Advanced search
Publication Cover
Bioengineered Volume 13, 2022 - Issue 4
Submit an article Journal homepage
1,386
Views
2
CrossRef citations to date
0
Altmetric
Research Paper

Hyperoside exerts osteoprotective effect on dexamethasone-induced osteoblasts by targeting NADPH Oxidase 4 (NOX4) to inhibit the reactive oxygen species (ROS) accumulation and activate c-Jun N-terminal kinase (JNK) pathway

Siqi Fana Department of Orthopedics and Traumatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, ChinaView further author information
,
Haida Panb Research Student Academy, Guangxi University of Traditional Chinese Medicine, Nanning, ChinaView further author information
,
Jiaxing Huangc Yulin Orthopedics Hospital of Chinese and Western Medicine, Yulin, ChinaView further author information
,
Zhiqiang Leid Emergency Department, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, ChinaView further author information
&
Jinfu Liua Department of Orthopedics and Traumatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, ChinaCorrespondence[email protected]
View further author information
Pages 8657-8666 | Received 30 Dec 2021, Accepted 11 Mar 2022, Published online: 24 Mar 2022

References

  • Wu X, Sun W, Tan M. Noncoding RNAs in Steroid-Induced Osteonecrosis of the Femoral Head. Biomed Res Int. 2019;2019:8140595.
  • Wang A, Ren M, Wang J. The pathogenesis of steroid-induced osteonecrosis of the femoral head: a systematic review of the literature. Gene. 2018;671:103–109.
  • Chang C, Greenspan A, Gershwin ME. The pathogenesis, diagnosis and clinical manifestations of steroid-induced osteonecrosis. J Autoimmun. 2020;110:102460.
  • Zhan J, Yan Z, Zhao M, et al. Allicin inhibits osteoblast apoptosis and steroid-induced necrosis of femoral head progression by activating the PI3K/AKT pathway. Food Funct. 2020;11(9):7830–7841.
  • Wei A, Song Y, Ni T, et al. Hyperoside attenuates pregnancy loss through activating autophagy and suppressing inflammation in a rat model. Life Sci. 2020;254:117735.
  • Qiu J, Zhang T, Zhu X, et al. Hyperoside Induces Breast Cancer Cells Apoptosis via ROS-Mediated NF-κB Signaling Pathway. Int J Mol Sci. 2019;21(1):131.
  • Huang J, Tong X, Zhang L, et al. Hyperoside Attenuates Bleomycin-Induced Pulmonary Fibrosis Development in Mice. Front Pharmacol. 2020;11:550955.
  • Zhang N, Ying MD, Wu YP, et al. Hyperoside, a flavonoid compound, inhibits proliferation and stimulates osteogenic differentiation of human osteosarcoma cells. PloS one. 2014;9(7):e98973.
  • Chen Y, Dai F, He Y, et al. Beneficial effects of hyperoside on bone metabolism in ovariectomized mice. Biomed Pharmacothe. 2018;107:1175–1182.
  • Xu T, Wu X, Zhou Z, et al. Hyperoside ameliorates periodontitis in rats by promoting osteogenic differentiation of BMSCs via activation of the NF-κB pathway. FEBS Open Bio. 2020;10(9):1843–1855.
  • Yan Z, Zhan J, Qi W, et al. The Protective Effect of Luteolin in Glucocorticoid-Induced Osteonecrosis of the Femoral Head. Front Pharmacol. 2020;11:1195.
  • Kuang MJ, Zhang WH, He WW, et al. Naringin regulates bone metabolism in glucocorticoid-induced osteonecrosis of the femoral head via the Akt/Bad signal cascades. Chem Biol Interact. 2019;304:97–105.
  • Wang XY, Gong LJ, Huang JM, et al. Pinocembrin alleviates glucocorticoid-induced apoptosis by activating autophagy via suppressing the PI3K/Akt/mTOR pathway in osteocytes. Eur J Pharmacol. 2020;880:173212.
  • Peng P, Nie Z, Sun F, et al. Glucocorticoids induce femoral head necrosis in rats through the ROS/JNK/c-Jun pathway. FEBS Open Bio. 2021;11(1):312–321.
  • Fan ZQ, Bai SC, Xu Q, et al. Oxidative Stress Induced Osteocyte Apoptosis in Steroid-Induced Femoral Head Necrosis. Orthop Surg. 2021;13(7):2145–2152.
  • Farnsworth NR, Wagner H, Hörhammer L, et al. Aster pilosus (Compositae). I. Isolation of hyperoside (quercetin-3-beta-D-mono-galactoside) from the leaves. J Pharm Sci. 1968;57(6):1059–1061.
  • Li S, Zhang Z, Cain A, et al. Antifungal activity of camptothecin, trifolin, and hyperoside isolated from Camptotheca acuminata. J Agric Food Chem. 2005;53(1):32–37.
  • Wong RW, Rabie AB. Traditional Chinese medicines and bone formation–a review. J Oral Maxillofacial Surg. 2006;64(5):828–837.
  • Che CT, Wong MS, Lam CW. Natural Products from Chinese Medicines with Potential Benefits to Bone Health. Molecules (Basel Switzerland). 2016;21( 3):239.
  • Jang HO, Park YS, Lee JH, et al. Effect of extracts from safflower seeds on osteoblast differentiation and intracellular calcium ion concentration in MC3T3-E1 cells. Nat Prod Res. 2007;21(9):787–797.
  • Choi EM. Deoxyactein stimulates osteoblast function and inhibits bone-resorbing mediators in MC3T3-E1 cells. J Appl Toxicol. 2013;33(3):190–195.
  • Kim J, Lee H, Kang KS, et al. Cordyceps militaris mushroom and cordycepin inhibit RANKL-induced osteoclast differentiation. J Med Food. 2015;18(4):446–452.
  • Zalavras CG, Lieberman JR. Osteonecrosis of the femoral head: evaluation and treatment. J Am Acad Orthop Surg. 2014;22(7):455–464.
  • Boyce BF, Xing L. Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys. 2008;473(2):139–146.
  • Huang C, Gan D, Luo F, et al. Interaction Mechanisms Between the NOX4/ROS and RhoA/ROCK1 Signaling Pathways as New Anti- fibrosis Targets of Ursolic Acid in Hepatic Stellate Cells. Front Pharmacol. 2019;10:431.
  • Deng S, Zhou JL, Fang HS, et al. Sesamin Protects the Femoral Head From Osteonecrosis by Inhibiting ROS-Induced Osteoblast Apoptosis in Rat Model. Front Physiol. 2018;9:1787.
  • Liu Z, Tao X, Zhang C, et al. Protective effects of hyperoside (quercetin-3-o-galactoside) to PC12 cells against cytotoxicity induced by hydrogen peroxide and tert-butyl hydroperoxide. Biomed Pharmacothe. 2005;59(9):481–490.
  • Suzuki M, Bandoski C, Bartlett JD. Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling. Free Radic Biol Med. 2015;89:369–378.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.