. 2021;351:577457.
  • Wei H, Gao WS, Qi L, et al. Effect of cGMP-activated aquaporin 1 on TRPV4 in rats with allodynia induced by chronic compression of the dorsal root ganglion. Neurosci Lett. 2020;716:134630.
  • Fukuda AM, Badaut J. Aquaporin 4: a player in cerebral edema and neuroinflammation. J Neuroinflammation. 2012;9:279.
  • Buffoli B, Borsani E, Rezzani R, et al. Chronic constriction injury induces aquaporin-2 expression in the dorsal root ganglia of rats. J Anat. 2009;215(5):498–505.
  • Wu J, Wang C, Ding H. LncRNA MALAT1 promotes neuropathic pain progression through the miR 154 5p/AQP9 axis in CCI rat models. Mol Med Rep. 2020;21(1):291–303.
  • Chai RC, Jiang JH, Wong AY, et al. AQP5 is differentially regulated in astrocytes during metabolic and traumatic injuries. Glia. 2013;61(10):1748–1765.
  • Kondo M, Shibuta I. Extracellular signal-regulated kinases (ERK) 1 and 2 as a key molecule in pain research. J Oral Sci. 2020;62(2):147–149.
  • Obata K, Yamanaka H, Kobayashi K, et al. Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation. J Neurosci. 2004;24(45):10211–10222.
  • Jin SX, Zhuang ZY, Woolf CJ, et al. p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. J Neurosci. 2003;23(10):4017–4022.
  • Yang J, Zhang JN, Chen WL, et al. Effects of AQP5 gene silencing on proliferation, migration and apoptosis of human glioma cells through regulating EGFR/ERK/ p38 MAPK signaling pathway. Oncotarget. 2017;8(24):38444–38455.